[PDF] Top 20 A non-specific effect associated with conditional transgene expression based on Cre-loxP strategy in mice.
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A non-specific effect associated with conditional transgene expression based on Cre-loxP strategy in mice.
... the Cre-loxP technology was first applied to conditionally express transgenes in mice in 1992 ...[1,2]. In recent years, the use of loxP-containing transgenes in ... See full document
9
Genome engineering via homologous recombination in mouse embryonic stem (ES) cells: an amazingly versatile tool for the study of mammalian biology
... strategies in which the expression of a mutation would be rendered con- ditional (for a review, see Gu et ...are based on the remarkable properties of the Cre/loxP ...consists ... See full document
19
A neuron-specific deletion of the microRNA-processing enzyme DICER induces severe but transient obesity in mice.
... small, non-coding RNA molecules that regulate gene expression ...implicated in various biological processes associated with obesity, including adipocyte differentiation and lipid ... See full document
18
Rev. psiquiatr. Rio Gd. Sul vol.28 número2 en v28n2a04
... been associated with the growing use of antipsychotics, although it is difficult to determine whether the prevalence of these complications would be specific, or independent of specific drug ... See full document
20
The murine stem cell virus promoter drives correlated transgene expression in the leukocytes and cerebellar Purkinje cells of transgenic mice.
... However, in our study, there were 12 founder mice that express quite different levels of the transgene in leukocytes and cerebellar Purkinje cells, and wild-type animals obtained from a same ... See full document
13
Conditional treatment and its effect on recidivism
... effect on reducing criminal activity, unless for those who succeeded in secur- ing a job for a long ...but, in fact, should be viewed as just a first step to the design of bet- ter ...contact ... See full document
28
Conditional ablation of the choroideremia gene causes age-related changes in mouse retinal pigment epithelium.
... formation in that cathepsin D is important for the degradation of POS whilst nephrilysin is important for the degradation of beta amyloid, a component of drusen/basal ...contrasts with most existing models ... See full document
11
Dysautonomia Due to Reduced Cholinergic Neurotransmission Causes Cardiac Remodeling and Heart Failure
... lower in VAChT mutants than in WT mice under baseline con- ditions (Table ...absolute effect shows a decrease in the ISO-mediated response by VAChT mutants, the relative increases ... See full document
11
Factors associated with asthma expression in adolescents
... factors associated with asthma symptoms in adolescents in the 13- to 14-year age ...enrolled in randomly selected public schools in the city of Belo Horizonte, Brazil, and ... See full document
6
Dyskeratosis Congenita Associated Non-Specific Interstitial Pneumonia
... symptomatic with exertional dyspnea, dry cough since 5-6 ...diagnosed in view of classical mucocutaneous triad of skin pigmentation, nail dystrophy, ...cirrhosis with portal hypertension and right ... See full document
5
TRAF6 is essential for maintenance of regulatory T cells that suppress Th2 type autoimmunity.
... role in the regulation of innate and adaptive immunity by mediating signals from various receptors including the T-cell receptor ...TRAF6 in Tregs remains to be investigated. Here, we generated ... See full document
12
Mig-6 plays a critical role in the regulation of cholesterol homeostasis and bile acid synthesis.
... used in the alternative pathway of bile acid synthesis ...mRNA expression of these genes decreased in the Mig-6 d/d ...decreased in the ...deregulated in the liver upon ablation of ... See full document
7
Endothelial nitric oxide synthase single nucleotide polymorphism and left ventricular function in early chronic kidney disease.
... conflicts with the current study, and with that of other reports [7, 8], it should be noted that 84% of patients dis- played an ejection fraction 35% ...were in NYHA stage II or greater, with ... See full document
10
Rev. Saúde Pública vol.44 número6
... statistically associated with prior history of stroke, signs of dementia and disability in activities of daily ...care in traditional primary care settings while nursing staff provided most ... See full document
9
Effect of myrrh and thyme on Trichinella spiralis enteral and parenteral phases with inducible nitric oxide expression in mice
... BALB/c mice (25-30 g) aged six- eight weeks were ...temperature with standard diet and water ...orally with about 300 larvae per mouse while the remaining 10 were kept as the nonin- fected nontreated ... See full document
7
Direct and specific effect of sevoflurane anesthesia on rat Per2 expression in the suprachiasmatic nucleus.
... placed in ice-cold Hank’s balanced salt solution (HBSS: Thermo Fisher Scientific, Boston, ...made with a microslicer DTK-3000 ...selected based on surrounding anatomical landmarks under a ... See full document
9
Genome-wide association analysis of tolerance to methylmercury toxicity in Drosophila implicates myogenic and neuromuscular developmental pathways.
... present in seafood that can compromise the developing nervous system in ...variation in the effects of MeHg on development, measured by eclosion rate, giving a broad sense heritability of ... See full document
15
Conditional Reduction of Predation Risk Associated with a Facultative Symbiont in an Insect.
... hosts with a higher resistance to pathogens ...metabolites with known toxic functions is often taken as prima facie evidence of these protective symbioses ...symbiont in hoopoe preen ...observed ... See full document
12
Resposta imune mediada por linfócitos T CD8+ na infecção experimental pelo Trypanosoma cruzi
... No trabalho anterior, nós descrevemos a cinética de ativação de células T CD8+ específicas para epítopos de T. cruzi, em camundongos selvagens e vacinados, após a infecção experimental. Neste trabalho, nós levantamos a ... See full document
97
PDGFRβ Is a Novel Marker of Stromal Activation in Oral Squamous Cell Carcinomas.
... gene expression data pertaining to Adrenocortical carcinoma (ACC), Bladder urothelial carcinoma (BLCA), Colon adenocarcinoma (COAD), Kidney renal clear cell carci- noma (KIRC), Acute myeloid leukemia (LAML), Liver ... See full document
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