[PDF] Top 20 P-glycoprotein and Its Role in Treatment Resistance

... çalışmalarda P-gp’nin beyin kapiller endotel hücrelerinde ve ayrıca BOS’u üreten sıkı kavşaklı koroid pleksus epitel hücrelerinde yüksek oranda eksprese edildiği gösterilmiş- tir (Urquhart ve Kim 2009, Fromm ... See full document

... evaluated and also paranasal patholo- gies that may lead to nasolacrimal canal stenosis may be detected with CT-dacryocytography ...dacryocystography. In this way, de- velopment of an iatrogenic trauma that ... See full document

... transport in platinum resistance (Figure ...reduced in IGROVCDDP in response to cisplatin drug treatment (Figure 2C), which may contribute to the decrease in platinum ... See full document

... Drug resistance is one of the main hurdles for the successful treatment of breast ...apoptosis resistance and survival signal transduction pathways may be a promising approach to overcome drug ... See full document

... increase in the biosynthesis of 17-hydro- xypregnenolone, dehydroepiandrosterone, progesterone and tetra- hydroprogesterone and a decrease in the production of dihydroprogesterone (do Rego et ... See full document

... cancer and healthy cells, which induce severe systemic toxicity and produce drug ...nanotechnology in cancer therapy is the specific targeting of malignant cells while sparing the healthy ...cells ... See full document

... 2+ and regulated by cAMP- dependent protein kinases. For its part, the so-called acid trehalase (optimum pH about ...We and others have previously demonstrated that the enzymes involved in the ... See full document

... serious and life-threatening diseases presents a difficult challenge for clinicians, especially when an appropriate initial therapy must be ...pneumoniae and multidrug-resistant Gram-negative ...of ... See full document

... the role of GSK3A in colon carcinoma cells we first established a stable cell line depleted of the protein by transducing drug-resistant HCT116p53KO cells with retroviruses expressing shRNAs to GSK3A ... See full document

... After treatment, cells were fixed with a ...solution in PBS for ten ...disruption and antibody access entry into the ...4ºC and followed by three washes (five minutes each) with ...minutes ... See full document

... hosts and the ...characterised and their role in determining spore architecture and spore function is still poorly ...altered resistance properties, and coats appear ... See full document

... material and offers wide range of mechanical properties with simultaneous high wear resistance and dumping capacity ...that in many cases production of ductile iron ensure fulfillment the ... See full document

... sharing its clinical, immunological and pathological characteristics ...inflammation in MS and EAE involve generation of autoreactive, myelin specific T helper (Th) cells in the ... See full document

... A resistência a múltiplas drogas (MDR) é um grande problema na terapia do câncer. Esta é um tipo de resistência adquirida, mas que pode ser revertida por fármacos ou drogas conhecidos como moduladores, reversores ou, ... See full document

... interest in melatonin all over the ...biological and physiological processes of the ...system and body tempera- ture regulation are other tasks of ...with its lipophilic property, is the most ... See full document

... rado and the decoction of its roots has been used by folk medicine for the therapy of inflammatory ...diseases. In this study we aimed to investigate the effect of the dichloromethane–ethanolic ... See full document

... disorders and it is estimated to affect more than 50 million people worldwide (P ERUCCA 2001; G ALANOPOULOU ET AL ...though, and besides the fact of more than twenty AEDs are today clinically ... See full document

... the P-gp transporter, including verapamil, cyclosporin (cyclosporin A), tamoxifen, and several calmodulin antagonists, were identified in the ...results in vivo because their low binding ... See full document

... alloy in modern cored wire injection method for production of nodular and vermicular graphite cast irons were ...a treatment method which can be used to process The injection of Mg cored wire length ... See full document

... management and data mining are still in the development phase and they represent interest- ing areas for ...management in the context of marketing, there are critical research chal- lenges ... See full document