Nesse estudo nós mostramos que os tratamentos com injeções repetidas de DM i.n. ou i.c.v. foram capazes de causar alterações cognitivas e emocionais, na ausência de alterações motoras. Essas alterações foram acompanhadas da redução de neurônios TH+ na SNpc e VTA, mostrando o envolvimento da via dopaminérgica. O curso temporal das alterações motoras e cognitivas, associados à redução de neurônios dopaminérgicos, podem ser relacionados com diferentes estágios da DP, em humanos e em modelos animais progressivos da doença, sugerindo que esse seja um possível modelo animal para se compreender melhor possíveis alterações envolvidas na natureza progressiva da DP. Porém, outros estudos deverão ser realizados para se conhecer melhor os efeitos causados por esse pesticida sobre os mecanismos comportamentais e neuroquímicos.
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