[PDF] Top 20 Neuropathology in mice expressing mouse alpha-synuclein.

... aSN in Thy1-maSN mice, we perfomed solubility assays (see ...3–5 mice were pooled, yielding matched starting tissue wet weight of ...homogenized in Tris buffer, and the buffer-insoluble ... See full document

... neurogenesis in the murine tg mThy1 WTS model due to changed differentiation but not survival of newly generated ...deficits in these ...kinetics in different WTS tg mice points beyond a ... See full document

... The neuropathology of Parkinson’s disease (PD) includes loss of dopaminergic neurons in the substantia nigra, nitrated a-synuclein (N-a-Syn) enriched intraneuronal inclusions or Lewy bodies and ... See full document

... Syn-GFP mouse mimics human duplication and triplication mutations to model cellu- lar changes that occur due to 2-3-fold over-expression of ...microaggregates in presynaptic terminals, but not cell bodies, ... See full document

... recombinant mouse -syn fibrils in the dorsal striatum of young wt mice induced pathological -syn transformation leading to motor deficits ...described in another study comparing the effect ... See full document

... analysis in total mouse brain ...peptides in red and aSyn peptides in ...cells expressing the indicated proteins were lysed and immunoprecipitated (IP) with anti-aSyn (left panels) or ... See full document

... standards. Mice were maintained on a B6/C3H background. All animals were housed in their home cages and maintained on a reverse day/night cycle by artificially changing the light of the ...animals in ... See full document

... demonstrates in vivo co-localization and accumulation of a-Syn, p-Tau and p-GSK-3b into aggregates, as evidenced from immunohistochemical staining of striatal slices from A53T ...change in p-Tau, defined by ... See full document

... Proteins involved in reverse cholesterol transport (RCT) can markedly modify the turnover rate of HDL-cholesterol and the development of atherosclerosis. RCT is an efficient mechanism for removing excess ... See full document

... variability in a-Syn-nAbs-related OD measurement has previously been reported between three independent assays of the same serum sample ...differences in a-Syn coating on the inter-assay ...differences ... See full document

... differing in stimulation intensity, to explore whether A53T overexpression modified DA re-release in ...Release in a mild paired-pulse paradigm was not different between genotypes but following a ... See full document

... scattered in both the dorsomedial and ventrolateral SCN (see Figure 7A and [15,17,20]), which are two functionally and morphologically distinct sub-regions that are frequently recognized as vasopressin- (AVP) or ... See full document

... decrease in the numbers of a4b2 nicotinic acetylcholine receptors (a4b2-nAChRs) in PD patients suggests an a4b2-nAChR-mediated cholinergic deficit in ...involved in the pathogenesis of PD, ... See full document

... evaluated in DMD. In eleven DMD patients treated with diethylstilbestrol, a reduction in the levels of CK and LDH was observed with no analysis of the muscular strength parameters ... See full document

... created alpha-synuclein variants with cysteine instead of alanine at the C-terminal position ...done in a freshly prepared working protein solution in PBS pretreated with DTT to minimize ... See full document

... shRNAs in adeno-associated virus vectors were unilaterally injected into the rat substantia nigra pars compacta ...neurons. In the present study, the effects of siRNA directed against a-synuclein ... See full document

... impairments in Q58 PCs have also been reported, nearly concomitant with the onset of behavioral anomalies, suggesting that the burst firing of these neurons is directly linked with the ataxic symptoms (Kasumu et ... See full document

... aggregation in cells, it does not provide information regarding the changes in the oligomerization of ...a-syn in SHSY5Y cells. WT a-syn expression in SHSY5Y cells was mainly eluted at a major ... See full document

... used mouse models for EOAD are based on the overexpression of mutant forms of human APP, presenilins or a combination of both ...observed in human patients ...mutations in APP, or APP processing ... See full document

... especially in the area of the medicine and ...fragrances. In addition, many of them are found to exhibit varied biologic properties (Craveiro et ...present in many essential oils possess ... See full document