BVS (Portug - Mylene Martins Monteiro

uese and Spanish ) (tw:("transtornos do metabolismo de glucose" OR "trastornos del metabolismo de la glucosa" OR "diabetes mellitus" OR "diabetes mellitus tipo 2")) AND (tw: ("periodontite crônica" OR "periodontitis crónica" OR periodontite OR periodontitis OR "doenças periodontais" OR

"enfermedades periodontales")) AND (tw: ("raspagem dentária" OR "raspado dental" OR "aplainamento radicular" OR

"aplanamiento de la raíz" OR "curetagem subgengival" OR "curetaje subgingival" OR "desbridamento periodontal" OR

"desbridamiento periodontal" OR cirurgia OR cirurgía OR "terapia por láser" OR "terapia a laser" OR antibacterianos OR fototerapia)) AND (tw:("hemoglobina A glicosilada" OR "hemoglobina A glucosilada" OR "Hemoglobina A" OR "hemoglobinas"))

ProQue st

noft(("glucose metabolism disorders" OR diabetes OR "diabetes mellitus" OR "diabetes mellitus type 2" OR "diabetes type 2" OR "diabetes mellitus, type II" OR "diabetes mellitus, type 2" OR "type 2 diabetes mellitus")) AND noft((periodontitis OR "Periodontal Diseases" OR "periodontal disease" OR "Chronic Periodontitis" OR "adult periodontitis" OR "loss, periodontal attachment" OR "attachment loss, periodontal" OR "Periodontitis, Adult" OR "Periodontitis, Chronic" OR "periodontal attachment loss")) AND noft(("non-surgical periodontal therapy" OR "nonsurgical periodontal therapy" OR "periodontal therapy" OR ("phase 1" AND "periodontal therapy") OR "periodontal diseases

therapy" OR "chronic periodontitis therapy" OR "scaling and root planing" OR "dental scaling" OR "dental scaling methods" OR "root planing" OR "root planing methods" OR "gingival curettage" OR "periodontal treatment" OR "periodontal intervention" OR "subgingival curettage" OR "root scaling" OR "subgingival scaling" OR "supragingival scaling" OR "periodontal therapeutics" OR "periodontal debridement" OR "nonsurgical periodontal debridement" OR "low-level light therapy" OR "laser phototherapy" OR "laser therapy" OR phototherapy OR "anti-bacterial agents" OR (anti-bacterial AND agents) OR

"antibacterial agents" OR antibiotics OR antibiotic OR "anti bacterial agents" OR bacteriocides OR "periodontal debridement methods" OR "chronic periodontitis

surgery" OR "periodontal diseases surgery" OR "periodontal diseases therapy" OR "periodontal pocket surgery")) AND noft(("advanced glycation end products" OR "glycosylated hemoglobin" OR "HbA1c" OR "hemoglobin A1c protein, human" OR "glycohemoglobin A" OR "hemoglobin A, glycosylated" OR "hemoglobin A,

glycosylated analysis" OR "hemoglobins, 9

Open Grey

("glucose metabolism disorders" OR diabetes OR "diabetes mellitus" OR "diabetes mellitus type 2" OR "diabetes type 2" OR "diabetes mellitus, type II" OR "diabetes mellitus, type 2" OR "type 2 diabetes mellitus") AND (periodontitis OR "Periodontal Diseases" OR "periodontal disease" OR "Chronic Periodontitis" OR "adult periodontitis" OR "loss, periodontal attachment" OR "attachment loss, periodontal" OR "Periodontitis, Adult" OR "Periodontitis, Chronic" OR "periodontal attachment loss") AND ("non-surgical periodontal therapy" OR "nonsurgical periodontal therapy" OR "periodontal therapy" OR ("phase 1" AND "periodontal therapy") OR "periodontal diseases

"antibacterial agents" OR antibiotics OR antibiotic OR "anti bacterial agents" OR bacteriocides OR "periodontal debridement methods" OR "chronic periodontitis

surgery" OR "periodontal diseases surgery" OR "periodontal diseases therapy" OR "periodontal pocket surgery") AND ("advanced glycation end products" OR "glycosylated hemoglobin" OR "HbA1c" OR "hemoglobin A1c protein, human" OR "glycohemoglobin A" OR "hemoglobin A, glycosylated" OR "hemoglobin A, glycosylated analysis" OR "hemoglobins,

Google Scholar

("diabetes mellitus" OR "diabetes mellitus type 2" OR "diabetes type 2" OR "diabetes mellitus type II") AND (periodontitis OR "Chronic Periodontitis" OR "adult

periodontitis" OR "periodontal attachment loss") AND ("non-surgical periodontal therapy" OR "scaling and root planing" OR "low-level light therapy" OR "laser therapy" OR phototherapy OR "anti-bacterial agents" OR antibiotics OR "chronic periodontitis/ surgery" OR "periodontal surgery") AND ("glycosylated hemoglobin" OR "HbA1c")

A

PPENDIX

S2. E

XCLUDEDARTICLESANDREASON FOR EXCLUSION

. (

= 63).

Author, year Reason for exclusion

Acharya et al., 2015 4 Alsheri et al., 2015 10 Al Mubarak et al., 2002 5 Al Mubarak et al., 2010 5 Alshorman, 2008 11 Borgnakke et al., 2014 1 Botero et al., 2013 5 Camargo et al., 2014 4 Campus et al., 2007 1 Chapple et al., 2014 1 Chee et al., 2006 1 Dodwad, et al., 2012 4

Engebretson and Hey-Hadavi, 2011 6

Fu et al., 2000 4

Guo and Zhu, 2004 4

Haerian Ardakani, A 2014 11

Hungund and Panseriya, 2012 4

Ivanaga, 2019 4

Javid et al., 2017 10

Kapellas et al., 2016 10

Katagiri et al., 2009 9

Long and Ru-Fan, 2011 4

Macedo et al., 2014 9 Masi, S., 2018 10 Matsumoto et al., 2009 6 Mendonça et al., 2012 6 Merchant et al., 2014 1 Munenaga et al., 2013 4 Navarro-Sanchez et al., 2007 4 Ramos et al., 2016 9

Santoso and Waspadji, 2008 9

Supraneni et al., 2018 10

Vergnes et al., 2014 1

Xu et al., 2013 4

Zare, Javid A., 2016 6

NCT00801164 12

NCT02735837 12

NCT02845024 12

NCT00016835 12

NCT03343366 12 IRCT2014082417587N7 12 IRCT2015010517587N 12 IRCT2015010517587N9 12 RBR-4tq9yq 12 RBR-9sq542 12 CTRI/2017/11/010348 12 CTRI/2018/01/011227 12 CTRI/2016/03/006764 12 IRCT2013092614774N1 12 IRCT2017011631993N1 12 IRCT2017030432874N1 12 NCT02794506 12 IRCT201411023690N5 12 NCT03444363 12 NCT02437747 12 ISRCTN11742127 12 ChiCTR1800018165 12 NCT02062047 12 CTRI/2017/11/010604 12 CTRI/2018/03/012726 12 CTRI/2018/03/012689 12

1- Review, letters, personal opinions, book chapters, panels, editorial and conference abstracts (n= 6), 2- In vitro studies or studies in animal models (n= 0), 3- Qualitative Research (n= 0), 4 - Observational Studies (Case-Control, Cohort and Cross-sectional), non-randomized or non- parallel clinical trials (n= 11), 5 - Studies that have considered diabetes type 1 or Periodontal Disease other than Chronic Periodontitis. (n= 3), 6 - Studies without considered outcomes (glycosylated hemoglobin A or periodontal clinical parameters) (n= 5), 7 - Studies that have included patients with comorbidities or metabolic syndrome (n= 0), 8 - Studies in which relevant systemic health conditions, such as hypertension and smoking, were not balanced between the groups (n= 0); 9 - Studies in which control group received any therapy other than NSPT alone or remained untreated (n= 4); 10 - Studies in which no adjunctive treatment to NSPT was tested (n= 5); 11- Studies written in non-Latin alphabet (n= 2); 12 - Study protocols (n=27).

REFERENCES

1. Acharya, A. B., et al. (2015). Effect of scaling and root planing on serum interleukin-10 levels and glycemic control in chronic periodontitis and type 2 diabetes mellitus. Journal of Indian Society of Periodontology 19(2): 188-193.

2. Alshehri M, Alshail F, Alshehri FA. Effect of scaling and root planing with and without adjunctive use of an essential-oil- based oral rinse in the treatment of periodontal inflammation in type-2 diabetic patients. J Investig Clin Dent. 2017;8(1):1– 6.

3. Al-Mubarak, S., et al. (2002). Comparative evaluation of adjunctive oral irrigation in diabetics. J Clin Periodontol 29(4): 295-300.

4. Al-Mubarak, S., et al. (2010). A new paradigm between mechanical scaling and root planing combined with adjunctive chemotherapy for glycated hemoglobin improvement in diabetics. International Journal of Diabetes Mellitus 2(3): 158-164.

5. Alshorman, H. M. (2008). The association between periodontal disease and type 2 diabetes mellitus in jordanian patients. Ann Arbor, Queen's University Belfast (United Kingdom). U234158: 1.

6. Borgnakke, W. S., et al. (2014). The multi-center randomized controlled trial (RCT) published by the journal of the american medical association (JAMA) on the effect of periodontal therapy on glycated hemoglobin (hba1c) has fundamental problems. Journal of Evidence-Based Dental Practice 14(3): 127-132.

7. Botero JE, Yepes FL, Ochoa SP, Hincapie JP, Roldan N, Ospina CA, Castrillon CA, Becerra MA. Effects of periodontal non-surgical therapy plus azithromycin on glycemic control in patients with diabetes: a randomized clinical trial. J Periodont Res 2013; 48: 706–712.

8. Camargo, G. A. C. G., et al. (2013). Effect of periodontal therapy on metabolic control and levels of IL-6 in the gingival crevicular fluid in type 2 diabetes mellitus. Indian Journal of Dental Research 24(1): 110-116.

9. Campus, G., et al. (2007). Clinical effects of mechanical periodontal therapy in type 2 diabetic patients. Diabetes Res Clin Pract 75(3): 368-369.

10. Chapple, I. L. C., et al. (2014). Hemoglobin A1c levels among patients with diabetes receiving nonsurgical periodontal treatment [2]. JAMA - Journal of the American Medical Association 311(18): 1919-1920.

11. Chee, H. K., et al. (2006). Non-surgical periodontal therapy and serum lipid levels in patients with diabetes mellitus. Ann R Australas Coll Dent Surg 18: 46.

12. Dodwad V, Ahuja S, Kukreja BJ. Effect of locally delivered tetracycline hydrochloride as an adjunct to scaling and root planing on Hba1c, C-reactive protein, and lipid profile in type 2 diabetes: A clinico-biochemical study. Contemp Clin Dent 2012;3:150-4.

13. Engebretson SP, Hey-Hadavi J. Sub-antimicrobial Doxycycline for Periodontitis Reduces Hemoglobin A1c in Subjects with Type 2 Diabetes: a Pilot Study. Pharmacol Res. 2 0 11 D e c e m b e r ; 6 4 ( 6 ) : 6 2 4 – 6 2 9 . d o i : 1 0 . 1 0 1 6 / j.phrs.2011.06.024.

14. Fu, Y., et al. (2000). "The effect of non-surgical periodontal therapy on blood sugar level of non-insulin dependent

diabetes mellitus diabetics with periodontitis." Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology 35(6): 444-446.

15. Guo, Y. H.; Zhu, B. L. (2004). "The effect of initial therapy on periodontal status and saccharified Hb (HbAIc) of patients with type II diabetes mellitus." Shanghai Kou Qiang Yi Xue 13(2): 150-151.

16. Haerian Ardakani A, Asadi Y, Afkhami Ardakani M, Nooorelahi M, Sooratgar A. Effect of Topical Tetracycline Gel with Non Surgical Periodontal Therapy on Hba1c and Lipid Profile in Type 2 Diabetic Patients: A Clinico- Biochemical Study. JSSU. 2014; 22 (4) :1387-1395

17. Hungund, S. and B. J. Panseriya (2012). "Reduction in HbA1c levels following non-surgical periodontal therapy in type-2 diabetic patients with chronic generalized periodontitis: A periodontist's role." Journal of Indian Society of Periodontology 16(1): 16-21.

18. Ivanaga, Camila Ayumi. Efeitos fotodinâmicos da curcumina no tratamento de bolsas residuais de pacientes portadores de periodontite crônica e Diabetes mellitus tipo 2 : estudo de boca dividida randomizado / Camila Ayumi Ivanaga. - Araçatuba, 2019 65 f. : il.; tab.

19. Javid AZ, Hormoznejad R, Yousefimanesh HA, Zakerkish M, Haghighi-Zadeh MH, Dehghan P, Ravanbakhsh M. The Impact of Resveratrol Supplementation on Blood Glucose, Insulin, Insulin Resistance, Triglyceride, and Periodontal Markers in Type 2 Diabetic Patients with Chronic Periodontitis. Phytother. Res. 2007;31: 108–114.

20. Ahmad Zare Javid, Leila Maghsoumi-Norouzabad, Elnaz Ashrafzadeh, Hojat Allah Yousefimanesh, Mehrnoosh Zakerkish, Kambiz Ahmadi Angali, Maryam Ravanbakhsh & Hosein Babaei (2017): Impact of Cranberry Juice Enriched with Omega-3 Fatty Acids Adjunctwith Nonsurgical Periodontal Treatment on Metabolic Control and Periodontal Status in Type 2 Patients with Diabetes with Periodontal Disease, Journal of the American College of Nutrition, DOI: 10.1080/07315724.2017.1357509

21. Kapellas, K., et al. (2016). "Periodontal therapy and glycaemic control among individuals with type 2 diabetes: reflections from the PerioCardio study." Int J Dent Hyg. 22. Katagiri, S., et al. (2009). "Multi-center intervention study on

glycohemoglobin (HbA1c) and serum, high-sensitivity CRP (hs-CRP) after local anti-infectious periodontal treatment in type 2 diabetic patients with periodontal disease." Diabetes research and clinical practice 83(3): 308-315.

23. Long, O. and L. Ru-Fan (2011). "Effect of periodontal treatment on glycosylated hemoglobin levels in elderly patients with periodontal disease and type 2 diabetes." Chinese Medical Journal 124(19): 3070-3073.

24. Macedo, G. O., et al. (2014). "Additional effects of aPDT on nonsurgical periodontal treatment with doxycycline in type II diabetes: a randomized, controlled clinical trial." Lasers Med Sci 29(3): 881-886.

25. Masi, S., Orlandi, M., Parkar, M., Bhowruth, D., Kingston, I., O'Rourke, C., Virdis, A., Hingorani, A., Hurel, S.J., Donos, N., D'Aiuto, F., Deanfield, F. Mitochondrial oxidative stress, endothelial function and metabolic control in patients with type II diabetes and periodontitis: a randomized controlled clinical trial. Int. J. Cardiol. 2018 Nov 15;271:263–268

26. Matsumoto, S., et al. (2009). "Effect of antimicrobial periodontal treatment and maintenance on serum adiponectin in type 2 diabetes mellitus." J Clin Periodontol 36(2): 142-148. 27. Mendonça, A. C., et al. (2012). "Surgical and non-surgical therapy with systemic antimicrobials for residual pockets in type 2 diabetics with chronic periodontitis: a pilot study." J Clin Periodontol 39(4): 368-376.

28. Merchant, A. T. (2014). "Hemoglobin A1c levels among patients with diabetes receiving nonsurgical periodontal treatment [1]." JAMA - Journal of the American Medical Association 311(18): 1919.

29. Munenaga Y, Yamashina T, Tanaka J, Nishimura F and The Hiroshima Study Group. Improvement of glycated hemoglobin in Japanese subjects with type 2 diabetes by resolution of periodontal inflammation using adjunct topical antibiotics:

Results from the Hiroshima Study. Diabetes research and clinical practice. 2013; 100(54):53-60.

30. Navarro-Sanchez, A. B., et al. (2007). "Effect of non-surgical periodontal therapy on clinical and immunological response and glycaemic control in type 2 diabetic patients with moderate periodontitis." J Clin Periodontol 34(10): 835-843. 31. Ramos, U. D., et al. (2016). "Antimicrobial photodynamic

therapy as an alternative to systemic antibiotics: results from a double-blind, randomized, placebo-controlled, clinical study on type 2 diabetics." J Clin Periodontol 43(2): 147-155. 32. Santoso, O. and S. Waspadji (2008). "The effect of non-

surgical periodontal therapy on systemic immune response and blood glucose level of NIDDM patients." Medical Journal of Indonesia 17(1): 20-24.

33. Supraneni, Kinnera., Koduganti, Rekha. (2018). Efficacy of Systemic Administration of Alpha Lipoic Acid and Scaling and Root Planning in Patients with Chronic Periodontitis and Type 2 Diabetes Mellitus-A Randomised Controlled Trial. Journal of Clinical and Diagnostic Research. Vol-12. 10.7860/JCDR/ 2018/29200.11397.

34. Vergnes, J. N. (2014). "Hemoglobin A1c levels among patients with diabetes receiving nonsurgical periodontal treatment." JAMA - Journal of the American Medical Association 311(18): 1920-1921.

35. Xu, J. L., et al. (2013). "[Effect of periodontal therapy on metabolic control and serum biochemical markers in subjects with type 2 diabetes and chronic periodontitis]." Beijing Da Xue Xue Bao 45(1): 27-32.

36. Zare Javid A., Hormoznejad R., Yousefimanesh H.A., Zakerkish M., Haghighi-Zadeh M.H., Dehghan P., Ravanbakhsh M. The Impact of Resveratrol Supplementation on Blood Glucose, Insulin, Insulin Resistance, Triglyceride, and Periodontal Markers in Type 2 Diabetic Patients with Chronic Periodontitis. Phytother. Res. 2017;31:108–114. doi: 10.1002/ptr.5737.

37. NCT00801164, Exploratory Study of Iocide Oral Rinse in a Diabetic Population. Https://clinicaltrials.gov/show/ nct00801164 - Volume 0, Issue 0, pp. - published 2008-01-01 38. NCT02735837, The Effect of Topical Doxycycline Gel on

HbA1c in Patients With Type 2 Diabetes Mellitus(DM). Https:// clinicaltrials.gov/show/nct02735837 - Volume 0, Issue 0, pp. - published 2016-01-01

39. NCT02845024, The Effect of Non-surgical Periodontal Therapy Plus Doxycycline on HbA1c in Patients With Type 2 Diabetes Mellitus. Https://clinicaltrials.gov/show/nct02845024 - Volume 0, Issue 0, pp. - published 2016-01-01

40. NCT00016835, Treating Periodontal Infection: effects on Glycemic. Https://clinicaltrials.gov/show/nct00016835 - Volume 0, Issue 0, pp. - published 2001-01-01

41. IRCT2016110430694N1, Impact of probiotic supplementation in treatment of periodontal patients with type 2 diabetes mellitus. Http://www.who.int/trialsearch/trial2.aspx? Trialid=irct2016110430694n1 - Volume 0, Issue 0, pp. - published 2017-01-01.

42. NCT03343366, Glycemic Control in T2DM Through Non- Surgical Periodontal Therapy. Https://clinicaltrials.gov/show/ nct03343366 - Volume 0, Issue 0, pp. - published 2017-01-01. 43. IRCT2014082417587N7, A randomized double-blind placebo-

controlled, clinical trial on the effect of non-surgical periodontal therapy plus doxycycline on HbA1c in patients with type 2 diabetes mellitus (DM). Http://www.who.int/ trialsearch/trial2.aspx? Trialid=irct2014082417587n7 - Volume 0, Issue 0, pp. - published 2014-01-01

44. I R C T 2 0 1 5 0 1 0 5 1 7 5 8 7 N , A r a n d o m i z e d , p l a c e b o controlled trialThe effect of non-surgical periodontal therapy with adjunctive topical doxycycline gel on HbA1c in patients with type 2 diabetes mellitus (DM). Http://www.who.int/ trialsearch/trial2.aspx? Trialid=irct2015010517587n8 - Volume 0, Issue 0, pp. - published 2015-01-01.

45. IRCT2015010517587N9, A randomized double-blind placebo- controlled, clinical trial the effect of non-surgical periodontal therapy plus subgingivally azithromycin gel on HbA1c in

patients with type 2 diabetes mellitus (DM). Http:// w w w . w h o . i n t / t r i a l s e a r c h / t r i a l 2 . a s p x ? Trialid=irct2015010517587n9 - Volume 0, Issue 0, pp. - published 2015-01-01.

46. RBR-4tq9yq, Effect of Curcumin associated with LED application in the treatment of residual pockets of patients with Chronic Periodontitis and type 2 Diabetes Mellitus. Http:// www.who.int/trialsearch/trial2.aspx? Trialid=rbr-4tq9yq - Volume 0, Issue 0, pp. - published 2018-01-01

47. RBR-9sq542, Efficacy of the treatment of chronic periodontitis with antimicrobial Photodynamic therapy associated with conventional treatment in diabetic patients. Http:// www.who.int/trialsearch/trial2.aspx? Trialid=rbr-9sq542 - Volume 0, Issue 0, pp. - published 2017-01-01

48. CTRI/2017/11/010348, Laser treatment of the gums. Http:// w w w. w h o . i n t / t r i a l s e a r c h / t r i a l 2 . a s p x ? Tr i a l i d = c t r i / 2017/11/010348 - Volume 0, Issue 0, pp. - published 2017-01-01.

49. CTRI/2018/01/011227, Effect of oral prophylaxis with and without oral antibiotic on systemic biomarker levels in patients with pyorrhoea having diabetes mellitus. Http://www.who.int/ trialsearch/trial2.aspx? Trialid=ctri/2018/01/011227 - Volume 0, Issue 0, pp. - published 2018-01-01.

50. CTRI/2016/03/006764, Effect of Vitamin C supplementation on Diabetes Mellitus and assessment of salivary vitamin C along with periodontal health. Http://www.who.int/trialsearch/ trial2.aspx? Trialid=ctri/2016/03/006764 - Volume 0, Issue 0, pp. - published 2016-01-01.

51. IRCT2013092614774N1, Effects of SRP on blood glucose level reduction in diabetic patients. Http://www.who.int/ trialsearch/trial2.aspx? Trialid=irct2013092614774n1 - Volume 0, Issue 0, pp. - published 2014-01-01.

52. IRCT2017011631993N1, The effect of melatonin supplementation in the treatment of type 2 diabetic patients with chronic periodontitis disorder. Http://www.who.int/

trialsearch/trial2.aspx? Trialid=irct2017011631993n1 - Volume 0, Issue 0, pp. - published 2017-01-01.

53. I R C T 2 0 1 7 0 3 0 4 3 2 8 7 4 N 1 , T h e e f f e c t o f G i n g e r supplementation in the treatment of type 2 Diabetic patients with Periodontitis. Http://www.who.int/trialsearch/trial2.aspx? Trialid=irct2017030432874n1 - Volume 0, Issue 0, pp. - published 2017-01-01.

54. NCT02794506, Propolis Improves Glycemic Control in Subjects With Type 2 Diabetes and Chronic Periodontitis. Https://clinicaltrials.gov/show/nct02794506 - Volume 0, Issue 0, pp. - published 2016-01-01.

55. IRCT201411023690N5, Effect of Chlorhexidine gel in diabetic and gum disease patients. Http://www.who.int/trialsearch/ trial2.aspx? Trialid=irct201411023690n5 - Volume 0, Issue 0, pp. - published 2015-01-01.

56. NCT03444363, Periodontal Treatment With Diode Laser in the Patients With Diabetes Melitus. Https://clinicaltrials.gov/ show/nct03444363 - Volume 0, Issue 0, pp. - published 2018-01-01.

57. NCT02437747, Locally Delivered Aloe Vera Gel in the Treatment of Chronic Periodontitis Patients With Diabetes Mellitus. Https://clinicaltrials.gov/show/nct02437747 - Volume 0, Issue 0, pp. - published 2015-01-01

58. ISRCTN11742127, Periodontal therapy in diabetic subjects. H t t p : / / w w w . w h o . i n t / t r i a l s e a r c h / t r i a l 2 . a s p x ? Trialid=isrctn11742127 - Volume 0, Issue 0, pp. - published 2008-01-01.

59. ChiCTR1800018165, Clinical effect of Er: YAG laser-assisted SRP for type 2 diabetes-associated periodontitis and dynamic changes of subgingival flora before and after treatment. H t t p : / / w w w . w h o . i n t / t r i a l s e a r c h / t r i a l 2 . a s p x ? Trialid=chictr1800018165 - Volume 0, Issue 0, pp. - published 2018-01-01

60. NCT02062047, Full-mouth and Partial-mouth Scaling and Root Planing in Type 2 Diabetic Subjects. Https:// clinicaltrials.gov/show/nct02062047 - Volume 0, Issue 0, pp. - published 2014-01-01.

61. CTRI/2017/11/010604, Effect of vitamin E on gum health and blood sugar level in TypeII diabetic patient suffering from pyorrhea. Http://www.who.int/trialsearch/trial2.aspx? Trialid=ctri/2017/11/010604 - Volume 0, Issue 0, pp. - published 2017-01-01.

62. CTRI/2018/03/012726, Assess the use of Gum-paint and Tablets applied over gums along with Cleaning in Diabetic patients with Gum Disease. Http://www.who.int/trialsearch/ trial2.aspx? Trialid=ctri/2018/03/012726 - Volume 0, Issue 0, pp. - published 2018-01-01.

63. CTRI/2018/03/012689, Efficacy of Coconut Oil Therapy as supplementary to Scaling in Diabetic patients with Gum Disease. Http://www.who.int/trialsearch/trial2.aspx? Trialid=ctri/2018/03/012689 - Volume 0, Issue 0, pp. - published 2018-01-01.

A

NEXOS

N

ORMASDA

R

EVISTA

Journal of Periodontal and Implant Science

AIM AND SCOPE

Renamed from the Journal of the Korean Academy of Periodontology, the Journal of Periodontal & Implant Science (JPIS) is a peer-reviewed and open-access journal providing up- to-date information in the scope of professionalism of periodontology and dental implantology.

PUBLICATION TYPES AND LANGUAGE

JPIS encompasses a wide range of publication types including clinical and experimental research articles, sophisticated reviews, letters to the editor, and editorials, covering a variety of interests in the field of periodontal or implant science. Manuscripts written in British or American English with consistency from any researcher across the world will be welcomed if they are within the aim & scope of this journal.

RESEARCH AND PUBLICATION ETHICS

All of the manuscripts should be prepared in strict observation of research and publication ethics guidelines recommended by the C o u n c i l o f S c i e n c e E d i t o r s ( h t t p : / / www.councilscienceeditors.org/), International Committee of Medical Journal Editors (ICMJE, http://www.icmje.org/), World Association of Medical Editors (WAME, http://www.wame.org/), and the Korean Association Medical Journal Editors (http:// www.kamje.or.kr/intro.php?body=eng_index).

Conflict-of-interest statement

A conflict of interest may exist when an author has financial or personal relationships or affiliations that could bias the author's decisions of the manuscript. Authors are expected to provide detailed information about all relevant financial conflicts, particularly those present during the process of research and publication, as well as other financial interests (such as patent applications in preparation) that represent potential financial gain in the future. All disclosures of any potential conflicts of interest including specific financial interests, relationships, and affiliations (other than those affiliations listed in the title page of the manuscript) relevant to the subject of the manuscript will be reported by the corresponding author on behalf of each co-author, if any, as part of the submission process. Likewise, authors without conflicts of interest will be requested to state so as part of the submission process. If authors are uncertain about what constitutes relevant financial interests or relationships, they should contact the editorial office.

Statement of informed consent

Copies of written informed consents and Institutional Review Board (IRB) approval for clinical research should be kept. If necessary, the editor or reviewers may request copies of these documents to resolve questions about IRB approval and study conduct.

Statement of human and animal rights

Clinical research should be performed in accordance with the Ethical Principles for Medical Research Involving Human Subjects, outlined in the Declaration of Helsinki (http:// www.wma.net/en/30publications/10policies/b3/index.html). Clinical studies that do not comply with it will not be considered

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