[PDF] Top 20 WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling.
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WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling.
... whether WIKI4 is sufficient to inhibit expression of Wnt/ß-catenin target genes in DLD1 colorectal carcinoma cells, which express a truncated form of the Wnt/ß- ... See full document
10
Biphasic role of chondroitin sulfate in cardiac differentiation of embryonic stem cells through inhibition of Wnt/β-catenin signaling.
... a novel role of CS as biphasic regulators of cardiac differentiation of ES ...elimination of endogenous CS at early stages promotes cardiac differentiation, whereas elimination ... See full document
13
A framework for the establishment of a cnidarian gene regulatory network for "endomesoderm" specification: the inputs of ß-catenin/TCF signaling.
... majority of the selected genes (,66%, 64/104) belonged to various families of transcription factors (Table 2), defined by their structure and DNA binding motifs, and involved in diverse ... See full document
28
Common activation of canonical Wnt signaling in pancreatic adenocarcinoma.
... number of studies have demonstrated that Hedgehog and Wnt pathways regulate each other’s activity, the molecular mechanisms underlying this regulation remain ...tion of the canonical ... See full document
9
A high throughput screen identifies Nefopam as targeting cell proliferation in β-catenin driven neoplastic and reactive fibroproliferative disorders.
... effects of high levels of b-catenin due to activation by a Wnt ligand, a growth factor known to activate b-catenin mediated transcription, and an oncogenic mutation in ... See full document
8
Role of Wnt signaling in heart disease
... presence of a stress situation the heart triggers cardioprotective responses, which enable the heart to pump enough blood to meet the metabolic demands of the ...result of several adaptive ... See full document
116
Inhibition of Wnt/β-catenin signaling by a soluble collagen-derived frizzled domain interacting with Wnt3a and the receptors frizzled 1 and 8.
... The Wnt/b-catenin pathway controls cell proliferation, death and ...families of extracellular proteins can antagonize Wnt/b-catenin signaling, including the decoy ... See full document
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Improved elucidation of biological processes linked to diabetic nephropathy by single probe-based microarray data analysis.
... We thank all participating centers of the European Renal cDNA Bank- Kroener-Fresenius biopsy bank (ERCB-KFB) and their patients for their cooperation. Active members at the time of the study: C. D. ... See full document
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High glucose induces podocyte injury via enhanced (pro)renin receptor-Wnt-β-catenin-snail signaling pathway.
... The Wnt gene encodes a large family of secreted proteins that have been identified from Hydra to Human ...polarity and death [27,28,29] through at least three distinct intracellular pathways, ... See full document
8
Identification of proteins with potential osteogenic activity present in the water-soluble matrix proteins from crassostrea gigas nacre using a proteomic approach
... tissue and bone development ...development and expressed in kidney cells ...synthesis of specific bone proteins [48]. It also promotes proliferation of fibroblasts [49], smooth muscle [50] ... See full document
10
Wnt/β-catenin signaling enhances cyclooxygenase-2 (COX2) transcriptional activity in gastric cancer cells.
... upstream of the human COX2 promoter there are four putative TBE sites (core: CTTTG), one of which has been previously studied by Araki and cols ...regulation of the transcriptional activity ... See full document
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Interruption of Wnt signaling in Muller cells ameliorates ischemia-induced retinal neovascularization.
... Guidelines of the National Institutes of Health for the Use of Animal in Research and were approved by the Institutional Animal Care and Use Committees of the University ... See full document
12
Maternal Wnt/β-catenin signaling coactivates transcription through NF-κB binding sites during Xenopus axis formation.
... corollary of the enormous diversity of biological roles assigned to the NF-kB system is that perturbation of its functions can have broad deleterious ...Loss of NF-kB function through targeted ... See full document
14
Efeito do tratamento com lítio sobre a habilidade motora e o sistema Wnt-catenina-caderina durante o desenvolvimento inicial de Zebrafish
... effects of lithium exposed babies, we have observed a prominent neuromuscular deficit in 10dpf larvae exposed to lithium during early developmental period at the ...levels of the therapeutic ...description ... See full document
53
Renal Metastasis of a Malignant Myopericytoma: A Case Report and Review of Literature
... tumour of the kidney with irregular contrast captation. C) Haematoxylin and eosin staining of the kidney lesion showing a highly cellular tumour ...Hematoxylin and eosin staining of the ... See full document
6
Factors associated with Clostridium difficile diarrhea in a hospital in Beijing, China
... cause of hospital-acquired diarrhea in patients treated with antibiotics, chemotherapeutic agents, and other drugs that alter the normal equilibrium of the intestinal ...understanding of the ... See full document
6
Modulation of β-catenin signaling by glucagon receptor activation.
... association of GCGR and Lrp5 was independent of GCG1-29 ...Lrp5 and anti-v5 antibody did not pull down HA-tagged ...GCGR and Lrp5 interaction by tagging GCGR with YFP and Lrp5 ... See full document
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UBE3C promotes growth and metastasis of renal cell carcinoma via activating Wnt/β-catenin pathway.
... malignancy of the kidney and one of the most lethal genitourinary ...because of a high potential for tumor growth, vascular inva- sion, metastasis and ...mechanism of RCC growth ... See full document
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Endocardial to myocardial notch-wnt-bmp axis regulates early heart valve development.
... that Wnt and Bmp, two critical signaling pathways that have been shown to regulate EMT and heart valve formation [1], are dramatically attenuated in AVC cushions of endocardial Notch1 ... See full document
12
Tcf3 represses Wnt-β-catenin signaling and maintains neural stem cell population during neocortical development.
... domain, and Wnt signaling induces expression of these isoforms as a negative feedback ...by Wnt signal activation, suggesting that the repressor types are functionally dominant among ... See full document
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