• Nenhum resultado encontrado

Pacientes tratados para a infecção por HCMV apresentaram dados laboratoriais semelhantes aos pacientes transplantados renais com ausência da infecção pelo citomegalovírus. Não observamos diferenças significativas nas dosagens de fósforo, potássio, vitamina D, hemoglobina, leucócitos e plaquetas quando comparamos o grupo pp65+ e pp65-. Foi observada melhora na taxa de filtração glomerular estimada e dos níveis de creatinina além de uma redução dos níveis de paratormônio em ambos os grupos.

Deste modo, a infecção por citomegalovírus nos pacientes transplantados renais não se correlaciona com a hipovitaminose D, sendo necessário mais estudos a fim de buscar novos candidatos a biomarcadores no contexto das doenças renais.

REFERÊNCIAS BIBLIOGRÁFICAS

AGGARWAL M, Sahoo SP, Bhandari HS, Kriplani J, Mithal A. Prevalence of vitamin D deficiency in post renal transplant patients. Indian Journal of Endocrinology and

Metabolism, v.16,n.2,p: 274-276, 2012.

AMBRUS, C., Molnar, MZ, Czira, ME et al. Calcium, phosphate and parathyroid metabolism in kidney transplanted patients.Int Urol Nephrol,n.41,p: 1029,2009. BELTRAN PMJ, CRISTEA IM. The life cycle and pathogenesis of human cytomegalovirus infection: lessons from proteomics. Expert review of proteomics,,v.11,n.6,p: 697-711, 2014

BURTIS, C.A., ASHWOOD, E.R. Tietz Fundamentos de Química Clínica e

Diagnóstico Molecular, 7ºed., Rio de Janeiro: Elsevier,2016

BLOSSER, Christopher D.; BLOOM, Roy D., Posttransplant anemia in solidorganrecipients, Transplantation Reviews, v. 24, n. 2, p. 89–98, 2010.

CALVO MS, Lamberg-Allardt CJ. Phosphorus. Advances in Nutrition,v.6,n.6, p:860- 862, 2015.

BRONNER, F. Recent developments in intestinal calcium absorption. Nutrition

Reviews, v. 67, p. 109–113, 2009.

CANUTO, Juliana Maria Palmeira et al. Fatores de risco associados à hipovitaminose D em indivíduos adultos infectados pelo HIV/aids. Arch. Endocrinol. Metab,São Paulo , v. 59, n. 1, p. 34-41, 2015

CASTRO, Luiz Claudio Gonçalves de. O sistema endocrinológico vitamina D.Arquivo

Brasileiro Endocrinologia Metabologia, São Paulo, v. 55, n. 8, p. 566-575, 2011.

CIANCIOLO, Giuseppe; GALASSI, Andrea; CAPELLI, Irene; et al. Vitamin D in Kidney Transplant Recipients: Mechanisms and Therapy. American Journal of Nephrology, v. 43, n. 6, p. 397–407, 2016.

CROUGH, Tania e Rajiv Khanna. “Imunobiologia do citomegalovírus humano: do banco ao leito”. Clinical Microbiology Reviews,v. 22,n.1,p: 76–98, 2009

CSABA P.Kovesdy,IstvanMucsi, et al. Association of serum phosphorus level with anemia in kidney transplant recipients.Transplantation,v.91,n.8,p:875–882,2011.

DE OLIVEIRA, Vanessa et al. Influência da vitamina D na saúde humana. Acta bioquím.

clín. latinoam., LaPlata, v. 48, n. 3, p. 339-347, 2014

EVENEPOEL P, Meijers BKI, de Jonge H, et al. Recovery of Hyperphosphatoninism and Renal Phosphorus Wasting One Year after Successful Renal Transplantation.

Clinical Journal of the American Society of Nephrology: CJASN.v.3, n.6,p: 1829-

1836,2008.

EVENEPOEL Pieter, Bammens Bert, Claes Kathleen, Kuypers Dirk, Meijers Björn K.I., Vanrenterghem Yves. Measuring Total Blood Calcium Displays a Low Sensitivity for the Diagnosis of Hypercalcemia in Incident Renal Transplant Recipients.CJASN, v.5, n.11, p: 2085-2092, 2010

FRANCO, Rodrigo Fontanive et al. Evaluation of diagnostic tests for cytomegalovirus active infection in renal transplant recipients. J. Bras. Nefrol., SãoPaulo, v. 39, n. 1, p. 46-54, 2017.

GARCIA, Maria Alice Terra; KANAAN, Salim. Bioquímica clínica. São Paulo: Atheneu, 2008.

GOODRUM, Felicia. “HUMAN CYTOMEGALOVIRUS LATENCY: Approaching the Gordian Knot.” Annual review of virology v.3, n.1,p: 333–357,2016.

HAMDY, Neveen A. T. Calcium and Bone Metabolism Pre- and Post-Kidney Transplantation. Endocrinology and Metabolism Clinics of North America,

v. 36, n. 4, p. 923–935, 2007.

HERRMANN, Markus; FARRELL, Christopher-John L.; PUSCEDDU, Irene; et al. Assessment of vitamin D status – a changing landscape. Clinical Chemistry and

Laboratory Medicine (CCLM), v. 55, n. 1, p. 3–26, 2016.

HIRUKAWA, Takashi et al. Mineral and bone disorders in kidney transplant recipients: reversible, irreversible, and de novo abnormalities. Clinical and Experimental

Nephrology, v. 19, n. 4, p. 543–555, 2015.

Human Cytomegalovirus (HCMV) | British Society for Immunology, disponível em:

<https://www.immunology.org/public-information/bitesized-immunology/pathogens-and- disease/human-cytomegalovirus-hcmv>, acesso em: 4 ago. 2018.

INDA FILHO, Antonio Jose; MELAMED, MichalLeora. Vitamina D e doença renal: o que nós sabemos e o que nós não sabemos. J. Bras. Nefrol., São Paulo, v. 35, n. 4, p. 323- 331, 2013.

KALLURI HV, Sacha LM, Ingemi AI, et al. Low vitamin D exposure is associated with higher risk of infection in renal transplant recipients. Clin Transplant.; v: 31, n.12,p: 955,2017.

JACKSON, Sarah E. et al, Human Cytomegalovirus (HCMV)-Specific CD4+ T Cells Are Polyfunctional and Can Respond to HCMV-Infected Dendritic Cells In Vitro,

Journal of Virology, v. 91, n. 6, p. e02128-16, 2017.

JAFARI A, Najivash P, Khatami MR, Dashti-Khavidaki S. Cytopenia Occurrence in Kidney Transplant Recipients Within Early Post-transplant Period. J Res Pharm

Pract., v.6, n.1, p: 31-39, 2017.

LOPES, Vinicius Medina et al. Highly prevalence of vitamin D deficiency among Brazilian women of reproductive age. Arch. Endocrinol. Metab.,São Paulo, v. 61, n. 1, p. 21-27, 2017.

MAEDA, Sergio S, Borba VZ, Camargo MB, Silva DM, Borges JL, Bandeira F, et al. Recommendations of the Brazilian Society of Endocrinology and Metabology (SBEM) for the diagnosis and treatment of hypovitaminosis D.ArquivosBrasileiros de

Endocrinologia e Metabologia,v.58,n.5,p:411-33,2014

MAEDA, Sergio S.; BATISTA, Marcelo C.; et al. Consensus – reference ranges of vitamin D [25(OH)D] from the Brazilian medical societies. Brazilian Society of Clinical Pathology/Laboratory Medicine (SBPC/ML) and Brazilian Society of Endocrinology and Metabolism (SBEM). Jornal Brasileiro de Patologia e Medicina Laboratorial, v. 53, n. 6, 2017.

MESSA P, Regalia A, Alfieri CM. Nutritional Vitamin D in Renal Transplant Patients: Speculations and Reality. Nutrients, v.9, n.6,p:550,2017.

MILLER, Otto. Laboratório para o Clínico. 8a. Edição.Atheneu, 1995.

MOSCARELLI L, Antognoli G, Buti E, Dervishi E, Fani F, et al.1,25 dihydroxyvitamin D circulating levels, calcitriol administration, and incidence of acute rejection, CMV infection, and polyomavirus infection in renal transplant recipients. Clin Transplant., v.30,v.10,p:1347-1359,2016.

NAIBEDYA Chattopadhyay, AmbrishMithal, Edward M. Brown; The Calcium-Sensing Receptor: A Window into the Physiology and Pathophysiology of Mineral Ion Metabolism, Endocrine Reviews, v.17, n. 4, p: 289–307,1996

PESTANA, Jose Osmar Medina; FREITAS, Tainá Veras de Sandes; JUNIOR, Hélio Tedesco Silva. Transplante Renal - Manual Prático - Uso Diário Ambulatorial e

RAZEGHI, E. et al, Clinical Manifestation, Laboratory Findings, and the Response of Treatment in Kidney Transplant Recipients With CMV Infection, Transplantation

Proceedings, v. 39, n. 4, p. 993–996, 2007.

REQUIÃO-MOURA, Lúcio Roberto; et al. Cytomegalovirus infection in renal transplantation: clinical aspects, management and the perspectives. Einstein (São Paulo), São Paulo, v. 13, n. 1, p. 142-148, 2015.

RECH, Megan A.; FLEMING, James N.; MOORE, Carol L. 25-hydroxyvitamin D deficiency and opportunistic viral infections after kidney transplant. Experimental and

Clinical Transplantation: Official Journal of the Middle East Society for Organ Transplantation, v. 12, n. 2, p. 95–100, 2014.

RIEDER FJ, Gröschel C, Kastner M-T, et al. Human Cytomegalovirus Infection Downregulates Vitamin-D Receptor in Mammalian Cells. The Journal of steroid

biochemistry and molecular biology.n165(Pt B), p:356-362,2017.

SABER A, Fotuhi F, Rostami Z, Einollahi B, Nemati E. et al. Vitamin D Levels After Kidney Transplantation and the Risk of Cytomegalovirus Infection, Nephro-Urol Mon. v.7, n.6, p:e29677,2015.

SAMPAIO Ms, MOLNAR Mz, KOVESDY CP, et al. Association of Pretransplant Serum

Phosphorus with Posttransplant Outcomes. ClinicalJournalofthe

AmericanSocietyofNephrology: CJASN.v.6, n.11, p:2712-2721, 2011

SARNO, Gerardo; DANIELE, Giuseppe; TIRABASSI, Giacomo; et al. The impact of vitamin D deficiency on patients undergoing kidney transplantation: focus on cardiovascular, metabolic, and endocrine outcomes. Endocrine, v. 50, n. 3, p. 568– 574, 2015.

SEED Hematologia Melhoramento e Desenvolvimento Educacional da Sysmex

N.4/2012. Disponível em:

https://www.sysmex.co.za/fileadmin/media/f112/SEED/Portuguese/Sysmex_SEED_0 4_2012_PT.pdf>. Acesso em: 14 ago. 2018.

SEZER, S.; OZDEMIR, F. N.; TUTAL, E.; et al. Prevalence and Etiology of Anemia in Renal Transplant Recipients. Transplantation Proceedings, v. 38, n. 2, p. 537–540, 2006.

SIDDIQUI, Wasim,Salmi, IssaJha, Amitabh, Pakkyara, Abbas, Yasir, Mohammad, Shaheen,Faissa.Early clinical manifestations and laboratory findings before and after treatment of cytomegalovirus infection in kidney transplant patients. Saudi Journal of

Kidney Diseases and Transplantation, v.28,n.4, p:774-781,2017.

SUBSTANTIAL EQUIVALENCE DETERMINATION DECISION SUMMARY

INSTRUMENT ONLY TEMPLATE. Disponível em:

https://www.accessdata.fda.gov/cdrh_docs/reviews/K061574.pdf>. Acesso em: 14 ago. 2018.

SCHEFFEL, Thamires B; SCHROEDER, Regina B; KEITEL, Elizete; et al. INFECÇÃO CITOMEGÁLICA PÓS-TRANSPLANTE RENAL. Jornal Brasileiro de Transplantes, v. 18, n. 1, p. 16–25, 2015.

SCHOTTSTEDT V, Blümel J, Burger R, et al. Human Cytomegalovirus (HCMV) – Revised. Transfusion Medicine and Hemotherapy.v.37,n.6, p:365-375, 2010.

SCHAEFFNER, E. S., Födinger, M.,Kramar, R., Sunder‐Plassmann, G. and Winkelmayer, W. C., Prognostic associations of serum calcium, phosphate and calcium phosphate concentration product with outcomes in kidney transplant recipients. Transplant

International, n.20, p: 247-255, 2007

VIKAS SHARMA, Mobeen Fauzul, PRAKASH, Tulika, “Comparative Genomics of Herpesviridae Family to Look for Potential Signatures of Human Infecting

Strains,” International Journal of Genomics, vol. 2016, Article ID 9543274, 10 pages, 2016

STAVROULOPOULOS, A. et al, Vitamin D Status in Renal Transplant Recipients,

American Journal of Transplantation, v. 7, n. 11, p. 2546–2552, 2007.

Transplante Renal/Sociedade Brasileira de Transplante renal. Disponível em:

<https://sbn.org.br/publico/tratamentos/transplante-renal/>.Acessoem: 5. maio. 2018. TOMTISHEN III, John Paul. “Human Cytomegalovirus Tegument Proteins (pp65, pp71, pp150, pp28).” Virology Journal n.9,p: 22, 2012

STUART M. Sprague,et al. Abnormal bone and mineral metabolism in kidney transplant patients a review. Am J Nephrol. v.28, n.2, p: 246–253, 2008

UNAL, A.; SIPAHIOGLU, M. H.; AKCAKAYA, M.; et al. An Underappreciated Problem in Renal Transplant Recipients: Anemia. Transplantation Proceedings, v. 40, n. 5, p. 1399–1403, 2008.

UNGER, Marianna D. et al. Vitamin D status in a sunny country: Where has the sun gone? Clinical Nutrition, v. 29, n. 6, p: 784 – 788, 2010

UWITONZE AM, Razzaque MS. Role of Magnesium in Vitamin D Activation and Function. J Am Osteopath Assoc v.118, n.3, p: 181–189, 2018

VILARTA CF, Unger MD, Dos Reis LM, et al. Hypovitaminosis D in patients undergoing kidney transplant: the importance of sunlight exposure. Clinics (Sao Paulo).v.72,n.7,p:415-421,2017

YANG Y, Yu B, Chen Y. Blood disorders typically associated with renal transplantation. Front Cell Dev Biol. v.3, n.18, p.19, 2015

YVES Vanrenterghem.Anaemia after renal transplantation.Nephrol Dial Transplant. v.19 n.5, p.54–58, 2004.

Documentos relacionados