[PDF] Top 20 Role of IL-1β in rheumatoid arthritis

Role of IL-1β in rheumatoid arthritis

... locally in the joints, also revealed a similar cytokine ...observed in the very early phase of the disease, it is tempting to consider that after an initial unknown triggering event, macrophages and ... See full document

165

Plasma levels of IL-37 and correlation with TNF-α, IL-17A, and disease activity during DMARD treatment of rheumatoid arthritis.

... level of IL-37 in HCs and RA patients were assayed using a commercially available enzyme-linked immunosorbent assay (ELISA) kit (human IL-37 ELISA, AdipoGen, ...for IL-37 was used for ... See full document

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Ganglioside GM3 has an essential role in the pathogenesis and progression of rheumatoid arthritis.

... production of IL-6 and TNFa, which lead to joint inflammation [25,26]. In the present study, the ratio of Th17 cells in CIA was significantly higher in the iLN of GM3S 2/2 ... See full document

9

Concentration of Nitric Oxide in Saliva of Patients with Rheumatoid Arthritis

... isoforms of NOS (eNOS and nNOS) are dependent on intracellular concentration of calcium and ...calmodulin. In basal, physiological conditions low, transient levels of NO is continually being ... See full document

10

Distinct licensing of IL-18 and IL-1β secretion in response to NLRP3 inflammasome activation.

... expression of the Lm p60 protein is clearly important for bacterial pathogenicity during systemic infection ...protective in many disease settings? IL-1b has been ascribed a pro-bacterial role ... See full document

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Potential role of decoy B7-H4 in the pathogenesis of rheumatoid arthritis: a mouse model informed by clinical data.

... present in these patients for a long period of time, our findings suggest a possible mechanism for persistent ...inflammation. In addition to their antimicrobial effect, Gr-1+ neutrophils have been ... See full document

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Diet as a modulator of intestinal microbiota in rheumatoid arthritis

... modulation of intestinal permeability is another mechanism that may explain the influence of gut microbiota on the appearance and perpetuation of inflammatory diseases [48], leading to systemic ... See full document

19

Anemia versus disease activity as cause of fatigue in rheumatoid arthritis

... cells of the reticu- lo-endothelial system leading to low circulating iron levels, low serum binding capacity despite adequate iron ...part of the host defense 15 . IL-6 ... See full document

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Protective Role of the Interleukin 33 rs3939286 Gene Polymorphism in the Development of Subclinical Atherosclerosis in Rheumatoid Arthritis Patients.

... selection of single-nucleotide polymorphisms (SNPs) was based on their position with regards to the IL33-IL1RL1 region and their previously reported associations with several inflammatory ...(data in S1 and ... See full document

8

Apoptosis as a Target for Gene Therapy in Rheumatoid Arthritis

... inhibition of pro-inflammatory cytokines such as TNF-α, IL-1 and IL-15, (b) bias of the cytokine profile from a Th-1 towards a Th- 2-polarized immune reaction (using IL-4, IL-10, ... See full document

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Effect of celastrol in leukocytes from rheumatoid arthritis patients

... e IL-1β, directamente relacionadas com a inflamação e a degradação óssea na ...celastrol in vitro e in vivo, maioritariamente atribuídas à regulação da produção de citocinas e quimiocinas, à ... See full document

157

B cells contribute to heterogeneity of IL-17 producing cells in rheumatoid arthritis and healthy controls.

... exposure of synovium explants to IL-17 in vitro was demonstrated to induce molecular mechanisms of joint destruction ...level of IL-17 in patients' serum, synovial ... See full document

11

TREATMENT OF RHEUMATOID ARTHRITIS BY A

... Toll like receptors [TLR’s] which are pathogen recognition receptors, when recognize specific chemical signature of pathogen, mature DC’s are produced. These DC’s present pathogen fragments at cell surface using ... See full document

5

Role of Wnt pathway on rheumatoid arthritis

... cohorts of patients have osteoporotic T-scores (lower than - ...are in accordance with previous studies that didn’t found statistical differences between serum levels of these biomarkers between RA ... See full document

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The role of B cells in the early phase of rheumatoid arthritis

... cohort of RA patients with established disease and under B cell depletion therapy with RTX was also ...important role that BAFF has in B cell maturation and survival, it was hypothesized that the ... See full document

7

IL-17, IL-21 and IL-22 polymorphisms in rheumatoid arthritis: A systematic review and meta-analysis.

... Submission of an article implies that the work described has not been published previously (except in the form of an abstract, a published lecture or academic thesis, see ' Multiple, redundant or ... See full document

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A role for angiogenesis in rheumatoid arthritis

... control of angiogenic responses may be possible by coordinately inhibiting complementary potentiating events involved in ...neovascularization. In the case of RA, the ongoing inflammatory ... See full document

9

Tocilizumab - a new step in rheumatoid arthritis treatment

... Regardless of the safety profile, with lipid eleva- tions and reversible neutropenia associated with IL-6R inhibition, TCZ’s superior efficacy seems to provide evidence of a benefit-risk that ... See full document

11

Indirect costs of rheumatoid arthritis in Brazil

... estimates. In addition to differences in the health systems and social security support available for patients unable to work because of disease-related reasons, the study populations are ... See full document

9

Study of advanced rheumatoid arthritis

... involvement of smoking in the aggravation of the positivity of RF and ACPA rheumatic ...the role of smoking in the inlammatory process is still ...frequency of ... See full document

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