[PDF] Top 20 Reliability in long-term clinical studies of disease-modifying therapies for relapsing-remitting multiple sclerosis: A systematic review

... All studies were found to have serious or critical methodological ...extension studies were all deemed to have critical risks of bias because the lack of a comparison group automatically ... See full document

... Observational studies, ...5. studies reporting the use of drugs that are still not officially approved ...6. studies reporting brain vol- ume data with median values or not providing measures ... See full document

... prevalence in the geographic area, our study seems to have caught most of its MS ...Because of the low proportion of patients reaching high EDSS scores, we decided not to use time to EDSS ... See full document

... Multiple sclerosis (MS) is an inflammatory, chronic, and degenerative autoimmune disease of the central nervous system that, at present, cannot be ...ease modifying-drugs (DMDs), have ... See full document

... search of the Cochrane Database of Systematic Reviews, JBI Database of Systematic Reviews and Implementation Reports (JBISRIR), Campbell Collaboration Online Library and PROS- PERO ... See full document

... lence of clinical pain in Parkinson’s disease (PD), experimental research is equivocal and mechanisms are poorly ...meta-analysis of studies comparing PD patients to healthy con- ... See full document

... standard of care for patients in ...history studies or placebo-controlled clinical trials for ...patients in the responder and partial responder groups progressed slower (median NIS ... See full document

... instead of SNPs, and DNA pool- ing was ...differences in allelic chromatographic peak heights in DNA pools to infer allelic ...cost of screening a large population for a given marker allele is ... See full document

... Introdução: As lesões pulmonares decorrentes da inalação de fumaça tóxica são as principais causas de morte em vítimas de incêndio; no entanto, informações a respeito das repercussões agudas no sistema respiratório ... See full document

... progress in dietary practices of PKU since its first introduction by Bickel and colleagues in 1951 ...[7]. In the early years of treatment, protein requirements were not fully ... See full document

... participated in a common training session and was blinded to the MRI ...(BRB) of Neuropsychological Tests [38], which incorpo- rates tests of verbal memory acquisition and delayed recall (Selective ... See full document

... A systematic review of prospective, population-based studies of circulating IL-6 levels and CHD risk was conducted according to QUOROM (Quality of Reporting of Meta- ... See full document

... majority of the studies adopted qualitative approaches, which tend not to explicitly adhere to a theoretical ...theories of ageism, even in strongly inductive qualitative studies, would ... See full document

... RESUMO. Um dos mecanismos hipotéticos relacionados a cognição é o IGF-1 induzido pelo exercício. Objetivo: O objetivo deste estudo foi analisar os efeitos do exercício físico nos níveis de IGF-1 e na cognição de idosos. ... See full document

... factors, in addition to the complexity of treatments and the time involved in enacting ...identity. In this way, we have shown that treatments and their total workload cause disruptions to a ... See full document

... two studies included in this review, the patient groups, interventions, and relevant outcomes were addressed to prove the efficacy of physical therapy treatment using the MMSE score as the ... See full document

... none of the included trials reported severe adverse events possibly related to Huperzine A, we cannot draw firm conclusions about the safety of Huperzine A since seven trials did not report information on ... See full document

... simulate disease progression, measured by Kurtzke Expanded Disability Status Scale (EDSS), relapses, and conversion to secondary-progressive MS ...loss of efficacy due to waning ...Columbia Multiple ... See full document

... began in PubMed, using the keywords “Amyotrophic Lateral Sclerosis Treatment”, “Amyotrophic Lateral Sclerosis Etiology”, “Amyotrophic Lateral Sclerosis Genetics” and “Clinical Trials ... See full document

... — Long Term Evolution (LTE) is one of the major technologies on the rise in the world as of ...change of radio interface and core ...increase in the number of users ... See full document