[PDF] Top 20 The role of SMN protein in microRNA biogenesis
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The role of SMN protein in microRNA biogenesis
... proteína SMN afecta especificamente os neurónios motores ...do microRNA-183 (miR-183) em neurónios com expressão nula da proteína ...de SMN. Uma vez estando o complexo SMN envolvido no ... See full document
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New molecular partners involved in the pathophysiology of cystic fibrosis:a role in the biogenesis, processing and trafficking of CFTR
... pathway of eukaryotic cells is the sequential movement of a protein transported from the ER through the cis, medial and trans cisternae of the Golgi ...proteins ... See full document
168
Disruption of microRNA biogenesis confers resistance to ER stress-induced cell death upstream of the mitochondrion.
... activation in Exn5/Exn5 cells, we compared the levels of BCL-2 family members in WT and Exn5/Exn5 cells during 0-24 h treatment with 500 ng/ml of ...Bfa. The expression levels ... See full document
13
Mechanisms and role of microRNA deregulation in cancer onset and progression
... preserved in paraffin are also useful in eval- uating the action of a miRNA on a target gene and deter- mining whether it may result in a change in the expression ... See full document
8
Phosphorylation of CFTR and other membrane proteins: a role in biogenesis and traffic?
... impairment in channel gating. On the other hand, T1471D-CFTR is not processed into a mature form (Luz, 2008), implying that there might be higher turnover and/or increased endocytosis for this ... See full document
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microRNA as a potential vector for the propagation of robustness in protein expression and oscillatory dynamics within a ceRNA network.
... embedded in feedback and feed-forward regulatory motifs, which may improve the robustness of protein expression towards molecular noise ...During the development of an organism, ... See full document
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Widespread regulation of miRNA biogenesis at the Dicer step by the cold-inducible RNA-binding protein, RBM3.
... novel role for RBM3 in the posttranscrip- tional regulation of miRNA biogenesis, one with important implications for how pre-miRNAs are regulated as ...RNPs. The majority ... See full document
12
Nitric Oxide in Skeletal Muscle: Role on Mitochondrial Biogenesis and Function
... mechanisms of NO-dependent regulation of PGC-1 α/ mitochondrial biogenesis also involve 5'-AMP-activated protein kinase (AMPK), a heterotrimeric kinase allosterically activated by AMP and ... See full document
25
Stathmin1 plays oncogenic role and is a target of microRNA-223 in gastric cancer.
... total of 111 gastric adenocarcinoma samples were retrieved from the tissue bank of Anatomical and Cellular Pathology, Prince of Wales Hospital, Shatin, Hong ...pairs of primary tumors ... See full document
10
Identification of human microRNA-like sequences embedded within the protein-encoding genes of the human immunodeficiency virus.
... on the RNA structure and folding parameters consistent with cellular miRNA molecules, five HIV-1-encoded miRNAs have been predicted computationally ...about the existence of vmiRNAs in HIV-1 ... See full document
10
Biogenesis of peroxisomal intrinsic membrane proteins: unveiling the role of pex19p.
... with the energetics reported for the in vitro import of rat PMP22 and PMP70 [84, 85] and ...although the latter authors suggest that ATP may stimulate the assembly of ... See full document
93
Role of microRNA in microglial phenotype during the progression of Alzheimer’s disease
... mediator of microglial quiescence by directly targeting CCAAT/enhancer-binding protein α (C/EBP-α), consequently affecting the ...On the one hand, inhibition of C/EBP-α reduces ... See full document
88
The bacterial MrpORP is a novel Mrp/NBP35 protein involved in iron-sulfur biogenesis
... component of the CIA machinery to be identified was the essential and highly conserved Cfd1, iso- lated from yeast 7 ...This protein belongs to the Mrp/NBP35 ATP-binding protein ... See full document
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Unique haploinsufficient role of the microRNA-processing molecule Dicer1 in a murine colitis-associated tumorigenesis model.
... determine the function of Dicer and its downstream miRNAs in intestinal epithelia, we generated mutant mice lacking Dicer specifically in intestinal epithelial cells (Villin Cre -Dicer D/D ) ... See full document
9
The miRNA biogenesis in marine bivalves
... regulators of gene expression, transposon mobility and virus activity. Among the various categories, mature microRNAs (miR- NAs) guide the translational repression and decay of several ... See full document
25
Epigenetic regulation of microRNA genes and the role of miR-34b in cell invasion and motility in human melanoma.
... is the most lethal form of skin cancer. The treatment of melanoma-derived cell lines with 5-aza-29- deoxycytidine (5-Aza-dC) markedly increases the expression of several miRNAs, ... See full document
12
Analysis of microRNA expression in the prepubertal testis.
... for the need to identify additional miRNA transcriptional regulators capable of acting in cis on chromosomes 2, 12, and ...that the developmental associations with these three chromosomes ... See full document
9
Role of X11 and ubiquilin as in vivo regulators of the amyloid precursor protein in Drosophila.
... Precursor Protein (APP) undergoes sequential proteolytic cleavages through the action of b- and c-secretase, which result in the generation of toxic b-amyloid (Ab) peptides and a ... See full document
11
The role of environmental stress on protein synthesis fidelity
... aggresomes, the the juxtanuclear quality-control compartment (JUNQ) adjacent to the nuclear membrane or the insoluble protein deposit (IPOD) adjacent to the ...protect the ... See full document
247
Multi-tasking role of the mechanosensing protein Ankrd2 in the signaling network of striated muscle.
... and the Renilla luciferase reporter plasmids, were treated with tumor necrosis factor (TNFa) for 20 ...from the cytoplasm to the ...used in dual luciferase assays, nuclear and cytoplasmic ... See full document
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