[PDF] Top 20 Remodeling of the methylation landscape in breast cancer metastasis.

... for methylation (n = 44) and gene expression analysis (n = 36) were collected at the time of primary surgery and banked at ...a breast cancer pathologist and microdissected to obtain ... See full document

... Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among females worldwide, with an estimated ...deaths in 2012, It alone ... See full document

... to the other cell lines. Re-expression of claudin 1 protein on the surface of treated HCC1569 and MDA‑MB‑453 cells was confirmed by flow ...increase in claudin 1 signal in both ... See full document

... Brain metastasis of breast cancer is an important clinical problem, with few therapeutic options and a poor ...(MLK3) in controlling the in vitro migratory capacity ... See full document

... levels of ICAM-1 in breast tumors are associated with a more aggressive phenotype [30], and by studies highlighting the importance of vascular cell adhesion molecules in ... See full document

... staging of patients with early-stage breast cancer is essential in the treatment ...times in association with fine-needle aspiration biopsy or core needle ...However, the ... See full document

... Background: Breast cancer is the most common malignant neoplasm in the female ...for metastasis, and can show up many years after initial diagnosis and treatment of ... See full document

... pattern of male breast cancer follows that of female breast cancer in that the bones, lungs, and liver are the most common ...Splenic metastasis ... See full document

... The breast tumor was classified as clinical stage IV, with metastasis to the lungs (lymphangitis carcinomatosa identified on CT) and bones, and surgery for the breast lesion was ... See full document

... characterization of crucial gene target(s) that will allow focused therapeutics development remains a ...interrogated the putative therapeutic targets associated with the transcription factor Grainy ... See full document

... but the last is preferred by breast tumor ...involved in cell adhesion and proteolysis, causing metastasis, such as ADAMs, a family of multi-domain and multi-functional proteins that ... See full document

... Loss of Rb expression promotes metastatic behavior in human breast cancer cell ...quantification of mammosphere-forming potency of MCF7ras and T47D cells with Rb ...Morphology ... See full document

... examination of the tumor revealed an undifferentiated carcinoma (T3N0Mx). The lack of dysplasia and atypia of the intestinal epithelium and the normal glands surrounding ... See full document

... expression of CDKN2A and MTAP; however. the MTAP promoter was partially ...deletion of CDKN2A in this cell line but not a deletion of CDKN2B or INK4A genes, which are closely located on ... See full document

... purpose of this study was to develop quantitative liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods for the analysis of proteins involved in metastasis of ... See full document

... function of Rrp1b and its exact role in metastasis remain unclear at this ...regulator of Rap1 by serving as a GAP for Rap1 ...implicated in maintaining the integrity of ... See full document

... overt metastasis remains largely unknown, in large part due to the lack of appropriate animal models that closely reca- pitulate the ...mimic the activation of indolent ... See full document

... xenograft, breast cancer development has shown a low success rate in most trials due to the technically limited occurrence of mammary glands in neonatal ...inoculation of ... See full document

... with the advent of high-throughput technolo- gies, gene expression profiling has enabled a more com- prehensive view of the molecular identity of breast ...6–8]. Breast ... See full document

... define breast cancer metastasis ...performed in this report provide a comprehensive view of changes in gene expression elicited by over-expression of WNT5A in ... See full document