[PDF] Top 20 PI3K inhibition enhances doxorubicin-induced apoptosis in sarcoma cells.
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PI3K inhibition enhances doxorubicin-induced apoptosis in sarcoma cells.
... presented in Figure 5A, the animals were treated with the drugs for a period of 22 ...days. In order to avoid overlooking transient effects on apoptosis, the tumors of the animals were harvested ... See full document
The role of nibrin in doxorubicin-induced apoptosis and cell senescence in Nijmegen Breakage Syndrome patients lymphocytes.
... deficient cells are characterized by genomic instability and NBS patients suffer from haematopoietic malignancies, we hypothesized that the molecular pathways leading to DNA damage-induced senescence might ... See full document
Cathepsin inhibition-induced lysosomal dysfunction enhances pancreatic beta-cell apoptosis in high glucose.
... role in maintaining cellular ...the inhibition of autophagy causes pancreatic β-cell apoptosis, suggesting that autophagy is a protective mechanism for the survival of pancreatic ...caspase-dependent ... See full document
Andrographolide Analogue Induces Apoptosis and Autophagy Mediated Cell Death in U937 Cells by Inhibition of PI3K/Akt/mTOR Pathway.
... usage in India and other Southeast Asian ...not apoptosis in human liver cancer cells . In another study, it has been shown that Andrographolide suppresses autophagy, and sensitizes ... See full document
TGF-β-Neutralizing Antibody 1D11 Enhances Cytarabine-Induced Apoptosis in AML Cells in the Bone Marrow Microenvironment.
... leukemia-driven inhibition of osteoblastic function and transient increase of osteoclasts has been demon- strated in a murine model of AML ...MSCs in the bone ...AML cells are exposed to a ... See full document
2-Methyl 2-butanol suppresses human retinoblastoma cells through cell cycle arrest and autophagy
... activity in our previous ...normal cells at higher ...dependent inhibition of HXO-RB44 ...role in cell cycle regulation whereas cyclin-B1 is a regulatory protein involved in ...arrest ... See full document
Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma.
... Fuji cells were harvested during mid-log phase growth, and resuspended in HBSS with 50% ...7 cells (0.1 mL cell suspension) subcutaneously in the right ...Tween-80 in water) was ... See full document
Inhibition of histone deacetylases 1 and 6 enhances cytarabine-induced apoptosis in pediatric acute myeloid leukemia cells.
... sensitivities in pediatric AML ...involved in cytarabine sensitivity, we examined the expression profiles of class I, II, and IV HDACs in 4 pediatric AML cell ...involved in cytarabine ... See full document
E3 ubiquitin ligase Cbl-b potentiates the apoptotic action of arsenic trioxide by inhibiting the PI3KAkt pathway Yingchun Li, Xiujuan Qu, Jinglei Qu, Ye Zhang, Jing Liu, Yuee Teng, Xuejun Hu, Kezuo Hou and Yunpeng Liu
... of apoptosis in malignant hematological ...ATO. In the present study, we evaluated whether E3 ubiquitin ligase Cbl-b, a negative regulator of PI3K activation, is involved in the action ... See full document
Inhibition of methyltransferases accelerates degradation of cFLIP and sensitizes B-cell lymphoma cells to TRAIL-induced apoptosis.
... results in robust pro-proliferative and anti-apoptotic signaling in NHL cells ...stability in DZNep-treated cells compared to buffer treated controls ...of cells with the ... See full document
Characterization of TRIB2 following PI3K inhibition
... affect apoptosis by the phosphorylation of BAD (Bcl-2-associated death ...cytosol. In addition, AKT will also phosphorylate BAX (Bcl-2- associated X protein), blocking its translocation to the mitochondria ... See full document
Follistatin is a novel biomarker for lung adenocarcinoma in humans.
... levels in patients and healthy subjects were measured using ...FST in 40 patients with ovarian adenocarcinoma (60%, 24/40) using the 95th confidence interval for the healthy subject group as the cut-off ... See full document
Disruption of a GATA4/Ankrd1 signaling axis in cardiomyocytes leads to sarcomere disarray: implications for anthracycline cardiomyopathy.
... to doxorubicin, ARVMs were incubated at different concentrations of doxorubicin for 24 h and CARP levels analyzed by ...to doxorubicin when compared to actin; as little as 0.5 m M doxorubicin ... See full document
Chemoprevention of skin cancer with 1,1-Bis (3'-indolyl)-1-(aromatic) methane analog through induction of the orphan nuclear receptor, NR4A2 (Nurr1).
... present in crucifer- ous vegetables such as brussels sprouts, broccoli and ...interest in cancer research because of its low toxicity and cytotoxic effects on cancer cells in vitro and ... See full document
O prurido mediado pelo receptor para o peptídeo liberador de gastrina (GRPR) é dependente da via de sinalização PI3KΎ/Akt
... kidney cells (HEK293; ATCC CRL-1573) were transfected with the GRPR plasmid ...HEK293 cells transfected with ...the cells were rinsed with PBS three times. Transfected HEK293 cells were ... See full document
Stabilization of Nrf2 protein by D3T provides protection against ethanol-induced apoptosis in PC12 cells.
... min in untreated cells ...resulting in its accumulation in the cells ...role in facilitating the degradation of Nrf2 .... In addition, mitogen-activated protein ... See full document
Are iron oxide nanoparticles safe? Current knowledge and future perspectives
... increase in the incidence of chromosome aberrations in Chinese hamster lung cells treated with ION (10 nm) with positively charged PEI surface or with neutral non-functional PEG-coated ION (10 and 30 ... See full document
Lapatinib induces autophagy, apoptosis and megakaryocytic differentiation in chronic myelogenous leukemia K562 cells.
... giant cells (Fig. 3A). These changes resembled changes in K562 cells treated with TPA, a drug known to induce K562 cells to differentiate towards the megakaryocytic lineage ... See full document
PI3K and ERK-induced Rac1 activation mediates hypoxia-induced HIF-1α expression in MCF-7 breast cancer cells.
... of PI3K or ERK by inhibitor did not change the activated HIF-1a mRNA transcription level under hypoxia in MCF-7 human breast cancer ...of PI3K and ERK in controlling HIF-1a expression remains ... See full document
<i>In Silico</i>, <i>In Vitro</i> and <i>In Vivo</i> Assessment of Safety and Anti-inflammatory Activity of Curcumin
... stored in rat mast cells granules and is released from the mast cells in parallel with histamine upon stimulation (Lynch et ...mast cells (Schwartz et ...immune cells has been ... See full document