A padronização do protocolo de purificação de glicolipídios acídicos foi eficaz e possibilitou a produção de anticorpos policlonais contra antígenos de natureza glicolipídica
Os anticorpos policlonais gerados contra os glicolipídios acídicos foram capazes de aumentar a atividade fagocítica, a produção de
óxido nítrico e morte das leveduras de Pb 18, por macrófagos
peritoneais in vitro
O anticorpo policlonal contra antígenos glicolipídicos em modelo profilático e terapêutico de PCM experimental, reduziu a carga
fúngica dos pulmões, além de evitar a disseminação
A transferência passiva deste anticorpo policlonal foi capaz de reduzir
os danos teciduais dos animais infectados, além de induzir a
secreção de IFN-γ e IL-12, modulando a resposta imune para o padrão Th1 e clearance do fungo
O anticorpo policlonal contra o glicolipídio acídico de
Paracoccidioides brasiliensis mostra-se promissor tanto como vacina
(modeloprofilático) quanto como imunomodulador do tratamento da PCM (modelo terapêutico)
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