[PDF] Top 20 Tissue-specific effects of genetic and epigenetic variation on gene regulation and splicing.

... how genetic variation affects distinct cellular phenotypes, such as gene ex- pression levels, alternative splicing and DNA methylation levels, is essential for better un- derstanding ... See full document

... Decades of research have shown that abuse and neglect in early childhood increase the probability of unhealthy and psychopathological outcomes in ...mediator and moderator variables are ... See full document

... germination and growth of most plant species are inhibited by salinity (Anuradha and Rao, 2001; Agarwal and Pandey, 2004; Kirmizi and Bell, ...disruption of ionic equilibrium, ... See full document

... Epigenetics of paternal programming on the ...to genetic information contained in the ...in specific promoter regions most often pre- vents gene transcription by inactivating the ... See full document

... heterogeneous and changing ...spatial and temporal variation in habitat ...distribution of suitable environments, range expansion through frequent colonization of new sites has occurred ... See full document

... control of whole body metabolism. Besides the more recent DNA methylome and microRNA arrays, gene expression profiling is one of the most comprehensive omics technologies, which permits ... See full document

... metal, and at the latest at the beginning of crystallization of silumin, ...cooling of the other zones, which will no longer supply the zone 1 with the liquid metal,, but instead accelerate ... See full document

... mechanism of modification of these precipitations one should take into account that effect of modification of hypereutectic silumins depends on earlier transition to liquid phase ... See full document

... obtained and isolated from bone marrow and adipose tissue as described previously ...subjects, and with the approval of the Ethics Committee of Fundac¸a˜o Oswaldo Cruz, Brazil ... See full document

... based on their relatively higher GC content with respect to the rest of the ...2444 and +280 mainly in the proximal part, and the second one was identified between +525 and +1059 in the ... See full document

... 2 and 4 did not show any difference compared to those of the wild- type littermates (Student’s t-Test, p = ...females and p = ...paternal and maternal transmission ...peak of weight ... See full document

... between epigenetic gene regulation and genomic instability because the atxr5/6 mutant exhibits both de-repression of transposons in pericentromeric het- erochromatin, as well as an ... See full document

... number of species recog- nized for Lasiurus is highly variable, and reports on their evolutionary history have used cytogenetic and molecular analyses for the characterization of ... See full document

... methylation specific qPCR and an ARMS-qPCR based methods were used for SEPT9 methylation and KRAS mutation analyses, ...[19] and new deep sequences approaches [20] are now available, thus ... See full document

... resistance and is further characterized by metabolically elic- ited chronic inflammation of the liver as well as the adipose tissue ...liver and the disability of adipose tissue ... See full document

... rely on a large panel of matched employer- employee data. Based on administrative files maintained by the federal government in Brazil (Rela¸c˜ao Anual de Informa¸c˜oes Sociais - RAIS ), the data ... See full document

... effect of the treatment in a DID model is not the marginal impact of the interaction between time and treatment, but the difference of the cross-differences, as described by Puhani ...results ... See full document

... upregulation of intracellular inflammatory pathways such as IkB kinase complex (IKKB), inhibitor of nuclear factor-kB (IkBa) and NF-kB ...production of high levels of reactive oxygen ... See full document

... In the current study, we investigated the mutations in the PAX9 , MSX1 , AXIN2 and EDA genes in a Chinese family and evaluated the association of gene variation and epigenetic f[r] ... See full document

... fraction of alternatively-spliced Arabidopsis genes was initially estimated to be only 5% (Brett et ...Wang and Brendel, 2006; Filichkin et ...alternative splicing in plants is known to be regulated ... See full document