Em sete das 20 lâminas, tomadas aleatoriamente, a análise histopatológica mostrou em percentagens da área das peças histológicas utilizadas

com a presença de glândulas endometriais em 3,27%±2%, estroma endometrial em 6,18±5%, glândulas e estroma em 9,45±6%, tecido adiposo em 8,35±13%, perímetro recoberto por tecido adiposo em 17,21±20,9%, e fibrose em 72,5±12% (Tabela 4, p. 47). Significa isto um papel expressivo da fibrose sobre todo o padrão clássico histopatológico da endometriose de uma maneira geral, que propõe o diagnóstico de endometriose, simplesmente pela presença de estroma e/ou glândulas, aceitando ainda a visualização de macrófagos hemossiderófagos (MURPHY, 2002).

4 A análise imuno histoquímica, reforçando os achados histológicos na fisiopatologia do desenvolvimento e manutenção dos endometriomas, mostrou diferentes padrões de intensidade de coloração (Figura 3, p. 25 e Tabela 7, p. 53). Surpreendentemente, não foi encontrada significante elevação da expressão da proteína Ki-67 nas lesões endometrióticas que ora se estudam e reputa-se este achado às baixas taxas de apresentação de tecidos glandular e estromal nas lesões que foram evidentemente substituídas por intensa e extensa fibrose (Tabela 5, página 51).

5 A teletermografia digital, conforme demonstrado pela Figura 8, p. 30, indicou que, após a realização do teste de estresse pelo frio, foi observada uma assimetria teletermográfica da esquerda para a direita do corpo, mostrando um aumento de +0,6°C na temperatura mais alta do lado direito e maior número de

pontos isotérmicos de 36,7°C a 37,2°C, sugerindo indicar a presença de processos inflamatórios, os quais foram confirmados por meio da análise histopatológica, imunocitoquímica e imunohistoquímica da lesão.

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