Os resultados indicam que a neurotransmissão endocanabinóide no NLET, atuando via receptores CB1 locais, desempenha um papel inibitório na resposta de taquicardia ao estresse
agudo de restrição. Os nossos dados também fornecem evidências de que este efeito pode ser mediado pela liberação local no NLET tanto de anandamida quanto de 2-AG.
39
REFERÊNCIAS BIBLIOGRÁFICAS
ADHIKARI, A. Distributed circuits underlying anxiety. Frontiers in behavioral
neuroscience, v. 8, p. 112, 2014.
ALHEID, G. F. Extended amygdala and basal forebrain. Ann N Y Acad Sci, v. 985, p. 185– 205, 2003.
ALHEID, G. F.; HEIMER, L. New perspectives in basal forebrain organization of special relevance for neuropsychiatric disorders: The striatopallidal, amygdaloid, and corticopetal components of substantia innominata. Neuroscience, v. 27, n. 1, p. 1–39, 1988.
BELTRAMO, M. Functional Role of High-Affinity Anandamide Transport, as Revealed by Selective Inhibition. Science, v. 277, n. 5329, p. 1094–1097, 1997.
BISOGNO, T.; LIGRESTI, A.; DI MARZO, V. The endocannabinoid signalling system: Biochemical aspects. Pharmacology Biochemistry and Behavior, v. 81, n. 2 SPEC. ISS., p. 224–238, 2005.
BUSNARDO, C. et al. Paraventricular nucleus of the hypothalamus glutamate neurotransmission modulates autonomic, neuroendocrine and behavioral responses to acute restraint stress in rats. European neuropsychopharmacology : the journal of the European
College of Neuropsychopharmacology, v. 23, n. 11, p. 1611–22, nov. 2013.
CARRIVE, P. Dual activation of cardiac sympathetic and parasympathetic components during conditioned fear to context in the rat. Clinical and experimental pharmacology &
physiology, v. 33, n. 12, p. 1251–4, dez. 2006.
CHOI, D. C. et al. Bed Nucleus of the Stria Terminalis Subregions Differentially Regulate Hypothalamic – Pituitary – Adrenal Axis Activity : Implications for the Integration of Limbic Inputs. Animals, v. 27, n. 8, p. 2025–2034, 2007.
CHOI, D. C. et al. The anteroventral bed nucleus of the stria terminalis differentially regulates hypothalamic-pituitary-adrenocortical axis responses to acute and chronic stress.
Endocrinology, v. 149, n. 2, p. 818–826, 2008.
CRESTANI, C.C. et al. Role of the bed nucleus of the stria terminalis in the cardiovascular responses to acute restraint stress in rats. Stress, v. 12, n. 3, p. 268–78, 2009.
CRESTANI, C. C. et al. Effect of acute restraint stress on the tachycardiac and bradycardiac responses of the baroreflex in rats. Stress (Amsterdam, Netherlands), v. 13, n. 1, p. 61–72, 2010.
CRESTANI, C. C. et al. Mechanisms in the bed nucleus of the stria terminalis involved in control of autonomic and neuroendocrine functions: a review. Current neuropharmacology, v. 11, n. 2, p. 141–59, 2013.
CRUZ, F. C. et al. Influence of the single or combined administration of cocaine and testosterone in autonomic and neuroendocrine responses to acute restraint stress. Journal of
40
DAMPNEY, R.A.L.; HORIUCHI, J.; MCDOWALL, L.M. Hypothalamic mechanisms coordinating cardiorespiratory function during exercise and defensive behaviour. Autonomic
Neuroscience, v. 142, n. 1-2, p. 3–10, nov. 2008.
DEVANE, W. et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science (New York, N.Y.), v. 258, n. 5090, p. 1946–9, 18 dez. 1992.
DINH, T. P. et al. Brain monoglyceride lipase participating in endocannabinoid inactivation.
Proceedings of the National Academy of Sciences of the United States of America, v. 99, n.
16, p. 10819–24, 2002.
DONG, H.; SWANSON, L. W. Organization of axonal projections from the anterolateral area of the bed nuclei of the stria terminalis. The Journal of comparative neurology, v. 468, n. 2, p. 277–98, 6 jan. 2004.
DOS REIS, D. G. et al. Role of the autonomic nervous system and baroreflex in stress-evoked cardiovascular responses in rats. Stress (Amsterdam, Netherlands), v. 17, n. 4, p. 362–72, jul. 2014.
FERREIRA-JUNIOR, N. C. et al. Medial prefrontal cortex endocannabinoid system modulates baroreflex activity through CB(1) receptors. American journal of physiology.
Regulatory, integrative and comparative physiology, v. 302, n. 7, p. R876–85, 2012.
FIGUEIREDO, H. F. et al. The medial prefrontal cortex differentially regulates stress-induced c-fos expression in the forebrain depending on type of stressor. The European journal of
neuroscience, v. 18, n. 8, p. 2357–64, out. 2003.
GLANGETAS, C. et al. Stress switches cannabinoid type-1 (CB1) receptor-dependent plasticity from LTD to LTP in the bed nucleus of the stria terminalis. The Journal of
neuroscience : the official journal of the Society for Neuroscience, v. 33, n. 50, p. 19657–63,
11 dez. 2013.
GLASER, S. T. et al. Evidence against the presence of an anandamide transporter.
Proceedings of the National Academy of Sciences of the United States of America, v. 100, n.
7, p. 4269–4274, 2003.
GOMES, F. V. et al. Cannabidiol administration into the bed nucleus of the stria terminalis alters cardiovascular responses induced by acute restraint stress through 5-HT₁A receptor.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, v. 23, n. 9, p. 1096–104, set. 2013.
GOUVEIA, M. K. et al. Dissociation in control of physiological and behavioral responses to emotional stress by cholinergic neurotransmission in the bed nucleus of the stria terminalis in rats. Neuropharmacology, v. 101, p. 379–88, fev. 2016.
GRAY, T. S. et al. Ibotenic acid lesions in the bed nucleus of the stria terminalis attenuate conditioned stress-induced increases in prolactin, ACTH and corticosterone.
Neuroendocrinology, v. 57, n. 3, p. 517–24, mar. 1993.
GRAY, T. S.; MAGNUSON, D. J. Neuropeptide neuronal efferents from the bed nucleus of the stria terminalis and central amygdaloid nucleus to the dorsal vagal complex in the rat. The
41
HERKENHAM, M. et al. Cannabinoid receptor localization in brain. Proceedings of the
National Academy of Sciences of the United States of America, v. 87, n. 5, p. 1932–6, 1990.
HILL, M. N.; TASKER, J. G. Endocannabinoid signaling, glucocorticoid-mediated negative feedback, and regulation of the hypothalamic-pituitary-adrenal axis. Neuroscience, v. 204, p. 5–16, 1 mar. 2012.
HILL, M.N.; MCEWEN, B.S. Involvement of the endocannabinoid system in the neurobehavioural effects of stress and glucocorticoids. Progress in Neuro- Psychopharmacology and Biological Psychiatry, v. 34, n. 5, p. 791–797, 2010.
HILLARD, C. J. et al. Accumulation of N-arachidonoylethanolamine (anandamide) into cerebellar granule cells occurs via facilitated diffusion. Journal of neurochemistry, v. 69, n. 2, p. 631–638, 1997.
HOWLETT, A. C. et al. International Union of Pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacological reviews, v. 54, n. 2, p. 161–202, 2002.
HOWLETT, A. C. et al. Cannabinoid physiology and pharmacology: 30 Years of progress.
Neuropharmacology, v. 47, n. SUPPL. 1, p. 345–358, 2004.
JOËLS, M.; BARAM, T. Z. The neuro-symphony of stress. Nature reviews. Neuroscience, v. 10, n. 6, p. 459–66, jun. 2009.
KATONA, I.; FREUND, T. F. Multiple functions of endocannabinoid signaling in the brain.
Annual review of neuroscience, v. 35, p. 529–58, 2012.
KVETNANSKY, R et al. Sympatho-adrenal responses of spontaneously hypertensive rats to immobilization stress. The American journal of physiology, v. 236, n. 3, p. H457–62, mar. 1979.
LISBOA, S. F. et al. Activation of cannabinoid CB1 receptors in the dorsolateral periaqueductal gray induces anxiolytic effects in rats submitted to the Vogel conflict test.
European journal of pharmacology, v. 593, n. 1-3, p. 73–8, 28 set. 2008.
MASSI, L. et al. Cannabinoid receptors in the bed nucleus of the stria terminalis control cortical excitation of midbrain dopamine cells in vivo. The Journal of neuroscience : the
official journal of the Society for Neuroscience, v. 28, n. 42, p. 10496–508, 15 out. 2008.
MATSUDA, L. A.; BONNER, T. I.; LOLAIT, S. J. Localization of cannabinoid receptor mRNA in rat brain. The Journal of comparative neurology, v. 327, n. 4, p. 535–50, 22 jan. 1993.
MCKINNEY, M. K.; CRAVATT, B.F. Structure and function of fatty acid amide hydrolase.
Annual review of biochemistry, v. 74, p. 411–32, 2005.
MECHOULAM, R et al. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochemical pharmacology, v. 50, n. 1, p. 83–90, 29 jun. 1995.
MECHOULAM, R. Marihuana chemistry. Science (New York, N.Y.), v. 168, n. 3936, p. 1159–66, 5 jun. 1970.
42
MORENA, M. et al. Neurobiological interactions between stress and the endocannabinoid system. Neuropsychopharmacology, v. 41, n. 1, p. 80–102, 2016.
MUNRO, S.; THOMAS, K. L.; ABU-SHAAR, M. Molecular characterization of a peripheral receptor for cannabinoids. Nature, v. 365, n. 6441, p. 61–5, 2 set. 1993.
MYERS, B. et al. Central stress-integrative circuits: forebrain glutamatergic and GABAergic projections to the dorsomedial hypothalamus, medial preoptic area, and bed nucleus of the stria terminalis. Brain structure & function, v. 219, n. 4, p. 1287–303, jul. 2014.
NEWSOM, R. J. et al. Cannabinoid receptor type 1 antagonism significantly modulates basal and loud noise induced neural and hypothalamic-pituitary-adrenal axis responses in male Sprague-Dawley rats. Neuroscience, v. 204, p. 64–73, 1 mar. 2012.
OLIVEIRA, L. A. et al. CRF1 and CRF2 receptors in the bed nucleus of the stria terminalis modulate the cardiovascular responses to acute restraint stress in rats. Pharmacological
research, v. 95-96, p. 53–62, 2015.
PACHER, P.; BÁTKAI, S.; KUNOS, G. The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacological reviews, v. 58, n. 3, p. 389–462, set. 2006.
PAXINOS, G.; WATSON, C. The rat brain in stereotaxic coodinates. Sidney, Australia: [s.n.], 1997.
PERTWEE, R. G. et al. International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB₁ and CB₂. Pharmacological reviews, v. 62, n. 4, p. 588–631, dez. 2010.
PIOMELLI, D. The molecular logic of endocannabinoid signalling. Nature reviews.
Neuroscience, v. 4, n. 11, p. 873–84, nov. 2003.
PUENTE, N. et al. Localization and function of the cannabinoid CB1 receptor in the anterolateral bed nucleus of the stria terminalis. PloS one, v. 5, n. 1, p. e8869, 2010.
RESSTEL, L. B. M. et al. Anxiolytic-like effects induced by acute reversible inactivation of the bed nucleus of stria terminalis. Neuroscience, v. 154, n. 3, p. 869–76, 26 jun. 2008.
RODER, S; CIRIELLO, J. Contribution of bed nucleus of the stria terminalis to the cardiovascular responses elicited by stimulation of the amygdala. Journal of the autonomic
nervous system, v. 45, n. 1, p. 61–75, out. 1993.
RUSSO, E.B. et al. Agonistic properties of cannabidiol at 5-HT1a receptors. Neurochemical
research, v. 30, n. 8, p. 1037–43, ago. 2005.
SCHLICKER, E; KATHMANN, M. Modulation of transmitter release via presynaptic cannabinoid receptors. Trends in pharmacological sciences, v. 22, n. 11, p. 565–72, nov. 2001.
SUGIURA, T. et al. 2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain. Biochemical and biophysical research communications, v. 215, n. 1, p. 89–97, 4 out. 1995.
43
TAVARES, R. F.; CORRÊA, F. M. A.; RESSTEL, L. B. M. Opposite role of infralimbic and prelimbic cortex in the tachycardiac response evoked by acute restraint stress in rats. Journal
of neuroscience research, v. 87, n. 11, p. 2601–7, 15 ago. 2009.
THOMAS, B. F. et al. Comparative receptor binding analyses of cannabinoid agonists and antagonists. The Journal of pharmacology and experimental therapeutics, v. 285, n. 1, p. 285–292, 1998.
TSOU, K. et al. Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system. Neuroscience, v. 83, n. 2, p. 393–411, mar. 1998.
ULRICH-LAI, Y.M.; HERMAN, J.P. Neural regulation of endocrine and autonomic stress responses. Nature Reviews Neuroscience, v. 10, n. 6, p. 397–409, 13 jun. 2009.
VIANNA, D.M. L.; CARRIVE, P. Changes in cutaneous and body temperature during and after conditioned fear to context in the rat. The European journal of neuroscience, v. 21, n. 9, p. 2505–12, maio 2005.
WALKER, D. L.; MILES, L. A.; DAVIS, M. Selective participation of the bed nucleus of the stria terminalis and CRF in sustained anxiety-like versus phasic fear-like responses. Progress
in neuro-psychopharmacology & biological psychiatry, v. 33, n. 8, p. 1291–308, 13 nov.
2009.
ZHANG, Z. Q.; JULIEN, C.; BARRÈS, C. Baroreceptor modulation of regional haemodynamic responses to acute stress in rat. Journal of the autonomic nervous system, v. 60, n. 1-2, p. 23–30, 27 ago. 1996.
ZHU, W. et al. Involvement of the bed nucleus of the stria terminalis in hippocampal cholinergic system-mediated activation of the hypothalamo--pituitary--adrenocortical axis in rats. Brain research, v. 916, n. 1-2, p. 101–6, 19 out. 2001.
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