CAPÍTULO VI – CONCLUSÃO GERAL
A casca da jabuticaba (Myrciaria jaboticaba) é uma fonte reconhecida de compostos bioativos, particularmente antocianinas. Os resultados in vitro deste trabalho apontaram que a infusão aquosa foi um eficiente método de extração; o extrato apresentou uma alta capacidade antioxidante. A avaliação in vivo também comprovou ação favorável do extrato aquoso da casca sobre o estado antioxidante a nível sérico e intestinal, bem como modulação da microbiota de ratos saudáveis, sem provocar toxicidade hepática. Finalmente, o tratamento com o extrato foi capaz de reduzir a severidade de colite induzida por meio de inibição do estresse oxidativo, efeito anti-inflamatório, modulação da microbiota e preservação da mucosa do cólon. Portanto, o extrato aquoso da casca de jabuticaba é uma alternativa prática para o aproveitamento deste subproduto e obtenção de composto bioativos da fruta, demonstrando efeitos benéficos em condições fisiológicas e em situações patológicas, poderia ser futuramente utilizado tanto como uma estratégia de manutenção da saúde quanto um adjuvante no tratamento de inflamações intestinais.
REFERÊNCIAS
ABDULLAH, M. et al. New insights on the pathomechanisms of inflammatory bowel disease. Journal of Digestive Diseases, v. 14, n. 9, p. 455-462, 2013. Disponível
em: < http://www.scopus.com/inward/record.url?eid=2-s2.0-
84881639643&partnerID=40&md5=522113ecfc2f544fd1a8907ddca82977 >.
ABE, L. T.; LAJOLO, F. M.; GENOVESE, M. I. Potential dietary sources of ellagic acid and other antioxidants among fruits consumed in Brazil: Jabuticaba (Myrciaria jaboticaba (Vell.) Berg). Journal of the Science of Food and Agriculture, v. 92, n. 8, p. 1679-1687, Jun 2012. ISSN 0022-5142. Disponível em: < <Go to ISI>://000302951000016 >.
AJILA, C. M. et al. Mango peel powder: A potential source of antioxidant and dietary fiber in macaroni preparations. Innovative Food Science & Emerging Technologies, v. 11, n. 1, p. 219-224, 2010. ISSN 1466-8564. Disponível em: < http://www.sciencedirect.com/science/article/pii/S1466856409001192 >.
AKIYAMA, S. et al. Effects of anthocyanin-rich tea “Sunrouge” on dextran sodium sulfate-induced colitis in mice. Biofactors, v. 38, n. 3, p. 226-233, 2012. ISSN 1872- 8081. Disponível em: < http://dx.doi.org/10.1002/biof.1008 >.
ALEZANDRO, M. R.; GRANATO, D.; GENOVESE, M. I. Jaboticaba (Myrciaria jaboticaba (Vell.) Berg), a Brazilian grape-like fruit, improves plasma lipid profile in streptozotocin-mediated oxidative stress in diabetic rats. Food Research International, v. 54, n. 1, p. 650-659, 2013. ISSN 0963-9969. Disponível em: < http://www.sciencedirect.com/science/article/pii/S0963996913004079 >.
ALGIERI, F. et al. Intestinal anti-inflammatory activity of hydroalcoholic extracts of Phlomis purpurea L. and Phlomis lychnitis L. in the trinitrobenzenesulphonic acid model of rat colitis. Journal of Ethnopharmacology, v. 146, n. 3, p. 750-759, 2013.
ISSN 0378-8741. Disponível em: <
http://www.sciencedirect.com/science/article/pii/S0378874113000706 >.
ANANTHAKRISHNAN, A. N. Epidemiology and risk factors for IBD. Nat Rev Gastroenterol Hepatol, v. 12, n. 4, p. 205-217, 04//print 2015. ISSN 1759-5045. Disponível em: < http://dx.doi.org/10.1038/nrgastro.2015.34 >.
ANDUJAR, I. et al. Inhibition of ulcerative colitis in mice after oral administration of a polyphenol-enriched cocoa extract is mediated by the inhibition of STAT1 and STAT3 phosphorylation in colon cells. J Agric Food Chem, v. 59, n. 12, p. 6474-83, Jun 22 2011. ISSN 1520-5118 (Electronic)
0021-8561 (Linking). Disponível em: < http://www.ncbi.nlm.nih.gov/pubmed/21574661 >.
AOAC. Official methods of analysis of AOAC International. Gaithersburg, Md.: AOAC International, 2002.
AZUMA, T. et al. Supplemental naringenin prevents intestinal barrier defects and inflammation in colitic mice. Journal of Nutrition, v. 143, n. 6, p. 827-834, 2013. Disponível em: < http://www.scopus.com/inward/record.url?eid=2-s2.0- 84878258216&partnerID=40&md5=cee98cf53835716c9d856685f9581d8b >.
BAILÃO, E. et al. Bioactive Compounds Found in Brazilian Cerrado Fruits. International Journal of Molecular Sciences, v. 16, n. 10, p. 23760, 2015. ISSN 1422-0067. Disponível em: < http://www.mdpi.com/1422-0067/16/10/23760 >.
BALERDI, C. F.; RAFIE, R.; CRANE, J. Jaboticaba (Myrciaria cauliflora, Berg.) a delicious fruit with an excellent market potential. Proceedings of the 119th Annual Meeting of the Florida State Horticultural Society, v. 119, p. 66-68, 2006. ISSN 0886-7283. Disponível em: < <Go to ISI>://000247372700020 >.
BARROS, R. S.; FINGER, F. L.; MAGALHAES, M. M. Changes in non-structural carbohydrates in developing fruit of Myrciaria jaboticaba. Scientia Horticulturae, v. 66, n. 3-4, p. 209-215, Oct 1996. ISSN 0304-4238. Disponível em: < <Go to ISI>://A1996VZ17100008 >.
BATISTA, A. G. et al. Polyphenols, antioxidants, and antimutagenic effects of Copaifera langsdorffii fruit. Food Chem, v. 197 Pt B, p. 1153-9, Apr 15 2016. ISSN 0308-8146 (Print)
0308-8146 (Linking). Disponível em: < http://www.ncbi.nlm.nih.gov/pubmed/26675852 >.
BATISTA, A. G. et al. Effects of jaboticaba (Myrciaria jaboticaba) peel on blood glucose and cholesterol levels in healthy rats. African Journal of Biotechnology, v. 13, n. 37, p. 3805-3811, 2014.
BATISTA, Â. G. et al. Intake of jaboticaba peel attenuates oxidative stress in tissues and reduces circulating saturated lipids of rats with high-fat diet-induced obesity. Journal of Functional Foods, v. 6, p. 450-461, 2014. ISSN 1756-4646. Disponível em: < http://www.sciencedirect.com/science/article/pii/S175646461300265X >. BAUMGART, D. C.; CARDING, S. R. Inflammatory bowel disease: cause and immunobiology. Lancet, v. 369, n. 9573, p. 1627-40, May 12 2007. ISSN 1474-547X (Electronic)
0140-6736 (Linking). Disponível em: < http://www.ncbi.nlm.nih.gov/pubmed/17499605 >.
BAUMGART, D. C.; SANDBORN, W. J. Gastroenterology 2 - Inflammatory bowel disease: clinical aspects and established and evolving therapies. Lancet, v. 369, n. 9573, p. 1641-1657, May 12 2007. ISSN 0140-6736. Disponível em: < <Go to ISI>://000246488800033 >.
BENZIE, I. F. F.; STRAIN, J. J. The ferric reducing ability of plasma (FRAP) as a measure of ''antioxidant power'': The FRAP assay. Analytical Biochemistry, v. 239, n. 1, p. 70-76, Jul 15 1996. ISSN 0003-2697. Disponível em: < <Go to ISI>://A1996UY64800010 >.
BHEBHE, M. et al. Effect of Solvent Type on Total Phenolic Content and Free Radical Scavenging Activity of Black Tea and Herbal Infusions. Food Analytical Methods, v. 9, n. 4, p. 1060-1067, 2016// 2016. ISSN 1936-976X. Disponível em: < http://dx.doi.org/10.1007/s12161-015-0270-z >.
BIEDERMANN, L. et al. Bilberry ingestion improves disease activity in mild to moderate ulcerative colitis - an open pilot study. J Crohns Colitis, v. 7, n. 4, p. 271-9, May 2013. ISSN 1873-9946.
BIRBEN, E. et al. Oxidative Stress and Antioxidant Defense. World Allergy Organization Journal, v. 5, n. 1, p. 1-11, 2012. ISSN 1939-4551. Disponível em: < http://dx.doi.org/10.1097/WOX.0b013e3182439613 >.
BITTER, T.; MUIR, H. M. A modified uronic acid carbazole reaction. Analytical Biochemistry, v. 4, n. 4, p. 330-334, 1962/10/01 1962. ISSN 0003-2697. Disponível em: < http://www.sciencedirect.com/science/article/pii/0003269762900957 >.
BJORNDAL, B. et al. Tetradecylthioacetic acid attenuates inflammation and has antioxidative potential during experimental colitis in rats. Dig Dis Sci, v. 58, n. 1, p. 97- 106, Jan 2013. ISSN 1573-2568 (Electronic)
0163-2116 (Linking). Disponível em: < http://www.ncbi.nlm.nih.gov/pubmed/22855292 >.
BLIGH, E. G.; DYER, W. J. A Rapid Method of Total Lipid Extraction and Purification. Canadian Journal of Biochemistry and Physiology, v. 37, n. 8, p. 911-917, 1959. ISSN 0576-5544. Disponível em: < <Go to ISI>://A1959WM52500001 >.
BLUMBERG, J. B. et al. Cranberries and their bioactive constituents in human health. Adv Nutr, v. 4, n. 6, p. 618-32, Nov 2013. ISSN 2156-5376 (Electronic)
2161-8313 (Linking). Disponível em: < http://www.ncbi.nlm.nih.gov/pubmed/24228191 >.
BOUGHTON-SMITH, N. K. et al. Nitric oxide synthase activity in ulcerative colitis and Crohn's disease. Lancet, v. 342, n. 8867, p. 338-40, Aug 7 1993. ISSN 0140-6736 (Print)
0140-6736 (Linking). Disponível em: < http://www.ncbi.nlm.nih.gov/pubmed/7687730 >.
BRADFORD, M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem, v. 72, p. 248-54, May 7 1976. ISSN 0003-2697 (Print)
0003-2697 (Linking). Disponível em: < http://www.ncbi.nlm.nih.gov/pubmed/942051 >. BRÜCKNER, M. et al. Green tea polyphenol epigallocatechin-3-gallate shows therapeutic antioxidative effects in a murine model of colitis. Journal of Crohn's and Colitis, v. 6, n. 2, p. 226-235, 2012. Disponível em: < http://www.scopus.com/inward/record.url?eid=2-s2.0-
CABRERA, C.; ARTACHO, R.; GIMENEZ, R. Beneficial effects of green tea--a review. J Am Coll Nutr, v. 25, n. 2, p. 79-99, Apr 2006. ISSN 0731-5724 (Print)
0731-5724 (Linking). Disponível em: < http://www.ncbi.nlm.nih.gov/pubmed/16582024 >.
CAMUESCO, D. et al. Preventative effects of lactulose in the trinitrobenzenesulphonic acid model of rat colitis. Inflamm Bowel Dis, v. 11, n. 3, p. 265-71, Mar 2005. ISSN 1078-0998 (Print)
1078-0998 (Linking).
CARDONA, F. et al. Benefits of polyphenols on gut microbiota and implications in human health. Journal of Nutritional Biochemistry, v. 24, n. 8, p. 1415-1422, 2013. ISSN 0955-2863. Disponível em: < http://dx.doi.org/10.1016/j.jnutbio.2013.05.001 >. Acesso em: 2016/08/15.
CARLBERG, I.; MANNERVIK, B. Glutathione-Reductase. Methods in Enzymology, v. 113, p. 484-490, 1985. ISSN 0076-6879. Disponível em: < <Go to ISI>://A1985ATW0200059 >.
CAVALCANTI, R. N.; VEGGI, P. C.; MEIRELES, M. A. A. Supercritical fluid extraction with a modifier of antioxidant compounds from jabuticaba (Myrciaria cauliflora) byproducts: economic viability. Procedia Food Science, v. 1, n. 0, p. 1672-1678,
2011. ISSN 2211-601X. Disponível em: <
http://www.sciencedirect.com/science/article/pii/S2211601X11002483 >.
CAZARIN, C. B. B. et al. Intake of Passiflora edulis leaf extract improves antioxidant and anti-inflammatory status in rats with 2,4,6-trinitrobenzenesulphonic acid induced colitis. Journal of Functional Foods, v. 17, p. 575-586, 8// 2015. ISSN 1756-4646.
Disponível em: <
http://www.sciencedirect.com/science/article/pii/S1756464615002728 >.
CELANT, V. M. et al. PHENOLIC COMPOSITION AND ANTIOXIDANT CAPACITY OF AQUEOUS AND ETHANOLIC EXTRACTS OF BLACKBERRIES. Revista Brasileira de Fruticultura, v. 38, 2016. ISSN 0100-2945. Disponível em: < http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-
29452016000200202&nrm=iso >.
CERQUEIRA, F. M.; MEDEIROS, M. H. G.; AUGUSTO, O. Dietetic antioxidants: controversies and perspectives. Quimica Nova, v. 30, n. 2, p. 441-449, 10/01/2007 2007. ISSN 0100-4042.
CHAOVANALIKIT, A.; WROLSTAD, R. E. Anthocyanin and polyphenolic composition of fresh and processed cherries. Journal of Food Science, v. 69, n. 1, p. C73-C83, Jan-Feb 2004. ISSN 0022-1147. Disponível em: < <Go to ISI>://000220142100029 >. CHEAH, K. Y. et al. Grape Seed Extract Reduces the Severity of Selected Disease Markers in the Proximal Colon of Dextran Sulphate Sodium-Induced Colitis in Rats. Digestive Diseases and Sciences, v. 58, n. 4, p. 970-977, 2013// 2013. ISSN 1573- 2568. Disponível em: < http://dx.doi.org/10.1007/s10620-012-2464-1 >.
CHEN, L. et al. Phytochemical properties and antioxidant capacities of various colored berries. Journal of the Science of Food and Agriculture, v. 94, n. 2, p. 180-188, 2014. ISSN 1097-0010. Disponível em: < http://dx.doi.org/10.1002/jsfa.6216 >.
CHINEN, T. et al. Prostaglandin E2 and SOCS1 have a role in intestinal immune tolerance. Nat Commun, v. 2, p. 190, 2011. ISSN 2041-1723 (Electronic)
2041-1723 (Linking). Disponível em: < http://www.ncbi.nlm.nih.gov/pubmed/21304519 >.
CLERICI, M. T. P. S.; CARVALHO-SILVA, L. B. Nutritional bioactive compounds and technological aspects of minor fruits grown in Brazil. Food Research International, v. 44, n. 7, p. 1658-1670, 2011. ISSN 0963-9969. Disponível em: < http://www.sciencedirect.com/science/article/pii/S096399691100250X >.
COSNES, J. et al. Epidemiology and Natural History of Inflammatory Bowel Diseases. Gastroenterology, v. 140, n. 6, p. 1785-1794.e4, 2011. ISSN 0016-5085. Disponível em: < http://www.sciencedirect.com/science/article/pii/S0016508511001648 >.
D'ARGENIO, G. et al. Apple polyphenols extract (APE) improves colon damage in a rat model of colitis. Digestive and Liver Disease, v. 44, n. 7, p. 555-562, 2012. Disponível em: < http://www.scopus.com/inward/record.url?eid=2-s2.0- 84861349298&partnerID=40&md5=d368f54c4e245106fd2c09bb953a47e1 >.
D'ARMIENTO, J. et al. Bioactive depside and anthocyanin compounds, compositions, and methods of use. U.S. Patent PCT/US07/17087, 12/309, 804. 2007.
DA SILVA, J. K. et al. Functional tea from a Brazilian berry: Overview of the bioactives compounds. LWT - Food Science and Technology, ISSN 0023-6438. Disponível em: < http://www.sciencedirect.com/science/article/pii/S0023643816303486 >.
DA SILVA, J. K. et al. Passion fruit (Passiflora edulis) peel increases colonic production of short-chain fatty acids in Wistar rats. LWT - Food Science and Technology, v. 59, n. 2, Part 2, p. 1252-1257, 12// 2014. ISSN 0023-6438. Disponível em: < http://www.sciencedirect.com/science/article/pii/S0023643814003193 >.
DA SILVA, J. K. et al. Antioxidant activity of aqueous extract of passion fruit (Passiflora edulis) leaves: In vitro and in vivo study. Food Research International, v. 53, n. 2, p.
882-890, 2013. ISSN 0963-9969. Disponível em: <
http://www.sciencedirect.com/science/article/pii/S0963996913000033 >.
DA SILVA, J. K. et al. Bioactive compounds of juices from two Brazilian grape cultivars. Journal of the Science of Food and Agriculture, p. n/a-n/a, 2015. ISSN 1097-0010. Disponível em: < http://dx.doi.org/10.1002/jsfa.7309 >.
DAI, J. et al. A comprehensive study of anthocyanin-containing extracts from selected blackberry cultivars: Extraction methods, stability, anticancer properties and mechanisms. Food and Chemical Toxicology, v. 47, n. 4, p. 837-847, 2009. ISSN
0278-6915. Disponível em: <
DAI, J.; MUMPER, R. J. Plant Phenolics: Extraction, Analysis and Their Antioxidant and Anticancer Properties. Molecules, v. 15, n. 10, p. 7313-7352, Oct 2010. ISSN 1420-3049. Disponível em: < <Go to ISI>://000283587400044 >.
DAVALOS, A.; GOMEZ-CORDOVES, C.; BARTOLOME, B. Extending applicability of the oxygen radical absorbance capacity (ORAC-fluorescein) assay. Journal of Agricultural and Food Chemistry, v. 52, n. 1, p. 48-54, Jan 14 2004. ISSN 0021- 8561. Disponível em: < <Go to ISI>://000187941900009 >.
DE ASSIS, S. A. et al. Antioxidant activity, ascorbic acid and total phenol of exotic fruits occurring in Brazil. International Journal of Food Sciences and Nutrition, v. 60, n. 5, p. 439-48, Aug 2009. ISSN 1465-3478 (Electronic)
0963-7486 (Linking). Disponível em: < http://www.ncbi.nlm.nih.gov/pubmed/18785051 >.
DE FARIA, F. M. et al. Effects of Rhizophora mangle on Experimental Colitis Induced by TNBS in Rats. Evid Based Complement Alternat Med, v. 2012, p. 753971, 2012. ISSN 1741-4288 (Electronic)
1741-427X (Linking). Disponível em: <
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Cita tion&list_uids=23056142 >.
DE MEJÍA, E. G. et al. Yerba mate tea (Ilex paraguariensis): Phenolics, antioxidant capacity and in vitro inhibition of colon cancer cell proliferation. Journal of Functional Foods, v. 2, n. 1, p. 23-34, 2010. ISSN 1756-4646. Disponível em: < http://www.sciencedirect.com/science/article/pii/S1756464609000814 >.
DENIS, M. C. et al. Apple peel polyphenols: a key player in the prevention and treatment of experimental inflammatory bowel disease. Clin Sci (Lond), v. 130, n. 23, p. 2217-2237, Dec 1 2016. ISSN 0143-5221.
DESSIMONI-PINTO, N. A. V. et al. Jaboticaba peel for jelly preparation: an alternative technology. Ciência e Tecnologia de Alimentos, v. 31, p. 864-869, 2011. ISSN
0101-2061. Disponível em: <
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101- 20612011000400006&nrm=iso >.
DI SABATINO, A. et al. Oral butyrate for mildly to moderately active Crohn's disease. Aliment Pharmacol Ther, v. 22, n. 9, p. 789-94, Nov 01 2005. ISSN 0269-2813 (Print) 0269-2813.
DI SARIO, A. et al. Biologic Drugs in Crohn's Disease and Ulcerative Colitis: Safety Profile. Curr Drug Saf, v. 11, n. 1, p. 55-61, 2016. ISSN 1574-8863.
DILLARD, C. J.; GERMAN, J. B. Phytochemicals: nutraceuticals and human health. Journal of the Science of Food and Agriculture, v. 80, n. 12, p. 1744-1756, 2000. ISSN 1097-0010. Disponível em: < http://dx.doi.org/10.1002/1097- 0010(20000915)80:12<1744::AID-JSFA725>3.0.CO;2-W >.
DOLARA, P. et al. Red wine polyphenols influence carcinogenesis, intestinal microflora, oxidative damage and gene expression profiles of colonic mucosa in F344 rats. Mutat Res, v. 591, n. 1-2, p. 237-46, Dec 11 2005. ISSN 0027-5107 (Print) 0027-5107.
DONADIO, L. C. Jabuticaba (Myrciaria jaboticaba (Vell.) Berg). Jaboticabal: FUNEP 2000.
DRAGANO, N. R. et al. Freeze-dried jaboticaba peel powder improves insulin sensitivity in high-fat-fed mice. Br J Nutr, v. 110, n. 3, p. 447-55, Aug 28 2013. ISSN 1475-2662 (Electronic)
0007-1145 (Linking). Disponível em: < http://www.ncbi.nlm.nih.gov/pubmed/23415177 >.
DRAGANO, N. R. V. et al. Freeze-dried jaboticaba peel powder improves insulin sensitivity in high-fat fed mice. British Journal of Nutrition, v. In press, 2012. ______. Freeze-dried jaboticaba peel powder improves insulin sensitivity in high-fat fed mice. British Journal of Nutrition, v. In press, 2013.
DUDONNÉ, S. et al. Comparative Study of Antioxidant Properties and Total Phenolic Content of 30 Plant Extracts of Industrial Interest Using DPPH, ABTS, FRAP, SOD, and ORAC Assays. Journal of Agricultural and Food Chemistry, v. 57, n. 5, p. 1768-
1774, 2009/03/11 2009. ISSN 0021-8561. Disponível em: <
http://dx.doi.org/10.1021/jf803011r >.
DURAK, I. et al. Mucosal antioxidant defense is not impaired in ulcerative colitis. Hepato-gastroenterology, v. 47, n. 34, p. 1015-1017, 2000 Jul-Aug 2000. ISSN 0172- 6390. Disponível em: < http://europepmc.org/abstract/MED/11020867 >.
EL-BESHBISHY, H. A. Hepatoprotective effect of green tea (Camellia sinensis) extract against tamoxifen-induced liver injury in rats. Journal of Biochemistry and Molecular Biology, v. 38, n. 5, p. 563-570, Sep 30 2005. ISSN 1225-8687. Disponível em: < <Go to ISI>://000232212100009 >.
ELFALLEH, W. et al. Total phenolic contents and antioxidant activities of pomegranate peel, seed, leaf and flower. Journal of Medicinal Plants Research, v. 6, n. 32, p.
4724-4730, 2012. Disponível em: <
http://www.academicjournals.org/journal/JMPR/article-abstract/A0B26C529029 >. ESWARAN, S.; MUIR, J.; CHEY, W. D. Fiber and Functional Gastrointestinal Disorders. Am J Gastroenterol, v. 108, n. 5, p. 718-727, 2013. ISSN 0002-9270. Disponível em: < http://dx.doi.org/10.1038/ajg.2013.63 >.
FARZANEH, V.; CARVALHO, I. S. A review of the health benefit potentials of herbal plant infusions and their mechanism of actions. Industrial Crops and Products, v. 65, p. 247-258, 3// 2015. ISSN 0926-6690. Disponível em: < http://www.sciencedirect.com/science/article/pii/S092666901400675X >.
FAURE, M. et al. Mucin production and composition is altered in dextran sulfate sodium-induced colitis in rats. Digestive Diseases and Sciences, v. 48, n. 7, p. 1366- 1373, Jul 2003. ISSN 0163-2116. Disponível em: < <Go to ISI>://000183476200025 >.
FLOHE, L.; GUNZLER, W. A. Assays of Glutathione-Peroxidase. Methods in Enzymology, v. 105, p. 114-121, 1984. ISSN 0076-6879. Disponível em: < <Go to ISI>://A1984AAB8100013 >.
FRANKEL, E. N.; MEYER, A. S. The problems of using one-dimensional methods to evaluate multifunctional food and biological antioxidants. Journal of Science of Food and Agriculture v. 50, p. 1925–1941, 2000.
GHASEMI, K.; GHASEMI, Y.; EBRAHIMZADEH, M. A. Antioxidant activity, phenol and flavonoid contents of 13 citrus species peels and tissues. Pak J Pharm Sci, v. 22, n. 3, p. 277-81, Jul 2009. ISSN 1011-601X (Print)
1011-601X (Linking).
GORINSTEIN, S. et al. Application of Analytical Methods for the Determination of Bioactive Compounds in Some Berries. Food Analytical Methods, v. 6, n. 2, p. 432-
444, 2013/04/01 2013. ISSN 1936-9751. Disponível em: <
http://dx.doi.org/10.1007/s12161-012-9453-z >.
GORINSTEIN, S. et al. Antioxidant properties and bioactive constituents of some rare exotic Thai fruits and comparison with conventional fruits: In vitro and in vivo studies. Food Research International, v. 44, n. 7, p. 2222-2232, 2011. ISSN 0963-9969.
Disponível em: <
http://www.sciencedirect.com/science/article/pii/S0963996910003704 >.
GUO, H. H. et al. Cyanidin 3-glucoside attenuates obesity-associated insulin resistance and hepatic steatosis in high-fat diet-fed and db/db mice via the transcription factor FoxO1. Journal of Nutritional Biochemistry, v. 23, p. 349–360, 2012. GURAK, P. D. et al. Jaboticaba Pomace Powder Obtained as a Co-product of Juice Extraction: A Comparative Study of Powder Obtained from Peel and Whole Fruit. Food Research International, v. 62, p. 786-792, Aug 2014. ISSN 0963-9969. Disponível em: < <Go to ISI>://000340015100093 >.
HABIB, H. M.; IBRAHIM, W. H. Effect of date seeds on oxidative damage and antioxidant status in vivo. J Sci Food Agric, v. 91, n. 9, p. 1674-9, Jul 2011. ISSN 1097-0010 (Electronic)
0022-5142 (Linking). Disponível em: < http://www.ncbi.nlm.nih.gov/pubmed/21480263 >.
HÅKANSSON, Å. et al. Blueberry husks and probiotics attenuate colorectal inflammation and oncogenesis, and liver injuries in rats exposed to cycling DSS-
treatment. PLoS One, v. 7, n. 3, 2012. Disponível em: <
http://www.scopus.com/inward/record.url?eid=2-s2.0-
HALL, K. D. et al. The Progressive Increase of Food Waste in America and Its Environmental Impact. PLOS ONE, v. 4, n. 11, p. e7940, 2009. Disponível em: < http://dx.doi.org/10.1371%2Fjournal.pone.0007940 >.
HALLIWELL, B. Free radicals, reactive oxygen species and human disease: a critical evaluation with special reference to atherosclerosis. Br J Exp Pathol, v. 70, n. 6, p. 737-57, Dec 1989. ISSN 0007-1021 (Print)
0007-1021 (Linking). Disponível em: < http://www.ncbi.nlm.nih.gov/pubmed/2557883 >.
HAMINIUK, C. W. I. et al. Chemical, antioxidant and antibacterial study of Brazilian fruits. International Journal of Food Science & Technology, v. 46, n. 7, p. 1529- 1537, 2011. ISSN 1365-2621. Disponível em: < http://dx.doi.org/10.1111/j.1365- 2621.2011.02653.x >.
HAYASHI, Y. et al. Oral administration of mesalazine protects against mucosal injury and permeation in dextran sulfate sodium-induced colitis in rats. Scandinavian Journal of Gastroenterology, v. 44, n. 11, p. 1323-1331, 2009. ISSN 0036-5521. Disponível em: < <Go to ISI>://000272484000008 >.
HAYAT, K. et al. Tea and its consumption: benefits and risks. Crit Rev Food Sci Nutr, v. 55, n. 7, p. 939-54, 2015. ISSN 1040-8398.
HEIM, K. E.; TAGLIAFERRO, A. R.; BOBILYA, D. J. Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships. The Journal of Nutritional Biochemistry, v. 13, n. 10, p. 572-584, 10// 2002. ISSN 0955-2863. Disponível em: < http://www.sciencedirect.com/science/article/pii/S0955286302002085 >.
HIGBY, W. K. A Simplified Method for Determination of Some Aspects of the Carotenoid Distribution in Natural and Carotene-Fortified Orange Juice. Journal of Food Science, v. 27, n. 1, p. 42-49, 1962. ISSN 1750-3841. Disponível em: < http://dx.doi.org/10.1111/j.1365-2621.1962.tb00055.x >.
HOENTJEN, F. et al. Reduction of colitis by prebiotics in HLA-B27 transgenic rats is associated with microflora changes and immunomodulation. Inflamm Bowel Dis, v. 11, n. 11, p. 977-85, Nov 2005. ISSN 1078-0998 (Print)
1078-0998 (Linking).
HOOPER, L. V.; LITTMAN, D. R.; MACPHERSON, A. J. Interactions between the microbiota and the immune system. Science, v. 336, n. 6086, p. 1268-73, Jun 8 2012. ISSN 0036-8075.
HUOPONEN, S.; BLOM, M. A Systematic Review of the Cost-Effectiveness of Biologics for the Treatment of Inflammatory Bowel Diseases. PLoS One, v. 10, n. 12, p. e0145087, 2015. ISSN 1932-6203.
HUR, S. J. et al. Review of natural products actions on cytokines in inflammatory bowel disease. Nutr Res, v. 32, n. 11, p. 801-16, Nov 2012. ISSN 1879-0739 (Electronic) 0271-5317 (Linking).
HUR, S. J. et al. Review of natural products actions on cytokines in inflammatory bowel disease. Nutrition Research, v. 32, n. 11, p. 801-816, 2012. ISSN 0271-5317.
Disponível em: <
http://www.sciencedirect.com/science/article/pii/S0271531712001959 >.
INADA, K. O. P. et al. Screening of the chemical composition and occurring antioxidants in jabuticaba (Myrciaria jaboticaba) and jussara (Euterpe edulis) fruits and their fractions. Journal of Functional Foods, v. 17, p. 422-433, Aug 2015. ISSN 1756- 4646. Disponível em: < <Go to ISI>://000360253300040 >.
INOUE, H. et al. Low and medium but not high doses of green tea polyphenols ameliorated dextran sodium sulfate-induced hepatotoxicity and nephrotoxicity. Bioscience, Biotechnology and Biochemistry, v. 77, n. 6, p. 1223-1228, 2013. Disponível em: < http://www.scopus.com/inward/record.url?eid=2-s2.0- 84880146988&partnerID=40&md5=dd0ee3988baa432e5473c3e0e2e2b01c >.
JING, P.; GIUSTI, M. M. Effects of Extraction Conditions on Improving the Yield and Quality of an Anthocyanin-Rich Purple Corn (Zea mays L.) Color Extract. Journal of Food Science, v. 72, n. 7, p. C363-C368, 2007. ISSN 1750-3841. Disponível em: <