Os animais que receberam a dieta de cafeteria chegaram ao perfil metabólico da obesidade, a administração da liraglutida por 10 dias apresentou redução do consumo alimentar dos animais obesos no final do experimento. A intervenção do exercício físico foi eficaz na redução dos estoques de gordura mesentérica, epididimal e retroperitoneal, também reduziu parâmetros bioquímicos como glicose, o índice de Lee, ganho de peso e aumentou o peso da glândula adrenal em animais obesos. Nos animais do grupo controle reduziu o peso do pâncreas, índice de Lee e colesterol total. A associação do exercício físico com a liraglutida apresentou melhores resultados na redução do peso corporal no final do experimento, redução do consumo dos 80-90 dias de vida, peso do fígado, níveis circulantes de triglicerídeos e insulina, índice HOMA-IR, nos animais obesos, porém aumentou o TNF-α em ambos os grupos, obeso e controle. A intervenção do exercício físico é eficaz na redução de alguns parâmetros relacionados ao desenvolvimento da obesidade, porém a sua associação com a liraglutida por 10 dias apresentou melhores resultados na redução do peso corporal, consumo alimentar e parâmetros bioquímicos, de animais obesos obtidos por dieta de cafeteria.
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