[PDF] Top 20 Role of glial cells in neuropathic pain: potential therapeutic advantages with use of opioids
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Role of glial cells in neuropathic pain: potential therapeutic advantages with use of opioids
... levels of ions, astrocytes are also key actors in maintaining glutamate at appropriate low levels, having high affinity transporters such as glutamate transporter 1 (GLT-1, responsible for over 90% ... See full document
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Carbamazepine potentiates the effectiveness of morphine in a rodent model of neuropathic pain.
... that opioids such as morphine and opioid metabolites induce glial-associated inflammatory responses within the brain and spinal cord via the non-classical opioid receptor, TLR4 ...activation of ... See full document
9
Unravelling the Role of Descending Pain Facilitation During Opioid-Induced Hyperalgesia. -Studies in a Model of Chronic Neuropathic Pain-
... from opioids use can be partly explained by neuronal mechanisms, the emerging role of central immune signalling is revolutionizing opioid pharmacology ...well-established role in ... See full document
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The analgesic effect on neuropathic pain of retrogradely transported botulinum neurotoxin A involves Schwann cells and astrocytes.
... to use BoNT/A as therapeutic agent in a variety of neurological disorders due to hyperfunctionality of cholinergic terminals ...[9]. In the therapy of the hypercholinergic ... See full document
12
Proliferation of differentiated glial cells in the brain stem
... distribution of DM-20 mRNA (58) and the capacity of divisions of the early embryonic brain to generate oligodendro- cytes in culture (94) that the midbrain lacks early oligodendroglial ... See full document
14
Therapeutic use of sport climbing for patients with multiple sclerosis
... klini in omogočajo varno vzpenjanje plezalca v plezalni ...rokami) in stopov (na katere stopijo), ti so tudi večjih dimenzij kot pri plezalni steni za naprednejše ...pas in so varovani na tako ... See full document
16
The potential role of Th17 lymphocytes in patients with psoriasis
... differentiation of keratinocytes. Although the exact mecha- nism(s) of psoriasis is still unknown, it is assumed that T cells play a dominant pathogenic role in the initiation and ... See full document
4
Automatic Analysis of Glial Cells and Photoreception in Drosophila Melanogaster
... that glial cells play an extremely important role in our nervous system, still very little is known about the mechanisms that regulate these ...cells. In order to simplify the ... See full document
193
Role of PAF receptor in proinflammatory cytokine expression in the dorsal root ganglion and tactile allodynia in a rodent model of neuropathic pain.
... mainly in medium- to large-diameter DRG neurons [5], but COX-1 was present around the perinuclear region of small-sized DRG ...neurons. In addition, our behavioral studies demonstrated that ... See full document
11
Effects of N-acetylcysteine on spinal cord oxidative stress biomarkers in rats with neuropathic pain
... elevated in the spinal cord of saline- and NAC-treated sham rats for 1, 3, and 7 ...manipulation of deep tissues, such as muscles and adjacent connective tissue, which induce pain ...levels ... See full document
7
Evaluation of the mutagenic potential in a mouse model of peripheral neuropathic pain / Avaliação do potencial mutagênico em um modelo de dor neuropática periférica em camundongos
... Objetivo: Este estudo para avaliar o potencial mutagênico de um modelo de dor neuropática induzida por ligadura compressiva parcial do nervo ciático após 30 horas, 7, 14, 42 e 70 dias de pós-lesão, através de teste de ... See full document
11
The Use of Laparoscopy in Women with Acute Abdominal Pain
... Abdominal pain of uncertain etiology is the commonest reason for surgical ...admission. In this report, we retrospectively evaluate the effect of a laparoscopic approach in the ... See full document
6
Biopsychosocial characteristics of patients with neuropathic pain following spinal cord trauma injury : case reports
... up of 13 patients with spi- nal cord trauma injury and neuropathic pain, hospitalized for rehabilitation in a health ...Brief Pain Inventory, in addition to demogra- phic ... See full document
6
Involvement of adenosine A1 receptor in electroacupuncture-mediated inhibition of astrocyte activation during neuropathic pain
... cage with a wire mesh bottom, 20 minutes before ...threshold in the right hind ...surface of the hind paw (area between the third and fourth ...surface of the hind paw with increasing ... See full document
7
Treatment with ascorbic acid and a-tocopherol modulates oxidative-stress markers in the spinal cord of rats with neuropathic pain
... cord of vehicle-treated CCI ...maintenance of neuropathic pain (2,7). The lack of a decrease in total thiol content of the vitamin-treated CCI rats may be related to the ... See full document
11
In vitro downregulation of matrix metalloproteinase-9 in rat glial cells by CCR5 antagonist maraviroc: therapeutic implication for HIV brain infection.
... Effect of MVC treatment on MMP-2 and MMP-9 levels in astrocyte culture ...5 cells/ml), incubated in serum-free DMEM, were treated with MVC at the indicated concentrations in the ... See full document
9
Delta-opioid receptor analgesia is independent of microglial activation in a rat model of neuropathic pain.
... lack of DOR in microglia cell cultures by using Western blot and immunocytochemistry, therefore, our results are not consistent with those that were obtained by immunostaining by Turchan-Cholewo et ... See full document
14
Therapeutic effect and potential mechanism of pioglitazone in rats with severe acute pancreatitis
... upstream of the nuclear factor kappa B (NF-kB) and p38 mitogen-activated protein kinase (MAPK) inflammatory ...the therapeutic effect and potential mechanism of pioglitazone in rats ... See full document
8
Bioprospection of Natural Sources of Polyphenols with Therapeutic Potential for Redox-Related Diseases
... genus of the Rosaceae family comprising more than 250 species with the most commonly known being red and black raspberries and ...source of (poly)phenols with potential importance for ... See full document
24
Opioids for Cancer Pain and its Use under Particular Conditions: A Narrative Review
... aware of the importance of evaluating pain - fifth vital sign- in cancer ...severe pain, particularly cancer ...loss of oral route, renal impairment (hemodialysis), hepatic ... See full document
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