[PDF] Top 20 Population-wide emergence of antiviral resistance during pandemic influenza.

... the pandemic burden. If followed by a timely increase in the level of drug-use, this strategy would preserve the potential for minimizing the final size of a pandemic (Figures 5c,d), while ... See full document

... estimate of the burden of severe influenza during the 2010/11 season, there are several limitations to these ...lack of individual-level data on underlying risk factors for severe ... See full document

... the emergence of new influenza viruses, however, is the degree of antigenic mismatch that can be tolerated before virus- neutralising antibodies are no longer capable of inhibiting ... See full document

... transmission of the influenza A(H1N1)pdm09 virus during the pandemic in Madagascar, like in other countries, appeared to be inevitable, presumably due to the nature of the infection: ... See full document

... reads of up to 250 bp in length in a single sequencing ...fourth of the maximal expected yield, mainly due to an excess of short reads that are discarded during the signal processing and ... See full document

... avian influenza H1N5 prompted many countries to establish a stockpile of antiviral drugs, [1,2,3,4], such as oseltamivir and ...size of the antiviral stockpile and its proposed use, ... See full document

... three of our patients. However, all three patients suffered from a mild form of infection, thus our analysis does not support the concept that Q293H mutation is readily associated with a more severe form ... See full document

... H1N1 influenza approximately one year post- ...61 of 105 donors (58%) had detectable circulating CD8 T cell memory to H1N1 ...magnitude of the T cell memory pool and the markers of T cell ... See full document

... light of the methods and data ...to influenza epidemics but only associ- ated with the occurrence of the ...culation of other respiratory virus, like the respiratory syncytial virus, were not ... See full document

... review of medical charts of children admitted to six ter- tiary pediatric centers in Porto Alegre, Brazil, during the first pandemic wave in 2009, from July 2 to October ...capital of ... See full document

... inhibition of IFNAR2 markedly reduced IFN-b-induced apoptosis and increased viral ...The antiviral effect of type I IFN in reducing viral replication is well established [51], and we have previously ... See full document

... aerosol of the appropriate concentration does reach a health care worker and is inhaled, inhalation does not necessarily equate to ...route of inhalation (nose or mouth), tidal volume, breathing rate, ... See full document

... a pandemic must be associated with Rw1, our final ‘‘best’’ estimate (R best ) was defined Figure ...installations during the 2009 pandemic. (a, b, c, and d) Comparison of model fits with ... See full document

... vírus Influenza persiste sendo importante problema de saúde ...por influenza, assim como a possibilidade de novas opções terapêuticas persistem sendo importante questão de ... See full document

... human influenza A virus subtypes coupled with the perpetual genomic mutations and segment reassortment events challenge the development of effective thera- ...strains of the most prevalent subtypes ... See full document

... Brazil’s influenza vaccination campaigns target persons 65 years of age and older for 1999-2001, and 60 years of age and older in 2002; 74% to 87% of those population subgroups were ... See full document

... patients enrolled in this study are particularly interesting since C. albicans were isolated from different sites. In all cases the analysis confirmed that the clinical isolates were identical to each other (Table 3) ... See full document

... Este estudo teve como objetivo fazer uma revisão da literatura a respeito da infecção pelo vírus influenza A subtipo H5N1, levando em conta a possibilidade de as crianças serem um dos grupos etários mais ... See full document

... hub of the South Eastern spread is in Alabama or Georgia, and Dothan, Alabama had the earliest onset in these states (see also Figure ...estimates of onset dates with four different putative drivers ... See full document

... divisions of mainland China (22 provinces, 4 municipalities, 5 autonomous regions) that were divided into eastern, central and western regions by the National Bureau of Statistics of ...Eleven ... See full document