1. O Fármaco RUT-BPY-IMI possui um efeito relaxante da musculatura lisa de corpos cavernosos de humanos.
2. O Fármaco parece possuir efeito, in vitro, comparável ao SNP, BAY 41-2272 e Vardenafila.
3. Não parece haver ativação direta dos canais de potássio durante o processo de relaxamento induzido por essa substância.
4. O agente possivelmente age liberando óxido nítrico.
5. O RUT-BPY-IMI parece atuar no sistema de sinalização celular NO/GMPc, ativando a enzima guanilato ciclase solúvel.
6. Não há aparente ativação dos canais de potássio dependente de ATP, durante o processo de relaxamento da musculatura lisa cavernosa.
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APÊNDICE – Termo de Consentimento
TERMO DE CONSENTIMENTO LIVRE E ESCLARECIDO
Pelo presente termo de consentimento,
eu__________________________________________(Responsável pela doação), ________________________(identidade), ________________________ (naturalidade), _________________________ (estado civil), residente a _______________________
______________________________________________(endereço), cidade de _________________, ______________________ (parentesco) do ______________________ (doador), internado no Hospital___________________________ no dia ____________, prontuário: ______________, que teve sua morte encefálica e/ou PCR às _______ do dia _____________, e após exames clínicos e complementares por equipe médica especializada, autorizo, de minha livre e espontânea vontade, a remoção de fragmentos de corpo cavernoso, os quais serão utilizados para fins de pesquisa científica nos termos da lei n° 8.489 de 18 de novembro de 1992, regulamentada pelo decreto n° 879 de 22 de julho de 1993. Fui informado(a) claramente que a referida remoção é realizada pela mesma incisão (corte) utilizada para retirada dos órgãos para transplante, e que os fragmentos destinam-se a fins científicos (pesquisa in vitro). A publicação dos resultados deste estudo não terá identificação do doador. ______________________ , _____ de _________________ de ______ ass: _________________________________________ Testemunhas: _________________________________________ RG: ____________________ _________________________________________ RG: ____________________ ___________________________________________________________________ Dr.Alexandre Saboia Leitão Júnior
Pesquisador Responsável Universidade Federal do Ceará UNIVERSIDADE FEDERAL DO CEARÁ FACULDADE DE MEDICINA
ANEXO– Material cirúrgico utilizado nos experimentos
2 pinças preensão tipo mosquito Edlo, Brasil
2 pinças anatômicas tipo addison Edlo, Brasil
1 tesoura oftálmica Edlo, Brasil
2 placas de Petri