[PDF] Top 20 Phase II Trial of Sorafenib in Patients with Chemotherapy Refractory Metastatic Esophageal and Gastroesophageal (GE) Junction Cancer.

... role of angiogenesis in the progression of esophago- gastric cancer, two first line trials exploring chemotherapy in combination with bevacizumab (anti-VEGF A ligand ... See full document

... clinical trial was conducted prior to routine addition of targeted therapy to cytotoxic regimens, a relatively recent revolution in cancer ...to patients with CUP is ongoing. For ... See full document

... activity of sorafenib independent of BRAF inhibition might be explained by the effect of sorafenib on other targets, such as VEGFR2 (which has recently been associated with ... See full document

... admitted patients with biopsy confirmed adenocarcinoma at the gastro-esophageal junction or in the stomach were included in the study after being considered potentially ... See full document

... ESCRIPTION OF EVIDENCE COLLECTION METHOD Through the elaboration of six relevant clinical questions related to the proposed theme, we sought to present the main evidence regarding safety, toxicity ... See full document

... Nachdem laut Folprecht et al. [2] eine deutliche Korrelation zwischen Responserate und Resektionsrate vorliegt, sind auch die Responseraten der CRYSTAL-Studie so einzustufen: Bei der Subgruppe der Patienten mit auf die ... See full document

... Pazopanib ist ein oraler TKI von VEGFR 1–3, PDGFR alpha/beta und „fibroblast growth factor receptor“ 1. In einer ran- domisierten Phase-III-Studie wurde es gegen Placebo verglichen. Das mediane PFS wurde um ... See full document

... grinding and polishing. Back scattered electrons (BSE) were utilized in SEM in order to reveal difference in chemical compositions of microcomponents present in particular ... See full document

... study of 125 children and adolescents with esophageal stricture submitted to endoscopic dilatation between July 1993 and January ...endoscopy in the city of Belo ... See full document

... Many of the established and emerging treatments for mRCC have similar or overlapping biologic actions and we need more information about how they might influence each other’s effi- cacy and ... See full document

... iciency of communication between the healthcare team and the patient, especially when dealing with practical aspects of the morbid condition and its treatment, as well as physi- ... See full document

... types of blasts were considered, I, II and III) (4) and differential counts for bone marrow ...percentage of ringed sideroblasts was counted in Perl’s stained ...counted ... See full document

... physicians with the automated statistical parametric mapping program using SPECT datasets from 14 patients with neu- rological disorders ...images and found that statistical parametric mapping ... See full document

... 3.2% of all cancers ...carcinoma of the bladder is still an important epidemiologic problem whose incidence continues to increase every ...activation of protooncogenes or through loss of tu- ... See full document

... Hypotonia of the LES figured as the most common manometric abnormality and also as the only such abnormality for which there was a statis- tically significant difference between the groups (p < ... See full document

... minimized in MS is the accumulation and progression of disability, with this representing the central goal in plan- ning therapeutic ...effect of current DMTs is, in fact, ... See full document

... from refractory congestive heart failure and two due to high-dose ...DP and three died from sepsis while in ...evolved with myelodysplastic syndrome (MDS) and died from sepsis ... See full document

... (IPD). Trial-level data, as described here, are not necessarily linked to individual-level data, so our data cannot always be used to predict an individual’s chance of survival on the basis of MPFS ... See full document

... proliferation and is required for the generation and maintenance of memory T cells in vivo ...frequency of T cells expressing CD27 increases gradually after ACT and may be ... See full document

... metastasis, and on the contrary, it stimulates to distant metastasis of tumor cells to some ...statistic of latest 30a, survival rates of UM patients with metastasis is still ... See full document