[PDF] Top 20 Striking differences between knockout and wild-type mice in global gene expression variability.
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Striking differences between knockout and wild-type mice in global gene expression variability.
... observed variability differences merely represent an artifact of inconsistencies in the experimental procedures used during generation of the microarray ...example, wild-type and ... See full document
7
11β-hydroxysteroid dehydrogenase type 1 gene knockout attenuates atherosclerosis and in vivo foam cell formation in hyperlipidemic apoE⁻/⁻ mice.
... associated-11bHSD1 in atherosclerosis development. In these studies, plaque burden in the thoracic aorta was reduced 39% with 11bHSD1 deficiency ...obtained in the diet-induced atherosclerosis ... See full document
15
Global analysis of gene expression in the developing brain of Gtf2ird1 knockout mice.
... second global analysis of gene expression in vivo has been reported recently ...Gtf2ird1 knockout mouse model, Gtf2ird1 Gt(XE465)Byg/Gt(XE465)Byg (Gtf2ird1 Gt/Gt ), generated from a ... See full document
10
The α and Δ isoforms of CREB1 are required to maintain normal pulmonary vascular resistance.
... a and D isoforms resulted in increased expression of these genes in the hypoxic lungs whereas it had been previously demonstrated that dominant negative suppression of CREB1 activity or ... See full document
13
Neuronal and endothelial nitric oxide synthase gene knockout mice
... mutant mice provided an op- portunity to test whether reduction in endo- thelial NO production would influence the development of neointima following vessel ...injury. In a cuff model of vessel ... See full document
7
Obesity impairs lymphatic fluid transport and dendritic cell migration to lymph nodes.
... microlymphangiography and to better analyze three-dimensional structural changes in the lymphatic system, we used a technique recently described by our group using Positron Emission Tomography (PET) ... See full document
14
Mitochondrial Dysfunction Plus High-Sugar Diet Provokes a Metabolic Crisis That Inhibits Growth.
... changes in NADPH, which also correlated with the severity of the mutant phenotype on different diets, might also be influenced by excessive lac- tate and ...enzymes in extracts from tko 25t ... See full document
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Identification of miR-26a as a target gene of bile acid receptor GPBAR-1/TGR5.
... involved in regulating obesity and glucose levels are ...miRNA expression has not been reported ...target gene of ...miR-26a in glucose regulation and lipid metabo- lism [15, ... See full document
12
Pulmonary hypertension in wild type mice and animals with genetic deficit in KCa2.3 and KCa3.1 channels.
... liver and left lung were determined and expressed as percentage of body ...isolated and both atria were ...ventricle and septum (LV+S). Each part was weighed and the ratios of right ... See full document
11
Absence of intestinal PPARγ aggravates acute infectious colitis in mice through a lipocalin-2-dependent pathway.
... increase in Lcn2 secretion from the intestinal epithelium during ...challenge in this ...Lcn2 in the intestinal milieu leads to stabilization and a significant increase in MMP-9 ... See full document
16
Distinct actions of akt1 on skeletal architecture and function.
... growth in the absence of Akt1 The decrease in femoral strength and BMD, and the reduction in other long bone parameters in mice lacking Akt1 could be caused by a decline ... See full document
12
Transgenic mice for a tamoxifen-induced, conditional expression of the Cre recombinase in osteoclasts.
... E17.5 and then processed to detect b-galactosidase activity in ...#4 and #284 showed intense staining in long ...seen in vertebrae, calvaria and craniums ...observed in ... See full document
7
Limiting glutamate transmission in a Vglut2-expressing subpopulation of the subthalamic nucleus is sufficient to cause hyperlocomotion
... STN and quantified the expression of Vglut1 and Vglut2 through both in situ hybridization and single-cell RT-PCR ...Vglut2 expression was easily detected by both techniques, ... See full document
6
EphA4 receptor tyrosine kinase is a modulator of onset and disease severity of experimental autoimmune encephalomyelitis (EAE).
... present in MOG- EAE white matter ...magnification and quantified as a proportion of the total spinal cord section area ...(p.0.05) between EAE-affected wild- type and EphA4 ... See full document
11
Gene expression dosage regulation in an allopolyploid fish.
... a global strict full “functional diploidization” of triploids, the majority of transcripts is less represented in PAA then it is in PA and AA ...of gene expression would change ... See full document
24
Cell cycle- and cancer-associated gene networks activated by Dsg2: evidence of cystatin A deregulation and a potential role in cell-cell adhesion.
... (desmoplakin) and keratin families, assemble with the armadillo (plakoglobin and plakophilins) and cadherin (desmogle- ins and desmocollins) protein families ...structure and integrity, ... See full document
20
Global identification of multiple OsGH9 family members and their involvement in cellulose crystallinity modification in rice.
... The in situ hybridization of endo-b-1, 4-glucanase in differential tissues has been reported in pine [47], Brassica napus [48], and aspen trees ...sensitivity in muro cellulase enzyme ... See full document
10
Yunqiang Liu, Dachang Tao, Yongjie Lu, Yuan Yang, Yongxin Ma and Sizhong Zhang
... Znf230 gene, which encodes a type of RING finger protein, is present primarily in the nu- clei of spermatogonia, the acrosome and the tail of ...Znf230 in spermato- genesis, we ... See full document
8
The Adaptor Protein Myd88 Is a Key Signaling Molecule in the Pathogenesis of Irinotecan-Induced Intestinal Mucositis.
... response and the production of pro-inflammatory mediators including interleukin–1β (IL–1β) [ 11], nitric oxide [12] and interleukin–18 [ 13], whose role in intestinal mucositis has been previously ... See full document
21
Neonatal periostin knockout mice are protected from hyperoxia-induced alveolar simplication.
... null mice we used were developed in the 129 strain and backcrossed to ...C57BL/6 mice for this purpose. Nevertheless, strain differences in the response to hyperoxia could have ... See full document
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