- A atividade antioxidante pelo método de DPPH obteve seus melhores valores quando foram utilizados extratos mais hidrofílicos;
- A atividade antioxidante pelo método de ABTS apresenta valores ótimos quando são utilizados extratos etanólicos, sendo superiores aos encontrados pelo método DPPH.
- A extração de compostos fenólicos apresenta seus melhores valores com extratos intermediários combinados com níveis de agitação média, indicando interação entre as variáveis explanatórias do estudo;
- A cúrcuma parece apresentar potencial atividade antidepressiva em animais submetidos ao teste de natação forçada, já que reduziu o tempo de imobilidade.
REFERÊNCIAS
AARSLAND, D.; PAHLHAGEN, S.; BALLARD, C.G.; EHRT, U.; SVENNINGSON, P. Depression in Parkinson disease: epidemiology, mechanisms and management. Nature
reviews neurology, London, v.8, p.35-47, Jan. 2012.
ABELAIRA, H.M.; RÉUS, G.Z.; QUEVEDO, J. Animal models as tools to study the pathophysiology. Revista Brasileira de Psiquiatria, São Paulo, v.35, p.112-120, 2013. AGGARWAL, B.B.; HARIKUMAR, K.B. Potential therapeutic effects of curcimin, the anti- inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. International Journal of Biochemistry and Cell
Biology, Exeter, v. 41, p. 40-59, Jan, 2008.
AGRAWAL, S.; GULLAIYA S.; DUBEY, V.; SINGH, V.; KUMAR, A.; NAGAR, A.; TIWARI, P. Neurodegenerative shielding by curcumin and its derivates on brain lesions induced by 6-OHDA model of Parkinson’s disease in albino Wistar rats. Cardiovascular
psychiatry and neurology, Cairo, v. 2012, p.1-8, Aug. 2012.
AK, T.; GÜLÇIN, I. Antioxidant and radical scavenging properties of curcumin. Chemical-
Biological Interactions, Amsterdam, v. 174, p. 27-37, Jul. 2009.
AMERICAN PSYCHIATRIC ASSOCIATION. Diagnostic and Statistical Manual Of Mental Disorders. 5 th ed. Washington.2013, 991 p.
ANDRADE, J. W. S. Produção e crescimento do açafrão (Curcuma longa L.) em função
do tamanho do rizoma e densidade do plantio, em Goiás. 2004. 62 p. Tese- Escola de
Agronomia e Engenharia de Alimentos, Universidade Federal de Goiás, 2004.
ASSOCIATION OF OFFICIAL ANALYTICAL CHEMISTS. AOAC. 16th ed. Official
methods of analysis. Arlington, 1995. Cap.43, p.3.
BABU, K.G.D.; SHANMUGAM, V.; RAVINDRANATH, S.D.; JOSHI, V.P. Comparison of chemical composition and antifungal activity of Curcuma longa L., leaf oils produced by different water distillation techniques. Flavour and Fragance Journal, New York, v.22, p.191-196, 2007.
BARROS NETO, B.; SCARMINIO, I.S.; BRUNS, R.E. Planejamento e otimização de
experimentos. 2 ed. Campinas: Unicamp, 1996. 299p.
BARROS-NETO, B.B.; SCARMINIO, I.S.; BRUNS, R.E. Como fazer experimentos: pesquisa e desenvolvimento na ciência e na indústria. Campinas: UNICAMP. 2001. 401 p. BEGUM, A.N.; JONES, MR.; LIM, G.P.; MORIHARA, T.; KIM, P.; HEATH, D.D.; ROCK, C.L. PRUITT, M.A.; YANG, F.; HUDSPETH, B.; HU, S.; FAULL, K.F.; TETER, B.;COLE, G.M.; FRAUTSCHY, S.A.Curcumin structure-function, bioavailability and efficacy in models of neuroinflammation and Alzheimer’s disease. The Journal of Pharmacology and
BHUTANI, M.K.; BISHNOI, M.; KULKARNI, S.K. Anti-depressant like effect of curcumin and its combination with piperine in unpredictable chronic stress-induced behavioral,
biochemical and neurochemical changes. Pharmacology Biochemistry and Behavior, Phoenix, v.91, n.1, p.39-43, Mar, 2009.
BORSINI, F.; MELI, A. Is the forced swimming test a suitable model for revealing antidepressant activity? Psychopharmachology, Berlin, v.94, p.147-161, 1988.
BOX, G.E.P.; HUNTER, W.G.; HUNTER, J.S. Statistics for experiments: as introduction to design, data analysis and model building. New York: John Wiley and Sons, 1978. p.510 – 539.
BOX, G.E.P; DRAPER, NR. Empirical model-building and response surface. New York: John Wiley & Sons, 1987. 688 p.
BRANCO, A.C.S.C.; DINIZ, M.F.F.M.; ALMEIRA, R.N..; SANTOS, H.B.; OLIVEIRA, K.M.; RAMALHO, J.A.; DANTA, J.G. Parâmetros bioquímicos e hematológicos de ratos Wistar e camundongos Swiss do Biotério Professor Thomar George. Revista Brasileira de
Ciências da Saúde, São Caetano do Sul, v.15, n.2, p.209-214, 2011.
BRAND-WILLIAMS, W.; CUVELIER, M. E.; BERSET, C. Use of a free radical method to evaluate antioxidant activity. Food Science and Technology, London, v. 28, n. 1, p. 25-30, July, 1995.
BREMNER, JD. Does stress damage the brain? Biology Psychiatry, New York, v.45, p.797- 805, Apr.1999.
CACACE, J.E.; MAZZA, G. Extraction of Anthocyanins and Other Phenolics from Black Currants with Sulfured Water. Journal of Agricultural and Food Chemistry,
Washington,v.50, p.5939-5946, Oct, 2002.
CALIL.C.M.; BIANCHI, F.J.; TANNO, A.P.; CUNHA, T.S.; MARCONDES, F.K. Análise do significado do tempo de imobilidade em modelos experimentais de natação. Revista
Brasileira de Ciências Farmacêuticas, São Paulo, v.38, n.4, p.479-485, 2002
CALIL, C. M.; MARCONDES, F. K. The comparison of immobility time in experimental rat swimming models. Life Sciences, Oxford, v. 79, p. 1712-1719, Sep. 2006.
CERNY, D.; LEKIC, N.; VANOVA, K.; MUCHOVA, L.; HORINEK, A.; KMONICKOVA, E.; ZIDEK, Z.; KAMENIKOVA, L.; FARGHALI, H.; Hepatoprotective effect of curcumin in lipopolysaccharide/-galactosamine model of liver injury in rats: relationship to HO-1/CO antioxidant system. Fitoterapia, Milano, v. 82, p.786-791, 2011.
CHADIPIRALLA, K.; REDDANA, P.; CHINTA, R.M.; REDDY, P.V. Thioacetamide- induced fulminant hepatic failure induces cerebral mitochondrial dysfunction by altering the electron transport chain complexes. Neurochemical Research, New York v.37, p. 59–68, Jan. 2012.
CHEN, H.; PANDEY, G.H.; DWIVEDI, Y. Hippocampal cell proliferation regulation by repeated stress and antidepressants. Neuroreport, Oxford, v.17, n.9, p.863-867, June 2006.
CIFTCI, O.; OZDEMIR, I.; TANYILDIZI, S.; YILDIZ, S.; OGUZTURK, H. Antioxidative effects of curcumin, beta-myrcene and 1,8-cineoleagainst 2,3,7,8-tetrachlorodibenzo-p- dioxin-induced oxidativestress in rats liver. Toxicology and Industrial Health, Princeton, v.27, p. 447–453, 2011
DASTMALCHI, K.; FLORES, G.; PETROVA, V.; PEDRAZA-PENALOSA, P.; KENNELLY, E.J. Edible Neotropical Blueberries: Antioxidant and Compositional
Fingerprint Analysis. Journal of Agricultural and Food Chemistry, Davis, v.59, n.7, p. 3020–3026, Mar. 2011.
DELLAGIOIA, N.; HANNESTAD, J. A critical review of human endotoxin administration as an experimental paradigma of depression. Neuroscience and Biobehavioral Reviews, New York, v.34, p.130-143, Jan.2010
DREVETS, W.C. Neuroimaging studies of mood. Biology Psychiatry, New York, v.48, p.813-829, 2000.
EMBRAPA. Metodologia científica: determinação da atividade antioxidante total em frutas pela captura do radical livre ABTS. Fortaleza, 2007. 4p. Disponível em:
<www.cnpat.embrapa.br/cnpat/down/index.php?pub/Cot_128.pdf>. Acesso em: 10 jun. 2014. FEINSTEIN, A.; MAGALHAES, S.; RICHARD, J.F.; AUDET, B.; MOORE, C. The link between multiple sclerosis and depression. Nature reviews neurology, London, v.10, p.507- 517, Sep. 2014.
GARCIA, R. Stress, metaplasticity, and antidepressants. Current Molecular Medicine, Boca Raton, v.2, p.629-638, Nov. 2002
GARCIA, L. S.; COMIM, C. M.; VALVASSORI, S. S.; REUS, G. Z.; STERTZ, L.;
KAPCZINSKI, F.; GAVIOLI, E. C.; QUEVEDO, J. Ketamine treatment reverses behavioral and physiological alterations induced by chronic mild stress in rats. Progress in
Neuropsychopharmacology and Biology Psychiatry, Oxford, v. 33, n. 3, p. 450-455, Apr.
2009.
GILLESPIE, C. F.; NEMEROFF, C. B. Hypercortisolemia and depression. Psychosomatic
Medicine, Baltimore, v. 67, p. 26-28, May/June 2005.
GOEL, A.; KUNNUMAKKARA, A.B. Curcumin as “curecumin”: From kitchen to clinic.
Biochemistry Pharmacology, Oxford, v. 75, p. 787-809, Feb. 2008.
GOVINDARAJAN, V.S. Turmeric – chemistry, technology and quality. CRC – Critical
Review in Food Science and Nutrition, Boca Raton, v.12, n.3, p.199-301, 1980.
GRIPPO, A.; JOHNSON, A.K. Biological mechanisms in the relationship between
depression and heart disease. Neuroscience and Biobehavioral Reviews, New York, v.26, n.8, p. 941-962, Dec.2002.
GRIPPO, A.J.; BELTZ, T.G.; JOHNSON, A.K. Behavioral and cardiovascular changes in the chronic mild stress model of depression. Physiology & Behavior, Oxford, n.78, p.703-710, 2003.
GRIPPO, A.J.; FRANCIS, J.; BELTZ, T.G. FELDER, R.B.; JOHNSON, A.K.
Neuroendocrine and cytokine profile of chronic mild stress-induced anhedonia. Physiology &
Behavior, Oxford, v.84, p.697-706, Mar, 2005.
HAMAGUCHI, T.; ONOL, K.; YAMADA, M.; Curcumin and Alzheimer’s Disease. CNS
neuroscience and therapeutics, Oxford. v.16, n.5, p.285-297, Oct. 2010.
HARRO, J.; TONISSAAR, M.; ELLER, M.; KASK, A.; ORELAND, L. Chronic variable stress and partial 5-HT denervation by parachloroamphetamine treatment in the rat: effects on behavior and monoamine neurochemistry. Brain Research, Amsterdam, v. 899, n. 1-2, p. 227-239, Apr.2001.
HIDAKA, B.H. Depression as a disease of modernity: explanations for increasing prevalence.
Journal of Affective Disorders, Amsterdam, v.140, p.205-2014, Nov. 2012.
HIRUN, S.; UTAMAM-ANG, N.; ROACH, P.D. Turmeric (Curcuma longa L.) drying: an optimization approach using microwave-vacuum drying. Journal Food Science and
Technology, Mysore, v.51, n.9, Sep. 2014.
HURLEY, L.L.; AKINFIRESOYE, L.; NWULIA, E.; KAMIYA, A.;KULKARNI, A.A.; TIZABI, Y.Antidepressant-like effects of curcumin in WKY rat model of depression is associated with an increase in hippocampal BDNF. Behavioural Brain Research, Amsterdam, n.239, p.27-30, Feb. 2013.
JOHNSON, C.E.; OLADEINDE, F.O.; KINYUA, A.M.; MICHELIN, R.; MAKINDE, J.M; JAIYESIMI, A.A..; MBITI, W.N.; KAMAU, G.N.; KOFI-TSEKPO, W.M.; PRAMANIK, S.; WILLIAMS, A.; KENNEDY, A.; BRONNER, Y.; CLARKE, K.; FOFONOFF, P.;
NEMERSON, D. Comparative assessment of total phenolic in selected medicinal plants.
Nigeriam Journal of Natural Products and Medicine, Lle-Lfe v.12, p.40-42, Jan. 2008.
KARACABEY, E.; MAZZA, G. Optimisation of antioxidant activity of grape cane extrats using response surface methodology. Food Chemistry, Barking,v.119, p.343-348, 2010. KATZ, R.J.; ROTH, K.A.; CARROL, B.J. Acute and chronic stress effects on open field activity in the rat: implications for a model of depression. Neuroscience and biobehavioral
reviews, New York, v.5, n.2, p.247-251,1981.
KONARSKA, M.; STEWART, R. E.; MCCARTY, R. Predictability of chronic intermittent stress: effects on sympathetic-adrenal medullary responses of laboratory rats. Behavioral
Neural Biology, New York, v. 53, n. 2, p. 231-243, Mar.1990.
KULKARNI, S.K.; BHUTANI, M.K; BISHNOI, M. Antidepressant activity of curcumin: involvement of serotonin and dopamine system. Psychopharmacology, Berlin, v.201, p. 435- 442, 2008.
LIU, G.X.; CAI, G.Q.; CAI.; SHENG, ZJ.; JIANG, J.; MEI, Z.; WANG, Z.G.; GUO, L.; FEI, J. Reduced Anxiety and Depression-Like Behaviors in Mice Lacking GABA Transporter Subtype. Neuropsychopharmacology, London, n.32, p.1531-1539, 2007.
LUCCA, G.; COMIM, C. M.; VALVASSORI, S. S.; PEREIRA, J. G.; STERTZ, L.; GAVIOLI, E. C.; KAPCZINSKI, F.; QUEVEDO, J. Chronic mild stress paradigm reduces sweet food intake in rats without affecting brain derived neurotrophic factor protein levels.
Current Neurovascular Research, Amsterdam, v. 5, n. 4, p. 207-213, Nov. 2008.
LUCCA, G.; COMIM, C. M.; VALVASSORI, S. S.; REUS, G. Z.; VUOLO, F.;
PETRONILHO, F.; DAL-PIZZOL, F.; GAVIOLI, E. C.; QUEVEDO, J. Effects of chronic mild stress on the oxidative parameters in the rat brain. Neurochemistry International, Oxford, v. 54, n. 5-6, p. 358-362, May/June 2009.
LUO, J.; ZHANGA, L.; NINGA, N.; JIANGC.; YUA, S.Y. Neotrofin reverses the effects of chronic unpredictable mild stress on behavior via regulating BDNF, PSD-95 and
synaptophysin expression in rat. Behavioural Brain Research, Amsterdam, v.253, p. 48-53, Sep. 2013
MCEWEN, B.S. Glucocorticoids, depression, and mood disorders: structural remodeling in the brain. Metabolism, Philadelphia, v.54, p.20-23, May 2005
MESA, M.D.; RAMIREZ-TORTOSA, M.C.; AGUILERA, C.M.; RAMIREZ-BOSCA, A; GIL, A. Efectos farmacológicos e nutricionales de los extractos de Curcuma longa L. y delos curcuminoides. Ars Pharmaceutica, Granada, v. 41, n.3, p. 307-321, 2000.
MICHELON, L.; CORDEIRO, Q.; VALLADA, H. Depressão. Revista Brasileira De
Medicina, São Paulo, v.65, n.12 p. 15-25, Dez.2008.
MOREAU, J.L.; JENCK, F.; MARTIN, J.R.; PERRIN, S.; HAEFELY, W.E. Effects of repeated mild stress and two antidepressant treatments on the behavioral response to 5HT1C receptor activation in rats. Psychopharmacology, Berlin, v.110, p. 140-144,1993.
MOREAU, J.L. Validation of an animal model of anhedonia, a major symptom of depression.
Encephale, Paris, v.23, n.4,p.280-289, Jul.1997.
MOURE, A.; CRUZ, J.M.; FRANCO, D.; DOMINGUEZ, J.M.; SINEIRO, J.;
DOMINGUEZ, H.; NUÑEZ, M.J.; PARAJÓ, J.C. Natural antioxidants from residual sources.
Food Chemistry, Barking, v.72, p.145-171, 2001.
MÜLLER, L.; FRÖHLICH, K.; BÖHM, V. Comparative antioxidant activities of carotenoids measured by ferric reducing antioxidant power (FRAP), ABTS bleaching assay (aTEAC), DPPH assay and peroxyl radical scavenging assay. Food Chemistry, Barking, v. 129, n.1, p. 139-148, Nov. 2011.
MUSCAT, R.; PAPP, M.; WILLNER, P. Reversal of stress-induced anhedonia by the atypical antidepressants, fluoxetine and maprotiline. Psychopharmacology, Berlin, v.109, p.433-438, 1992.
NAM, S.M.; CHOI. J.H.; YOO.D.Y.; KIM, W.; JUNG, H.Y.; KIM, J.W.; YOO, M.; LEE, S.; KIM, C.J.; YOON, Y.S.; HWANG, I.K. Effects of Curcumin (Curcuma longa) on learning and spatial memory as well as cell proliferation and neuroblast differentiation in adult and agedmice by upregulating brain-derived neurotrophic factor and CREB signaling. Journal of
NESTLER, E.J.; HYMAN, S.E. Animal models of neuropsychiatric disorders. Nature
Neuroscience, New York, v.13, n.10, p.1161-1169, Sep. 2010
NEVES, V.J.; MOURA, M.J.C.S.; TAMASCIA, M.L.; FERREIRA, R.; SILVIA, N.S.; COSTA, R.; MONTEMOR, P.L.; NARVAES, E.A.O.; BERNARDES, C.F.; NOVAES, P.D.; MARCONDES, F.K. Proatherosclerotic effects of chronic stress in male rats: Altered
phenylephrine sensitivity and nitric oxide synthase activity of aorta and circulating lipids.
Stress, Amsterdam, v.12, n.4 p.320-327, Nov. 2009.
NEVES, V.J.; MOURA, M.J.C.S.; ALMEIDA, B.S.; COSTA, R.; SANCHES, A.,
FERREIRA, R.; TAMASCIA, M.L; ROMANI, E.A.; NOVAES, PD.; MARCONDES, F.K; Chronic stress, but not hypercaloric diet, impairs vascular function in rats. Stress,
Amsterdam, v.15, n.2, p.138-148, Jul.2012.
NOGUEIRA, S. O Veneno do remédio: Efeitos nocivos limitam potenciais usos terapêuticos da curcumina. Pesquisa FAPESP, São Paulo, n.168, p.48-51, Fev. 2010
ORSOLIN, P.C.; NEPOMUCENO, J.C. Potencial carcinogênico do açafrão (Curcuma longa
L.) identificado por meio do teste para detecção de clones de tumor em Drosophila
melanogaster. Perquirere Revista do Núcleo Interdisciplinar de Pesquisa e Extensão do
UNIPAM, Patos de Minas, n.6, p. 55-69, 2009.
PEREIRA, C.A; MOREIRA, M.R. Cultivo da Curcuma longa L. (Açafrão-da-Índia ou
Cúrcuma). Fortaleza: Embrapa Agroindústria Tropical , 2009. p.2. ( Comunicado Técnico).
PORSOLT, R.D.; LE PICHON, M.; JALFRE, M. Depression: a new animal model sensitive to antidepressant treatments. Nature, London, v. 266, p. 730-732, Apr.1977.
RAWAL, S.; SINGH, P.; GUPTA, A.; MOHANTY. Dietary intake of Curcuma longa and
Emblica officinalis increases life span in Drosophila melanogaster. BioMed Research
International, New York, p.1-7, May. 2014.
RIBEIRO, J.M.; INGLEZ-DIAS, A. Políticas e inovação em atenção a saúde mental: limites ao descolamento do desempenho do SUS. Ciência & Saúde Coletiva, Rio de Janeiro, v.16, n.12, p. 4623-4633, Dez. 2011.
RIVERA-ESPINOZA, Y.; MURIEL, P. Pharmacological actions of curcumin in liver diseases or damage. Liver International, Oxford, v. 39, p.1457-1466, 2009.
ROBERTS, I.; KWAN, I.; EVANS, P.; HAIG, S. Does animal experimentation inform human
healthcare? Observations from a systematic review of international animal experiments on fluid resuscitation. British Medical Association, London, v.324, p.474-476, Fev, 2002
ROSSI, L.; MAZZITELLI, S.; ARCIELLO, M.; CAPO, C.R.; ROTILIO, G. Benefits from dietary polyphenols for brain aging and Alzheimer’s disease. Neurochemical Research, Nova York, v. 33, n.12, p.2390-2400, Dec. 2008.
SAVLA, U. Responsible conduct in animal research.The Journal of clinical investigation, New York, v.112, n.10, Nov, 2003
SENGUPTA, G.; SHARMA, G.D.; CHAKRABORRY, B. Hepatoprotective and
immunodulatory properties of aqueous extract of Curcuma longa in carbon tetra chloride intoxicated Swiss albino mice. Asian Pacific Journal of Tropical Biomecine, Haikon, v.1, n.1, p.193-199, Jun. 2011.
SIEGRIST, J.; LUNAU, T.; WAHRENDORF, M.; DRAGANO, N. Depressive symptoms and psychosocial stress at work among older employees in three continents. Globalization
and Health, London, v.8, p.1-8, Jul. 2012.
SIGLETON, V.L.; ROSSI, J.A. Jr. Colorimetry of total phenolics with phosphomolybdic- phosphotungstic ácid reagents. American Journal of Enology and Viticulture, Davis, v. 16, n. 3, p. 144-158, Feb. 1965.
SIRÓ, I.; KÁPOLNA, E.; KÁPOLNA, E.; LUGASI, E. Functional food. Product
development, marketing and consumer acceptance – A review. Elsevier, London, v. 51, p. 456-467, Mai. 2008.
STATSOFT. STATISTICA for Windows- Release 10.0 A. Tulsa, OK, USA; StatSoft, Inc., 2010.
TENG, C.T.; CEZAR, L.T.S. Depressão. Revista Brasileira de Medicina. São Paulo, v.67, p.37-52, Dez.2010.
THAIKERT, R.; PAISOOKSAANTIVATANA, Y. Variation of Total Curcuminoids Content, Antioxidant Activity and Genetic Diversity in Turmeric (Curcuma longa L.) Collections.
Kasetsart Journal, Bangkok, v.43, p.507-518, 2009.
TILAK, J.C.; BANERJEE, M.; MOHAN, H.; DEVASAGAYAM, T.P.A. Antioxidant availability of turmeric in relation to its Medicinal and Culinary uses. Phytotherapy
Research, London, v.18, p.798-804, Nov. 2004.
TIVERON, A.P. Atividade antioxidante e composição de fenólica de legumes e verduras
consumidos no Brasil. 2010. 102 p.Dissertação (Mestrado em Ciência e Tecnologia de
Alimentos)- Escola Superior de Agricultura “Luiz de Queiroz”, Piracicaba, 2010. VILELA, C.A.A.; ARTUR, P.O. Secagem do açafrão (Curcuma longa L.) em diferentes cortes geométricos. Ciência e Tecnologia de Alimentos, Campinas, v.28,p. 387-394, Abril- Junho, 2008.
WILLNER, P. The validity of animal models of depression. Psychopharmacology, Berlin, v.83, n.1, p.1-16, 1987.
______. Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. Neuropsychobiology, New York, v.52, p.90-110, Jul. 2005.
WOISKY, R.G.; SALATINO, A. Analysis of propolis: some parameters and procedures for chemical quality control. Journal of Apicultural Research, London, v.37, n.2, p. 99-105, Jun. 1998.
XIA, X.; CHENG, G.; PANA, Y.; XIA, Z.H.; KONG, L.D. 2007. Behavioral, neurochemical and neuroendocrine effects of the ethanolic extract from Curcuma longa L. in the mouse forced swimming test. Journal Ethnopharmacology, Lausanne, v.2, p.356-363, Oct.2007. XINXING, W.; WEI, L.; LEI, W.; RUI, Z.; BAOYING, J.; LINGJIA, Q. A neuroendocrine mechanism of co-morbidity of depression-like behavior and myocardial injury in rats. Plos
One, São Francisco v.9, n.2, p.1-9. Feb, 2014.
XU, Y.; KU, B.S; YAO, H.Y.; LIN, Y.H; MA, X.; ZHANG, Y.H. et al. The effects of curcumin on depressive-like behaviors in mice. European Journal Pharmacology, Amsterdam, v.518, p.40–46, Jul.2005.
XU, Y.; KU, B.; YAO, I.; JIANG, W.; MA, X.; LI, X. Curcumin reverses the effects of chronic stress on behavior the HPA axis, BDNF expression and phosphorylation of CREB.
Brain Research, Amsterdam, v.1122, p. 56-57, Nov. 2006.
YUN, S.S.; KIM, S. P.; KANG, M,Y.; NAM, S.H. Inhibitory effect of curcumin on liver injury in a murine model of endotoxemic shock. Biotechnology Letters, Dordrecht, v.32, n.2 p.209-214, Oct. 2010.
ZHANG, J., JINNAL, S.; IKEDA, R.; WADA, M.; HAYASHIDA, S.; NAKASHIMA. A simple HPLC- fluorescence method for quantitation of curcuminoids and its application on turmeric produts. Analytical Sciences, Tokyo,v.25, p.385-389, Mar. 2009.
ZHU, X.; XIA, O.; HAN.; SHAO, M.; JING, L.; FAN, Q.; LIU, Y.; DIAO, J.; LV, Z.; SUN, X. Xiao Yao San Improves depressive-like behavior in rats through modulation of �-arrestin 2-mediated pathways in hippocampus, Evidence-Basead Complementary And Alternative