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[PDF] Top 20 Phosphatidylinositol 3-Kinase γ is required for the development of experimental cerebral malaria.

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Phosphatidylinositol 3-Kinase γ is required for the development of experimental cerebral malaria.

Phosphatidylinositol 3-Kinase γ is required for the development of experimental cerebral malaria.

... Experimental cerebral malaria (ECM) is characterized by a strong immune response, with leukocyte recruitment, blood-brain barrier breakdown and hemorrhage in the central ner- vous ... See full document

13

Uncovering the role of IFNAR1 in Experimental Cerebral malaria

Uncovering the role of IFNAR1 in Experimental Cerebral malaria

... experiments. The irradiated parasite is unable to re-invade RBC, and therefore (exposed) donor mice do not develop parasitemia or ...analyzed the T cell profiles of C57BL/6 mice that received ... See full document

162

Cognitive dysfunction is sustained after rescue therapy in experimental cerebral malaria, and is reduced by additive antioxidant therapy.

Cognitive dysfunction is sustained after rescue therapy in experimental cerebral malaria, and is reduced by additive antioxidant therapy.

... CM is characterized by brain edema, parenchy- mal lesions, blood brain barrier breakdown, and reduced cerebral blood ...in the corpus callosum and striatum [30]. The corpus callosum is ... See full document

16

Real-time imaging reveals the dynamics of leukocyte behaviour during experimental cerebral malaria pathogenesis.

Real-time imaging reveals the dynamics of leukocyte behaviour during experimental cerebral malaria pathogenesis.

... visualize the superficial intact pial vasculature in living mice in situ ...understanding of how leukocytes contribute to vascular inflammation during ECM, we adopted this approach for mice infected with ... See full document

17

Both functional LTbeta receptor and TNF receptor 2 are required for the development of experimental cerebral malaria.

Both functional LTbeta receptor and TNF receptor 2 are required for the development of experimental cerebral malaria.

... signs of incipient CM, together with a slight anemia and slight increase in parasitaemia, that further increased ...disruption of LTbR signaling while protecting from ECM development, had no strong ... See full document

12

The human adenovirus E4-ORF1 protein subverts discs large 1 to mediate membrane recruitment and dysregulation of phosphatidylinositol 3-kinase.

The human adenovirus E4-ORF1 protein subverts discs large 1 to mediate membrane recruitment and dysregulation of phosphatidylinositol 3-kinase.

... reconstitution of Dlg1-depleted MCF10A cells with each Dlg1 isoform restores E4-ORF1-induced PI3K activation and/or PI3K protein eleva- ...transfected the Dlg1 shRNA-expressing MCF10A line with a wt E4-ORF1 ... See full document

15

Resveratrol inhibits LPS-induced MAPKs activation via activation of the phosphatidylinositol 3-kinase pathway in murine RAW 264.7 macrophage cells.

Resveratrol inhibits LPS-induced MAPKs activation via activation of the phosphatidylinositol 3-kinase pathway in murine RAW 264.7 macrophage cells.

... ELISA. The mRNA and protein levels of proinflammatory proteins and cytokines were analysed by ELISA, RT-PCR and double immunofluorescence labeling, ...levels of Akt, cyclic AMP-responsive ... See full document

13

The Impact of the Expansion of the Bolsa Familia Program on the Time Allocation of Youths And Their Parents Lia Chitolina Miguel Nathan Foguel Naercio Menezes-Filho

The Impact of the Expansion of the Bolsa Familia Program on the Time Allocation of Youths And Their Parents Lia Chitolina Miguel Nathan Foguel Naercio Menezes-Filho

... transfer of the two main variable benefits of the program is conditioned on health and education ...85% of school days. Enrollment in school is also required for ... See full document

39

LAMMER Kinase LkhA plays multiple roles in the vegetative growth and asexual and sexual development of Aspergillus nidulans.

LAMMER Kinase LkhA plays multiple roles in the vegetative growth and asexual and sexual development of Aspergillus nidulans.

... growth of vegetative hyphae To understand the functions of lkhA, a gene-deletion assay was performed by homologous recombination using lkhA knock-out cassette and confirmed by Southern analysis (data ... See full document

14

The polycomb group protein ring1b/rnf2 is specifically required for craniofacial development.

The polycomb group protein ring1b/rnf2 is specifically required for craniofacial development.

... amongst the most common genetic birth defects and result from defects in cranial neural crest patterning and ...However, the molecular mecha- nisms regulating cranial neural crest differentiation are not ... See full document

11

The 3-hydroxy-2-butanone pathway is required for Pectobacterium carotovorum pathogenesis.

The 3-hydroxy-2-butanone pathway is required for Pectobacterium carotovorum pathogenesis.

... stability of a key ...(acyl-HSL), is also affected by pH and it is hydrolyzed into an inactive form above pH ...affects the regulation of approximately one quarter of ... See full document

11

A cyclic GMP signalling module that regulates gliding motility in a malaria parasite.

A cyclic GMP signalling module that regulates gliding motility in a malaria parasite.

... whether the substrate specificity of pded is conserved in ...once the ookinetes were fully mature cGMP-PDE levels again became indistinguishable between wild type and the pded ... See full document

14

MyD88 Signaling Is Directly Involved in the Development of Murine Placental Malaria

MyD88 Signaling Is Directly Involved in the Development of Murine Placental Malaria

... consequence of TLR activation is the production of proin- flammatory ...that the soluble levels of TNF receptors are correlated with ...production of TNF-␣ has been ... See full document

9

The Current State of Neoadjuvant Chemotherapy for Muscle-Invasive Bladder Cancer

The Current State of Neoadjuvant Chemotherapy for Muscle-Invasive Bladder Cancer

... and the outcomes of randomised trials, the rate of patients receiving NAC has seen little ...increase. The reason for this low rate might be due to some concerns from urologists, such ... See full document

6

BAF200 is required for heart morphogenesis and coronary artery development.

BAF200 is required for heart morphogenesis and coronary artery development.

... throughout the whole embryos ...vessel development in other organs or tissues ...defect is cardiac-specific. To test if other type of vessels like cardiac Figure ...staining of E13.0 ... See full document

8

Polarization of migrating monocytic cells is independent of PI 3-kinase activity.

Polarization of migrating monocytic cells is independent of PI 3-kinase activity.

... on the model. In movie S5 we show the repeated rapid reversal of the polarization axis in monocytes which were attracted with 10 m M ...Thus, the reorientation initiates at a site with ... See full document

15

Rho Kinase ROCK2 Mediates Acid-Induced NADPH Oxidase NOX5-S Expression in Human Esophageal Adenocarcinoma Cells.

Rho Kinase ROCK2 Mediates Acid-Induced NADPH Oxidase NOX5-S Expression in Human Esophageal Adenocarcinoma Cells.

... cause the changes such as high levels of ROS, increased cell proliferation and decreased apoptosis, which may lead to DNA damage and increased mutations and thereby contribute to the progression from ... See full document

17

CARACTERIZAÇÃO MOLECULAR E IMUNOLÓGICA DA VIA DOS ESFINGOLIPÍDIOS EM TECIDO TUMORAL E EM CÉLULAS DO SISTEMA IMUNE NO CÂNCER DE MAMA Aluna: Larissa Prado Maia

CARACTERIZAÇÃO MOLECULAR E IMUNOLÓGICA DA VIA DOS ESFINGOLIPÍDIOS EM TECIDO TUMORAL E EM CÉLULAS DO SISTEMA IMUNE NO CÂNCER DE MAMA Aluna: Larissa Prado Maia

... investigated the sphingolipid pathway on breast cancer immune response through the analyses of the expression of the major functional genes of the pathway, all five ... See full document

76

Metabolism of phosphatidylinositol 4-kinase IIIα-dependent PI4P Is subverted by HCV and is targeted by a 4-anilino quinazoline with antiviral activity.

Metabolism of phosphatidylinositol 4-kinase IIIα-dependent PI4P Is subverted by HCV and is targeted by a 4-anilino quinazoline with antiviral activity.

... of close apposition between ER and ...regulate the PI4P metabolism at the plasma membrane ...Osh, the yeast ortholog of the human OSBP and the ER membrane VAP proteins ... See full document

17

Plasma membrane phosphatidylinositol 4,5 bisphosphate is required for internalization of foot-and-mouth disease virus and vesicular stomatitis virus.

Plasma membrane phosphatidylinositol 4,5 bisphosphate is required for internalization of foot-and-mouth disease virus and vesicular stomatitis virus.

... relocation of the fluorescent reporter protein. The effect of this drug on clathrin- mediated endocytosis was further analyzed by using fluorescent transferrin (TF), a marker of ... See full document

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