... 5-Substituted-naphtho[2,1- b ]furan-2-carboxylic acids (3a- c): 2-Ethyl naphtho[2,1-b]furan 2-carboxylate was dissolved in methanol and mixed with 10% NaOH solution. The mixture was refluxed for 2h. After the ...
... The formation of alcohol (2a-b) from ester (1a-b) was confirmed by mass, IR and NMR. In the mass spectrum of 2a, the molecular ion peak appeared at m/z 197. The IR spectrum of 2a has shown broad absorption band ...
... literature studies revealed that Mannich bases are very reactive and can be easily converted to other compounds, for example, reduced to form physiologically active amino alcohols 1 ...
... 5- substituted thiouracils possess chemotherapeutic activity against cancer cells as well as antifungal, antiviral and antiparasitic ...cancerostatic. Studies have shown that arylazo groups are active in ...
... functional group are crucial in medicinal chemistry for the design of drugs with a broad spectrum of biological ...Industrially, sulphonamides are useful in the production of some health products, ...
... ongoing studies in developing new antimicrobials, a novel series of N-(1, 3-benzothiazol-2-yl)- 2-[(2Z)-2-(substituted arylidene) hydrazinyl] acetamide (5a–j) was synthesized in order to determine ...
... of some new substituted pyrazolone derivatives containing different functional groups have been synthesized by the condensation reaction of 2-methoxy-5-methyl ethyl aceto hydrazone (1a) and different ...
... preparation, characterization and pharmacological evaluation of bis heterocycles containing piperidine moiety in combination with N- ...the synthesis is shown in Scheme ...
... A series of 3-[(2,4-Dinitro phenyl)-(substituted amino)-1-ylmethyl-amino]-2-substituted phenyl-5-(3,4,5-trimethoxy benzylidene)-3,5-dihydro-imidazol-4-one derivatives were synthesized by the condensation of ...
... clinically useful DNA-intercalating agents involves the inhibition of the enzyme DNA- topoisomerase I or II. Several detailed SAR studies of acridine-based DNA-intercalating agents suggest that the mode of binding ...
... the synthesis of different heterocyclic scaffolds such as 1, 3, 4-oxadiazolines, azetidin-2-ones, coumarins, 1, 3-thiazolidin-4-ones and 1,3-benzothiazin-4-ones ...activities. Some widely used antibacterial ...
... The antimicrobial activity of the ligand and itsCu(II) metal complexes were assayed against Gram- positive and Gram-negative ...of antimicrobial activity are summarized in Table 3 and ...
... N-1 substituted fluoroquinolonic derivatives were synthesized and evaluated for antimicrobial and antioxidant ...sulphonyl substituted derivatives of the title compounds have been synthesized to ...
... Antimicrobial screening of synthesized pyrozolines compounds (I-X) was conducted by using cup plate method [20-21] at a concentration of 100µ g/ml. The compound were evaluated for antibacterial activity against ...
... M.Ps. reported are uncorrected and were recorded on ‘Tempo’ melting point apparatus. The purity of the compounds synthesized was tested by TLC on microscopic slides with silica gel-G layers. The Infra red spectra were ...
... ring. PMR spectrum of the compound exhibited signals of propyl side chain, a triplet at d1.04 due to methyl group, sextet for methylene at d1.77 and triplet at d 2.68 for another methylene. Compound 2g, in its IR ...
... The newly synthesized pyrazoline derivatives exhibited moderate to promising antimicrobial activity against standard strains. This class of compounds certainly holds great promise to discover novel classes ...
... of substituted acetophenone with thiosemicarbazone in the presence of hot ...as antimicrobial, antifungal, antiviral, insecticides, and antitumor ...
... benzothiophene substituted 1,3,4-oxadiazole derivatives substituted at 2 and 5 positions were synthesized and evaluated for their antibacterial and antifungal ...
... invitro antimicrobial activity of test compounds were assessed against 24 hr cultures of several selected bacteria and ...The antimicrobial activity was performed by broth dilution method in ...