Top PDF Relationship between C-reactive protein and stroke: a large prospective community based study.

Relationship between C-reactive protein and stroke: a large prospective community based study.

Relationship between C-reactive protein and stroke: a large prospective community based study.

Statistical analyses were performed using SAS software, version 9.1 (SAS Institute, Cary, North Carolina, USA). As all the continuous variables were in skewed distribution, median were used for analysis, and compared using analysis of variance (ANOVA). Hs-CRP was log-transformed as a continuous variable to fit a less skewed distribution. Categorical variables were described by percentages, and compared using Chi-Square tests. Direct standardization method was used to calculate the age- and sex-standardized incidence rates according the National popula- tion census in 2010. Hazard ratios (HRs) and 95% confidence intervals (CI) of stroke and its subtypes were estimated according to different hs-CRP concentrations and 1-SD increment of log- transformed hs-CRP (antilog of SD = 3.0 mg/L) with Cox proportional hazards regression models [17]. Adjustment was made for age, sex, hypertension, diabetes, dyslipidemia and for SBP, DBP, BMI, TC, TG, LDL, GLU, current smoking, alcohol intake, and antihypertensive treatment, lipid-lowering treatment, hypoglycemic treatment were also conducted. The Kaplan-Meier curves for cumulative stroke and its subtypes were plotted according to hs-CRP concentrations and compared with the log- rank test. Receiver Operating Characteristic (ROC) analysis was used to determinate the cut-off-points of hs-CRP concentrations for the prediction of all stroke and stroke subtypes, as well as their predicted efficiency. All statistical tests were 2-sided, and the significant level was set at 0.05.
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TO STUDY THE RELATIONSHIP OF SERUM HIGH SENSITIVE C REACTIVE  PROTEIN AND ITS SHORT TERM PROGNOSTIC SIGNIFICANCE IN ACUTE  ISCHEMIC STROKE

TO STUDY THE RELATIONSHIP OF SERUM HIGH SENSITIVE C REACTIVE PROTEIN AND ITS SHORT TERM PROGNOSTIC SIGNIFICANCE IN ACUTE ISCHEMIC STROKE

ABSTRACT: Ischemic stroke is one of the most common causes of death worldwide and is most often caused by thrombotic processes. The study was based on 50 patients with ischemic stroke; coming to SGDRIMSR, Amritsar. In this study the level of hsCRP was estimated which is one of the risk factors in cases of acute ischemic stroke and the relationship between its levels and the short term prognosis was evaluated. Patients with history of acute infection or injury in the past 10-14 days before admission, suffering from Diabetes Mellitus, Pregnancy/Nursing Mothers, with Acute Liver disease, with history of Rheumatoid Arthritis, Osteoarthritis or malignancy, with history of skeletal muscle disease, with heart disease which could have led to embolism such as atrial fibrillation or Valvular disease, with thyroid or renal dysfunction were excluded from the study. It was concluded that acute ischemic stroke had higher circulating serum high sensitive CRP and the high sensitive CRP levels was maximum after 2 days of the stroke. Short term unfavorable prognosis seems to be associated with elevated serum high sensitive CRP levels in patients with ischemic stroke in our study.
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C-reactive protein and albumin kinetics after antibiotic therapy in community-acquired bloodstream infection

C-reactive protein and albumin kinetics after antibiotic therapy in community-acquired bloodstream infection

The Danish national health system, covering both primary and hospital care, is tax financed and consequently free of charge for the individual patient. All residents have a unique civil registration number used for all health contacts and linkage between health administrative registries (Schmidt et al., 2014). The admission of all residents with acute illnesses from a well-de fined geographical region to a hospital prompted a population-based study based on data from registries (vital status, diagnoses, laboratory data) and the medical records (sepsis severity and CNS dysfunction on admission) in the DORIS research database (Gradel et al., 2013, 2018b). Sepsis was categorized as severe sepsis/septic shock if organ dysfunction or hypotension (systolic blood pressure <90 mmHg) occurred. Because data on hypoperfusion were not valid we did not distinguish between severe sepsis and septic shock (Gradel et al., 2013).
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Patterns of c-reactive protein RATIO response in severe community-acquired pneumonia: a cohort study

Patterns of c-reactive protein RATIO response in severe community-acquired pneumonia: a cohort study

We conducted a prospective observational cohort study in two medical-surgical ICUs at tertiary hospitals (Barra D’Or Hospital, Rio de Janeiro, Brazil, and Garcia de Orta Hospital, Almada, Portugal). Patients with severe CAP that required ICU admission were consecutively included between November 2001 and December 2002 at Garcia de Orta Hospital and between August 2003 and June 2007 at Barra D’Or Hospital. To perform the present analysis, the independent databases were merged. The institutional review boards approved the study design and waived the need for informed consent. The present study was strictly observational and did not interfere in the decision-making process or clinical man- agement. Patients were treated according to best stan- dard ICU practice without any reference to the response patterns of CRP in their daily evaluation.
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Correlates of C-reactive protein levels in young adults: a population-based cohort study of 3827 subjects in Brazil

Correlates of C-reactive protein levels in young adults: a population-based cohort study of 3827 subjects in Brazil

Individuals with ongoing inflammatory conditions were not excluded, which is a potential limitation of this study. However, given the young age of the cohort, it is likely that few individuals had chronic disorders and therefore this is unlikely to distort the results. Moreover, exclusion of indi- viduals with CRP >10 mg/L did not significantly impact the findings in either sex. We did not utilize direct measure- ments of body fat and fat distribution, though the indirect methods of BMI and waist circumference are adequate for large samples and widely used in the literature. Nonethe- less, this study was unique because it investigated a novel inflammatory biomarker in a representative sample of young Latin American adults. The fact that the sample is part of a prospective birth cohort opens possibilities for longitudinal and lifecourse analyses as the cohort ages.
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Depressive symptoms and C-reactive protein in a Brazilian urban community

Depressive symptoms and C-reactive protein in a Brazilian urban community

could be spurious; however, there were no differences in symptom reports between the two interviewers in the study, nor did they interview different proportions of men and women. Second, as noted above, we do not have a simple random sample of the popula- tion, but rather a stratified random sample designed to insure the inclusion of higher income respondents. This could possibly af- fect the estimate of the relationship between CRP and depressive symptoms in the popu- lation; however, our aim here was not to estimate population parameters, but rather to employ a sample that would be more effective in taking into account the well- known socioeconomic variability in Brazil- ian communities and hence provide a stron- ger test of the hypothesis by insuring the representation of upper-income groups. We did, however, replicate these analyses using sample weights based on the income distri- bution in the study community, in order to adjust the sample statistically to resemble more the overall population. There were no differences in the results using these sample weights. Nevertheless, it would be useful to repeat this study in samples designed to be more broadly representative of the overall population.
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Arq. Bras. Cardiol.  vol.96 número1

Arq. Bras. Cardiol. vol.96 número1

A questionnaire-based interview was used to collect information on smoking habits, use of chewing tobacco, alcohol consumption, personal and family medical history of hypertension, diabetes and myocardial infarction. The participants were interviewed about their menopausal status and history of any surgical intervention, such as hysterectomy. Women were considered pre-menopausal if they had experienced 1 or more regular bleeding episodes in the past 12 months. Women were considered postmenopausal if their menses had ceased naturally or surgically (e.g. hysterectomy) for a period of at least 12 months. The participants were also interviewed about their history of dyslipidemia, current use of anti-hypertensive or hypoglycemic or lipid-lowering drugs and use of postmenopausal hormone therapy. The validity of responses to questions on drug use was confirmed by checking medical records.
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C-reactive protein, erythrocyte sedimentation rate and orthopedic implant infection.

C-reactive protein, erythrocyte sedimentation rate and orthopedic implant infection.

For patients undergoing uncomplicated spinal surgery, investi- gators have described ESR peaking earlier than described above, on the fourth day, and normalizing within a two week period in the majority of patients [17]. Additionally, levels in patients undergoing fusion surgery were higher than in those patients undergoing herniated disc removal [17]. In patients with known vertebral osteomyelitis the ESR may be elevated for a prolonged period of time, even in the face of appropriate non-operative treatment [18]. In the referenced series, many patients went on to a successful clinical outcome in spite of the elevated ESR, illustrating the poor specificity of the test when used alone to predict treatment failure [18]. The current study differs in that the ESR was used in a predictive fashion preoperatively, in
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Anorexia nervosa e família : estudo de caso

Anorexia nervosa e família : estudo de caso

CASPER, R. C. et al. (1980). Bulimia: its incidence and clinical importance in patients with anorexia nervosa. Arch. Gen. Psychiatry, 37, p.1030-1035, 1980. CLAUDINO, A. M.; CORDÁS, T.A. Transtornos alimentares: fundamentos históricos. Revista Brasileira de Psiquiatria, ano 24, nº3, 03-06, 2002.

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Interrelationship between serum and sputum inflammatory mediators in chronic obstructive pulmonary disease

Interrelationship between serum and sputum inflammatory mediators in chronic obstructive pulmonary disease

Little information is available regarding the airway in- flammatory markers present in patients with moderate or severe COPD (13), with this inflammation being character- ized by elevated numbers of neutrophils and macrophages in the airways (14). Neutrophils are the main producers of proinflammatory mediators such as cytokines and pro- teases (15) and the induced sputum technique permits the investigation of these patients (16,17). Inflammation and oxidative stress can be evaluated not only in the airways and other pulmonary compartments but also in blood (18). Is it possible to demonstrate in peripheral blood the repercussions of inflammatory alterations that occur in the airways and lungs? The purpose of the present study was to assess the relationships between serum inflammatory markers, induced sputum and lung function in these pa- tients. A correlation between these findings might be use- ful for the medical management of these patients.
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Interplay between temperature gradients field and C - E transformation in solidifying rolls

Interplay between temperature gradients field and C - E transformation in solidifying rolls

Finally, observations of the macrosegregation or microsegregation and phase or structure appearance in the cast iron ingot / roll (made in laboratory) has also been done in order to confront them with theoretical predictions. An equation for macrosegregation identification is suggested. Additionally, a new equation for redistribution studied across a given grain and its surrounding (precipitates) is also delivered. The role of the back-diffusion parameter is emphasized as a factor responsible for homogenization of the massive roll ingots.

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Metabolic syndrome, C-reactive protein and cardiovascular risk in psoriasis patients: a cross-sectional study

Metabolic syndrome, C-reactive protein and cardiovascular risk in psoriasis patients: a cross-sectional study

Absolute CVR within ten years of the subjects was deter- mined by the Framingham risk score (FRS), values under 10% were classified as low risk; between 10% to 20%, intermediate risk, and above 20% as high-risk for fatal or non-fatal myocardial infarction events. In the global risk assessment, according to NCEPT- ATP III, all patients with DM or existing coronary heart disease (CHD) were categorized as high risk (CHD high-risk equivalents), as well as oth- er manifestations of atherosclerosis, event or procedure previously performed, according to patient file or patient report. MetS and fam- ily history of premature CHD (CHD in male first-degree relative < 55 years of age; CHD in female first-degree relative < 65 years of age) were considered risk-enhancer factors. 19 Low and intermediate-risk
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MORBIDITY PROFILE OF RURAL POPULATION OF RAJASTHAN: A PROSPECTIVE COMMUNITY BASED STUDY

MORBIDITY PROFILE OF RURAL POPULATION OF RAJASTHAN: A PROSPECTIVE COMMUNITY BASED STUDY

Table 3 shows the system involvement of the patients attending the camps. The most common system involvement was Medicine, Pediatrics and Orthopedics with 39.2%, 19.6% and 12.8% patients respectively. The least common system involvement was surgery with only 3.1% patients.

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Rev. odontol. UNESP  vol.42 número5

Rev. odontol. UNESP vol.42 número5

Introduction: Periodontal disease is an inflammatory response to bacteria that reside in the gum tissue and can have systemic repercussion. Objective: The aim of this study was to assess the relationship between periodontitis and markers of cardiovascular risk. Material and method: Ninety selected patients were assigned into two groups in accordance with their levels of probing pocket depth (PPD) and Clinical Attachment Level (CAL): control group, n= 45 (< 4 sites with PPD ≥ 4.0 mm and CAL ≥ 3.0 mm) and case group, n= 45 (≥ 30% of sites with PPD ≥ 4.0 mm and CAL ≥3.0 mm). Plasma concentrations of C-reactive protein, high sensitive CRP, high-density lipoproteins (HDL-c) and electronegative low density lipoproteins (LDL) were assessed in all participants. Data from medical history and socioeconomic level were also collected from patients. Result: Plasma levels of HDL-c were lower in subjects with periodontal disease (p = 0.016) and were inversely associated with the number of sites with PPD ≥ 3 mm (rho= –0.325) and number of sites with PPD ≥ 3 mm and CAL ≥ 3 mm (rho= –0.216). These associations remained significant after adjustments for dental plaque and smoking using Univariate Analysis of Covariance (p < 0.05). Adjusted odds ratio between periodontal disease and levels of HDL-c was 0.94 (CI95% 0.88–0.99) after adjusting for age, smoking and dental plaque. Other investigated markers of cardiovascular risk were not related to periodontal disease. Conclusion: Clinical parameters of periodontitis were inversely associated with plasma concentrations of HDL-c.
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The Effects of Season of Birth on the Inflammatory Response to Psychological Stress in Hainan Island, China.

The Effects of Season of Birth on the Inflammatory Response to Psychological Stress in Hainan Island, China.

The current study was designed to build on and extend the earlier study by McDade and colleagues in several ways. First, the current study was undertaken in China—a country which experienced especially dramatic societal changes during the second half of the twentieth cen- tury. Given the unique social, economic and political events that occurred during that period, and the possibility that they may have impacted on the early life environment in different ways (e.g., through improvement in agricultural technology [13]), we examined the SOB—CRP asso- ciation for participants born in three distinct historical epochs: (i) after World War II to the end of the Great Leap Forward (1953–1962), (ii) the Cultural Revolution (1963–1977) and (iii) the period of early economic reforms (1978–1990) [14,15]. Second, it is also possible that inter- year variation in population nutritional status within each epoch further affected the SOB— CRP association. Indeed, there is evidence that food production and availability fluctuated greatly across the period [16], to the point where there was even famine (in 1958 to 1962) [14]. Thus, to examine the effects of early life nutritional status on inflammatory response in adult- hood we used data on per capita annual rice production (available from 1953 to 1990 [16]) as a proxy measure for population nutritional status in the year when people were born. Third, this historical focus enabled us to use data from participants with a much broader age range than had been previously examined.
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J. Appl. Oral Sci.  vol.20 número1

J. Appl. Oral Sci. vol.20 número1

regarding the topics of an association between periodontal disease and high levels of C-reactive protein and the use of periodontal therapy for reducing the levels of this protein, th[r]

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The bidirectional relationship between quality of life and eating disorder symptoms: a 9-year community-based study of Australian women.

The bidirectional relationship between quality of life and eating disorder symptoms: a 9-year community-based study of Australian women.

The university/college subsample was recruited through advertisements in four regional universities and colleges in the Australian states of Queensland and Victoria (see [20]). Seven hundred and six participants returned the surveys and agreed to take part in the longitudinal study. Due to the method of recruitment, the response rate was impossible to estimate. There was no age cut-off for participant selection, however 86.6% of participants were younger than 42 years of age, with a further 9.7% being 43 to 50 years and 4.7% being 51 to 67 years of age. The ED symptomatic subsample was identified from a larger group of 5255 (response rate 52.6%) participants randomly selected from the Australian Capital Territory (ACT) electoral roll between the ages of 18 and 42, who responded to a postal survey. An analysis of pilot data found no evidence of non-response bias [21]. The sample represented approximately 10% of all female residents aged 18 to 42 in the greater ACT region, and were representative of this population in all demographic features assessed [22]. In a follow-up interview of the partici- pants who had scored > 2.5 on the global scale of the Eating Disorder Examination Question- naire (EDE-Q; see below) and endorsed at least one ED behaviour (objective or subjective binge eating, purging, compulsive exercise, and/or severe dietary restriction), 122 were identi- fied as having ED symptoms of ‘clinical severity’ and agreed to join the longitudinal study [ 23]. Clinical severity was defined as endorsing extreme weight/shape concerns and/or engaging in one or more ED behaviours (binge eating, purging, compulsive exercise, and/or severe dietary restriction) on at least a weekly basis over the previous three months. For additional details on the recruitment and selection of participants see Mitchison, Crino, and Hay [24].
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Rev. Nutr.  vol.27 número3

Rev. Nutr. vol.27 número3

200 children and adolescents after addition of 20% of eventual losses. Of these, two were excluded due to the use of corticosteroids and two were considered as loss for not attending blood collection. For purposes of statistical analysis, 11 were excluded for showing CRP equal or greater than 10 mg/dL, and the final sample was composed of 185 children and adolescents. A questionnaire including socioeconomic personal and family history issues was applied and anthropometric measurements and laboratory tests were performed.

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Arq. Bras. Cardiol.  vol.98 número3 en v98n3a12

Arq. Bras. Cardiol. vol.98 número3 en v98n3a12

2. Bickel C, Rupprecht HJ, Blankenberg S, Espiniola-Klein C, Schlitt A, Rippin G, et al. Relation of markers of inflammation (C-reactive protein, fibrinogen, von Willebrand factor, and leukocyte count) and statin therapy to long-term mortality in patients with angiographically proven coronary artery disease. Am J Cardiol. 2002;89(8):901-8.

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Rev. Assoc. Med. Bras.  vol.59 número1 en v59n1a16

Rev. Assoc. Med. Bras. vol.59 número1 en v59n1a16

characteristics are increasing CRP use in place of ESR, despite greater experience and familiarity with the latter. None of the tests are typically useful when assessing conditions with vague clinical presentation, although they are frequently used in this context; in any case, they should not be used to screen inflammation in asymptomatic individuals (possible exception: risk stratification for cardiovascular disease). In the presence of suggestive clinical evidence, it can be useful to screen for inflammatory conditions, however, without accurately distinguishing the etiologic mechanism. Increases occurr not only in infections, but also in the presence of systemic inflammation caused by rheumatoid arthritis, myocardial infarction, necrotizing pancreatitis, multiple trauma, neoplasias, vasculitis, and even possibly in some cases of serotonin syndrome, only to mention some conditions.
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