[PDF] Top 20 Orthologous microRNA genes are located in cancer-associated genomic regions in human and mouse.

... (miRNAs) are short non-coding RNAs that regulate differentiation and development in many organisms and play an important role in ...various mouse models of cancer we ... See full document

... seven regions of known differential methylation in human ...involved in regulating the DLK1/MEG3 imprinted domain on chromosome ...DMR and the MEG3 DMR), one at the MEST promoter at ... See full document

... mutations in miRNA genes contribute to altered miRNA activity in ovarian cancer, 86 primary epithelial ovarian tumors were assessed for somatic mutations in genomic ... See full document

... Japan), and dissolved in nuclease-free water (Life Technologies Corporation, Carlsbad, CA, USA) containing 1 mM DTT (Promega Corporation, Tokyo, Japan) and ...s, and annealing and ... See full document

... role in regulating the expression of the miR-200c/141 cluster (Vrba et ...was associated with almost all cancer types and other targets were described, however the main action of this miRNA ... See full document

... structural and numerical variations ...state and genome structural variation have recently come to light in cancer cells, where disrupted methylation patterns are common ...blocks ... See full document

... a human RNA helicase from the DEAD-box family, was cloned and charac- terized based on similarity to a yeast ortholo- gous gene ...the human genomic sequence and to predict gene ... See full document

... more genes related to sex and reproduction than we would be expected by chance ...critical genes responsible for placental and normal fetal development, including PLAC1 gene [2], which ... See full document

... double-minutes, and a presence of susceptible genomic ...suppressive genes, Cav1 [58,59] and ST7 [60], surrounded the Met locus ...mutation and chromosomal ...corresponding human ... See full document

... change in this study was not found to be accompanied by gene expression change for all of the studied ...changes are important in stem cell commitment to differentiated cells ...change in ... See full document

... early in 2005 (Shastri and Morgan, 2005) and only included the evaluation of central metabolic pathways, under different light and media conditions ...mixotrophic, and heterotrophic). ... See full document

... apoptosis and the high demands imposed on protein synthesis by hemoglobin accumulation [7, 18, ...number and activity appear to be heavily modulated during physiologi- cal terminal erythroid ... See full document

... cases associated with a known genetic ...factors are implicated in the etiology of the ...perturbations in the molecular processes that precede the beginning of heart development might also be ... See full document

... resulting in the elimination of one of the strands, leaving the mature single-stranded miRNA associated with the effector protein Ago, as shown in figure ...miRNA and the mRNA is more ... See full document

... [18] in addition to a well developed DNA molecular marker resource, Populus has mature genomic resources that should allow for in- depth characterization of loci of ...of genes, candidate gene ... See full document

... tips and micropipettes during endoscopic examination under general anesthesia with ...placed in pre-chilled 1.5-ml microcentrifuge tubes con- taining and equal volume of Saliva protect reagent ... See full document

... breast cancer cases (41 invasive and 8 in situ) in the CCSS ...Test and reference DNA (from Promega, Madison, WI) were labeled with Cy5 and Cy3, respectively, and ... See full document

... pAmpC-encoding genes are often located on large plasmids, which are associated with mul- tidrug resistance ...identified in the present study also harboured an ESBL ...mechanisms ... See full document

... variation in their recent divergence and evolution, suggesting that a small accumulation of genic changes, following a Bateson-Dobzhansky-Muller (BDM) model, might be involved in the establishment of ... See full document

... hour in human cells. Mitosis can be divided in 6 stages: prophase, prometaphase, metaphase, anaphase, telophase and ...chromosomes and the two Microtubule Organizing Centres (MTOCs), ... See full document