• Nenhum resultado encontrado

Pacientes internados na UTI B em VM por mais de 24 horas são, em usa maioria, homens, com menos de 60 anos, provenientes principalmente, do Pronto Socorro do hospital, que esperam cerca de 4 dias por uma vaga na UTI; permanecem cerca de 16 dias em VM, apresentam taxa de ocorrência de eventos adversos de 55,4%, taxa de sucesso da extubação de 67,7% e mortalidade geral de 26,9%. Nosso estudo mostrou taxa de reintubação elevada principalmente nos pacientes mais velhos, acima dos valores reportados em estudos nacionais e internacionais, com identificação de duas variáveis independentemente associadas ao fracasso da extubação, idade e tempo de VM, compatíveis com os resultados de outros estudos. Não houve a confirmação do papel preditivo do BNP em relação ao resultado do TRE, talvez por número insuficiente de pacientes submetidos á dosagem. Observamos que nossos pacientes submetidos ao TRE são, mais graves e esperam mais tempo por um leito em UTI, quando comparado com outros serviços, variáveis que, certamente, interferem no resultado do DVM e na evolução dos pacientes.

Nossos dados estão de acordo com os relatos da literatura que sugerem que idade, escore de gravidade, tempo de internação hospitalar antes da transferência para a UTI, tempo de VM e gravidade do comprometimento pulmonar são variáveis associadas tanto à dificuldade do DVM quanto ao risco de morrer.

Tais dados sugerem que devemos implementar melhorias nos cuidados aos doentes gravemente enfermos em nosso hospital e, em nossa UTI, diminuindo o tempo de espera por um leito em UTI além da revisão dos procedimentos relativos a identificação e manejo dos pacientes prontos ao TRE e à extubação, como a implantação de protocolo que associe outros índices preditores do resultado do desmame ventilatório ao Teste de Respiração Espontânea, uma vez que o sucesso da extubação é uma variável diretamente relacionada à sobrevida dos pacientes.

REFERÊNCIAS

1. Barbas CSV, Ísola AM, Farias AMC, Cavalcanti AB, Gama AMC, Duarte ACM, Vianna A, Serpa Neto A, Bravim BA, Pinheiro BV, Mazza BF, Carvalho CRR, Toufen Júnior C, David CMN, Taniguchi C, Mazza DDS, Dragosavac D, Toledo DO, Costa EL, Caser EB, Silva E, Amorim FF, Saddy F, Galas FRBG, Silva GS, Matos GFJ, Emmerich JC, Valiatti JLS, Teles JMM, Victorino JA, Ferreira JC, Prodomo LPV, Hajjar LA, Martins LC, Malbouisson LMS, Vargas MAO, Reis MAS, Amato MBP, Holanda MA, Park M, Jacomelli M, Tavares M, Damasceno MCP, Assunção MSC, Damasceno MPCD, Youssef NCM, Teixeira PJZ, Caruso P, Duarte PAD, Messeder O, Eid RC, Rodrigues RG, Jesus RF, Kairalla RA, Justino S, Nemer SN, Romero SB, Amado VM. Recomendações brasileiras de ventilação mecânica 2013. Rev Bras Ter Intens. 2014;26(2):89-121.

2. Schettino G, Cardoso LF, Mattar Júnior J, Ganem F. Paciente crítico: diagnóstico e tratamento: Hospital Sírio Libanês. 2ª ed. Barueri (SP): Manole; 2012.

3. Schettino G. Adding value to mechanical ventilation. J Bras Pneumol.

2014;40(5):455-7.

4. Moraes RS, Fonseca JM, di Leoni CB. Mortalidade em UTI, fatores associados e avaliação do estado funcional após a alta hospitalar. Rev Bras Ter Intens, 2005;17(2):80-4.

5. Loss SH, Oliveira RP, Maccari JG, Savi A, Boniatti MM, Hetzel MP, Dallegrave DM, Balzano PC, Oliveira ES, Höher JA, Torelly AP, Teixeira C. The reality of patients requiring prolonged mechanical ventilation: a multicenter study. Rev Bras Ter Intensiva. 2015;27(1):26-35.

6. Azevedo LC, Park M, Salluh JI, Rea-Neto A, Souza-Dantas VC, Varaschin P, Oliveira MC, Tierno PF, dal-Pizzol F, Silva UV, Knibel M, Nassar AP Jr, Alves RA, Ferreira JC, Teixeira C, Rezende V, Martinez A, Luciano PM, Schettino G, Soares M; ERICC (Epidemiology of Respiratory Insufficiency in Critical Care) investigators. Clinical outcomes of patients requiring ventilatory support in Brazilian intensive care units: a multicenter, prospective, cohort study. Crit Care.

2013;17(2):R63.

7. Lai CC, Chen CM, Chiang SR, Liu WL, Weng SF, Sung MI, Hsing SC, Cheng KC. Establishing predictors for successfully planned endotracheal extubation.

Medicine (Baltimore). 2016;95(41):e4852.

8. Brasil. Ministério da Saúde. Portaria n. 1101, de 12 de junho de 2002. Estabelece, na forma do anexo desta Portaria, os parâmetros de cobertura assistencial no âmbito do SUS. Diário Oficial da União, Brasília (DF); 13 jun 2002; Seção 1:36-42.

9. Associação de Medicina Intensiva Brasileira - AMIB. III Censo Brasileiro de UTI [Internet]. São Paulo (SP): AMIB; 2016 [citado 30 dez 2016]. Disponível em:

https://www.amib.com.br/censo/Analise_de_Dados_UTI_Final_Site_2.pdf

10. Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med. 1985;13(10):818-29.

11. Le Gall JR, Lemeshow S, Saulnier F. A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. JAMA.

1993;270(24):2957-63. Erratum in: JAMA 1994;271(17):1321.

12. Vincent JL, Moreno R, Takala J, Willatts S, De Mendonça A, Bruining H, Reinhart CK, Suter PM, Thijs LG. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med. 1996;22(7):707-10.

13. Keegan MT, Soares M. What every intensivist should know about prognostic scoring systems and risk-adjusted mortality. Rev Bras Ter Intensiva.

2016;28(3):264-9.

14. Keegan MT, Gajic O, Afessa B. Comparison of APACHE III, APACHE IV, SAPS 3, and MPM0III and influence of resuscitation status on model performance. Chest.

2012;142(4):851-8.

15. Nseir S, Martin-Loeches I. Ventilator-associated tracheobronchitis: where are we now? Rev Bras Ter Intensiva. 2014;26(3):212-4.

16. Nseir S, Martin-Loeches I, Makris D, Jaillette E, Karvouniaris M, Valles J, Zakynthinos E, Artigas A. Impact of appropriate antimicrobial treatment on transition from ventilator-associated tracheobronchitis to ventilator-associated pneumonia. Crit Care. 2014;18(3):R129.

17. Ranzani OT, Prina E, Torres A. Nosocomial pneumonia in the intensive care unit:

how should treatment failure be predicted? Rev Bras Ter Intensiva.

2014;26(3):208-11.

18. Mota EC, Oliveira SP, Silveira BRM, Silva PLN, Oliveira AC. Incidência da pneumonia associada à ventilação mecânica em unidade de terapia intensiva.

Medicina (Ribeirão Preto). 2017;50(1):39-46.

19. Doelken P, Sahn AS. Doença pleural no paciente em estado crítico. In: Irwin RS, Rippe JM, editores. Irwin & Rippe terapia intensive. 6ª ed. Rio de Janeiro:

Guanabara Koogan; 2010. p. 524-38.

20. Khalil Y, Ibrahim E, Shabaan A, Imam M, Behairy AE. Assessment of risk factors responsible for difficult weaning from mechanical ventilation in adults. Egypt J Chest Dis Tuberc. 2012;61(3):159-66.

21. Irwin SR, Hubmayer RD. Ventilação mecânica Parte III: Interrupção. In: Irwin RS, Rippe JM, editores. Irwin & Rippe terapia intensive. 6ª ed. Rio de Janeiro:

Guanabara Koogan; 2010. p. 567-76.

22. Schmidt GA, Girard TD, Kress JP, Morris PE, Ouellette DR, Alhazzani W, Burns SM, Epstein SK, Esteban A, Fan E, Ferrer M, Fraser GL, Gong MN, Hough CL, Mehta S, Nanchal R, Patel S, Pawlik AJ, Schweickert WD, Sessler CN, Strøm T, Wilson KC, Truwit JD. Liberation From Mechanical Ventilation in Critically Ill Adults: Executive Summary of an Official American College of Chest Physicians/American Thoracic Society Clinical Practice Guideline. Chest.

2017;151(1):160-5.

23. Ouellette DR, Patel S, Girard TD, Morris PE, Schmidt GA, Truwit JD, Alhazzani W, Burns SM, Epstein SK, Esteban A, Fan E, Ferrer M, Fraser GL, Gong MN, Hough CL, Mehta S, Nanchal R, Pawlik AJ, Schweickert WD, Sessler CN, Strøm T, Kress JP. Liberation From Mechanical Ventilation in Critically Ill Adults: An Official American College of Chest Physicians/American Thoracic Society Clinical Practice Guideline: Inspiratory Pressure Augmentation During Spontaneous Breathing Trials, Protocols Minimizing Sedation, and Noninvasive Ventilation Immediately After Extubation. Chest. 2017;151(1):166-80.

24. Funk GC, Anders S, Breyer MK, Burghuber OC, Edelmann G, Heindl W, Hinterholzer G, Kohansal R, Schuster R, Schwarzmaier-D'Assie A, Valentin A, Hartl S. Incidence and outcome of weaning from mechanical ventilation according to new categories. Eur Respir J. 2010;35(1):88-94.

25. Behrendt CE. Acute respiratory failure in the United States: incidence and 31-day survival. Chest. 2000;118(4):1100-5.

26. Rezende E, Silva JM Jr, Isola AM, Campos EV, Amendola CP, Almeida SL.

Epidemiology of severe sepsis in the emergency department and difficulties in the initial assistance. Clinics (Sao Paulo). 2008;63(4):457-64.

27. Somme D, Maillet JM, Gisselbrecht M, Novara A, Ract C, Fagon JY. Critically ill old and the oldest-old patients in intensive care: short- and long-term outcomes.

Intensive Care Med. 2003;29(12):2137-43.

28. Marik PE. Management of the critically ill geriatric patient. Crit Care Med.

2006;34(9 Suppl):S176-82.

29. Ely EW, Wheeler AP, Thompson BT, Ancukiewicz M, Steinberg KP, Bernard GR.

Recovery rate and prognosis in older persons who develop acute lung injury and the acute respiratory distress syndrome. Ann Intern Med. 2002;136(1):25-36.

30. Silva DV, Ximenes GC, Silva Junior JM, Isola AM, Rezende E. Aged patients with respiratory dysfunction: epidemiological profile and mortality risk factors.

Rev Bras Ter Intensiva. 2009;21(3):262-8.

31. Blackwood B, Burns KE, Cardwell CR, O'Halloran P. Protocolized versus non-protocolized weaning for reducing the duration of mechanical ventilation in critically ill adult patients. Cochrane Database Syst Rev. 2014 Nov 6;(11):CD006904.

32. Gonzalez S. Protocol-Directed Sedation Versus Non-Protocol-Directed Sedation to Reduce the Duration of Mechanical Ventilation in Intensive Care Patients. Crit Care Nurse. 2017;37(4):78-80.

33. Lima EJ. Respiratory rate as a predictor of weaning failure from mechanical ventilation. Braz J Anesthesiol. 2013;63(1):1-6.

34. Mekontso-Dessap A, de Prost N, Girou E, Braconnier F, Lemaire F, Brun-Buisson C, Brochard L. B-type natriuretic peptide and weaning from mechanical natriuretic peptides for prediction and diagnosis of weaning failure from cardiac origin. Intensive Care Med. 2011;37(3):477-85.

38. Antônio ACP, Teixeira AC, Castro PS, Zanardo AP, Gazzana MB, Knorst M.

Usefulness of radiological signs of pulmonary congestion in predicting failed spontaneous breathing trials. J Bras Pneumol. 2017;43(4):253-8.

39. Antonio AC, Teixeira C, Castro PS, Savi A, Oliveira RP, Gazzana MB, Knorst M.

48-Hour fluid balance does not predict a successful spontaneous breathing trial.

Respir Care. 2015;60(8):1091-6.

40. Shochat M, Shotan A, Trachtengerts V, Blondheim DS, Kazatsker M, Gurovich V, Asif A, Shochat I, Rozenman Y, Meisel SR. A novel radiological score to assess lung fluid content during evolving acute heart failure in the course of acute myocardial infarction. Acute Card Care. 2011;13(2):81-6.

41. Mekontso-Dessap A, Roche-Campo F, Kouatchet A, Tomicic V, Beduneau G, Sonneville R, Cabello B, Jaber S, Azoulay E, Castanares-Zapatero D, Devaquet J, Lellouche F, Katsahian S, Brochard L. Natriuretic peptide-driven fluid management during ventilator weaning: a randomized controlled trial. Am J Respir Crit Care Med. 2012;186(12):1256-63.

42. Ma G, Liao W, Qiu J, Su Q, Fang Y, Gu B. N-terminal prohormone B-type natriureytic peptide and weaning outcome in postoperative patients with pulmonary complications. J Int Med Res. 2013;41(5):1612-21.

43. Curiati MNC, Silvestre OM, Pires LJT, Mangini S, Pires PV, Gaiotto FA, Laurino AM, Pêgo-Fernandes PM, Ferreira CES, Bacal F. Agreement of BNP and NT-proBNP and the influence of clinical and laboratory variables. Einstein (São Paulo). 2013;11(3):272-7.

44. Chow SL, Maisel AS, Anand I, Bozkurt B, de Boer RA, Felker GM, Fonarow GC, Greenberg B, Januzzi JL Jr, Kiernan MS, Liu PP, Wang TJ, Yancy CW, Zile MR;

American Heart Association Clinical Pharmacology Committee of the Council on Clinical Cardiology; Council on Basic Cardiovascular Sciences; Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation; Council on Epidemiology and Prevention; Council on Functional Genomics and Translational Biology; and Council on Quality of Care and Outcomes Research. Role of Biomarkers for the Prevention, Assessment, and Management of Heart Failure: A Scientific Statement From the American Heart Association. Circulation. 2017;135(22):e1054-e1091. Erratum in: Circulation.

2017;136(19):e345.

45. Architect BNP [Bula]. Responsável técnica: Danielle P. Angelino. Chicago (IL):

Abbott Laboratories Diagnostics Division, 2015.

46. Moraes RS, Fonseca JML, di Leoni CBR. ICU Mortality, associated factors and funtional status after discharge. Rev Bras Ter Intensa, 2005;17(2):80-4.

47. El-Fakhouri S, Carrasco HVCG, Araújo GC, Frini ICM. Epidemiological profile of ICU patients at Faculdade de Medicina de Marília. Rev Assoc Med Bras.

2016;62(3):248-54.

48. Konomi I, Tasoulis A, Kaltsi I, Karatzanos E, Vasileiadis I, Temperikidis P, Nanas S, Routsi CI. Left ventricular diastolic dysfunction - an independent risk factor for weaning failure from mechanical ventilation. Anaesth Intensive Care.

2016;44(4):466-73.

49. Franca SA, Toufen C Jr, Hovnanian AL, Albuquerque AL, Borges ER, Pizzo VR, Carvalho CR. The epidemiology of acute respiratory failure in hospitalized patients: a Brazilian prospective cohoort study. J Crit Care 2011;26(3):330.e1-8.

50. Loss SH, Oliveira RP, Maccari JG, Savi A, Boniatti MM, Hetze MP, Dallegrave DM, Balzano PC, Oliveira ES, Höher JA, Torelly AP, Teixeira C. The reality of patients requiring prolonged mechanical ventilation: a multicenter study. Rev Bras Ter Intens. 2015;27(1):26-35.

51. Andriolo BN, Andriolo RB, Saconato H, Atallah ÁN, Valente O. Early versus late tracheostomy for critically ill patients. Cochrane Database Syst Rev. 2015 Jan 12;1:CD007271.

52. Hosokawa K, Nishimura M, Egi M, Vincent JA. Timing of tracheotomy in ICU patients: a systematic review of randomized controlled trials. Crit Care.

2015;19:424.

53. Passamani R, Souza SROS. Infecção relacionada a cateter venoso central um desafio na terapia intensiva. Rev Hosp Univ Pedro Ernesto. 2010;10(Supl. 1):100-8.

54. Farghaly S, Galal M, Hasan AA, Nafady A. Brain natriuretic peptide as a predictor of weaning from mechanical ventilation in patients with respiratory illness.Aust Crit Care. 2015;28(3):116-21.

55. Maraghi SE, Hosny M, Samir M, Radwan W. Usage of B-type natriuretic peptide for predictionof weaning outcome by spontaneous breathing trial. Egypt J Chest Dis Tuberc. 2014;63(3):671-8.

56. Freitas EE, David CM. Assessment of success in weaning from mechanical ventilation. Rev Bras Ter Intensiva. 2006;18(4):351-9.

57. Menon N, Joffe AM, Deem S, Yanez ND, Grabinsky A, Dagal AHC, Daniel S, Treggiari MM. Occurrence and complications of tracheal reintubation in critically ill adults. Respir Care. 2012;57(10):1555-63.

58. Chien JY, Lin MS, Huang YC, Chien YF, Yu CJ, Yang PC. Changes in B-type natriuretic peptide improve weaning outcome predicted by spontaneous breathing trial. Crit Care Med. 2008;36(5):1421-6. Vlasselaers D, Ferdinande P, Lauwers P, Bouillon R. Intensive insulin therapy in the critically ill patients. N Eng J Med. 2001;345(19):1359-67.

62. NICE-SUGAR Study Investigators, Finfer S, Chittock DR, Su SY, Blair D, Foster D, Dhingra V, Bellomo R, Cook D, Dodek P, Henderson WR, Hébert PC, Heritier S, Heyland DK, McArthur C, McDonald E, Mitchell I, Myburgh JA, Norton R, Potter J, Robinson BG, Ronco JJ. Intensive versus conventional glucose control in critically ill patients. N Engl J Med. 2009;360(13):1283-97.

63. Griesdale DE, Souza RJ, van Dam RM, Heyland DK, Cook DJ, Malhotra A, Dhaliwal R, Henderson WR, Chittock DR, Finfer S, Talmor D. Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including.

NICE-SUGAR study data. CMAJ 2009;180(8):821-7.

64. Yatabe T, Yamazaki R, Kitagawa H, Okabayashi T, Yamashita K, Hanazaki K, Yokoyama M. The evaluation of the ability of closed-loop glycemic control device to maintain the blood glucose concentration in intensive care unit patients.

Crit Care Med. 2011;39(3):575-8.

65. Rady MY, Johnson DJ, Patel BM, Larson JS, Helmers RA. Influence of individual characteristics on outcome of glycemic control in intensive care unit patients with or without diabetes mellitus. Mayo Clin Proc. 2005;80(12):1558-67.

66. Krinsley JS. Glycemic control, diabetic status, and mortality in a heterogeneous population of critically ill patients before and during the era of intensive glycemic management: six and one-half years experience at a university-affiliated community hospital. Semin Thorac Cardiovasc Surg. 2006;18(3):317-25.

67. Brown G, Dodek P. Intravenous insulin nomogram improves blood glucose control in the critically ill. Crit Care Med. 2001;29(9):1714-9.

68. Ali NA, O’Brien JM Jr, Dungan K, Phillips G, Marsh CB, Lemeshow S, Connors AF Jr, Preiser JC. Glucose variability and mortality in patients with sepsis. Crit Care Med. 2008; 36(8):2316-21.

69. Waeschle RM, Moerer O, Hilgers R, Herrmann P, Neumann P, Quintel M. The impact of the severity of sepsis on the risk of hypoglycaemia and glycaemic variability. Crit Care 2008;12(5):R129.

ANEXO A

Parecer Consubstanciado do CEP

ANEXO B

Termo de outorga e aceitação de auxílios

Documentos relacionados