[PDF] Top 20 Nef-specific CD8+ T cell responses contribute to HIV-1 immune control.
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Nef-specific CD8+ T cell responses contribute to HIV-1 immune control.
... of HIV infection suggest that Nef-specific CD8+ T-cell responses may mediate highly effective immune control of ...In HIV infection Nef ... See full document
10
A candidate HIV/AIDS vaccine (MVA-B) lacking vaccinia virus gene C6L enhances memory HIV-1-specific T-cell responses.
... and to investigate the possible immunomodulatory role of C6L we have removed from the MVA-B viral genome the C6L gene, generating the deletion mutant termed MVA-B ...four HIV-1 antigens (Env, Gag, ... See full document
14
Influenza-specific T cells from older people are enriched in the late effector subset and their presence inversely correlates with vaccine response.
... 1.4 to 16.7 deaths per 100 000 people occur annually due to influenza infections or related complications in the United States ...a specific strain, these antibody responses are generally not ... See full document
13
Unexpected Diversity of Cellular Immune Responses against Nef and Vif in HIV-1-Infected Patients Who Spontaneously Control Viral Replication
... method to assess CD8+ T cell responses to HIV-1 by measuring intracellular cytokine production, Betts et ...compared responses to HIV-1 ... See full document
9
Autologous HIV-1 clade-B Nef peptides elicit increased frequency, breadth and function of CD8+ T-cells compared to consensus peptides.
... on to control virus replication, disappeared in chronic infection (day 372), whereas the early response to peptide 5167 (WVYHTQGYFPDWQNY); which had identical consensus and autologous sequences in ... See full document
11
Cross-reactivity of anti-HIV-1 T cell immune responses among the major HIV-1 clades in HIV-1-positive individuals from 4 continents
... Pol, Nef, and Env proteins as the most common HIV- 1 antigen targets for CTL responses, whereas other studies have emphasized the importance of Rev and Tat responses ...cross-clade ... See full document
8
Neuroantigen-specific autoregulatory CD8+ T cells inhibit autoimmune demyelination through modulation of dendritic cell function.
... into CD8+CD11c+ lymphoid and CD11b+CD11c+ myeloid ...reported to play distinct roles in both immunity and in maintaining immune tolerance ...ability to support CD4+ T cell ... See full document
10
Subdominant/Cryptic CD8 T Cell Epitopes Contribute to Resistance against Experimental Infection with a Human Protozoan Parasite
... than control mice injected with pcDNA3/Adb-gal ...and control mice were challenged by the ...5. CD8 immune responses in A/Sn mice immunized with asp-2 using the heterologous DNA ... See full document
12
Effect of maraviroc intensification on HIV-1-specific T cell immunity in recently HIV-1-infected individuals.
... virus-specific T cells has also be linked to the availability of cognate ...lead to extended presence of cells. As shown in previous analyses, not all HIV-specific T ... See full document
11
Superior control of HIV-1 replication by CD8+ T cells targeting conserved epitopes: implications for HIV vaccine design.
... of HIV-1 clade-B amino acid sequences (bCSp) in the LANL DB that include the exact ...in HIV infection 60% (73 out of 123), were variable, and only 13% (16 out of 123) were conserved (Figure ... See full document
13
Interferon-alpha administration enhances CD8+ T cell activation in HIV infection.
... isotype control antibodies were used to establish background staining and ...used to establish back- ground staining and proper gating of cells expressing this ...of immune activation by ... See full document
8
A DNA Vaccine Encoding Multiple HIV CD4 Epitopes Elicits Vigorous Polyfunctional, Long-Lived CD4(+) and CD8(+) T Cell Responses
... able to induce Th1 cytokines. In order to analyze the vaccine induced cytokine secretion profile of BALB/c splenocytes incubated with the pooled HIV-1 peptides, we used the cytometric bead ... See full document
13
HIV-1 AND CD4 T CELL VESICLE EXOCYTOSIS
... remains to be determined. It is pos- sible that, akin to cytotoxic CD8 T cells, vesicle transfer occurs through the immunological synapse itself ...released to the extracellular space ... See full document
5
Vaccine efficacy against malaria by the combination of porcine parvovirus-like particles and vaccinia virus vectors expressing CS of Plasmodium.
... fused to the 59-end of the gene coding for PPV VP2 capsid ...1B. To study the ability of PPV-PYCS to induce a specific anti-CS T cell immune response, and to test ... See full document
10
Strong HIV-1-Specific T Cell Responses in HIV-1-Exposed Uninfected Infants and Neonates Revealed after Regulatory T Cell Removal
... was to measure HIV-1-specific T cell immune responses at the time of delivery and within the first year of ...wanted to establish whether these ... See full document
10
Cytotoxic T cell adjuvant effects of three Salmonella enterica flagellins
... cellular immune responses, has received considerable attention by several research groups dealing with vaccine ...fused to the target antigen (4,7). So far, the specific mechanisms by which ... See full document
6
Dendritic cells exposed to MVA-based HIV-1 vaccine induce highly functional HIV-1-specific CD8(+) T cell responses in HIV-1-infected individuals.
... lead to rRNA breakdown and apoptosis [18]. Thus, we next sought to precisely characterize the effects on the MDDC viability following MVA-B ...of cell viability was performed by flow cytometry ... See full document
17
Candida albicans Targets a Lipid Raft/Dectin-1 Platform to Enter Human Monocytes and Induce Antigen Specific T Cell Responses.
... impair immune recognition of ...believed to con- tribute both to its protective and toxic effects [63], but the ability to inhibit phagocytosis and antigen specific T cell ... See full document
18
Immunopathology in ocular toxoplasmosis: facts and clues
... host cell lysis is deemed to be an important cause of tissue destruction in ocu- lar toxoplasmosis (OT), the severity of the disease is probably correlated with hypersensitivity and ...autoimmune ... See full document
10
IMPACT OF MALNUTRITION ON IMMUNITY AND INFECTION França TGD (1), Ishikawa LLW (1), Zorzella-Pezavento SFG (1), Chiuso- Minicucci F (1), da Cunha MLRS (1), Sartori A (1)
... There is also a general consensus that PEM is associated with greater malaria morbidity and mortality in humans (65). Supporting this observation, controlled clinical trials of either vitamin A or zinc supplementation ... See full document
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