[PDF] Top 20 CDH1 mutations in gastric cancer patients from northern Brazil identified by Next- Generation Sequencing (NGS)
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CDH1 mutations in gastric cancer patients from northern Brazil identified by Next- Generation Sequencing (NGS)
... Gastric cancer is considered to be the fifth highest incident tumor worldwide and the third leading cause of cancer ...of gastric cancer in Brazil to confirm this fact. ... See full document
10
Identification of a comprehensive spectrum of genetic factors for hereditary breast cancer in a Chinese population by next-generation sequencing.
... breast cancer has not been fully elucidated. Although germ- line mutations of high-penetrance genes such as BRCA1/2 are implicated in development of hereditary breast cancers, at least half of all ... See full document
20
SubClonal Hierarchy Inference from Somatic Mutations: Automatic Reconstruction of Cancer Evolutionary Trees from Multi-region Next Generation Sequencing.
... configurations. In cases where muta- tion cluster cellularities were available [13], we used the hypothesis test on pairs of mutation clus- ...described in (S1 ...consistently identified phylogenies ... See full document
26
Somatic mutation profiles of MSI and MSS colorectal cancer identified by whole exome next generation sequencing and bioinformatics analysis.
... MMR. In addition, survival advantages and therapeutic consequences have been reported for patients with MSI tumors ...ultradeep sequencing of one conserved region, UCR41, de Grassi and colleagues ... See full document
10
Application of Next-generation Sequencing in Clinical Molecular Diagnostics
... modifications in gene activity and expression that occur without alteration in DNA sequence 38-40 ...regulated by two major epigenetic modifications: histone modifications and DNA methylation 38-40 ... See full document
15
Differential expression in “rogue” paramutation in peas (Pisum sativum L.): - from mRNA to siRNA
... provided by the manufacturer. Total RNA was resuspended in 500 μl Rnase free water in two sterile RNase-free ...resuspended by gently flicking the bottom of the tube until they were completely ... See full document
62
Identification and characterization of microRNAs in normal equine tissues by Next Generation Sequencing.
... miRNAs in major organs including liver, skeletal muscle, and large intestine has significant clinical relevance to important equine ...resulting from numerous factors including strangulation, obstruction ... See full document
10
Dissecting Genomic Aberrations in Myeloproliferative Neoplasms by Multiplex-PCR and Next Generation Sequencing.
... found in the 48 genes that were sequenced ranged from 2 to 6 in the different samples (S1 ...Table). Sequencing of the CML-BC cell line K562 confirmed the presence of a previously described ... See full document
18
VEZT, a novel putative tumor suppressor, suppresses the growth and tumorigenicity of gastric cancer.
... was identified as a putative tumor suppressor in our previous ...VEZT in tumorigenesis remains ...functions in gastric cancer. In this study, we show that the expression ... See full document
14
The fate of duplicate genes in plants
... are in fact paleopolyploids; that is, they descend from an ancient polyploid ancestor (Bowers et ...inferiority in the population, and exceed their parental species (Otto and Whitton ...which ... See full document
126
An integrated inspection of the somatic mutations in a lung squamous cell carcinoma using next-generation sequencing.
... substitution in LUDLU-1 is likely to lead to p53 ...ortholog in mice, does not directly cause cancer but increases the likelihood of spontaneous tumour formation [51] owing to defective DNA repair or ... See full document
8
Leukemia gene atlas--a public platform for integrative exploration of genome-wide molecular data.
... data by researchers is severely hampered by the lack of accessible integrative tools for viewing and ...published in the field of ...data from more than 5,800 leukemia and hematopoiesis ... See full document
7
Whole exome analysis identifies frequent CNGA1 mutations in Japanese population with autosomal recessive retinitis pigmentosa.
... performed by using the Agilent Bravo automated liquid-handling platform with SureSelect XT Human All Exon kit V4+ UTRs kit (Agilent Technologies, Santa Clara, ...sequenced by using an Illumina HiSeq2000 ... See full document
9
Targeted Next-Generation Sequencing Identifies a Recurrent Mutation in MCPH1 Associating with Hereditary Breast Cancer Susceptibility.
... MCPH1 in DNA damage response, we determined the impact of ...assessed by chromosomal analysis [15] in non- transformed peripheral blood lymphocytes of 7 mutation carriers negative for other known ... See full document
14
Arq. Gastroenterol. vol.38 número4
... collected from the two groups was placed in flasks with formol buffered at 10%, for fixing, and was then processed for histological examination and set into paraffin ... See full document
7
Development of Molecular Markers for Determining Continental Origin of Wood from White Oaks (Quercus L. sect. Quercus).
... [4]). In plants, the suc- cess of barcoding is highly dependent on several factors, including magnitude of primary diver- gence, frequency of secondary contact, and mutation rate of the DNA region [5], so the ... See full document
15
Unveiling distribution patterns of freshwater phytoplankton by a next generation sequencing based approach.
... dataset from 46 lakes revealed a clear separation of the phytoplankton communi- ties from lakes of different trophy suggesting that this metric has potential as a tool for water quality status ...problems ... See full document
10
João Paulo MENDES Jr.5 and Heloísa Prado SOARES6
... stomach cancer in the northern region of Brazil and the recognized relationship between chronic gastric inflammation caused by Helicobacter pylori, and its carcinogenic ... See full document
7
Quantifying Next Generation Sequencing Sample Pre-Processing Bias in HIV-1 Complete Genome Sequencing
... steps in the viral life cycle [18]. In recognition of this need, studies that combine both the full genome and deep sequencing dimensions have already been reported ...deep sequencing ... See full document
14
Probing the SELEX process with next-generation sequencing.
... behavior by a fluorescent dye-linked aptamer assay (FLAA) ...stringency in the course of the selection, a strong increase yield of PCR product was observed (see Table ...detected by FLAA until round ... See full document
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