[PDF] Top 20 Rev. bras. farmacogn. vol.24 número1

... DNA topoisomerases are a class of enzymes involved in the regulation of DNA supercoiling, crucial for the replication and transcription of DNA. Consequently, these enzymes are targets for chemotherapeutic intervention in ... See full document

... Onions (Allium cepa, 2 n = 16) were used in the Allium test system. Five onion bulbs were treated with distilled water and different concentrations of extracts (Table 1) for 72 h. At the end of 24, 48 and 72 h, ... See full document

... The tested chemical contents in plants varied significantly among populations (p < 0.01) except for, 2,4-dihydroxybenzoic acid ( 7 ) which was accumulated at similar levels between [r] ... See full document

... Besides the direct relationship between the social and economic conditions of the country and the health of its population, it was also concluded that there is a clear distancing, in t[r] ... See full document

... To support the template proposal, a comparative and exploratory study was performed by a comparison and consideration of the set of information presented in the monographs listed by A[r] ... See full document

... From December 2010 through May 2011, commercial samples of sarsaparilla were obtained, in sealed packages or in bulk, from establishments that sell medicinal plants (including compoun[r] ... See full document

... To investigate the possible interference of C. duarteanum or friedelin in the motor activity of the animals, we used the rota- rod apparatus according to method described Quintans-Junior et al. (2010). Initially, the ... See full document

... For the pharmacological analysis, mice were treated once with saline, 0.1 or 1.2 mg/kg of bee venom and 0.1 mg/kg of melittin, subcutaneously, 30 min before being submitted to behavior[r] ... See full document

... Leaves of Desmostachya bipinnata (L.) Stapf, Poaceae, were obtained along the riverbeds of River Cauvery in and around Thanjavur, India. The samples were authenticated by Dr. Jayendran from the Department of Botany of ... See full document

... The DPPH assay-guided HPLC-PDA-purification of the active solid-phase extraction fraction (50% methanol in water) of the methanolic extract exhibited verbascoside as the main free-radi[r] ... See full document

... The near infrared diffuses reflectance spectra of Chrysanthemum varieties were preprocessed by a first order derivative (D1) and autoscaling, and a modelwas built using partial least[r] ... See full document

... This analysis was employed to provide an overview of the capacity to distinguish essential oil components based on GC-MS data (select variables > 0.2% of 42 essential oil componen[r] ... See full document

... The results showed that the acute treatment with crude ethanolic extract of Lychnophora pinaster Mart., Asteraceae, by oral route at doses de 125, 250 or 500 mg/kg did not cause death in male and female mice for 7 or 14 ... See full document

... Fully expanded leaves were collected from the fourth node from the apex to the base of the plant. Segments of the median portion leaf were fixed in 2.5% glutaraldehyde in 0.1 M sodium cacodylate buffer, pH 6.9, ... See full document

... The chemical analyses of the essential oils obtained by the different drying methods presented the same chromatographic profile of the essential oils extracted at different drying tem[r] ... See full document

... Several compounds have been identified in Mikania such as coumarins, terpenoids, flavonoids, stigmasterol and a large number of glycosides. Among the sesquiterpenoids, sesquiterpene lactones have been isolated. In ... See full document

... A total of 24 peaks at between 15 and 52 min were detected in the chromatograms of the DCM fractions (Fig. 2) at a wavelength of 230 nm. The identification of the iridoids was carried out by comparison of the UV ... See full document

... applications are not related to CNS diseases. Currently, this plant is commonly known as: “calderona amarilla”, “flor estrella”, “hierba del cuervo”, “ojo de gallina”, “hierba del desprecio” among others, and is used by ... See full document

... in a 96-well plate overnight; then, the cells were treated in triplicate with various concentrations of the compounds. After 24 h of incubation, the cells were washed with phosphate buffer saline (PBS) and assayed ... See full document

... To evaluate genotoxicity and antigenotoxicity, a comet assay was performed on peripheral blood according to method proposed by Singh et al. (1988) with modifications proposed by Oliveira et al. (2009). A sample of ... See full document