[PDF] Top 20 Quantifying the underestimation of relative risks from genome-wide association studies.
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Quantifying the underestimation of relative risks from genome-wide association studies.
... some of the ‘‘missing’’ heritability for common disease actually resides in known GWAS loci and have estimated this deficit for three particular ...short of explaining all the missing ...on ... See full document
10
Statistical power of model selection strategies for genome-wide association studies.
... that the desired models are more likely to be found from the models with the best ...definitions, the performance of forward search relative to that of marginal ... See full document
14
RNAi-based functional profiling of loci from blood lipid genome-wide association studies identifies genes with cholesterol-regulatory function.
... levels of these genes as critical for maintenance of cellular cholesterol ...tailored studies will corroborate overexpression also of further candidates from our gene set as regulating ... See full document
13
Genome-Wide Association Studies of the Human Gut Microbiota.
... composition of the human fecal microbiome is influenced by many lifestyle factors, notably ...dictating the composition of bacteria living in the ...examined the ... See full document
22
The challenges of genome-wide interaction studies: lessons to learn from the analysis of HDL blood levels.
... Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands, 2 Max Planck-Institute of Psychiatry, Munich, Germany, 3 Icelandic Heart Association, Kopavogur, Iceland and ... See full document
13
The USDA barley core collection: genetic diversity, population structure, and potential for genome-wide association studies.
... sources of genetic diversity must be incorporated into plant breeding programs if they are to continue increasing grain yield and quality, and tolerance to abiotic and biotic ...source of genetic and ... See full document
13
A genomic background based method for association analysis in related individuals.
... Feasibility of genotyping of hundreds and thousands of single nucleotide polymorphisms (SNPs) in thousands of study subjects have triggered the need for fast, powerful, and reliable ... See full document
7
All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs.
... Members of The Schizophrenia Psychiatric Genomics Consortium are Ingrid Agartz, Margot Albus, Madeline Alexander, Richard L. Amdur, Farooq Amin, Nicholas Bass, Istva´n Bitter, Donald W. Black, Anders D. ... See full document
13
A comprehensive investigation on common polymorphisms in the MDR1/ABCB1 transporter gene and susceptibility to colorectal cancer.
... activity of the ABCB1 transporter may differ between individuals, due to either genetic polymorphisms or pathological conditions [24] and, as a result, this might be reflected in differences in the ... See full document
7
TERT-CLPTM1L Rs401681 C>T polymorphism was associated with a decreased risk of esophageal cancer in a Chinese population.
... Several studies addressing the association between the CLPTM1L rs401681 polymorphism and cancer have been published, with inconsistent results ...that the CLPTM1L T allele was ... See full document
7
Computational Characterization of Osteoporosis Associated SNPs and Genes Identified by Genome-Wide Association Studies.
... Tools of computational biology are powerful for post-GWAS studies, and could identify the potential and promising causal SNPs that deserve experimental test for follow-up functional ...through ... See full document
14
Properties of local interactions and their potential value in complementing genome-wide association studies.
... for the low power issue is the use of stringent genome-wide significance thresholds derived from Bonferroni adjustment for often several billions of pair-wise tests ... See full document
9
Epigenome-wide Association Studies and the Interpretation of Disease -Omics.
... example from Adrian Bird in 2007 uses the broad description “the structural adaptation of chromosomal regions so as to reg- ister, signal, or perpetuate altered activity states” ...scription ... See full document
9
Esophageal squamous cell carcinoma and gastric cardia adenocarcinoma shared susceptibility locus in PLCE1: a meta-analysis.
... obtained from genotype comparison under dominant model (GG +AG ...Furthermore, the association with PLCE1 rs2274223 allele G was stronger for GCA than for ...G-proteins of the Ras ... See full document
7
Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.
... in the MHC region was located near the HLA-C gene and in moderate LD with the particular HLA-C allele, which belongs to MHC class I ...encodes the a4 chain of the integrins, ... See full document
10
Differential gene expression at the maternal-fetal interface in preeclampsia is influenced by gestational age.
... some of our PE-associated transcripts may be linked to SGA pathogenesis or restricted to severe PE, and that it would have been preferable to use a more homogenous case ...group. The sample size of ... See full document
13
Association of PTPN22 (rs2476601) and STAT4 (rs7574865) polymorphisms with Rheumatoid Arthritis in the Western Algerian population
... significant association was obtained between RA and two SNPs (PTPN22-rs2476601 and STAT4- -rs7574865) in our population, since the other three SNPs (6q23-rs6927172, IRF5-rs2004640 and TRAF1/ /C5-rs10818488) ... See full document
7
<i>LIN28B</i> polymorphisms are associated with central precocious puberty and early puberty in girls
... to the onset of puberty. Epidemiological studies have indicated that early menarche or puberty is associated with decreased final height, and notably, LIN28B is the only gene, among the ... See full document
5
Evaluation of candidate nephropathy susceptibility genes in a genome-wide association study of African American diabetic kidney disease.
... address the effect of admixture in this African American dataset we performed a Principal Components Analysis (PCA) using all GWAS SNPs that passed quality control, excluding regions of high linkage ... See full document
6
Arq. NeuroPsiquiatr. vol.70 número12
... number of known heritable disorders account for only 5% of aneurysm cases, such as Ehlers-Danlos syndrome, autosomal dominant polycystic kidney disease, Marfan syndrome and others 2 ...series of ... See full document
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