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: +38(050)6189959; +38(063)3235718 E-mail: godovanets.yul@yandex.ru; neonatology@bsmu.edu.ua
: http: // www.bsmu.edu.ua/; http://www.neonatology.com.ua; http://ojs.bsmu.edu.ua/
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5. Galano . Melatoninas a naturalally against oxidative stress: a physicochemical examination. Review article / . Galano, Dun Xian Tanetal // Journal of Pineal Research /J. Pineal Res. 2011. 51. .1–16.
6. Tamura . The role of melatonin as an antioxidant in the follicle / . Tamura // Journal of Ovarian Research. 2012. 5. .5.
7. Velev Z. An initial low response predicts poor outcome invitro fertilization/intracytoplasmic sperm injection despite improved ovarian response inconsecutive cycles / Z.Velev
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OVARIAN RESERVE AND HORMONAL CORRECTION
USING ASSISTED
REPRODUCTIVE TECHNOLOGIES M. O. Scherbina, O.G. Gradil
Kharkiv national medical university HM of Ukraine
(Kharkiv, Ukraine)
Summary. The content of melatonin and 8-isoprostane in serum and follicular fluid on a background of ovarian stimulation in 66 patients suffering from infertility, which were divided in two equivalent groups, was studied. Control group consisted of 33 healthy women of reproductive age. It was found out that melatonin has a significant antioxidant action, thereby increasing the number of oocytes obtained from poor responders, and 8-isoprostane was a reliable indicator of oxidative stress and the antioxidant system state in blood serum and follicular liquid. The use of agonists and antagonists of gonadotropin hormones to induce superovulation leads to increased oxidative stress in the follicular liquid.
Keywords: infertility, oxidative stress, melatonin, 8-isoprostane, ovarian stimulation, in vitro fertilization.
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