Este estágio permitiu-me acompanhar as atividades do Médico Veterinário em contexto hospitalar e assim pôr em prática os conhecimentos adquiridos ao longo dos cinco anos do curso de Medicina Veterinária. Tomámos a decisão de realizar o estudo neste tema devido ao meu interesse nas áreas da Oncologia e da Nefrologia e à inexistência de estudos que avaliem a existência de proteinuria em gatos com linfoma ou outras neoplasias.
Apesar das suas várias limitações, este estudo preliminar permitiu tirar algumas conclusões, nomeadamente que os animais com linfoma têm ratios UPC em média, estatisticamente superiores aos de gatos saudáveis. Em estudos futuros, seria muito importante aumentar o numero da amostra analisada, o que poderia permitir a realização de um estudo comparativo por tipos de linfoma e por estádios clínicos, por forma a esclarecer a importância clínica da proteinuria como marcador de diagnóstico e de prognóstico nestas neoplasias.
A possibilidade de usar a proteinuria como marcador de outras doenças que não a doença renal crónica deve também ser investigada, uma vez que este é um parâmetro de fácil recolha e avaliação, sendo minimamente invasivo para o animal e pode ser determinado numa amostra momentânea de urina.
Bibliografia
Adams, L. G., Polzin, D. J., Osborne, C. A., and O’Brien, T. D., 1992. Correlation of Urine Protein/Creatinine Ratio and Twenty-Four-Hour Urinary Protein Excretion in Normal Cats and Cats with Surgically Induced Chronic Renal Failure. Journal of Veterinary
Internal Medicine, 6 (1), 36–40.
Alpers, C. and Cotran, R., 1986. Neoplasia and glomerular injury. Kidney International, 30 (4), 465–473.
Alshayeb, H. and Wall, B. M., 2009. Non Hodgkin’s lymphoma associated membranoproliferative glomerulonephritis: rare case of long term remission with chemotherapy: a case report. Cases Journal, 2 (1), 7201.
Argyle, D. J., Saba, C., and Paolini, M. C., 2008. Feline Lymphoma and Leukemia. In: Decision
Making in Small Animal Oncology. Ames, Iowa: Blackwell Pub. Professional, 197–209.
Avery, A., 2009. Molecular Diagnostics of Hematologic Malignancies. Topics in Companion
Animal Medicine, 24 (3), 144–150.
Barber, P. J., 2004. The Kideny. In: Feline Medicine and Therapeutics. Oxford: Blackwell Publishing, 281–311.
Bertone, E., Snyder, L., and Moore, A., 2002. Environmental tobacco smoke and risk of malignant lymphoma in pet cats (abstract). American Journal of Epidemiology, 156. Boyd, L. M., Langston, C., Thompson, K., Zivin, K., and Imanishi, M., 2008. Survival in Cats
with Naturally Occurring Chronic Kidney Disease (2000-2002). Journal of Veterinary
Internal Medicine, 22 (5), 1111–1117.
Brown, S. A., Brown, C. A., Crowell, W. A., Barsanti, J. A., Kang, C.-W., Allen, T., Cowell, C., and Finco, D. R., 2000. Effects of dietary polyunsaturated fatty acid supplementation in early renal insufficiency in dogs. Journal of Laboratory and Clinical Medicine, 135 (3), 275–286.
Brown, S., Brown, C., and Surdyk, K., 2006. The Importance of Proteinuria and Microalbuminuria. In: World Small Animal Veterinary Association World Congress
Proceedings. Presented at the World Small Animal Veterinary Association World
Congress, IVIS.
Bruggern, W., French, K., and Randall, D. J., 2011. Eckert Fisiologia Animal: Mecanysmos e
Adaptaciones. 4th ed. Espanha: McGraw-Hill Interamericana.
Castro, M. C. N., Marcello, G. C. G., Alencar, N. X., and Ferreira, A. M. R., 2009. Avaliação da relação proteína-creatinina urinária em gatos com doença renal crónica. Brazilian
Journal of Veterinary Research, 29 (8), 605–609.
Chew, D. J., DiBartola, S. P., and Schenck, P., 2010. Canine and feline nephrology and urology. Elsevier Health Sciences.
Chun, R., 2011. Feline Lymphoma. In: Proceedings of the 36th World Small Animal Veterinary
Congress WSAVA. Presented at the 36th World Small Animal Veterinary Congress
WSAVA, Jesu, Korea: IVIS, 741–743.
Cochran, P. E., 2011. Veterinary anatomy & physiology: a clinical laboratory manual. 2nd ed. Clifton Park, NY: Delmar, Cengage Learning.
Cunningham, J. G. and Klein, B. G., eds., 2013. Cunningham’s textbook of veterinary
physiology. 5th ed. St. Louis, Mo: Elsevier/Saunders.
Di Bella, A., Maurella, C., Cauvin, A., Schmidt, J. M., Tapia, B. B., and North, S. M., 2013. Proteinuria in canine patients with lymphoma. Journal of Small Animal Practice, 54 (1), 28–32.
DiBartola, S. P., 2010. Clinical Approach and Laboratory Evaluation of Renal Disease. In:
Textbook of Veterinary Internal Medicine. St. Louis, Mo: Elsevier/Saunders, 1955–
1969.
Dobson, J. M. and Lascelles, B. D. X., eds., 2011. BSAVA Manual of Canine and Feline
Oncology. 3rd ed. Quedgeley, Gloucester: British Small Animal Veterinary
Association.
Eagen, J. W. and Lewis, E. J., 1977. Glomerulopathies of neoplasia. Kidney International, 11, 297–306.
Elliott, J. and Grauer, G. F., eds., 2007. BSAVA Manual of Canine and Feline Nephrology and
Urology. 5th ed. Quedgeley, Gloucester: British Small Animal Veterinary Association.
Elliott, J. and Watson, A. D. J., 2009. Chronic Kideny Disease: Staging and Management. In:
Kirk’s Current Veterinary Therapy XIV. Saunders, 883–892.
Grant, I. A., 2013. Diagnosing lymphoma and leukaemia–when all cells are created equal.
Journal of Small Animal Practice, 54 (10), 505–506.
Grauer, G. F., 2006. Accuracy of Urine Dipstick For Proteinuria. In: Proceedings of the North
American Veterinary Conference. Presented at the North American Veterinary
Conference, Orlando, Florida: IVIS.
Grauer, G. F., 2009. Proteinuria: Implications for Management. In: Kirk’s Current Veterinary
Therapy XIV. Saunders, 860–863.
Grauer, G. F., 2012. Nuts and Bolts of Proteinuria. In: Proceedings of the South European
Veterinary Conference. Presented at the South European Veterinary Conference,
Barcelona, Spain: IVIS.
Harley, L. and Langston, C., 2012. Proteinuria in dogs and cats. Canadian Veterinary Journal, 53 (6), 631–638.
IRIS, 2016a. IRIS Kidney - Guidelines - IRIS Staging of CKD [online]. Available from: http://iris-kidney.com/guidelines/staging.html [Accessed 17 Aug 2016].
IRIS, 2016b. IRIS Kidney - Guidelines - IRIS Treatment Recommendations [online]. Available from: http://www.iris-kidney.com/guidelines/recommendations.html [Accessed 17 Aug 2016].
Iwanaga, N., Kamachi, M., Fujikawa, K., Aramaki, T., Izumi, Y., Arima, K., Tamai, M., Aratake, K., Nakamura, H., Origuchi, T., Ida, H., Kawakami, A., Taguchi, T., and Eguchi, K., 2006. Membranous glomerulonephritis and non-Hodkin’s lymphoma in patient with primary Sjögren’s syndrome. Internal Medicine, (46), 191–194.
King, J. N., Tasker, S., Gunn-Moore, D. A., and Strehlau, G., 2007. Prognostic Factors in Cats with Chronic Kidney Disease. Journal of Veterinary Internal Medicine, 21, 906–916. Knottenbelt, C. M. and Blackwood, L., 2004. The Blood. In: Feline Medicine and Therapeutics.
Oxford: Blackwell Publishing, 235–280.
Lees, G. E., Brown, S. A., Elliott, J., Grauer, G. F., and Vaden, S. L., 2005. Assessment and Management of Proteinuria in Dogs and Cats: 2004 ACVIM Forum Consensus Statement (Small Animal). Journal of Veterinary Internal Medicine, 19 (3), 377–385. Littman, M. P., 2011. Protein-losing Nephropathy in Small Animals. Veterinary Clinics of
North America: Small Animal Practice, 41 (1), 31–62.
Louwerens, M., London, C. A., Pedersen, N. C., and Lyons, L. A., 2005. Feline Lymphoma in the Post—Feline Leukemia Virus Era. Journal of Veterinary Internal Medicine, 19 (3), 329–335.
Mallouk, A., Pham, P.-T. T., and Pham, P.-C. T., 2006. Concurrent FSGS and Hodgkin’s lymphoma: case report and literature review on the link between nephrotic glomerulopathies and hematological malignancies. Clinical and Experimental
Nephrology, 10 (4), 284–289.
Marconato, L., Leo, C., Girelli, R., Salvi, S., Abramo, F., Bettini, G., Comazzi, S., Nardi, P., Albanese, F., and Zini, E., 2009. Association between Waste Management and Cancer in Companion Animals. Journal of Veterinary Internal Medicine, 23 (3), 564–569. Marynissen, S. J. J., Willems, A. L., Paepe, D., Smets, P. M. Y., Picavet, P., Duchateau, L., and
Daminet, S., 2017. Proteinuria in Apparently Healthy Elderly Dogs: Persistency and Comparison Between Free Catch and Cystocentesis Urine. Journal of Veterinary
Internal Medicine, 31 (1), 93–101.
Morrison, W. B., 2007. A Fresh Look at Lymphoma in Dogs and Cats. In: Proceedings of the
North American Veterinary Conference. Presented at the North American Veterinary
Murphy, S., 2013. Feline Lymphoma Part 1. In: Proceedings of the South European Veterinary
Conference and Congresso Nacional AVEPA. Presented at the Southern European
Veterinary Conference and Congreso Nacional AVEPA, Barcelona, Spain: IVIS, 5. Nabity, M. B., 2011. Urine protein and microalbuminuria. In: Nephrology and Urology of Small
Animals. Chichester, West Sussex, UK ; Ames, Iowa: Wiley-Blackwell, 58–61.
Nabity, M. B., Boggess, M. M., Kashtan, C. E., and Lees, G. E., 2007. Day-to-Day Variation of the Urine Protein: Creatinine Ratio in Female Dogs with Stable Glomerular Proteinuria Caused by X-Linked Hereditary Nephropathy. Journal of veterinary
internal medicine, 21 (3), 425–430.
Nelson, R. W. and Couto, C. G., eds., 2009. Small animal internal medicine. 4th ed. St. Louis, Mo: Mosby/Elsevier.
Norris, S., 1993. Paraneoplastic glomerulopathies (abstract). Seminars in Nephrology, 13 (3). Page, R. L., Stiff, M. E., McEntee, M. C., and Walter, L. G., 1990. Transient
Glomerulonephropathy Associated With Primary Erythrocytosis in a Dog (abstract).
Journal of the American Veterinary Medical Association, (196), 620–622.
Plantinga, E. A., Everts, H., Kastelein, A. M., and Beynen, A. C., 2005. Retrospective study of the survival of cats with acquired chronic renal insufficiency offered different commercial diets. Veterinary Record, 157 (7), 185.
Pressler, B. M., 2006. How I Treat Proteinuria. In: Proceedings of the North American
Veterinary Conference. Presented at the The North American Veterinary Conference,
Orlando, Florida, 688–689.
Pressler, B. M., Vaden, S. L., and Jensen, W., 2003. Urine albumin concentration is increased in dogs with lymphoma or osteosarcoma (abstracts). Journal of Veterinary Internal
Medicine, 17 (3), 404.
Reece, W. O., 2009. Functional anatomy and physiology of domestic animals. 4th ed. Ames, Iowa: Wiley-Blackwell.
Reece, W. O., Erickson, H. H., Goff, J. P., and Uemura, E. E., eds., 2015. Duke’s Physiology
of Domestic Animals. 13a. UK: Willey Blackwell.
Renwick, M. G. and Argyle, D. J., 2008. Paraneoplastic Syndromes. In: Decision Making in
Small Animal Oncology. Ames, Iowa: Blackwell Pub. Professional, 19–44.
Shelton, G. H., Grant, C. K., Cotter, S. M., Gradner, M. B., Hardy, W. D., and DiGiacomo, R. F., 1990. Feline immunodeficiency virus and feline leukemia virus infections and their relationships to lymphoid malignancies in cats: A retrospective study (1968-1988).
Syme, H. M., Markwell, P. J., Pfeiffer, D., and Elliott, J., 2006. Survival of cats with naturally occurring chronic renal failure is related to severity of proteinuria. Journal of Veterinary
Internal Medicine, 20 (3), 528–535.
Taylor, S. S., Goodfellow, M. R., Browne, W. J., Walding, B., Murphy, S., Tzannes, S., Gerou- Ferriani, M., Schwartz, A., and Dobson, J. M., 2009. Feline extranodal lymphoma: response to chemotherapy and survival in 110 cats. Journal of Small Animal Practice, (50), 584–592.
Vail, D. M., 2010. Hematopoeitic Tumors. In: Textbook of Veterinary Internal Medicine. St. Louis, Mo: Elsevier/Saunders, 2148–2163.
Vail, D. M., 2011. Tumours of the haemopoietic system. In: BSAVA Manual of Canine and
Feline Oncology. Quedgeley, Gloucester: British Small Animal Veterinary Association.
Verlander, J. W., 2013. Renal Physiology. In: Cunningham’s textbook of veterinary physiology. St. Louis, Mo: Elsevier/Saunders, 460–494.
Vilhena, H. C. R., Santos, R. R., Sargo, T. J., Lima, T. B., Dias, S. S., Pastorinho, M. R., Queiroga, F. L., and Silvestre-Ferreira, A. C., 2015. Urine protein-to-creatinine concentration ratio in samples collected by means of cystocentesis versus manual compression in cats. Journal of the American Veterinary Medical Association, 246, 862–867.
Watanabe, T. and Mishina, M., 2007. Effects of benazepril hydrochloride in cats with experimentally induced or spontaneously occurring chronic renal failure. Journal of
Veterinary Medical Science, 69 (10), 1015–1023.
Wehner, A., Hartmann, K., and Hirschberger, J., 2008. Associations between proteinuria, systemic hypertension and glomerular filtration rate in dogs with renal and non-renal diseases. Veterinary Record, (162), 141–147.
Withrow, S. J., Vail, D. M., and Page, R. L., eds., 2013. Withrow & MacEwen’s small animal