[PDF] Top 20 Telomere maintenance mechanisms in cancer
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Telomere maintenance mechanisms in cancer
... gathered in the last years unveiled a phenotype in which both telomerase (or TERT) expression and ALT were reported as absent, pointing to a novel TMM: the non-defined telomere maintenance ... See full document
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Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence.
... investment in mechanisms of cellular and molecular maintenance and repair causes a gradual accumulation of cellular damage, which in turn causes age-related frailty, disease, and death ... See full document
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HPV16 E7 protein and hTERT proteins defective for telomere maintenance cooperate to immortalize human keratinocytes.
... protein in the immortalization of primary keratinocytes. In the current study, we made the surprising finding that catalytically inactive hTERT (hTERT-D868A), elongation-defective hTERT (hTERT-HA), and ... See full document
13
Obesity and prostate cancer: epidemiology, genetics and molecular and cellular mechanisms
... role in immunoinflamatory-mediated lung cancer ...phisms in genes that express pro-inflammatory molecules), the inflammatory reaction may last longer and/or may be in- ...role in ... See full document
396
Multiple regulatory mechanisms to inhibit untimely initiation of DNA replication are important for stable genome maintenance.
... initiation in G1 phase, in addition to the previously described context of CDK phosphorylation of Sld2 and ...resulted in a higher GCR rate (Figure 5 and Table ...deregulated in human ... See full document
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Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancer
... six telomere-specific proteins; telomeric repeat binding factor 1 and 2 (TERF1, TERF2) and protection of telomeres pro- tein 1 (POT1) interact directly with TTAGGG ...[14–16]. Telomere shortening leads to a ... See full document
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Recombination-Mediated Telomere Maintenance in Saccharomyces cerevisiae Is Not Dependent on the Shu Complex.
... telomerase-independent mechanisms. In Saccharomy- ces cerevisiae , these cells are called ‘survivors’ and are dependent on Rad52-dependent homologous recombination and Pol32-dependent break-induced ...tions ... See full document
9
Clinical Relevance of Telomere Status and Telomerase Activity in Colorectal Cancer.
... and telomere dysfunction may be considered a major driving force in generating this feature ...progressive telomere shortening which is coupled to cell ...critical telomere length is reached, ... See full document
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Correlation of chromosomal instability, telomere length and telomere maintenance in microsatellite stable rectal cancer: a molecular subclass of rectal cancer.
... rectal cancer patients from three sources: (1) Biobank for Gastrointestinal Health Research, a prospective repository comprised of annotated biospecimens from individuals with CRC who had evaluation at Mayo Clinic ... See full document
11
Telomere length modulation in human astroglial brain tumors.
... PARP, in tumor tissues obtained during surgery and their paired normal ...tissue. In cancer cells telomere length depends on the balance between the loss of telomeric repeats during DNA ... See full document
8
Lead Exposure Induces Telomere Instability in Human Cells.
... the mechanisms responsible for Pb toxicity remain poorly ...role in determining the molecular mechanism responsible for their formation, we examined the localization of Pb-induced foci with respect to ... See full document
8
Mistranslation and telomere stability
... alterations in telomere length observed in this work for mistrans- lating strains, we may pose the following question: why are these alterations observed in mistranslating clones, relatively ... See full document
61
Exploring the molecular mechanisms underlying head and neck cancer cachexia
... seen in patients with locally advanced tumors (33) . In addition, it can cause pain, increased inflammatory activity, and altered metabolic function ...cause in other patients is a manifestation of a ... See full document
122
Healthy lifestyle and leukocyte telomere length in U.S. women.
... of telomere length assay may also result from DNA oxidation or degradation during long-term ...storage. In the NHS, buffy coat fractions were stored at #2130uC, and extracted DNA samples were stored at ... See full document
9
Genetic and epigenetic mechanisms involved in regulation of STEAP1 gene expression in LNCaP prostate cancer cells
... 48). In low-grade PIN, the nuclei of the cells are enlarged and the nucleoli are discreet or small, while in high-grade PIN the nuclei are large, the nucleoli are prominent and there is an increase of ... See full document
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Specific Localization of the Drosophila Telomere Transposon Proteins and RNAs, Give Insight in Their Behavior, Control and Telomere Biology in This Organism.
... (reviewed in [3]). The level of conservation of the genes encoded by the telomere retrotransposons, HeT-A gag, TART gag and pol, suggests the existence of a negative selective pressure ...for ... See full document
17
Extreme telomere length dimorphism in the Tasmanian devil and related marsupials suggests parental control of telomere length.
... observations in an XXY intersex quoll are consistent with this hypothesis. In this animal (with internal testes), one of the X chromosomes had short telomeres and the other long ...paternal in this ... See full document
10
Molecular mechanisms underlying the anticancer activity of lactoferrin in highly metastatic cancer cell lines
... are in disagreement with the visible amount of cells in suspension (dead cells) observed in the microplate wells corresponding to cells treated with bLf (see ...tested. In fact, for these two ... See full document
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Cytotoxicity of portoamides in human cancer cells and analysis of the molecular mechanisms of action
... deficiency in mice led to the depletion of NADPH and GSH, loss of mitochondrial transmembrane potential and mitochondrial mass, and was linked to many clinical diseases such as male in- fertility, chronic ... See full document
18
Failure Profiles for Maintenance in Industrial Facilities
... found in the practice of maintenance in the last decades and allows a better breakdown of behaviors of complex ...machinery. In this sense we can imagine a typical case of equipment for power ... See full document
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