[PDF] Top 20 Regulator of G-protein signaling - 5 (RGS5) is a novel repressor of hedgehog signaling.
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Regulator of G-protein signaling - 5 (RGS5) is a novel repressor of hedgehog signaling.
... Hh signaling at the level of Smo-mediated G-protein coupling to downstream effector pathways in mammalian ...GPCR-mediated signaling [25]. We found that over-expression of RGS5 ... See full document
11
Synergism between Hedgehog-GLI and EGFR signaling in Hedgehog-responsive human medulloblastoma cells induces downregulation of canonical Hedgehog-target genes and stabilized expression of GLI1.
... silent, repressor GLI3 protein was observed as the dominant GLI3 form (Figure 1 ...GLI3 repressor form disappeared so that GLI3A/GLI3R ratios increased and GLI3A became the dominant GLI3 isoform ... See full document
12
SDCCAG8 Interacts with RAB Effector Proteins RABEP2 and ERC1 and Is Required for Hedgehog Signaling.
... identification of several RAB effectors as novel interaction partners of SDCCAG8, none of which had been previously associated with the ...enrichment of RABEP2 and ERC1 at the ... See full document
19
Stac3 is a novel regulator of skeletal muscle development in mice.
... gene is exclusively expressed in skeletal muscle and that it is essential for development of functional skeletal muscle and mice viable at ...structures of Stac3 protein suggest that it ... See full document
8
In vivo RNAi screen reveals neddylation genes as novel regulators of Hedgehog signaling.
... abundance of CG13343 and CG7375 mRNA after RNAi manipulation or in loss-of-function mutant ...sample) of third-instar larvae that expressed RNAi transgene under the control of the MS1096-Gal4 ... See full document
15
Hedgehog inhibition promotes a switch from Type II to Type I cell death receptor signaling in cancer cells.
... initiates signaling cascades by ligating two death receptors, DR4 (TNFRSF10A, also referred to as TRAIL receptor 1) and DR5 (TNFRSF10B, also referred to as TRAIL receptor 2/KILLER/TRICK-2) ...oligomerization ... See full document
10
Hedgehog Is a Positive Regulator of FGF Signalling during Embryonic Tracheal Cell Migration
... ptc is a ...domain of ptc expression in embryonic tissues during tracheal development, we used a ptc-lacZ enhancer trap line ...(Fig. 5 C, D) and a monoclonal antibody against the first extracellular ... See full document
14
Alterations in Fibronectin Type III Domain Containing 1 Protein Gene Are Associated with Hypertension.
... els of human polygenic ...identifications of individual ...1 protein (Fndc1)/activator of G protein signaling 8 (Ags8) to be the strongest candidate for C1QTL1, since ... See full document
11
Sfrp5 modulates both Wnt and BMP signaling and regulates gastrointestinal organogenesis [corrected] in the zebrafish, Danio rerio.
... markers of mature organ function: fatty acid binding protein 10a (fabp10a) for liver, annexin A2b (anxa2b) for intestine, trypsin (try) for exocrine pancreas, and preproinsulin (ins) for endocrine ...pg ... See full document
16
Retinal cone photoreceptors require phosducin-like protein 1 for G protein complex assembly and signaling.
... rod signaling that could interfere with cone-driven optomotor ...sensitivity of PhLP1 F/F Cre + Gnat1 -/- and PhLP1 +/+ Cre + Gnat1 -/- mice were measured using a two-alternative forced-choice protocol ... See full document
17
Vimar Is a Novel Regulator of Mitochondrial Fission through Miro.
... effect of GOF vimar under the Miro RNAi background, because Miro RNAi did not induce the wing posture defects in the flight ...transgenes of constitutively GDP-bound or GTP-bound mutant of ... See full document
21
A novel effect of geraniin on OPGRANKL signaling in osteoblasts
... It is reported that RAW264.7 cells can express the marker gene of osteoclastic phenotype and shows the function of bone resorption (Walsh et ...number of mOC cultured in vitro, indicates the ... See full document
10
HIV-1 activates macrophages independent of Toll-like receptors.
... NaCl, 5 mM EDTA, 1 mM DTT, 1 mM NaF, 1mM Sodium Orthovanadate, 1 Protease Inhibitor Cocktail Tablet (Roche, Basel, Switzerland), 1% Phosphatase Inhibitor Cocktail I (Sigma-Aldrich), and 1% Phosphatase Inhibitor ... See full document
15
The you gene encodes an EGF-CUB protein essential for Hedgehog signaling in zebrafish.
... which is disrupted in syu, con, and smu [26,60], appears normal in you ...characteristic Hedgehog signaling defects in slow muscle specification, patterning of ventral spinal cord, and the ... See full document
12
Discovery of novel small molecule activators of β-catenin signaling.
... absence of b-catenin activation in any cell line other than U2OS-EFC cells and U2OS-Da-Nuc cells, our data do not suggest that activation of b-galactosidase activity by Cpd1 and Cpd2 is an assay ... See full document
7
J. Appl. Oral Sci. vol.20 número2
... This suggests that modulation of some cell signaling pathways may have negative effects; however another hallmark of cytokine cell signaling is that activation of these pathways by c[r] ... See full document
11
Identification of proteins with potential osteogenic activity present in the water-soluble matrix proteins from crassostrea gigas nacre using a proteomic approach
... Wnt signaling as a bone formation regulator and the identification in nacre WSM (Figure 1) of proteins homologous to Wnt inhibitory factor-1 leads us to suggest that Wnt antagonists present in nacre ... See full document
10
Retroactive signaling in short signaling pathways.
... analysis of retroactivity in a signaling cascade with an arbitrary number of ...analysis is based on the linearization of the steady state equations in order to predict how a small ... See full document
13
The adaptor protein myd88 is a key signaling molecule in the pathogenesis of irinotecaninduced intestinal mucositis
... Use of Laboratory Animals of the National Institutes of Health and the ARRIVE Guidelines (Animals in Research: Reporting In Vivo Experiments) ...injection of irinotecan. During the experiment, ... See full document
21
The V protein of Tioman virus is incapable of blocking type I interferon signaling in human cells.
... V protein of MuV, TioV-V hardly interacts with human STAT2, does not induce STAT1 degradation and is unable to block signal transduction downstream of IFN-a/b and IFN-l ...activities of ... See full document
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