Os extratos da macroalga marinha parda Lobophora variegata, preparados com diclorometano (DCM) e etanol a 70% (EtOH 70%), apresentaram rendimentos de 3,1% e 4,8%, respectivamente.
Os compostos fenólicos totais (CFT) e os teores de flavonoides totais (TFT) foram extraídos em maiores quantidades pelo EtOH 70%, provavelmente por causa da polaridade do solvente de extração e das substâncias extraídas.
As atividades antioxidantes in vitro, medidas pela capacidade de sequestro do radical DPPH, habilidade de quelação de íons ferrosos (FIC), poder de redução de íons férricos (FRAP) e branqueamento do -caroteno (BCB) foram mais elevadas no extrato EtOH 70%.
Duas das cinco subfrações DCM testadas contra Escherichia coli (ATCC 25922) foram efetivas nas concentrações de 100 e 1.000 g mL-1, enquanto três, na maior concentração, foram efetivas contra Staphylococcus aureus (ATCC 25923).
Nenhuma subfração testada apresentou atividade antifúngica contra Aspergillus niger ou Saccharomyces cerevisiae. Da mesma forma, nehuma subfração foi efetiva para promover a inibição da formação de biofilme de Pseudomonas spp.
O extrato DCM nas concentrações 125, 250 e 500 g mL-1 apresentou dose dependência no ensaio de citotoxicidade com náuplios da Artemia sp., matando 100% dos indivíduos após 48 h de exposição. Os resultados para o extrato EtOH 70% não foram apresentados porque o percentual de mortos no controle foi superior ao máximo admitido de 10%.
Em termos gerais, os resultados deste trabalho mostraram que os extratos DCM e EtOH 70% de L. variegata apresentaram diferentes atividades biológicas com potencial promissor de investigação.
Há necessidade de estudos mais aprofundados nas subfrações obtidas dos extratos DCM e EtOH 70% para avaliar a eficácia terapêutica da L. variegata, através de testes in vitro e in vivo. Com o extrato DCM, alguns desses estudos já estão sendo realizados, e os resultados obtidos serão utilizados para a publicação de um trabalho científico, cuja redação foi iniciada.
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