[PDF] Top 20 Progress on treatment of uveal melanoma

... 誗 Uveal melanoma ( UM) is the most common primary intraocular malignant tumor of ...traditional treatment is enucleation, but it cannot completely avoid metastasis, and on the contrary, ... See full document

... immunotherapy of cancer because of their critical role in mounting a specif- ic immune response where their intratumoral and peritumoral density as well as their functional status are correlated with ... See full document

... Based on the previous studies 8, 9 , dacarbazine has an overall response rate of ≤ 20% and complete response rate of 2–3% and this is in line with our ...Based on the European and US ... See full document

... Uveal Melanoma (UM) is a rare intraocular tumour occurring in the European population with a frequency of 7 cases per million ...respectively on chromosome 9q21.2 and 19p13.3. Since the vast ... See full document

... evaluation of carbon ion radiotherapy as compared with proton ...simulations of carbon ion beams, while in the simulation with proton beams irradiation line devices were included with different absorbing ... See full document

... consist of surgery, radiotherapy and chemotherapy [5,6]. However, these modes of treatment all have limitations, and are not particularly ...inhibition of combined H101-Notch1-siRNA on ... See full document

... approval of vemurafenib and ipilimumab ...year of follow-up [2–4,9,17]. Life expectancy in the absence of disease was based on Centers for Disease Control and Prevention population averages ... See full document

... with uveal melanoma and surgical indi- cation in three phases: diagnosis and preoperative, postsur- gery and late ...based on the following instruments: STAI - State, Trait Anxie- ty Inventory; BDI - ... See full document

... Cases of circumpapillary or peripapillary melanomas that could not be correctly irradiated with EBT were offered proton beam ...possibility of adequate irradiation with EBT plaques were offered ...evidence ... See full document

... incidence of brain metastasis, making them sub-optimal in brain metastatic ...from melanoma, lung adenocarcinomas or human breast cancers are injected systemically into nod/scid ...spread of cancers ... See full document

... course of the 12-week experiment and divided into two groups (n = ...expression of 84 genes related to tumor ...expression of genes related to ...expression of KISS1, a metastasis suppressor ... See full document

... a melanoma in situ, of slow radial growth, which affects sun-exposed areas, especially in the ...lack of studies on the surgical margin, and to name nonsurgical treatment options for ... See full document

... presence of the CXCR4/ CXCL12 axis in five uveal melanoma (UM) cell lines in ...ability of TN14003, a synthetic peptide inhibitor that targets the CXCR4 receptor complex, to inhibit this axis ... See full document

... many of which will be un- dergoing apoptosis and necrosis, along with several host components that include stromal cells, and a characteristic inflammatory infiltrate associated with constant tissue re- modeling ... See full document

... ICAM1 on the surface of activated ECs ...constitutively on ECs, albeit at lower levels than on activated ...observed on cutaneous melanoma cells ... See full document

... gene on chromosome 4 (locus 4q). It is detected at the basolateral membrane of the majority of epithelial tissue such as simple, pseudoes- tratified and transitional ...variety of epithelial ... See full document

... effects of ranibizumab and amfenac in human uveal melanoma cell lines and to explore the ability of these compounds to sensitize uveal melanoma cells to radiation ...human ... See full document

... effects of ranibizumab and amfenac in human uveal melanoma cell lines and to explore the ability of these compounds to sensitize uveal melanoma cells to radiation ...human ... See full document

... influence of aluminium (added in quantity from about 0.6% to about 2.8%) on both the alloy matrix and the shape of graphite precipitates in cast iron treated with a fixed amounts of cerium ... See full document

... de melanoma uveal, em casos difíceis como este, pode se mostrar de grande valia ao evidenciar lesão pigmentada sobre o disco, com total bloqueio da fluorescência associada à membrana neovascular sub- ... See full document