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[PDF] Top 20 Recognition of anesthetic barbiturates by a protein binding site: a high resolution structural analysis.

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Recognition of anesthetic barbiturates by a protein binding site: a high resolution structural analysis.

Recognition of anesthetic barbiturates by a protein binding site: a high resolution structural analysis.

... No structural information has been available about how barbiturates are recognized by their protein ...model protein that has previously been shown to bind many anesthetic agents ... See full document

8

Exploring the composition of protein-ligand binding sites on a large scale.

Exploring the composition of protein-ligand binding sites on a large scale.

... aspect of this study is our ability to compare the binding-site interaction patterns for valid ligands to those in sites of spurious ...type of ‘‘experimental control’’ which is usually ... See full document

14

Mutational analysis of the high-affinity zinc binding site validates a refined human dopamine transporter homology model.

Mutational analysis of the high-affinity zinc binding site validates a refined human dopamine transporter homology model.

... The high-resolution crystal structure of the leucine transporter (LeuT) is frequently used as a template for homology models of the dopamine transporter ...number of ways: (i) when ... See full document

14

Structural characterization of a recombinant fusion protein by instrumental analysis and molecular modeling.

Structural characterization of a recombinant fusion protein by instrumental analysis and molecular modeling.

... extensive structural characterization of conbercept by instrumental analysis and molecular ...spectrometry, high-performance liquid chromatography and capillary electrophoresis were ... See full document

8

Breakage-reunion domain of Streptococcus pneumoniae topoisomerase IV: crystal structure of a gram-positive quinolone target.

Breakage-reunion domain of Streptococcus pneumoniae topoisomerase IV: crystal structure of a gram-positive quinolone target.

... dimensions of 1006100650 A˚ and with a central hole approximately 30 A ˚ in diameter, which is wide enough to pass a duplex DNA (Figure ...dimer of GyrA59 from E. coli [19] (Figure 2C). Each monomer ... See full document

9

The location and nature of general anesthetic binding sites on the active conformation of firefly luciferase; a time resolved photolabeling study.

The location and nature of general anesthetic binding sites on the active conformation of firefly luciferase; a time resolved photolabeling study.

... one of the few soluble proteins that is acted upon by a wide variety of general anesthetics and alcohols; they inhibit the ATP–driven production of ...the binding sites of ... See full document

14

Ansamitocin P3 depolymerizes microtubules and induces apoptosis by binding to tubulin at the vinblastine site.

Ansamitocin P3 depolymerizes microtubules and induces apoptosis by binding to tubulin at the vinblastine site.

... The binding sites of maytansinoids were suggested to partially overlap with the vinblastine binding site on tubulin ...structure of vinblastine. The binding energy of the ... See full document

10

J. Braz. Chem. Soc.  vol.21 número10

J. Braz. Chem. Soc. vol.21 número10

... active site, leading to electrostatic and steric hindrances, thereby accounting in part for the higher K M values observed in both IMER ...the binding site entrance (Figure ...reaction, ... See full document

10

Plasmidbased controls to detect rpoB mutations in Mycobacterium tuberculosis by quantitative polymerase chain reactionhighresolution melting

Plasmidbased controls to detect rpoB mutations in Mycobacterium tuberculosis by quantitative polymerase chain reactionhighresolution melting

... specificity of HRM analysis, ge- nomic DNA samples with specific mutations are used as positive or negative controls (Choi et ...production of large amounts of genomic DNA carrying ... See full document

4

Quantitative chemical analysis for the standardization of copaiba oil by high resolution gas chromatograpy.

Quantitative chemical analysis for the standardization of copaiba oil by high resolution gas chromatograpy.

... CHEMICAL ANALYSIS FOR THE STANDARDIZATION OF COPAIBA OIL BY HIGH RESOLUTION GAS ...for analysis of methylated copaiba oils, using trans-(-)-caryophyllene or methyl ... See full document

5

Binding-site assessment by virtual fragment screening.

Binding-site assessment by virtual fragment screening.

... completion of the human genome, there has been much interest in the ‘‘druggability’’ of new potential drug targets, and what fraction of the proteome is ...with protein druggability in the ... See full document

10

A Method To Find The Area Of Sector Without The Usage Of Angle Made By The Chord

A Method To Find The Area Of Sector Without The Usage Of Angle Made By The Chord

... Thus if we prove that ΔL/ΔF =(r+a)/(r-a) then the theorem is proved. Now let us consider a circle with centre at origin and radius ‘r’. Thus the equation of circle is x²+y²=r².The equation of the chord at ... See full document

2

Regulation of CCL2 expression by an upstream TALE homeodomain protein-binding site that synergizes with the site created by the A-2578G SNP.

Regulation of CCL2 expression by an upstream TALE homeodomain protein-binding site that synergizes with the site created by the A-2578G SNP.

... ChIP analysis, we measured the interactions between the TALE proteins and the distal CCL2 promoter containing either the -2578 A allele or the -2578 G ...ChIP analysis was followed by quantitative ... See full document

8

Crystallization and preliminary diffraction data of a platelet-aggregation inhibitor from the venom of Agkistrodon piscivorus piscivorus (North American water moccasin)

Crystallization and preliminary diffraction data of a platelet-aggregation inhibitor from the venom of Agkistrodon piscivorus piscivorus (North American water moccasin)

... performed by the hanging-drop vapor-diffusion method using 24-well tissue- culture ...described by Jancarik & Kim (1991). Typically, 1 ml drops of protein solution were mixed with an equal ... See full document

3

Escherichia coli Protein Expression System for Acetylcholine Binding Proteins (AChBPs).

Escherichia coli Protein Expression System for Acetylcholine Binding Proteins (AChBPs).

... range of human ...Many of these structural insights for thera- peutic lead development have been obtained from co-crystal structures of nAChR agonists and antagonists with the acetylcholine ... See full document

15

IMPROVEMENT OF THERMAL ESTIMATION AT LAND COVER BOUNDARY BY USING QUANTILE

IMPROVEMENT OF THERMAL ESTIMATION AT LAND COVER BOUNDARY BY USING QUANTILE

... extracted by using the mask ...statistic analysis. However, difference of ground resolution between thermal infrared image and other band image influence these statistic ... See full document

4

Detection of somatic mutations by high-resolution DNA melting (HRM) analysis in multiple cancers.

Detection of somatic mutations by high-resolution DNA melting (HRM) analysis in multiple cancers.

... rate of 3%. The overall accuracy of the test was 89% (Table ...HRM analysis was compared to sequencing results, specificity increased to 94%, as well as the accuracy, 94% (kappa of ...Details ... See full document

9

Mycoleptones A−C and polyketides from the endophytem  indicus

Mycoleptones A−C and polyketides from the endophytem indicus

... spectrum of 2A and the experimental spectrum of 2 (Figure 7) shows that TD-DFT calculations are able to reproduce the experimental pattern of the transitions in the high-energy region, ... See full document

9

J. Braz. Chem. Soc.  vol.27 número10

J. Braz. Chem. Soc. vol.27 número10

... interaction of t-DCTN in the hydrophilic region, Sudlow’s site II (docking score ...hydrophobic binding pocket, Sudlow’s site I (docking score 41.5). The site II is a largely apolar ... See full document

8

Structural study of binding of flagellin by Toll-like receptor 5

Structural study of binding of flagellin by Toll-like receptor 5

... the binding regions within the complex formed by Toll-like receptor 5 (TLR-5) and flagellin, a complementary hydropathy between the two proteins was ...flagellins of Salmonella enterica serovar ... See full document

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