Os dados obtidos sessenta minutos após a administração de BIS e BIS/β- CD (50 mg/kg; v.o) no teste do aparato Rota rod não apresentaram resultados significativos (p > 0,05) quando comparados ao grupo controle. Tais resultados complementam os achados encontrados nos testes de força muscular e hiperalgesia mecânica, pois a substância não interfere na coordenação motora dos animais como mostra a figura 26 com tempo em segundos (s) em função do tempo (hora).
B 1h 0 50 100 150 200 CONTROLE BIS BIS-CD Tempo T e m p o ( s )
Figura 26. Efeito da administração de BIS e BIS/β-CD (50mg/kg; v.o.), veículo (controle) sobre a coordenação motora. Valores expressos em média ± E.P.M.. (n = 8/grupo). (ANOVA, seguido pelo pós teste de Bonferroni).
6 CONCLUSÃO
De acordo com os resultados obtidos no presente estudo, pode-se concluir que: BIS e BIS/β-CD foram capazes de reduzir a hiperalgesia mecânica induzida
por modelo de dor inflamatória crônica;
BIS e BIS/β-CD apresentaram um tempo de efeito superior a 7h na administração aguda no modelo de dor neuropática. Evidenciando que a complexação melhorou o efeito da substância, já que a quantidade de BIS no complexo foi 10 vezes menor do que a quantidade real administrada do composto puro;
BIS e BIS/β-CD mostraram ação antinociceptiva, reduzindo a hiperalgesia mecânica crônica, sem alteração da força muscular nem da coordenação motora dos animais testados no modelo de dor neuropática;
BIS e BIS/β-CD foi capaz de reduzir a alodinia ao frio em modelo de dor neuropática;
BIS e BIS/β-CD foram eficazes na redução as concentrações de TNF-α no nervo e medula espinhal, assim como atuaram no aumento dos níveis de IL- 10. Além disso, atenuaram a microgliose induzida pelo LPNC.
7 PERSPECTIVAS
Determinar o possível mecanismo de ação do BIS em modelo de dor neuropática, avaliando o envolvimento dos sistemas glutamatérgico, opioide, canabinoide, serotoninérgico, adrenérgico e GABAérgico ;
Avaliar a possível ação do BIS sobre as áreas encefálicas e medulares na modulação da dor por meio da expressão de c-FOS;
Avaliar a possível ação do BIS sobre os receptores de TNF-α, TNFR1 e TNFR2;
Determinar a possível atuação do BIS nos canais TRPV1;
Avaliar o efeito do BIS sobre o estresse oxidativo (CAT, SOD, TBARs); Avaliar o envolvimento da COX-2, NFκB, p38MAPK;
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