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[PDF] Top 20 Role of Wnt signaling in heart disease

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Role of Wnt signaling in heart disease

Role of Wnt signaling in heart disease

... presence of a stress situation the heart triggers cardioprotective responses, which enable the heart to pump enough blood to meet the metabolic demands of the ...result of several ... See full document

116

Wnt11b is involved in cilia-mediated symmetry breakage during Xenopus left-right development.

Wnt11b is involved in cilia-mediated symmetry breakage during Xenopus left-right development.

... a role of Wnt11b in Wnt/PCP dependent cilia polarization at the ...loss of non-canonical Wnt11b signaling, in agreement with findings in other systems in ... See full document

9

The effect of Calendula officinalis on oxidative stress and bone loss in experimental periodontitis

The effect of Calendula officinalis on oxidative stress and bone loss in experimental periodontitis

... exacerbation of inflammation culminates with collagen fiber destruction and bone resorption (Zheng et ...the role of RANK- RANKL-OPG axis on bone loss (Graves et ...another signaling pathway ... See full document

9

Cysteinyl leukotriene signaling aggravates myocardial hypoxia in experimental atherosclerotic heart disease.

Cysteinyl leukotriene signaling aggravates myocardial hypoxia in experimental atherosclerotic heart disease.

... mouse heart tissue and human left ventricular heart biopsies was isolated with RNeasy mini kit (Qiagen) according to the manufacturer’s ...mg of total RNA using random hexamer ... See full document

9

Common activation of canonical Wnt signaling in pancreatic adenocarcinoma.

Common activation of canonical Wnt signaling in pancreatic adenocarcinoma.

... Increased Wnt signaling in a mouse model of PDA Deregulation of Kras activity is observed in the vast majority of human PDA ...mutations in the Kras oncogene have ... See full document

9

Identification of proteins with potential osteogenic activity present in the water-soluble matrix proteins from crassostrea gigas nacre using a proteomic approach

Identification of proteins with potential osteogenic activity present in the water-soluble matrix proteins from crassostrea gigas nacre using a proteomic approach

... canonical Wnt signaling as a bone formation regulator and the identification in nacre WSM (Figure 1) of proteins homologous to Wnt inhibitory factor-1 leads us to suggest that ... See full document

10

FHL2 silencing reduces Wnt signaling and osteosarcoma tumorigenesis in vitro and in vivo.

FHL2 silencing reduces Wnt signaling and osteosarcoma tumorigenesis in vitro and in vivo.

... expression of the FHL2 protein in a panel of human (U2OS, HOS, SaOS2, MG63) osteosarcoma cells with distinct genotypes compared to normal human osteoblasts ...weight in all cell lines tested ... See full document

11

Biphasic role of chondroitin sulfate in cardiac differentiation of embryonic stem cells through inhibition of Wnt/β-catenin signaling.

Biphasic role of chondroitin sulfate in cardiac differentiation of embryonic stem cells through inhibition of Wnt/β-catenin signaling.

... Expression of the early and axial mesoderm marker Brachyury spiked on day 6, and was indistinguishable between control and ChABC-treated ...marker of paraxial mesoderm also spikes on day 6, but expression ... See full document

13

The role of adrenergic receptor polymorphisms in heart failure

The role of adrenergic receptor polymorphisms in heart failure

... ment of arginine with glycine at a critical point for G-protein coupling, with less cou- pling affinity for the ß1-389Gly allele ...(35,36). In transgenic mice, young Arg389 mice had enhanced receptor ... See full document

10

Differential role of Axin RGS domain function in Wnt signaling during anteroposterior patterning and maternal axis formation.

Differential role of Axin RGS domain function in Wnt signaling during anteroposterior patterning and maternal axis formation.

... Regulator of G-protein Signaling proteins (RGS ...subunits of heterotrimeric G-proteins, which are associated with G-protein-coupled receptors (GPCR), and accelerate their intrinsic GTPase ... See full document

11

A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis.

A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis.

... mutations in the adenomatous polyposis coli (APC) gene are responsible for familial adenomatous polyposis (FAP), an autosomal dominant hereditary predisposition to the development of multiple colorectal ... See full document

13

Nuclear receptor signaling pathways in cardiovascular disease: expression profile and pharmacogenetics of genes candidate to play a role in cardiovascular disease

Nuclear receptor signaling pathways in cardiovascular disease: expression profile and pharmacogenetics of genes candidate to play a role in cardiovascular disease

... hydrolysis of ATP (Meier and Stieger, 2002; Trauner and Boyer, ...expressed in the canalicular micovilli and subcanalicular vesicles of the hepatocytes and mediates the excretion of mainly ... See full document

199

The Tumor Suppressor BCL7B Functions in the Wnt Signaling Pathway.

The Tumor Suppressor BCL7B Functions in the Wnt Signaling Pathway.

... defects in cell differentiation, cell cycle progression, DNA repair mechanisms, or apoptotic pathways ...backgrounds of certain types of cancer—for example, the MSH2 gene in familial ... See full document

19

Enteroviruses other than poliovirus

Enteroviruses other than poliovirus

... Research is underway to elucidate the role of enteroviruses in certain sfiecific conditions-cardiac disease, ne#hritis, diabetes, hemorrhagic conjunctivitis.. Heart dis[r] ... See full document

4

Endocardial to myocardial notch-wnt-bmp axis regulates early heart valve development.

Endocardial to myocardial notch-wnt-bmp axis regulates early heart valve development.

... expression of Bmp2 and other genes involved in the EMT was regulated by Wnt ligands, we cultured ...with Wnt antagonist Wif1 [42] or recombinant mouse Wnt4 protein and examined their effect on ... See full document

12

Rev. Bras. Reumatol.  vol.52 número4 en v52n4a05

Rev. Bras. Reumatol. vol.52 número4 en v52n4a05

... involved in Wnt/beta-catenin signaling and which has a variant known to be consistently associated with type 2 diabetes risk and some studies have also indicated its association with risk of ... See full document

7

Interruption of Wnt signaling in Muller cells ameliorates ischemia-induced retinal neovascularization.

Interruption of Wnt signaling in Muller cells ameliorates ischemia-induced retinal neovascularization.

... producers of inflammatory and angiogenic cytokines which contribute to diabetic retinopathy ...Over-activation of the Wnt/b-catenin pathway has been shown to play an important pathogenic role ... See full document

12

CACN-1/Cactin plays a role in Wnt signaling in C. elegans.

CACN-1/Cactin plays a role in Wnt signaling in C. elegans.

... translation of mRNAs. In this role, CACN-1 might affect the levels or isoform expression of stage- or cell-type specific regulatory ...localization of LIT-1 and POP-1 in the ... See full document

15

Both canonical and non-canonical Wnt signaling independently promote stem cell growth in mammospheres.

Both canonical and non-canonical Wnt signaling independently promote stem cell growth in mammospheres.

... characterization of mammary stem cells, and signals that regulate their behavior, is of central importance in understanding developmental changes in the mammary gland and possibly for ... See full document

9

Integration of multiple signaling regulates through apoptosis the differential osteogenic potential of neural crest-derived and mesoderm-derived Osteoblasts.

Integration of multiple signaling regulates through apoptosis the differential osteogenic potential of neural crest-derived and mesoderm-derived Osteoblasts.

... Differences in the embryonic origin of mammalian bones composing the cranial vault have been established ...bones of the calvarium are neural crest in origin, the parietal bones arise from ... See full document

11

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