Top PDF Prevalence of Anemia in Renal Transplant Patients in Turkey

Prevalence of Anemia in Renal Transplant Patients in Turkey

Prevalence of Anemia in Renal Transplant Patients in Turkey

OBJecTIve: Post-transplant anemia is a common complication in renal allograft recipients. The most common causes are impaired graft function, immunosuppressive drugs, and infections. The aim of our study was to further investigate the prevalence of anemia before and after renal transplantation in renal allograft recipients in Turkey.

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Prevalence of low trauma fractures in long-term kidney transplant patients with preserved renal function

Prevalence of low trauma fractures in long-term kidney transplant patients with preserved renal function

2000. These patients were Brazilian men and women living in the São Paulo metro- politan area, Brazil, under regular follow-up at the Renal Transplant Center of São Paulo Hospital, São Paulo, SP, Brazil. After ap- proval from the local Ethics Committee, 207 patients were invited by telephone to partici- pate in the present study. Only first-KT re- cipients were selected. Patients were se- lected at random from those with a kidney transplant performed at least three years be- fore, and stable graft function (serum creati- nine 2.5 mg/dL or less). All patients gave written informed consent to participate. Of a total of 207 patients invited, 191 concluded the study. Six patients did not accept to participate in the study protocol and 10 oth- ers did not attend the first appointment. Mean age was 44.8 ± 0.8 years and average time since transplantation was 87 ± 3.7 months. The cause of renal failure was unknown in 80 patients (41.9%) whereas chronic glo- merulonephritis, hypertension, diabetes mel- litus, polycystic kidney disease, and obstruc- tive nephropathy were responsible for renal failure in 65 (34%), 18 (9.4%), 11 (5.7%), 5 (2.6%), and 4 (2.1%) cases, respectively. Other causes of renal failure were observed in 8 patients.
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ABSTRACT Objective: To estimate the prevalence of latent Mycobacterium tuberculosis infection

ABSTRACT Objective: To estimate the prevalence of latent Mycobacterium tuberculosis infection

Objective: To estimate the prevalence of latent Mycobacterium tuberculosis infection (LTBI) in renal transplant recipients and to assess sociodemographic, behavioral, and clinical associations with positive tuberculin skin test (TST) results. Methods: This was a cross-sectional study of patients aged ≥ 18 years who underwent renal transplantation at the Renal Transplant Center of the Federal University of Minas Gerais Hospital das Clínicas, located in the city of Belo Horizonte, Brazil. We included renal transplant recipients who underwent the TST between January 2011 and July 2013. If the result of the fi rst TST was negative, a second TST was administered. Bivariate and multivariate analyses using logistic regression were used to determine factors associated with positive TST results. Results: The sample included 216 patients. The prevalence of LTBI was 18.5%. In the multivariate analysis, history of contact with a tuberculosis case and preserved graft function (estimated glomerular fi ltration rate ≥ 60 mL/min/1.73 m 2 )
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Epidemiological aspects of hepatitis C virus infection among renal transplant recipients in Central Brazil

Epidemiological aspects of hepatitis C virus infection among renal transplant recipients in Central Brazil

The present study is the first concerning HCV infec- tion in RTP in Central Brazil. The prevalence of HCV infection of 16.1% found in these patients in GO is al- most 12 times greater than that observed among local blood donors (1.4%) (Martins et al. 1994). Nevertheless, relative to other Brazilian renal transplant recipient pop- ulations, this prevalence is lower than those reported in the cities of Porto Alegre (33%) (Corrêa et al. 2003) and Campinas (54%) (Giordano et al. 2003); it was, however, in accordance with those carried out in other countries, where rates have been found to range from 7.2% to 63.8% (Fehr et al. 2003, Mitwalli et al. 2006). In addition, the prevalence among RTP we determined is similar to that reported for hemodialysis patients in GO (16.4%) (Car- neiro et al. 2007). These data demonstrate that HCV in- fection is a significant problem among RTP.
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Sao Paulo Med. J.  vol.131 número6

Sao Paulo Med. J. vol.131 número6

DESIGN AND SETTING: Retrospective cohort study in a renal transplantation unit at a tertiary hospital. METHODS: Anemia was deined as hemoglobin (Hb) < 12 g/dl in female adult recipients and < 13 g/dl in males. Donor and recipient age and gender, type of donor, creatinine, delayed graft function, acute rejection, use of angiotensin-converting enzyme inhibitors (ACEI) or angiotensin receptor blockers (ARB) and therapy without steroids were investigated as risk factors for PTA through multivariate logistical regression analysis. RESULTS: Evaluations were performed on 258 recipients (mean age: 38.8 years; 60.5% males; 35.7% did not receive steroids). Anemia was diagnosed in 38% of the patients (at the sixth month, M6), 28% (M12), 32% (M24) and 45% (at last follow up). Donor age > 50 years was associated with greater risks of PTA at M6 (odds ratio (OR) = 4.68) and M24 (OR = 6.57), as well as with therapy without steroids at M6 (OR = 2.96). Delayed graft function was independently associated with PTA at M6 (OR = 3.66) and M12 (OR = 2.85). CONCLUSION: The lowest prevalence of PTA was observed between M9 and M24 after renal transplanta- tion. Delayed graft function, donor age and therapy without steroids were the most important factors associated with PTA.
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Detection of cytomegalovirus infections by PCR in renal transplant patients

Detection of cytomegalovirus infections by PCR in renal transplant patients

illness (overt CMV disease) ranging from high fever to death. The rapid and specific diagnosis of active CMV infection in these patients is important since its manifestations may resemble those of transplant rejection but require distinct management (1-6). Sev- eral procedures for the detection of CMV are available, including conventional virus cul- ture, shell-vial, serology tests, antigenemia and PCR (7-12). In this paper we report the prevalence and clinical impact of CMV in- fection identified by serological tests and by PCR in a Brazilian population of kidney transplant patients.
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Renal transplantation in patients over 60 years of age: a single‐center experience.

Renal transplantation in patients over 60 years of age: a single‐center experience.

The prevalence of end-stage renal disease (ESRD) increases with advancing age. In most countries renal transplant recipients are getting older, too. Transplantation must be considered for ESRD patients older than 60 years; however, there are few data regarding outcomes in this population. We retrospectively reviewed the clinical course of recipients aged ⱖ60 years (n ⫽ 43) who underwent primary or repeated grafts from August 1988 to December 2004. We then compared recipient and donor characteristics as well as graft and patient survivals with recipients aged 18 to 59 years (n ⫽ 1058) who were transplanted during the same time. Donor age tended to be higher among the oldest recipient group (P ⬍ .001). Mean follow-up was significantly shorter in the group aged ⱖ60 years (P ⬍ .001), as our institution only recently has frequently accepted patients ⱖ60 years. Older recipients showed more frequent delayed graft function (P ⫽ .007), longer initial hospitalization (P ⫽ .005), and a significantly lower incidence of posttransplant acute rejection episodes (P ⫽ .015). Patient (P ⫽ .057), graft (P ⫽ .407), and death-censored graft (P ⫽ .649) survivals were not different between the two groups. Seven recipients aged ⱖ60 years died; the main cause of which was cardiovascular in origin. The loss of organs (n ⫽ 11) in the older patients was mainly due to death with a functioning kidney (54.5%). Our results confirm that renal transplant must be considered in selected patients older than 60 years as patient and graft survivals are similar to those of younger patients.
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Hepatice C em portadores de insuficiência renal crônica em tratamento hemodialítico: estudo clínico, epidemiológico e laboratorial

Hepatice C em portadores de insuficiência renal crônica em tratamento hemodialítico: estudo clínico, epidemiológico e laboratorial

Long-term outcome In Kidney transplant patients with hepatitis C (HCV ) infection. Prevalence of antibodies to hepatitis C virus among hemodialysis patients in Damascus. Home hemodialy[r]

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Assessment Of Some Acceleration Schemes In The Solution Of Systems Of Linear Equations.

Assessment Of Some Acceleration Schemes In The Solution Of Systems Of Linear Equations.

Many practical problems can be reduced to systems of linear equations Ax = b, where A, b are known matrices and x is a vector of unknowns. Systems of linear equations play a prominent role in economics, engineering, physics, chemistry, computer science and other fields of Pure and Applied Sciences [2]. A solution to a system of linear equations is a set of numerical values ….. that satisfies all the equations in a system [1]. There are two classes of iterative methods [3]: linear stationary and linear nonstationary. The stationary iterative methods are the Jacobi, Gauss-Seidel and SOR and Nonstationary include Krylov subspace methods: Conjugate Gradient, Minimal Residual, Quasi-Minimal Residual, Generalizes Minimal Residual and Biconjugate gradient methods. The choice of a method for solving linear systems will often depend on the structure of the matrix A. According to [8] ideally, iterative methods should have the property that for any starting vector , it converges to a solution Ax = b. [5] is of the view that examination of the Jacobi iterative method shows that in general one must save all the components of the vector while computing the components of the vector for an iterative method. According to Hadjidimos [6], the first step in the construction of solution of stationary iterative methods usually begins with splitting of matrix A. Thus, A = M – N where det M and M is easily invertible so that A = b is equivalent to = T + C , where T = and C = giving the iterative scheme = T + C , (k = 0,1,2……). [2] noted that for systems of linear equation A the splitting matrix may be chosen in a different way; that is, one can split matrix A as A = D L U where D is the diagonal matrix, L and U are strictly lower and strictly upper triangular matrices respectively. In solving the systems of linear equations Ax = b, therefore, we consider any convergent method which produces a sequence of iterates { [7] .Quite often the convergence is too slow and it has to be accelerated. According to [9] to improve the convergence rate of the basic iterative methods, one may transform the original system A = b into the preconditioned form PA = Pb, where � is called the preconditioned or a preconditioning matrix. Convergent numerical sequences occur quite often in natural Science and Engineering. Some of such sequences converge very slowly and their limits are not available without suitable convergent acceleration method. Some known acceleration schemes are: Chebyshev Extrapolation scheme [4] and residual Smoothing.
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J. Bras. Nefrol.  vol.38 número1

J. Bras. Nefrol. vol.38 número1

Anemia was present in 34 patients (28.3%). Table 1 shows the comparison between patients with and without anemia. When compared to patients without anemia, those with anemia received higher doses of iron and had lower concentrations of triglycerides. There was a trend towards a higher prevalence of women in the anemic group. Notably, there was no menstrual bleeding recorded in the files. There was also a trend of lower TSAT and albumin in the anemic group. In the logistic regression analysis, no variables were independently associated with the presence of anemia when gender (p = 0.08; 95%IC = 0.18-1.11), albumin (p = 0.45; 95%IC = 0.23-1.92), TSAT (p = 0.23; 95%IC = 0.95-1.01), triglycerides (p = 0.05; 95%IC = 0.99-1.00) and iron dosage (p = 0.42; 95%IC = 0.99-1.00) were included in the model.
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Study In Some Quality Attribute Of Meat

Study In Some Quality Attribute Of Meat

Abstract: The study aimed to evaluate the quality attributes of fresh camel meat and beef. The result showed that hunter lightness (L) values were highly significant (P< 0.001) between the types of meat. Beef recorded higher values of lightness compared to camel meat as (35.40 and 29.56) respectively. Redness (a) values was significantly (P< 0.01) between the types of meat studied, hence beef recorded the higher values than that in camel meat as (19.60 and 16.45) respectively. The yellowness (b) values were significantly (P< 0.001) different between treatments, However, beef recorded the higher values than in camel meat as (7.78 and 5.10) respectively. In general, camel meat appeared brighter red than beef. Water holding capacity (WHC) was not significantly (P> 0.05) different among the two types of meat studied. The WHC values were (3.07 and 2.67) for camel and beef respectively. Shear force, which measures muscle tenderness, was not significantly (P> 0.05) different among the two types of meat studied. However, beef recorded the lower values than in camel meat as (4.60 and 5.11) respectively. Connective tissue strength values were highly significant (P< 0.001) between the types of meat. Hence, camel meat recorded higher values than beef as (3.57 and 2.62) respectively.
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Use of alendronate sodium (Fosamax) to ameliorate osteoporosis in renal transplant patients: a case-control study.

Use of alendronate sodium (Fosamax) to ameliorate osteoporosis in renal transplant patients: a case-control study.

We randomly enrolled 84 kidney recipients (40 men and 44 women) who had undergone transplantation at least 5 months ago. We used DXA to obtain BMD measurements of the lumbar spine (LS), left hip (H), and femoral neck (FN) between September 2008 and March 2009 [24]. Bone condition was defined on the basis of the WHO criteria: a BMD value .2.5 standard deviations (SD, T score) below the young adult mean indicated osteoporosis and that between 1.0 and 2.5 SDs below the mean indicated osteopenia. The immunosuppressive agents that the patients had received included prednisolone (5 mg/tablet), cyclosporine (25 mg/tablet and 100 mg/tablet), tacrolimus (0.5 mg/tablet and 1 mg/tablet), sirolimus (1 mg/tablet), and mycophenolate (250 mg/tablet). Fosamax (alendronate sodium; 70 mg/tablet, 70 mg per week) was administered to the patients who were initially diagnosed with osteoporosis. Fasting blood levels of serum creatinine (Cr), blood urea nitrogen (BUN), calcium, inorganic phosphate, and uric acid were obtained. The patients’ medical records were studied for the history of diabetes mellitus (DM), smoking frequency, alcohol intake, and hepatitis B (HBV), hepatitis C (HCV), and cytomeg- alovirus (CMV) infections. All the doses of immunosuppressive agents administered between the 2 BMD measurements were considered as the accumulated dose. After 1461.6 months of follow-up, the 76 remaining patients (8 of the 84 patients were excluded—2 subjects had died, 2 had graft failure, and the initial BMD measurements of 4 patients was lost) received a second measurement of BMD and fasting blood tests.
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Clinics  vol.69 suppl.1

Clinics vol.69 suppl.1

adult allograft recipients but also to ensure that they have a smooth transition to adult physicians, surgeons and multi- disciplinary teams. The ideal transition process should be individualized according to the needs of the patient and not the requirements of the services. The patient transition should involve adolescent-trained physicians, surgeons, nurse specialists, pharmacists and allied health profes- sionals, including the psychosocial team and other multi- disciplinary team members, such as youth workers. Most transplant centers provide a dedicated clinic within the adult setting rather than a combined pediatric-adult clinic and have no direct input or continuity from pediatric services. However, the success of these clinics is dependent on good communication between the two services, includ- ing meetings between the pediatric and adult clinic staff to plan coordinated care and the involvement of youth workers and transition link staff, such as nurse specialists (who can escort young people to the adult clinics if required). However, a better model can be provided in which both pediatric and adult professionals provide ongoing care in a joint clinic from adolescence through to adulthood, the duration of which can be individualized (131). Transition programs are set up to improve patient- related outcome measures and patient experiences. However, improvement of patient outcomes can only be achieved by careful preparation during the transitioning process, with joint transition clinics identifying issues and overcoming potential difficulties. Initially, young adults should have their fears allayed through the allocation of a key liaison member of the staff assisting in an informal visit to the adult unit during the preparation for transfer. Young adults may be reluctant to leave friends and healthcare personnel, or they may lack maturity or have adherence issues and an ongoing dependence on their parents or guardians. The parents may be reluctant to leave
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Einstein (São Paulo)  vol.13 número2

Einstein (São Paulo) vol.13 número2

Europa. A introdução dos imunossupressores tacrolimo e micofenolato mofetila, a partir de 1994, propiciou a melhora significativa dos resultados e a consequente realização de transplantes em escala crescente em vários países. Segundo o Registro Internacional de Transplante de Pâncreas, foram realizados, até 31 de dezembro de 2010, mais de 35 mil transplantes de pâncreas. Sobrevida no primeiro ano dos pacientes e dos enxertos pancreáticos excede, respectivamente, 95 e 83%. A melhor sobrevida dos enxertos pancreático (86%) e renal (93%), no primeiro ano pós-transplante, está na categoria de transplante simultâneo de pâncreas e rim. As perdas imunológicas no primeiro ano pós-transplante para transplante simultâneo de pâncreas e rim, transplante de pâncreas após rim e transplante de pâncreas isolado foram, respectivamente, 1,8, 3,7, e 6%. O transplante de pâncreas apresenta de 10 a 20% de complicações cirúrgicas, necessitando laparotomia. O transplante de pâncreas, além de melhorar a qualidade de vida, proporciona o aumento da sobrevida em diabéticos urêmicos, comparados aos diabéticos em diálise ou transplantados renais.
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J. Braz. Chem. Soc.  vol.21 número4

J. Braz. Chem. Soc. vol.21 número4

All chemicals were of analytical grade purity. Water was puriied by a Milli-Q Ultra Pure Water System (Millipore, Bedford, MA, USA). All chemicals were of analytical- reagent grade. Solochrome violete RS (SVRS) and diethylenetriaminepentaacetic acid (DTPA) were obtained from Acros Organics (Morris Plains, NJ, USA). 30% (m/v) H 2 O 2 , 37% (m/v) hydrochloric acid, 98% (m/v) sulfuric acid and dimethylglyoxime (DMG) were obtained from Merck (Darmstadt, Germany). All aqueous solutions were prepared with distilled and deionized water, which was further puriied by a Milli-Q high purity water device. Metal stock solutions containing 1.00 ± 0.02 g L -1 in 0.5 mol L -1
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Lamivudine therapy for hepatitis B in renal transplantation

Lamivudine therapy for hepatitis B in renal transplantation

The aim of treating a chronic HBV car- rier with lamivudine is to suppress the viral replication before liver disease progresses and develops into cirrhosis. In the present study, lamivudine was effective in suppress- ing the replication of HBV in most of the transplant patients during the study period. After three months of treatment, HBV DNA decreased significantly and became unde- tectable in four patients. By the 12th month, all patients showed undetectable levels of HBV DNA. Similar results were also ob- served by Rostaing et al. (15), who revealed undetectable levels of HBV DNA after one month of treatment, in a study of six renal transplant patients receiving lamivudine. In another study, Jung et al. (16) treated six renal transplant patients who were HBV car- riers. They were negative for HBV six weeks after the beginning of therapy with lamivu- dine, with the virus remaining undetectable during 7 to 14 months of follow-up.
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J. Bras. Nefrol.  vol.33 número2 en a13v33n2

J. Bras. Nefrol. vol.33 número2 en a13v33n2

patients in a regular program of hemodialysis and 60 kidney transplant patients were examined. Xerosis was observed in 90.1% of the hemodialys patients, which was the most common characteristic of this group. Affected patients had been on hemodialysis for longer. Pruritus was seen in 58.2% of the hemodialysis patients, and this was the most frequent symptom of this group. Affected patients were older. Diffuse hyperpigmentation and half and half nails have also been frequent in patients on hemodialysis. Regarding hair changes, the most common ones were alopecia in the hemodialysis group and hypertrichosis in the transplanted one. Purpuric lesions were similarly prevalent in both groups, despite having different etiologies. Infectious dermatoses were the most common in transplant recipients. However, in both groups, fungal etiology was the most prevalent. Time of transplant was longer in patients with viral dermatoses,
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Prevalence of vancomycin-resistant Enterococcus fecal colonization among kidney transplant patients

Prevalence of vancomycin-resistant Enterococcus fecal colonization among kidney transplant patients

VRE infection is a growing problem in specific groups of patients. However there is no data of VRE colonization prevalence in kidney transplant patients. Our study dis- closed an unexpected high rate of VRE fecal colonization in such patients similar in the 3 groups of patients, in dif- ferent pos-transplantation periods. This high rate cannot be compared to a healthy Brazilian population, since no data is currently available. On the other hand, very similar rates were observed in Brazilian risk groups [8,11]. In group 1 (less than 30 days after transplantation), fecal VRE carriage probably represented colonization within the dialysis setting. In this group, we excluded from anal- ysis positive specimens that were collected more than 7 days apart because colonization could be associated with factors related to hospital admission, such as hospital transmission. In a simultaneous Brazilian study of 320 patients from an outpatient dialysis program, a prevalence
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J. bras. pneumol.  vol.34 número10 en v34n10a04

J. bras. pneumol. vol.34 número10 en v34n10a04

Immediately after the end of esophageal manom- etry, a semi-disposable pH-metry catheter with one or two antimony electrodes (Synectics, Stockholm, Sweden or Alácer Biomédica, São Paulo, Brazil) was introduced through the nose, and the distal electrode was positioned at 5 cm above the upper limit of the lower esophageal sphincter, which had been previously located by esophageal manom- etry. In the two-electrode catheters, the distance between the proximal and the distal electrode was 15 cm. The electrode was connected to a portable detector (Mk III; Synectics, Stockholm, Sweden) and remained connected for 24 h, during which the patient recorded meal and positioning times on a diary. At the end of pH-metry, data were trans- ferred to a personal computer with analysis software (Esophogram ® ; Synectics, Stockholm, Sweden). The
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J. Bras. Nefrol.  vol.37 número2

J. Bras. Nefrol. vol.37 número2

Introdução: O vírus da imunodeficiência hu- mana (HIV), o agente causador da síndrome da imunodeficiência adquirida (AIDS), é uma importante causa de doenças renais na África subsaariana. Há escassez de estudos sobre o impacto da doença renal crônica (DRC) em pa- cientes com HIV/AIDS na zona centro-norte da Nigéria. Métodos: Este é um estudo transversal com 227 pacientes recém-diagnosticados com HIV/AIDS, não tratados com agentes antir- retrovirais, atendidos no ambulatório de HIV do Hospital Universitário da Universidade de Ilorin (UITH). Eles foram pareados com 108 in- divíduos do grupo controle. Os pacientes foram submetidos a investigações laboratoriais. A DRC foi definida como taxa estimada de filtra- ção glomerular (eTFG) ≤ 60 ml/min/1,73m2 e/ ou a relação entre albumina e creatinina (RAC) ≥ 30 mg/g. Resultados: Houve 100 (44%) paci- entes do sexo masculino entre os pacientes e 47 (43,5%) entre os indivíduos do grupo controle. As médias de idade dos pacientes e controles foram de 40,3 ± 10,3 anos e 41,8 ± 9,5 anos, respectivamente. A DRC foi observada em 108 indivíduos (47,6%) entre os pacientes e em 18 (16,7%) dos controles (p = 0,01). A contagem mediana de linfócitos T CD4 foi significativa- mente menor nos pacientes com DRC. Noventa e três (41,0%) dos pacientes tiveram proteinúria ≥ 2+ no exame de dipstick (tiras reagentes). A mediana da relação entre creatinina e albu- mina (RAC) foi significativamente maior entre os indivíduos HIV-positivos (272,3 mg/g), em comparação com os controles HIV negativos (27,22 mg/g) p = 0,01. A contagem de linfócitos T CD4 correlacionou-se positivamente com a eTFG (r = 0,463, p = 0,001) e negativamente com o RAC (r = -0,806, p = 0,001). Conclusões: DRC é muito comum entre os pacientes com HIV/AIDS em Ilorin. Triagem e intervenção precoce para DRC devem fazer parte dos pro- tocolos de tratamento desses pacientes.
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