Superoxido dismutase (U/mg de proteína)
Tratamentos
24 horas
7 dias
14 dias
Controle
0,077
±0,007
0,087
±0,004
0,080
±0,007
3-NP
0,050
±0,001*
0,051
±0,001*
0,049
±0,002*
3-NP+400mg/kg
0,053
±0,002*
0,070
±0,001
#0,067
±0,002
#3-NP+800mg/kg
0,056
±0,003*
0,079
±0,002
#0,070
±0,002
#Os resultados expressam a média±E.P.M. * Estatisticamente significante em relação ao grupo controle:
p<0,05.
#Estatisticamente significante em relação ao grupo 3-NP: p<0,05. (ANOVA, seguida pelo teste de
Tukey).
90
91 6. CONCLUSÃO
Com base nos resultados obtidos, conclui-se que:
- O extrato de Schinus terebinthifolius e Cassia occidentalis na avaliação da atividade antioxidante in vitro apresentou expressiva atividade no teste de captura do radical DPPH˙, demonstrando a capacidade dessas espécies em combater os radicais livres, provavelmente relacionada à elevada quantidade de compostos fenólicos encontrados em ambas as espécies como descrito por vários autores.
- Os animais tratados durante 5 dias com ácido 3-nitropropiônico (30 mg/kg, i.p.) apresentaram significativa perda de peso, prejuízo motor e cognitvo, além de aumento da peroxidação lipídica e diminuição da atividade da superóxido dismutase.
- O tratamento diário com ST (300 e 600 mg/kg, v.o.) por 7 e 14 dias após a administração sistêmica de 3-NP atenuou as alterações comportamentais induzidas por essa neurotoxina. Adicionalmente, também foi observado que o extrato melhorou a peroxidação lipídica e a atividade da superóxido dismutase.
- Assim como o extrato de ST, a CO (400 e 800 mg/kg, v.o.) diminui as alterações metabólicas, neurocomportamentais e bioquímicas induzidas pelo tratamento com 3- NP.
- A partir destes estudos, ST e CO surgem como potencias agentes neuroprotetores com perspectiva de uso no tratamento de doenças neurodegenerativas, como a Doença de Huntington.
92
93 7. REFERÊNCIAS
Ahuja, M.; Bishnoi, M.; Chopra, K. Protective effect of minocycline, a semi-synthetic second-generation tetracycline against 3-nitropropionic acid (3-NP)-induced neurotoxicity. Toxicolology, v. 244, p. 111-122, 2008.
Ajagbonna O. P.; Mojiminiyi, F. B. O.; Sofola, O. A. Relaxant effects of the queous leaf extract of Cassia occidentallis on rat aortic rings. African Journal of Biomedical Research, v. 4, p. 127-129, 2001.
Akomolafe, R. O.; Adeoshun, I. O.; Elujoba, A. A.; Iwalewa, E. O.; Ayoka, A. O. Effects of Cassia sieberiena leaf extracts on the intestinal motility of rat. African Journal of Biomedical Research, v. 6, p. 141-145, 2003.
Ambasta, K. K. et al. Environ. Ecol., v. 8, p. 1033-1034, 1990. In: Di Stasi, L. C.; Hiruma-Lima, C. A. Plantas medicinais na Amazônia e na Mata Atlântica. 2ed. São Paulo: Editora UNESP, p. 282-295, 2002.
Amorim. M. M. R.; Santos, L. C. Tratamento da vaginose bacteriana com gel vaginal de aroeira (Schinus terebinthifolius Raddi): ensaio clínico randomizado. Rego, v. 25, p. 95-102, 2003.
Anderson, K. E. Huntington’s Disease and Related Disorders. Psychiatric Clinics of North America, v. 28, p. 275-290, 2005.
Aragão, T. P. Cassia Virgínica® (Cassia Occidentalis L.): Abordagem Farmacológica e Toxicológica. 2008. Dissertação (Mestrado em Ciências Farmacêuticas) – Universidade Federal de Pernambuco, Recife, 2008.
Aragão, T. P.; Lyra, M. M. A.; Silva, M. G. B.; Andrade, B. A.; Ferreira, P. A.; Ortega, L. F. et al. Toxicological reproductive study of Cassia occidentalis L. in female Wistar rats. Journal of Ethnopharmacology, v. 123, p. 163-166, 2009.
94 Araújo, E. L. Aroeira da praia – Estudo farmacognóstico e da atividade biológica de Schinus terebinthifolius, Raddi (Anacardiaceae). 2002. Dissertação (Mestrado em Ciências Farmacêuticas) – Universidade Federal de Pernambuco, Recife, 2002.
Aubeeluck, A.; Wilson, E. Huntington’s disease. Part 1: essential background and management. British Journal of Nursing, v. 17, p. 146-151, 2008.
Barbosa-Ferreira, M.; Dagli, M. L. Z.; Maiorka, P. C.; Górniak, S. L. Sub-acute intoxication by Senna occidentalis seeds in rats. Food and Chemical Toxicology, v. 43, p. 497-503, 2005.
Bastianetto, S.; Zheng, W. H.; Quirion, R. The Gingko biloba extract (Egb 761) protects and rescues hippocampal cells against nitric oxide-induced toxicity: Involvement of its flavonoids constituents and protein kinase C. Journal of Neurochemistry, v. 74, p. 2268-2277, 2000.
Beal, M. F.; Brouillet, E.; Jenkins, B. G.; Ferrante, R. J.; Kowall, N. W.; Miller, J. M.; et al. Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3- nitropropionic acid. Journal of Neuroscince, v. 13, p. 4181-4192, 1993.
Bellé, N. A. V. Efeitos da espermina sobre parâmetros motores, cognitivos e neuromorfológicos em um modelo experimental da doença de Huntington. 2008. 132 f. Tese (Doutorado em Bioquímica Toxicológica) - Universidade Federal de Santa Maria, Rio Grande do Sul, 2008.
Bianchi, M. L. P.; Antunes, L. M. G. Radicais livres e os principais antioxidantes da dieta. Revista de Nutrição, Campinas, v. 12, v. 123-130, 1999.
Borio, E. B. L.; Cecy, C.; Yasumoto, Y. Pharmacognostic study of the bark of Schinus terebinthifolius, Raddi. Ciencia e Cultura, v. 25, p.631-4, 1973.
95 Borlongan, C. V.; Koutouzis, T. K.; Randall, T. S.; Freeman, T. B.; Cahill, D. W.; Sanberg, P. R. Systemic 3-nitropropionic acid, behavioral deficits and striatal damage in adult rats. Brain Research Bulletin, v. 36, p. 549-556, 1995.
Bornhausen, R. Ervas do Sítio. Disponível em:
<http://www.ervasdositio.com.br/enciclopedia/enciclopedia.asp>. Acesso em: 04/ago/2009.
Braidy, N.; Grant, R.; Adams, S.; Brew, B. J.; Guillemin, G. J. Mechanism for quinolinic acid cytotoxicity in human astrocytes and neurons. Neurotoxicology Research, v. 16, p. 77-86, 2009.
Cáceres, A.; Lopez, B. R.; Giron, M. A.; Logemann, H. Plants used in Guatemala for the treatment of dermatophytic infections. Screening for antimycotic activity of 44 plant extracts. Journal of Ethnopharmacology, v. 31, p. 263-276, 1991.
Campello, J. P.; Marsaioli, A. J. Triterpenes of Schinus terebinthifolius. Phytochemistry, v.13, p.659-60, 1974.
Cardoso, F. Huntington Disease and Other Choreas. Neurology Clinical, v. 27 p. 719–736, 2009.
Castelo-Branco Neto, M. L.; Ribas Filho, J. M.; Malafaia, O.; Oliveira Filho, M. A.; Czeczko, N. G.; Aoki, S.; et al. Avaliação do extrato hidroalcoólico de aroeira (Schinus terebinthifolius Raddi) no processo de cicatrização de feridas em pele de ratos. Acta Cirúrgica Brasileira, v. 21, 17-22, 2006.
Ceruks, M.; Romoff, P.; Fávero, O. A.; Lago, J. H. G.; Constituintes fenólicos polares de Schinus terebinthifolius Raddi (Anacardiaceae). Química Nova, v. 30, p. 597-599, 2007.
Chaturvedi, R. K.; Shukla, S.; Seth, K.; Chauhan, S.; Sinha, C.; Shukla, Y.; Agrawal, A. K. Neuroprotective and neurorescue effect of black tea extract in 6-
96 hydroxydopamine-lesioned rat model of Parkinson’s disease. Neurobiology of Disease, v. 22, p. 421-434, 2006.
Chauhan, D.; Chauhan, J. S.; Siddiqui, I. R.; Singh, J. Two new anthraquinone glycosides from the leaves of Cassia occidentalis. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, v. 40, p. 860-863, 2001.
Clemente, A. D. Composição química e atividade biológica do óleo essencial da pimenta-rosa (Schinus terebinthifolius Raddi). 2006. 63 f. Tese (Doutorado em Agroquímica) – Universidade Federal de Viçosa, Minas Gerais, 2006.
Coimbra, R. Manual de Fitoterapia. Editora Cejup. Belém. 26 p., 1994.
Corrêa, M. Dicionário das plantas úteis do Brasil e das exóticas cultivadas. Rio de Janeiro: Imprensa Nacional, p.170-1, 1978b.
Corrêa, M. P. Dicionário de Plantas Úteis do Brasil e das Exóticas Cultivadas. Rio de Janeiro: Ministério da Agricultura, vol. III, p. 55-57, 1984.
Cruz, G. L. Dicionário de Plantas úteis do Brasil. Editora Bertrand. Rio de Janeiro, 1995.
Da Silva, L. B. L. Preparação e avaliação biofarmacêuticas de formas semi- sólidas da aroeira da praia (Schinus terebinthifolius, Raddi). 1999. Dissertação (Mestrado em Ciências Farmacêuticas) - Universidade Federal de Pernambuco, Recife, 1999.
Dajas, F.; Rivera-Megret, F.; Blasina, F.; Arredondo, F.; Abincarriquiry, J.A. Costa, G.; et al. Neuroprotection by flavonoids. Brazilian Journal of Medical and Biological Research, v. 36, p.1613-1620, 2003.
97 Damiano, M.; Galvan, L.; Déglon, N.; Brouillet, E. Mitochondria in Huntington's disease. Biochimica et Biophysica Acta, v.1802, p. 52-61, 2010.
Daulatabad, C. D.; Bhat, G. G.; Jamkhandi, A. M. A novel keto fatty acid from Cassia occidentalis seed oil. Fett/Lipid, v. 98, p. 176-177, 1996.
Degáspari, C. H.; Waszczynskyj, N.; Santos, R. J. Atividade antioxidante de extrato de fruto de aroeira (Schinus terebinthifolius Raddi). Visão Acadêmica, v. 5, p. 83-90, 2004.
Di Stasi, L. C.; Hiruma-Lima, C. A. Plantas medicinais na Amazônia e na Mata Atlântica. 2ed. São Paulo: Editora UNESP, p. 282-295, 2002.
DiFligia, M.; Sapp, E.; Chase, K.; Schwarz, C.; Meloni, A.; Young, C. et al. Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons. Neuron, v. 14, p. 1075-1081, 1995.
Elujoba, A. A.; Ajulo, O. O.; Iweibo, G. O. Chemical and Biological Analyses of Nigerian Cassia Species for Laxative Activity. Journal of Pharmaceutical and Biomedical Analysis, v. 7, p. 1453-1457, 1989.
Emperaire, L. Oréades. V. 8, p. 61-71, 1982.
Ferrante, R. J. Mouse models of Huntington's disease and methodological considerations for therapeutic trials. Biochimica et Biophysica Acta, v. 1792, p. 506- 520, 2009.
Ferreira, A. L. A.; Matsubara, L. S. Radicais livres: conceitos, doenças relacionadas, sistema de defesa e estresse oxidativo. Revista da Associação Médica Brasileira, v. 43 p. 61-68, 1997.
Fontaine, M. A.; Geddes, J. W.; Banks, A.; Butterfield, D. A. Effect of exogenous and endogenous antioxidants on 3-nitropionic acid-induced in vivo oxidative stress and
98 striatal lesions: insights into Huntington’s disease. Journal of Neurochemistry, v. 75, p. 1709-1715, 2000.
Gasquet, M.; Delmas, F.; Timon-David, P.; Keita, A.; Guindo, M.; Koita, N.; et al. Evaluation in vitro and in vivo of a traditional antimalarial drug, malarial . Fitoterapia, v. 64, p. 423-426, 1993.
Gavillanes, M. L., et al. Oréades. v. 8, p. 34-37, 1982. In: Di Stasi, L. C.; Gil, J. M.; Rego, A. C. Mechanisms of neurodegeneration in Huntington’s disease. European Journal of Neuroscience, v. 27, p. 2803-2820, 2008.
Gil, J. M.; Rego, A. C. Mechanisms of neurodegeneration in Huntington’s disease. European Journal of Neuroscience, v. 27, p. 2803-2820, 2008.
Gilgun-Sherki, Y.; Melamed, E.; Offen, D. Oxidative stress induced neurodegenerative diseases: the need for antioxidants that penetrate the blood brain barrier. Neuropharmacology, v. 40, p. 959-975, 2001.
Gilgun-Sherki, Y.; Melamed, E.; Offen, D. Oxidative stress induced- neurodegenerative diseases: the need for antioxidants that penetrate the blood brain barrier. Neuropharmacology, v. 40, p. 959-975, 2001.
Grandi, T. S. M.; et al. Oréades, v. 8, p. 16-25. 1982. In: Di Stasi, L. C.; Hirumalima, C. A. Plantas medicinais na Amazônia e na Mata Atlântica. 2ed. São Paulo: Editora UNESP, p. 282-295, 2002.
Gu, M.; Gash, M. T.; Mann, V. M.; Javoy-Agid, F.; Cooper, J. M.; Schapira, A. H. Mitochondrial defect in Huntington’s disease caudate nucleus. Annals of Neurology, v. 39, p. 385-389, 1996.
Guncová, I.; Mazurová, Y. The neurodegenerative process in a neurotoxic rat model and in patients with Huntington’s disease: Histopathological parallels and differences. Acta Histochemica, 2011 (doi:10.1016/j.acthis.2010.11.007).
99 Haddad, M. S. Doença de Huntington: aspectos clínicos em 81pacientes. 1995. Dissertação. São Paulo: Faculdade de Medicina de São Paulo; 1995.
Halliwell, B. Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment. Drugs & Aging, v. 18, p. 685-716, 2001.
Halliwell, B. Effect of diet on cancer development: is oxidative DNA damage a biomarker? Free Radical Biology & Medicine, v. 32, p. 968-974, 2002.
Halliwell, B. Oxidative stress and neurodegeneration: where are we now? Journal of Neurochemistry, v. 97, p. 1634-1658, 2006.
Haraguchi, M.; Górniak, S. L.; Dagli, M. L. Z.; Raspantini, P. C. F. Determinação dos constituintes químicos das frações tóxicas de fedegoso (Senna occidentalis (L.)). 1996. In: Annals of Reunião Anual da Sociedade Brasileira de Química. Poços de Caldas 19. In: Barbosa-Ferreira, M.; Dagli, M. L. Z.; Maiorka, P. C.; Górniak, S. L. Sub-acute intoxication by Senna occidentalis seeds in rats. Food and Chemical Toxicology, v. 43, p. 497-503, 2005.
Hersch, S. M.; Rosas, H. D. Neuroprotection for Huntington’s Disease: Ready, Set, Slow. Neurotherapeutics: The Journal of the American Society for Experimental NeuroTherapeutics, v. 5, p. 226-236, 2008.
Hiruma-Lima, C. A. Plantas medicinais na Amazônia e na Mata Atlântica. 2ed. São Paulo: Editora UNESP, p. 282-295, 2002.
Hussain, H. S. N.; Deeni, Y. Y. Plants in Kano Ethnomedicine: screening for antimicrobial activity and alkaloids. International Journal of Pharmacology, v. 29, p. 51-56, 1991.
100 Jafri, M. A.; Jalis Subhani, M.; Javed, K.; Singh, S. Hepatoprotective activity of leaves of Cassia occidentalis against paracetamol and ethyl alcohol intoxication in rats. Journal of Ethnopharmacology, v. 66, p. 355-361, 1999.
Jain, M. K.; Yu, B. Z.; Rogers, J. M.; Smith, A. E; Boger, E. T. A.; Ostrander, R. L.; Rheingold, A. L. Phytochemistry, v. 39, p.537-547, 1995.
Johann, S.; Pizzolatti, M. G.; Donnici, C. L.; Resende, M. A. Antifungal properties of plants used in Brazilian traditional medicine against clinically relevant fungal pathogens. Brazilian Journal of Microbiology, v. 3, p. 632-637, 2007.
Kim, J-H; Kim, S.; Yoon, I-S; Lee, J-H; Jang, B-J; Jeong, S. M.; et al. Protective effects of ginseng saponins on 3-nitropropionic acid-induced striatal degeneration in rats. Neuropharmacology, v. 48, p. 743-756, 2005.
Kitanaka, S.; Takido, M. Studies on the Constituents of Purgative Crude Drugs. New Bitetrahydroanthracenes from Roots of Cassia occidentalis L. Chemical & Pharmaceutical Bulletin, v. 37, p. 511-512, 1989.
Krobitscha, S.; Kazantsev, A. G. Huntington’s disease: From molecular basis to therapeutic advances. The International Journal of Biochemistry & Cell Biology, v. 43, p. 20-24, 2011.
Kumar, P.; Padi, S. S. V.; Naidu, P. V.; Kumar, A. 3-nitropropionic acid induced neurotoxicity: an animal model for Huntington’s disease. Journal of Cell & Tissue Research, v. 7, p. 853-860, 2007.
Lal, J.; Gupta, P. C. New Anthraquinones from seeds of Cassia occidentalis Linn. Experientia, v. 30, p. 850-851, 1974.
Lal, J.; Gupta, P. C. Physcion and Phytosterol from Roots of Cassia occidentalis. Phytochemistry, v. 12, p. 1186, 1973.
101 Lima, M. R. F..; Luna, J. S.; Santos, A. F.; Andrade, M. C. C.; Sant’ana, A. E. G.; Genet, J. P.; et al. Anti-bacterial activity of some Brazilian medicinal plants. Journal of Ethnopharmacology, v. 105, p. 137-47, 2006.
Lima, L. B.; Vasconcelos, C. F. B.; Maranhão, H. M. L.; Leite, V. R.; Ferreira, P. A.; Andrade, B. A.; et al. Acute and subacute toxicity of Schinus terebinthifolius bark extract. Journal of Ethnopharmacol, v. 126, p. 468-473, 2009.
Lima-Costa, M. F.; Veras, R. Saúde pública e envelhecimento. Cadernos de Saúde Pública, v. 19, p. 700-701, 2003.
Lin, M. T.; Beal, M. F. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature, v. 443, p. 787–795, 2006.
Lira, E. C.; Santos, V. L.; Silva, J. A. Avaliação da atividade antiulcerogênica do extrato bruto da raiz Cassia occidentalis L. (Mangerioba). Revista Brasileira de Farmácia, v. 86, p. 53- 56, 2005.
Lloyd, H.A.; Jaouni, T.M.; Evans, S.L.; Morton, J.F. Terpenes of Schinus terebinthifolius. Phytochemistry, v. 16, p.1301-2, 1977.
Lopes, G. S.; Mora, O. A.; Cerri, P.; Faria, F. P.; Jurkiewicz, N. H.; Jurkiewicz A.; Smaili, S. S. Mitochondrial alterations and apoptosis in smooth muscle from aged rats. Biochimica et Biophysica Acta, v. 1658, p. 187-194, 2004.
Lucena, P. L. H.; Ribas Filho, J. M.; Mazza, M.; Czeczko, N. G.; Dietz, U. A.; Correa Neto, M. A. et al. Avaliação da ação da aroeira (Schinus terebinthifolius Raddi) na cicatrização de feridas cirúrgicas em bexiga de ratos. Acta Cirúrgica Brasileira, v. 21, p. 44-49, 2006.
Machado, D. G.; Kaster, M. P.; Binfaré, R. W.; Dias, M.; Santos, A. R. S.; Pizzolatti, M. G.; Brighente, I. M. C.; Rodrigues, A. L. S. Antidepressant-like effect of the extract from leaves of Schinus molle L. in mice: Evidence for the involvement of the
102 monoaminergic system. Progress in Neuro-Psychopharmacology & Biological Psychiatry, v. 31, p. 421–428, 2007.
Macmillan, J.; Quarrell, O. The neurobiology of Huntington’s disease. In: Harper -PS (ed) Huntington’s disease. WB Saunders, London, p. 317358, 1996.
Mandel, S.; Youdim, M. B. H. Catechin polyphenols: neurodegeneration and neuroprotection in neurodegenerative diseases. Free Radical Biology & Medicine, v. 37, n. 3, p. 304-317, 2004.
Margolis, R. L.; Ross, C. A. Expansion explosion: new clues to the pathogenesis of repeat expansion neurodegenerative diseases. Trends in Molecular Medicine, v. 7, p. 479-482, 2001.
Martinez, M. J.; Betancourt, J.; Alonso-González, N.; Jauregui, A. Screening of Cuban medicinal plants for antimicrobial activity. Journal of Ethnopharmacology, v. 52, 171-174, 1996.
Martinez, M. J.; Barreiro, M. L.; Rodriguez, Z. M.; Rubalcaba, Y. Actividad antimicrobiana de um extrato fluido 80% de Schinus terebinthifolius Raddi (copal). Revista Cubana de Plantas Medicinales, v. 5, 23-25, 2000.
Mattson, M. P. Neuronal life-and-death signaling, apoptosis, and neurodegenerative disorders. Antioxidanty Redox Signal, v. 8, p. 1997–2006, 2006.
Medoua, G. N. & Mbofung, C. M. F. Evaluation du potentiel toxicologique de La boisson préparée à partir des graines de Cassia occidentales. Food-Africa Internacional Working Meeting on Improving Food Systems in Saharan Africa, p. 5-9, 2003.
Medoua, G. N. & Mbofung, C. M. F. Kinetics studies of some physico-chemical substances during roasting and preparation of beverage made by Cassia occidentalis seeds. LWT-Food Science and Technology, v. 40, p. 730-736, 2007.
103 Milioli, E. M., P.; Cologni, C. C.; Santos, T. D.; Marcos, V. M. Yunes, M. S.; Fernandes, T.; et al. Effect of Acute Administration of Hydroalcohol Extract of Ilex paraguariensis St Hilaire (Aquifoliaceae) in Animal Models of Parkinson’s Disease. Phytotherapy Research Phytotherapy ResearchI, v. 21, p. 771-776 2007.
Miralles, J.; Gaydou, E. M. Fatty acid and sterol composition of oils from three Senegalese Cassia seeds (Caesalpiniaceae) [Cassia alata, Cassia occidentalis, Cassia siberiana]. Revue Francaise des Corps Gras, v. 33, p. 381-384, 1986.
Mourelle, J. A. F.; Cao, M. C. F. L.; Rodríguez, F. M.; Gutiérrez, Z. P. Actividad antiinflamatoria del Schinus terebinthifolius, (copal) in ratas. Revista Cubana de Farmacia, v. 27, p.139-144, 1993.
Mutairy, A-Al; Kadasah, S-Al; Elfaki, I.; Arshaduddin, M.; Malik, D.; Moutaery, K-Al; et al. Trolox ameliorates 3-nitropropionic acid-induced neurotoxicity in rats. Neurotoxicology and Teratology, v. 32, p. 226-233, 2010.
Nagaraju, N.; Rao, K. N. A Survey of Plant crude drugs of Rayalaseema, Andhra- Pradesh, India. Journal of Ethnopharmacology, v. 29, p. 137-158, 1990.
Novak, M. J. U.; Tabrizi, S. J. Huntington’s disease. BMJ, v. 341, p. 34-40, 2010.
Pérez-De La Cruz, V.; Elinos-Calderón, D.; Robledo-Arratia, Y.; Medina-Campos, O. N.; Pedraza-Chaverrí, J.; Syed, F. A. et al. Targeting oxidative/nitrergic stress ameliorates motor impairment, and attenuates synaptic mitochondrial dysfunction and lipid peroxidation in two models of Huntington’s disease. Behavioural Brain Research, v. 199, p. 210-217, 2010.
Pieribattest, J.C.; Conan, J.Y.; Grodin, J.; Vicent, E.J.; Guerere, M. Contribution a l’étude chimique des baies roses de bourbon. Annales des falsifications de L’expertise et Toxicologique, v.74, p.11-16, 1981.
104 Pires, O. C.; Taquemasa, A. V. C.; Akisue, G.; Oliveira, F.; Araújo, C. E. P. Preliminary comparative analysis of the acute toxicity and median lethal dose (LD
50)
of the fruit of the Brazilian black pepper (Schinus terebinthifolius Raddi) and black pepper (Piper nigrum L.). Acta Farmaceutica Bonaerense, La Plata, v. 23, p. 176-82, 2004.
Poon, L. H.; Kang, G. A.; Lee, A. J. Role of Tetrabenazine for Huntington's Disease– Associated Chorea. The Annals of Pharmacotherapy, v. 44, p. 1080-1089, 2010.
Queires, L. C. S.; Rodrigues, L. E. A. Quantificação das substâncias fenólicas totais em órgãos da Aroeira Schinus terebinthifolius (Raddi). Brazilian Archives of Biology and Technology, v. 41, p. 247-253, 1999.
Rai, P. P.; Shok, M. Anthraquinone glycosides from plant parts of Cassia occidentalis. Indian Journal of Pharmaceutical Sciences, v. 45, p. 87-88, 1983.
Reiner, A.; Albin, R.; Anderson, K.; D'amato, C.; Penney, J.; Young, A. Differential loss of striatal projection neurons in Huntington's Disease. Proceedings of the National Academy of Science USA, v. 85, p. 5733-5777, 1988.
Revilla, F. J. Huntington Disease. Head of Division of Movement Disorders, Department of Neurology - University of Cincinnati College of Medicine, 2008.
Rosenstock, T. R.; Carvalho, A. C. P.; Jurkiewicz, A.; Frussa-Filho, R.; Smaili, SS. Mitochondrial calcium, oxidative stress, and apoptosis in a neurodegenerative disease model induced by 3-nitopropionic acid. Journal of NeurochemistryI, v. 88, p. 1220-1228, 2004.
Rosenstock, T. R.; Abílio, V. C.; Frussa-Filho, R.; Kiyomoto, B. H.; Smaili, SS. Old mice present increased levels of succinate dehydrogenase activity and lower vulnerability to dyskinetic effects of 3-nitropropionic acid. Pharmacology Biochemistry and Behavior, v. 91, p. 327-332, 2009.
105 Ross, C.; Shoulson, I. Huntington disease: pathogenesis, biomarkers, and approaches to experimental therapeutics. Parkinsonism and Related Disorders, v. 15, p.135-138, 2009.
Roze, E.; Saudouc, F.; Caboche, J. Pathophysiology of Huntington’s disease: from huntingtin functions to potential treatments. Current Opinion in Neurology, v. 21, p. 497-503, 2008.
Ruiz, A.R.; De La Torre, R.A.; Alonso, N.; Villaescusa, A.; Betancourt, J.; Vizoso, A. Screening of medicinal plants for induction of somatic segregation activity in Aspergillus nidulans. Journal of Ethnopharmacology, v.52, p.123-127, 1996.
Ryu, J. K.; Kim, J.; Cho, S.; Hatori, K.; Nagai, A.; Choi, H. B.; et al. Proactive transplantation of human neural stem cells prevents degeneration of striatal neurons in a rat model of Huntington disease. Neurobiology of Disease, v. 16, p. 68-77, 2004.
Sadique, J.; Chandra, T.; Thenmozhi, V.; Elango, V. Biochemical modes of action of Cassia occidentalis and Cardiospermum halicacabum in inflammation. Journal of Ethnopharmacology, v. 19, p. 201-212, 1987.
Sama, S. K.; Krishnamurthy, L.; Ramachandran, K.; Krishan L. Efficacy of an Indigenous Compound Preparation (liv-52) in Acute Viral Hepatitis – a Double Blind Study. Indian Journal of Medical Research, v. 64, p. 738, 1976.
Santos, O. J.; Ribas Filho, J. M.; Czeczko, N. G.; Castelo Branco Neto, M. L.; Naufel, C.; Ferreira, L. M.; et al. Avaliação do extrato de Aroeira (Schinus terebinthifolius Raddi) no processo de cicatrização de gastrorrafias em ratos. Acta Cirúrgica Brasileira, v. 21, p. 39-45, 2006.
Saraf, S.; Dixit, V. K.; Tripathi, S. C.; Patnaik, G. K. Antihepatotoxic activity of Cassia occidentalis. International Journal of Pharmacognosy, v. 32, p. 178-183, 1994.
106 Schapira, A. H. V. Mitochondrial involvement in Parkinson's disease, Huntington's disease, hereditary spastic paraplegia and Friedreich's ataxia. Biochimica et Biophysica Acta, v. 1410, p. 159-170, 1999.
Schapira, A. H. V. Mitochondrial disease. Lancet, v. 368, p. 70-82, 2006.
Schmeda-Hirschmann, G.; Arias, A. R. A screening method for natural products on triatomine bugs. Phytotherapy Research, v. 6, p. 68-73. 1992.
Schroeter, H. Flavonoids protect neurons from oxidized low-density-lipoprotein- induced apoptosis involving c-Jun N-terminal kinase (JNK), c-Jun and caspase-3. The Biochemical Journal, v. 358, p. 547-557, 2001.
Sies, H. Strategies of antioxidant. Review. European Journal of Biochemistry, v. 215, p. 213-219, 1993.
Silva Júnior, A. A. Plantas medicinais e aromáticas (CD-ROM). Itajaí: Epagri, 1997.
Singh, R. P.; Sharad, S.; Kapur, S. Free Radicals and Oxidative Stress in Neurodegenerative Diseases: Relevance of Dietary Antioxidants. Journal, Indian Academy of Clinical Medicine, v. 5, 2004.
Soukur, J. Vocabulary of the Common Names of the Peruvian Flora and Catalog of the Genera. Editorial Salesiano, p. 436, 1970.
Souza Brito, A. R. M.; Souza Brito A. A. Forty years of Brazilian medicinal plant research. Journal Ethnopharmacology, v. 39, p. 53-67, 1993.
Spencer, J. P. E.; Vauzour, D.; Rendeiro, C. Flavonoids and cognition: The molecular mechanisms underlying their behavioral effects. Archives of Biochemictry and Biophysic, v. 492, p. 1-9, 2009.
107 Sreejith, G.; Latha, P. G.; Shine, V. J.; Anuja, G. I. Suja, S. R.; Shyama, S. et al. Anti- allergic, anti-inflamatory and anti-lipidperoxidant effects of Cassia occidentalis Linn. Indian Journal of Experimental Biology, v. 48, p. 494-498, 2010.
Stack, C.; Ho, D.; Wille, E.; Calingasan, N. Y.; Williams, C.; Liby, K.; et al. Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington's disease. Free Radical Biology & Medicine, v. 49, p. 147-158, 2010.
Tabrizi, S. J.; Cleeter, M. W.; Xuereb, J.; Taanman, J. W.; Cooper, J. M.; Schapira, A. H. Biochemical abnormalities and excitotoxicity in Huntington’s disease brain. Annals of Neurology, v. 45, p. 25-32, 1999.
Tewari, R. D.; Gupta, P. C. Component fatty acids of the oil from the seeds of Cassia occidentalis. Journal of the Oil Technologists Association, v. 9, p. 59-64, 1953.
Traber, M. G. Cellular and molecular mechanisms of oxidants and antioxidants. Mineral and Electrolyte Metabolism, Basel, v. 23, p. 135-139, 1997.
Usha, K.; Mary, K. G.; Hemalatha, P. Hepatoprotective effect of Hygrophila spinosa and Cassia occidentalis on carbon tetrachloride induced liver damage in experimental rats. Indian Journal of Clinical Biochemistry, v. 22, p. 132-135, 2007.
Velázquez, E.; Tournierb, H. A.; Buschiazzob, M. P.; Saavedra, G.; Schinella, G. R. Antioxidant activity of Paraguayan plant extracts. Fitoterapia, v. 74, p.91-97, 2003.
Veras, R. Em busca de uma assistência adequada à saúde do idoso: revisão da literatura e aplicação de um instrumento de detecção precoce e de previsibilidade de agravos. Cadernos de Saúde Pública, v. 19, p. 705-715, 2003.
Viegas, C.; Rezende, A.; Silva, D. H. S.; Castro-Gambôa, I.; Bolzani, V.S. Aspectos químicos, biológicos e entnofarmacológicos do gênero Cassia. Química Nova, v. 29, p. 1279-1286, 2006.
108 Villarán, R. F.; Tomás-Camardiel, M.; de Pablos, R. M. Santiago, M.; Herrera, A. J.; Navarro, A. et al. Endogenous dopamine enhances the neurotoxicity of 3- nitropropionic acid in the striatum through the increase of mitochondrial respiratory inhibition and free radicals production. Neurotoxicology, v. 29, 244-258, 2008.
Vonsattel, J. P. G. Huntington disease models and human neuropathology: similarities and differences. Acta Neuropathology, v. 115, p. 55-69, 2008.
Wader, G. R.; Kudav, N. A. A chemical investigation of Cassia occidentalis Linn. with special reference to isolation of xanthones from Cassia species. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, v.26, p.703,1987.
Wang, L.; Qin, Z. Animal models of Huntington’s disease: implications in uncovering pathogenic mechanisms and developing therapies. Acta Pharmacologica Sinica, v. 27, p.1287-1302, 2006.
Whitton, P. S. Inflammation as a causative factor in the etiology of Parkinson’s disease. British Journal of Pharmacology, v. 150, p. 963-976, 2007.
Yadav, J. P.; Arya, V.; Yadav, S.; Panghal, M.; Kumar, S.; Dhankhar, S. Cassia occidentalis L.: A review on its ethnobotany, phytochemical and pharmacological profile. Fitoterapia, v. 81, p. 223-230, 2010.
Yen, G. C.; Chen, H. W.; Duh, P. D. Extraction and identification of an antioxidative component from juemingzi (Cassia tora L.). Journal of Agricultural and Food Chemistry, v. 46, p. 820-824, 1998.