[PDF] Top 20 Type I interferon: potential therapeutic target for psoriasis?

... keratinocytes, psoriasis is now recognized as a complicated immune system disorder that involves the interplay of innate immunity and adaptive immune response ...treat psoriasis target either T cells ... See full document

... in Psoriasis vulgaris lesions can produce type 1 cytokines, interferon-gamma, interleukin-2, and tu- mor necrosis factor- alpha, defining TC1 (cytotoxic T lymphocyte) and TH1 effector popula- tions: ... See full document

... Abstract: Interferon alpha (IFN-α) is a type I IFN with great therapeutic potential, since it is able to directly fight tumor cells and enhance the maturation of dendritic cells (DCs), ... See full document

... RIG-I-mediated type I IFN pathway is due to phosphorylated ...drug target that will specifically inhibit its role in promoting inflammation mediated by the RIG-I pathway and alleviate ... See full document

... Histone methyltransferase and demethylase enzymes are generally more specific than HDACs in that they target fewer residues. However, like HDACs, lysine and arginine methyltransferase enzymes also methylate the ... See full document

... The other important aspect we experimentally addressed in the context of this study is whether Elesclomol retained its effect at a state when mitochondrial functions were impaired in the melanoma cells. For example, ... See full document

... robust type I IFN response was induced by viable ...of type I IFN in host resistance to many types of viruses, only few papers report their involvement during bacterial infections ...that ... See full document

... The protein expression of Gli1, Gli2, Smo and SHh were characterized by immunohistocehmistry (IHC), and scored on a scale of 0–3 (negative, mild, moderate and strong positive). Representative samples in each category of ... See full document

... of type I IFN in reducing viral replication is well established [51], and we have previously shown that exogenous IFN-b was able to reduce viral replication of H3N2 and a low pathogenic avian H11N9 strain ... See full document

... sampling in Bt potatoes systems, and showed that the diversity of arthropod species and densities of predators and parasitic Hymenoptera increased with the use of transgenic potato varieties. Their overall conclusion was ... See full document

... of interferon stimulated genes (ISGs), termed interferon refractoriness, are less likely to mount a strong antiviral response and achieve viral clearance when placed on ...of interferon (IFN) ... See full document

... We next investigated whether the reduced anxiety of Fpr2/3 -/- mice could be mimicked by administering the FPR inhibitor Boc2 in wild type animals. As shown in Fig. 7, Boc2 had no significant effect on general ... See full document

... The E1B 55 kDa protein has been reported to repress transcription of p53-regulated genes via binding to p53 and to contain a repression domain that inhibits transcription of reporter genes when fused to an heterologous ... See full document

... por interferon (ISGs) e da alta frequência de neutrófilos de baixa ...por interferon do tipo ...que interferon do tipo I tem um papel crucial na ativação de neutrófilos e consequentemente na ... See full document

... hyperaldosteronism type II (FH-II), so named to distinguish the disorder from GRA or familial hyperaldosteronism type I (FH-I), is characterised by autosomal domi- nant inheritance of ... See full document

... We show that hPIV3-C expression enhances the phosphoryla- tion of S6 and eIF4E. The small ribosomal subunit protein S6 is the major phosphoprotein of eukaryotic ribosomes with five phosphorylation sites (Ser235, Ser236, ... See full document

... We started this work showing that TioV infection activates IFN signaling in human HEK-293 cells. This suggested that TioV is incapable of blocking IFN signaling, but also fails to control IFN production. This appears ... See full document

... In zones 3 and 4 the heads of family were predominantly manual workers (73 and 94%, respectively), only 3 and 10% of the houses had piped water and less than 14% of the dwellings wer[r] ... See full document

... the potential bias related to population strati- fication in the Brazilian ethnically heterogeneous population using thirty-five AIMs that show large differences in allele distribution among the three main ethnic ... See full document

... Interferon alpha (IFNα) was initially characterized as an antiviral cytokine. Subsequently, several of its effects were demonstrated. Among them, the antiproliferative effect is the best characterized [1] and ... See full document