[PDF] Top 20 The Economics of Rare Diseases: incentives and regulation

... Conforme os relatórios da European Medicines Agengy (2007, p. 1-2); Commission of the European Communities (2008, p. 1-5); European Organisation for Rare Diseases (2005, p.3-8) e Comissão ... See full document

... class of cis-acting elements that regulate translation ...including rare diseases. In this mini-review, we intend to highlight the mechanisms associated with the uORF-mediated ... See full document

... analyzes the available evidence on the adequacy of economic evaluation for deci- sion-making on the incorporation or exclusion of technologies for rare ...diseases. ... See full document

... nature of financial crashes has been intensely discussed for ...analyze and describe the dy- namics of changes in complex markets, based on different contributions from ...methods and ... See full document

... well-developed and accessible credit markets and institutions may be an important condition to economic ...Banks and other financial institutions are supposed to guarantee the financing ... See full document

... (4) and (7) in Table 2 imply that stock options affect positively the managerial decision to complete a M&A ...hypothesis and prior literature previously discussed, and hence stock options ... See full document

... develops and applies a stochastic geometry approach designed to describe the dynamics of the object emerging from the collective behavior of a complex ...In the current ... See full document

... that the selection process does not give rise to uniform densities of workers and firms on the hypercube: this pro- cess is spatially ...workers, the density of firms is also ... See full document

... process of national accounting practices into international standards requires significant changes on accounting ...examples of that: the creation of the Brazilian Accounting Standards ... See full document

... lack the microfoundations that would make them ...example, the Taylor rule, which today is widely used, is just a smart rule of thumb which emerged from the observation of the ... See full document

... part of our work used a much more restricted data set considering only observations from ...introducing the three latent motivation variables into the logistic model explaining the probability ... See full document

... with the aim of reducing the lessee’s cost of capital – reduction of the all-in ...Eisfeldt and Rampini (2009) argue that the benefit of leasing is that ... See full document

... shows the impulse-response functions to a shock in government revenue. The results suggest that government revenue declines steadily following the shock which erodes after 8 ...spending, the ... See full document

... result of past trends in fiscal policies in Portugal, it is not surprising that almost all existing studies regarding the sustainability of public finances recurrently have placed Portugal in ... See full document

... (2005) the composition of public outlays has a bearing on the nexus between budget deficits and ...summarizes the results of a series of panel regressions of per ... See full document

... while the other moves ...consideration the economic conditions under which a flight-to-quality ...Third, the total return-based technique we apply allows identifying the time frames and ... See full document

... explaining the divergence between the State Budget deficit forecasts and the final outcomes in the Portuguese official forecasts and in the European Commission semi- ... See full document

... On the other hand, a lower level of spending implies that fewer revenues are needed to achieve balanced budgets, which means that lower taxes can be levied, therefore contributing to stimulate growth ... See full document

... advantage of the debt ratio threshold dummy variables defined in (5) we can interact them with the overall fiscal rule at our ...disposal. The results reported in Table 4 show that when ... See full document

... with the location of input supply in a two country spatial ...THISSE and WANG (2006). Since the consumer good is non-tradable, the downstream industry locates in both countries ... See full document