[PDF] Top 20 Randomized trials to optimize treatment of multidrug-resistant tuberculosis.

... those of the authors and do not necessarily represent the views of the United States Department of Health and Human ...(2007) Randomized trials to optimize ... See full document

... course of routine clinical ...because of negative or contaminated baseline cultures resulting from issues at the national laboratory, and were excluded from the ...capacity to perform DST for ... See full document

... methods, treatment regimen doses and supervi- sion, and outcome ...tailored to individual patients’ characteristics such as prior therapy, or drug susceptibility testing (DST) ...site of disease, ... See full document

... sensitivity of the molecular diagnostic test for detection of INH resistance in our study was slightly lower than that for RIF and MDR detection (compared to conventional methods), it was in line ... See full document

... performed to analyze the relationship between socio-demographic, clinical, radiologi- cal, laboratory aspects, and drug regimens on MDRTB patient ...started treatment between January 1, 2005 to ... See full document

... end of intensive-phase treatment outcomes recorded so far in the program demonstrates the effectiveness of treating MDR- TB patients in a hospital ...findings of this study included the ... See full document

... course of chemotherapy, her sputum smear and culture were negative after six months of the second ...course of therapy, have developed mild renal and auditory impairment probably due to ... See full document

... interpretation of our results is that better houses—where walls, roofs and win- dows are built with more solid materials—are less well ventilated and therefore increase the risk of within-household ...those ... See full document

... location of residence, treatment time period); all DST results at or prior to initiation of the individualized regimen (distribution of resistance is reported out of the 12 ... See full document

... TB treatment to be a risk factor for MDR TB [15,16], little is known about the relative contribution of this and other risk factors in high HIV prevalence ...likely to differ in low- resource, ... See full document

... contribute to developing COPD ...anti-TB treatment is an established risk factor of MDR-TB ...chance of active TB infection [11,12]. In our analysis, the proportion of patients with ... See full document

... Mycobacterium tuberculosis is the oldest known in- fectious agent and remains a major public health problem (WHO ...detection of multidrug-resistant tuberculosis (MDR-TB) isolates ... See full document

... findings of this study support at least three ma- jor recommendations: (i) to develop strategies to im- prove the surveillance of MDR-TB in hyperendemic ar- eas ...(ii) to investigate ... See full document

... possible to evaluate the drug appropriately due to in- sufficient information in the ...not to fund bedaquiline widely awai- ting the results of the phase III CT requested and further safety ... See full document

... drug-susceptible tuberculosis household contacts started at the time of diagnosis of index case MDRTB and drug-susceptible tuberculosis, ...development of tuberculosis disease in ... See full document

... estimate of treatment success rates in different sub-groups Subgroup analyses were performed according to sample size, study years, treatment regimens, national income status, proportion ... See full document

... according to WHO guidelines with isoniazid (H), rifampicin (R), ethambutol (E) and pyrazinamide (Z) ...MDR-TB treatment is also standardized and until 2010 included a fluoroquinolone (FQ; mostly ofloxacine ... See full document

... shown to be not sufficiently effective in inactivating mycobacterial ...viability of cells retained on the FTA cards varied among broad groups of ...Therefore to ensure the safe handling ... See full document

... low to no discrimination demonstrated better ...about treatment and adherence issues is important for the family and the caretakers so that they understand the need to support the patient through ... See full document

... limitations of this meta-analysis need to be ...7 of the 11 RCTs were rated as high ...heterogeneity of endpoint symptomatic improvement resulting from methodological and clinical ...analyses ... See full document