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• A utilização de questionários, especialmente quando auto-preenchidos, sujeitam a pesquisa ao subrrelato. Apesar do questionário de Berlim ser um instrumento validado e confiável, a baixa prevalência de alto risco e baixa confiabilidade detectadas mostram que sua estrutura pode não ser adequada para essa população.

• O fato da atual pesquisa avaliar fatores como sonolência, cochilos ao volante e tabagismo, que comprometeriam a estabilidade dos trabalhadores em seus empregos, podem ter sido alguns dos grandes responsáveis pelo subrrelato.

• Por ser uma população específica de motoristas de máquinas de extração de minério de ferro, não é possível extrapolar nossos resultados para a população brasileira de trabalhadores de turnos alternantes.

7 CONCLUSÕES

• A prevalência de alto risco para AOS foi baixa quando comparada a outros estudos. Devido à alta prevalência de fatores de risco como obesidade, consumo de bebidas alcoólicas e por serem indivíduos do sexo masculino, esperava-se que essa prevalência fosse maior.

Os sintomas de AOS – sonolência ao acordar, sonolência durante o dia e dormir ao volante – apresentaram frequências inferiores a outros estudos. Dormir ao volante foi a questão que mais prejudicou a confiabilidade geral do questionário e, portanto, é necessário avaliar a sonolência considerando outras situações cotidianas para essa população.

• A presença de um entrevistador avaliando alguns dos sintomas presentes no questionário de Berlim proporcionou aumento na frequência de respostas positivas. Portanto, a utilização de questionários em presença de profissional da saúde poderia aumentar a confiança dos trabalhadores em assumir alguns dos sintomas relacionados à apnéia.

• Na população de trabalhadores o questionário de Berlim permitiu afirmar que indivíduos com estado nutricional adequado apresentam pouca probabilidade de desenvolver alto risco para AOS. Apesar disso, a grande proporção de erros de classificação e a baixa sensibilidade levam a concluir que sua utilização precisa ser melhor avaliada.

• A população avaliada apresentou alta prevalência de sobrepeso e obesidade. Também foi observado excesso de adiposidade corporal, com acúmulo de tecido adiposo na região central ou abdominal.

• Todos os indicadores de adiposidade corporal apresentaram relação positiva com o alto risco para AOS e podem, portanto, ser utilizados na prática clínica para avaliar o risco do trabalhador para desenvolver AOS.

• Idade maior que 40 anos e obesidade foram os fatores capazes de explicar a ocorrência de alto risco para AOS nessa população.

8 RECOMENDAÇÕES

O questionário desenvolvido e validado por Chung et al., o STOP-BANG Questionnaire foi elaborado a partir do questionário de Berlim. É uma ferramenta que inclui 8 questões com respostas sim/não, sendo elas: presença de ronco intenso; presença de cansaço, fadiga e sonolência excessivos; presença de pausas na respiração observadas por terceiros; hipertensão arterial sistêmica; IMC > 35kg/m²; idade > 50 anos; CP > 40 cm; gênero masculino. Trata-se de um questionário direto, que avalia os principais fatores relacionados à AOS e não inclui as 2 questões que prejudicaram a confiabilidade do questionário de Berlim no presente estudo (“Você ronca?” e “Já dormiu enquanto dirigia?”). Por esse motivo, recomenda-se que seja testado e validado na população de operadores de máquinas da Região dos Inconfidentes, MG.

• Todos os indicadores de adiposidade corporal utilizados neste estudo estiveram relacionados ao alto risco para apnéia e, portanto, podem ser incluídos em inquéritos clínicos para avaliar o risco desses trabalhadores de desenvolverem AOS.

• Para avaliar o grau de atividade física destes trabalhadores, recomenda-se a realização de outros estudos considerando apenas a seção 4 do IPAQ, que avalia somente situações de lazer, recreação e esportes. Isso evitaria a superestimação da real quantidade de exercício físico praticado pelos indivíduos.

• É necessário que os indivíduos avaliados neste estudo sejam submetidos à polissonografia para efetivar o diagnóstico de apnéia obstrutiva do sono. Assim, será possível determinar especificidade, sensibilidade e validade do questionário de Berlim para essa população, reprovando ou não sua adequação para indicar o alto risco para apnéia. Além disso, será possível decidir qual o melhor tratamento da apnéia de acordo com as características de cada trabalhador afetado.

9 REFERÊNCIAS BIBLIOGRÁFICAS

1. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, Jr., et al. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA. 2003;289(19):2560-72.

2. Young T, Finn L, Peppard PE, Szklo-Coxe M, Austin D, Nieto FJ, et al. Sleep disordered breathing and mortality: eighteen-year follow-up of the Wisconsin sleep cohort. Sleep. 2008 Aug;31(8):1071-8.

3. Flemons WW, Whitelaw WA, Brant R, Remmers JE. Likelihood ratios for a sleep apnea clinical prediction rule. Am J Respir Crit Care Med. 1994;150(5 Pt 1):1279-85.

4. Pang KP, Terris DJ. Screening for obstructive sleep apnea: an evidence-based analysis. Am J Otolaryngol. 2006 Mar-Apr;27(2):112-8.

5. Bouloukaki I, Kapsimalis F, Mermigkis C, Kryger M, Tzanakis N, Panagou P, et al. Prediction of obstructive sleep apnea syndrome in a large Greek population. Sleep Breath. 2011;15(4):657-64.

6. Duran J, Esnaola S, Rubio R, Iztueta A. Obstructive sleep apnea-hypopnea and related clinical features in a population-based sample of subjects aged 30 to 70 yr. Am J Respir Crit Care Med. 2001;163(3 Pt 1):685-9.

7. Tufik S, Santos-Silva R, Taddei JA, Bittencourt LR. Obstructive sleep apnea syndrome in the Sao Paulo Epidemiologic Sleep Study. Sleep Med. 2010 May;11(5):441-6. 8. Lorenzi-Filho G, Rodrigues Genta P, Drager LF. Sleep apnea in focus. Revista portuguesa de pneumologia. 2011 Mar-Apr;17(2):51-2.

9. Young T, Evans L, Finn L, Palta M. Estimation of the clinically diagnosed proportion of sleep apnea syndrome in middle-aged men and women. Sleep. 1997 Sep;20(9):705-6. 10. Cintra F, Tufik S, Paola A, Feres M, Melo-Fujita L, Oliveira W, et al. Perfil cardiovascular em pacientes com apneia obstrutiva do sono. Arquivos Brasileiros de Cardiologia. 2011;96(4):293-9.

11. American Academy of Sleep Medicine. Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. The Report of an American Academy of Sleep Medicine Task Force. Sleep. 1999;22(5):667- 89.

12. Tufik S. Medicina e biologia do sono: Manole; 2008.

13. Martins AB, Tufik S, Moura SMGPT. Síndrome da apnéia-hipopnéia obstrutiva do sono. Fisiopatologia. J Bras Pneumol. 2007;33(1):93-100.

14. Epstein LJ, Kristo D, Strollo PJ, Jr., Friedman N, Malhotra A, Patil SP, et al. Clinical guideline for the evaluation, management and long-term care of obstructive sleep apnea in adults. J Clin Sleep Med. 2009;5(3):263-76.

15. Jennum P, Riha RL. Epidemiology of sleep apnoea/hypopnoea syndrome and sleep- disordered breathing. Eur Respir J. 2009 Apr;33(4):907-14.

16. Bixler EO, Vgontzas AN, Ten Have T, Tyson K, Kales A. Effects of age on sleep apnea in men: I. Prevalence and severity. Am J Respir Crit Care Med. 1998;157(1):144-8. 17. Botros N, Concato J, Mohsenin V, Selim B, Doctor K, Yaggi HK. Obstructive sleep apnea as a risk factor for type 2 diabetes. Am J Med. 2009;122(12):1122-7.

18. Garrigue S, Pepin JL, Defaye P, Murgatroyd F, Poezevara Y, Clementy J, et al. High prevalence of sleep apnea syndrome in patients with long-term pacing: the European Multicenter Polysomnographic Study. Circulation. 2007;115(13):1703-9.

19. Namen AM, Dunagan DP, Fleischer A, Tillett J, Barnett M, McCall WV, et al. Increased physician-reported sleep apnea: the National Ambulatory Medical Care Survey. Chest. 2002 Jun;121(6):1741-7.

20. Soriano-Co M, Vanhecke TE, Franklin BA, Sangal RB, Hakmeh B, McCullough PA. Increased central adiposity in morbidly obese patients with obstructive sleep apnoea. Intern Med J. 2011 Jul;41(7):560-6.

21. Young T, Peppard PE, Gottlieb DJ. Epidemiology of obstructive sleep apnea: a population health perspective. Am J Respir Crit Care Med. 2002 May 1;165(9):1217-39. 22. Young T, Shahar E, Nieto FJ, Redline S, Newman AB, Gottlieb DJ, et al. Predictors of sleep-disordered breathing in community-dwelling adults: the Sleep Heart Health Study. Arch Intern Med. 2002 Apr 22;162(8):893-900.

23. Drager LF, Genta PR, Pedrosa RP, Nerbass FB, Gonzaga CC, Krieger EM, et al. Characteristics and Predictors of Obstructive Sleep Apnea in Patients With Systemic Hypertension. The American Journal of Cardiology. 2010;105(8):1135-9.

24. Hiestand DM, Britz P, Goldman M, Phillips B. Prevalence of symptoms and risk of sleep apnea in the US population: Results from the national sleep foundation sleep in America 2005 poll. Chest. 2006 Sep;130(3):780-6.

25. Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S. The occurrence of sleep- disordered breathing among middle-aged adults. N Engl J Med. 1993 Apr 29;328(17):1230-5. 26. Punjabi NM. The epidemiology of adult obstructive sleep apnea. Proc Am Thorac Soc. 2008 Feb 15;5(2):136-43.

27. Paim SL, Pires ML, Bittencourt LR, Silva RS, Santos RF, Esteves AM, et al. Sleep complaints and polysomnographic findings: a study of nuclear power plant shift workers. Chronobiol Int. 2008 Apr;25(2):321-31.

28. Bixler EO, Vgontzas AN, Lin HM, Ten Have T, Leiby BE, Vela-Bueno A, et al. Association of hypertension and sleep-disordered breathing. Arch Intern Med. 2000;160(15):2289-95.

29. Lavie P, Herer P, Hoffstein V. Obstructive sleep apnoea syndrome as a risk factor for hypertension: population study. BMJ. 2000 Feb 19;320(7233):479-82.

30. Fung JW, Li TS, Choy DK, Yip GW, Ko FW, Sanderson JE, et al. Severe obstructive sleep apnea is associated with left ventricular diastolic dysfunction. Chest. 2002;121(2):422- 9.

31. Shahar E, Whitney CW, Redline S, Lee ET, Newman AB, Javier Nieto F, et al. Sleep- disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health Study. Am J Respir Crit Care Med. 2001 Jan;163(1):19-25.

32. Resnick HE, Redline S, Shahar E, Gilpin A, Newman A, Walter R, et al. Diabetes and sleep disturbances: findings from the Sleep Heart Health Study. Diabetes Care. 2003 Mar;26(3):702-9.

33. Ip MS, Lam KS, Ho C, Tsang KW, Lam W. Serum leptin and vascular risk factors in obstructive sleep apnea. Chest. 2000 Sep;118(3):580-6.

34. Drager LF, Bortolotto LA, Lorenzi MC, Figueiredo AC, Krieger EM, Lorenzi-Filho G. Early signs of atherosclerosis in obstructive sleep apnea. Am J Respir Crit Care Med. 2005;172(5):613-8.

35. Drager LF, Bortolotto LA, Maki-Nunes C, Trombetta IC, Alves MJNN, Fraga RF, et al. The incremental role of obstructive sleep apnoea on markers of atherosclerosis in patients with metabolic syndrome. Atherosclerosis. 2010;208(2):490-5.

36. Akerstedt T. Shift work and disturbed sleep/wakefulness. Occup Med (Lond). 2003;53(2):89-94.

37. Silva E, Chaffin R, Silva-Neto V, Siqueira-Júnior C. Impactos gerados pelo trabalho em turnos. Perspectivas Online. 2010;4(13):65.

38. Paoli P, Merllie´ D, editors. Third European Survey on Working Conditions, 2000. European Foundation for the Improvement of Living and Working Conditions. Luxembourg: Office for Official Publications of the European Communities; 2001.

39. Simões MRL, Marques FC, Rocha AdM. O trabalho em turnos alternados e seus efeitos no cotidiano do trabalhador no beneficiamento de grãos. Rev Latino-Am Enfermagem. 2010;18(6):1-7.

40. Gerber M, Hartmann T, Brand S, Holsboer-Trachsler E, Pühse U. The relationship between shift work, perceived stress, sleep and health in Swiss police officers. Journal of Criminal Justice. 2010;38(6):1167-75.

41. Spiegel K, Leproult R, L'Hermite-Baleriaux M, Copinschi G, Penev PD, Van Cauter E. Leptin levels are dependent on sleep duration: relationships with sympathovagal balance, carbohydrate regulation, cortisol, and thyrotropin. J Clin Endocrinol Metab. 2004 Nov;89(11):5762-71.

42. Moreno CR, Carvalho FA, Lorenzi C, Matuzaki LS, Prezotti S, Bighetti P, et al. High risk for obstructive sleep apnea in truck drivers estimated by the Berlin questionnaire: prevalence and associated factors. Chronobiol Int. 2004;21(6):871-9.

43. Ghiasvand M, Heshmat R, Golpira R, Haghpanah V, Soleimani A, Shoushtarizadeh P, et al. Shift working and risk of lipid disorders: a cross-sectional study. Lipids Health Dis. 2006;5:9.

44. Redline S, Strohl KP. Recognition and consequences of obstructive sleep apnea hypopnea syndrome. Clin Chest Med. 1998 Mar;19(1):1-19.

45. Aza MG, Gómez-Abellán P, Pérez JAM. Chronobiology and metabolic syndrome. An interesting relationship. Revista Española de Obesidad. 2009;7(2):73-86.

46. Silveira JA, Oliveira KT, Batista RA, Ferreira LS, Couto HA. Impacto da sonolência excessiva na qualidade de vida e a influência do regime de turno de trabalho. Rev Med Minas Gerais. 2010;20(2):203-11.

47. Pietroiusti A, Neri A, Somma G, Coppeta L, Iavicoli I, Bergamaschi A, et al. Incidence of metabolic syndrome among night-shift healthcare workers. Occup Environ Med. 2010 Jan;67(1):54-7.

48. Fujino Y, Iso H, Tamakoshi A, Inaba Y, Koizumi A, Kubo T, et al. A prospective cohort study of shift work and risk of ischemic heart disease in Japanese male workers. Am J Epidemiol. 2006;164(2):128-35.

49. Tuchsen F, Hannerz H, Burr H. A 12 year prospective study of circulatory disease among Danish shift workers. Occup Environ Med. 2006 Jul;63(7):451-5.

50. Folkard S, Tucker P. Shift work, safety and productivity. Occup Med (Lond). 2003;53(2):95-101.

51. Pilcher JJ, Lambert BJ, Huffcutt AI. Differential effects of permanent and rotating shifts on self-report sleep length: a meta-analytic review. Sleep. 2000 Mar 15;23(2):155-63. 52. Santos EH, de Mello MT, Pradella-Hallinan M, Luchesi L, Pires ML, Tufik S. Sleep and sleepiness among Brazilian shift-working bus drivers. Chronobiol Int. 2004;21(6):881-8. 53. Dziewas R, Humpert M, Hopmann B, Kloska SP, Ludemann P, Ritter M, et al. Increased prevalence of sleep apnea in patients with recurring ischemic stroke compared with first stroke victims. J Neurol. 2005 Nov;252(11):1394-8.

54. Sorajja D, Gami AS, Somers VK, Behrenbeck TR, Garcia-Touchard A, Lopez- Jimenez F. Independent association between obstructive sleep apnea and subclinical coronary artery disease. Chest. 2008 Apr;133(4):927-33.

55. Al Lawati NM, Patel SR, Ayas NT. Epidemiology, risk factors, and consequences of obstructive sleep apnea and short sleep duration. Prog Cardiovasc Dis. 2009;51(4):285-93. 56. Czeisler CA, Johnson MP, Duffy JF, Brown EN, Ronda JM, Kronauer RE. Exposure to bright light and darkness to treat physiologic maladaptation to night work. N Engl J Med. 1990;322(18):1253-9.

57. Swanson LM, Arnedt JT, Rosekind MR, Belenky G, Balkin TJ, Drake C. Sleep disorders and work performance: findings from the 2008 National Sleep Foundation Sleep in America poll. J Sleep Res. 2011 Sep;20(3):487-94.

58. Lindberg E, Carter N, Gislason T, Janson C. Role of snoring and daytime sleepiness in occupational accidents. Am J Respir Crit Care Med. 2001 Dec 1;164(11):2031-5.

59. Spengler SE, Browning SR, Reed DB. Sleep deprivation and injuries in part-time Kentucky farmers: impact of self reported sleep habits and sleep problems on injury risk. AAOHN J. 2004 Sep;52(9):373-82.

60. Ulfberg J, Carter N, Talback M, Edling C. Excessive daytime sleepiness at work and subjective work performance in the general population and among heavy snorers and patients with obstructive sleep apnea. Chest. 1996 Sep;110(3):659-63.

61. Horstmann S, Hess CW, Bassetti C, Gugger M, Mathis J. Sleepiness-related accidents in sleep apnea patients. Sleep. 2000 May 1;23(3):383-9.

62. Kezirian EJ, Harrison SL, Ancoli-Israel S, Redline S, Ensrud K, Goldberg AN, et al. Behavioral correlates of sleep-disordered breathing in older men. Sleep. 2009 Feb;32(2):253-61.

63. Li C, Ford ES, Zhao G, Croft JB, Balluz LS, Mokdad AH. Prevalence of self-reported clinically diagnosed sleep apnea according to obesity status in men and women: National Health and Nutrition Examination Survey, 2005-2006. Prev Med. 2010 Jul;51(1):18-23. 64. Foley DJ, Monjan AA, Brown SL, Simonsick EM, Wallace RB, Blazer DG. Sleep complaints among elderly persons: an epidemiologic study of three communities. Sleep. 1995;18(6):425-32.

65. Shinohara E, Kihara S, Yamashita S, Yamane M, Nishida M, Arai T, et al. Visceral fat accumulation as an important risk factor for obstructive sleep apnoea syndrome in obese subjects. J Intern Med. 1997 Jan;241(1):11-8.

66. Martin SE, Mathur R, Marshall I, Douglas NJ. The effect of age, sex, obesity and posture on upper airway size. Eur Respir J. 1997 Sep;10(9):2087-90.

67. Bixler EO, Vgontzas AN, Lin HM, Ten Have T, Rein J, Vela-Bueno A, et al. Prevalence of sleep-disordered breathing in women: effects of gender. Am J Respir Crit Care Med. 2001;163(3 Pt 1):608-13.

68. Jordan AS, McEvoy RD, Edwards JK, Schory K, Yang CK, Catcheside PG, et al. The influence of gender and upper airway resistance on the ventilatory response to arousal in obstructive sleep apnoea in humans. J Physiol. 2004 Aug 1;558(Pt 3):993-1004.

69. Zhou XS, Rowley JA, Demirovic F, Diamond MP, Badr MS. Effect of testosterone on the apneic threshold in women during NREM sleep. J Appl Physiol. 2003 Jan;94(1):101-7. 70. Kuk JL, Lee S, Heymsfield SB, Ross R. Waist circumference and abdominal adipose tissue distribution: influence of age and sex. Am J Clin Nutr. 2005 Jun;81(6):1330-4.

71. Wetter DW, Young TB, Bidwell TR, Badr MS, Palta M. Smoking as a risk factor for sleep-disordered breathing. Arch Intern Med. 1994 Oct 10;154(19):2219-24.

72. Kashyap R, Hock LM, Bowman TJ. Higher prevalence of smoking in patients diagnosed as having obstructive sleep apnea. Sleep Breath. 2001 Dec;5(4):167-72.

73. Saint-Mleux B, Eggermann E, Bisetti A, Bayer L, Machard D, Jones BE, et al. Nicotinic enhancement of the noradrenergic inhibition of sleep-promoting neurons in the ventrolateral preoptic area. J Neurosci. 2004 Jan 7;24(1):63-7.

74. Wetter DW, Fiore MC, Baker TB, Young TB. Tobacco withdrawal and nicotine replacement influence objective measures of sleep. J Consult Clin Psychol. 1995 Aug;63(4):658-67.

75. Zhang L, Samet J, Caffo B, Punjabi NM. Cigarette smoking and nocturnal sleep architecture. Am J Epidemiol. 2006 Sep 15;164(6):529-37.

76. Mitler MM, Dawson A, Henriksen SJ, Sobers M, Bloom FE. Bedtime ethanol increases resistance of upper airways and produces sleep apneas in asymptomatic snorers. Alcohol Clin Exp Res. 1988 Dec;12(6):801-5.

77. Taasan VC, Block AJ, Boysen PG, Wynne JW. Alcohol increases sleep apnea and oxygen desaturation in asymptomatic men. Am J Med. 1981 Aug;71(2):240-5.

78. Sakurai S, Cui R, Tanigawa T, Yamagishi K, Iso H. Alcohol consumption before sleep is associated with severity of sleep-disordered breathing among professional Japanese truck drivers. Alcohol Clin Exp Res. 2007 Dec;31(12):2053-8. PubMed PMID: 18034698.

79. Scanlan MF, Roebuck T, Little PJ, Redman JR, Naughton MT. Effect of moderate alcohol upon obstructive sleep apnoea. Eur Respir J. 2000 Nov;16(5):909-13.

80. Tsutsumi W, Miyazaki S, Itasaka Y, Togawa K. Influence of alcohol on respiratory disturbance during sleep. Psychiatry Clin Neurosci. 2000 Jun;54(3):332-3.

81. Peppard PE, Austin D, Brown RL. Association of alcohol consumption and sleep disordered breathing in men and women. J Clin Sleep Med. 2007 Apr 15;3(3):265-70.

82. Stradling JR, Crosby JH. Predictors and prevalence of obstructive sleep apnoea and snoring in 1001 middle aged men. Thorax. 1991 Feb;46(2):85-90.

83. Bonora M, Shields GI, Knuth SL, Bartlett D, Jr., St John WM. Selective depression by ethanol of upper airway respiratory motor activity in cats. Am Rev Respir Dis. 1984;130(2):156-61.

84. Krol RC, Knuth SL, Bartlett D, Jr. Selective reduction of genioglossal muscle activity by alcohol in normal human subjects. Am Rev Respir Dis. 1984 Feb;129(2):247-50.

85. Bickelmann AG, Burwell CS, Robin ED, Whaley RD. Extreme obesity associated with alveolar hypoventilation; a Pickwickian syndrome. Am J Med. 1956;21(5):811-8.

86. Young T, Peppard PE, Taheri S. Excess weight and sleep-disordered breathing. J Appl Physiol. 2005 Oct;99(4):1592-9.

87. Young T, Skatrud J, Peppard PE. Risk factors for obstructive sleep apnea in adults. JAMA. 2004 Apr 28;291(16):2013-6.

88. Peppard PE, Young T, Palta M, Dempsey J, Skatrud J. Longitudinal study of moderate weight change and sleep-disordered breathing. JAMA. 2000 Dec 20;284(23):3015- 21.

89. Patel SR, Hu FB. Short sleep duration and weight gain: a systematic review. Obesity (Silver Spring). 2008 Mar;16(3):643-53.

90. Patel SR, Malhotra A, White DP, Gottlieb DJ, Hu FB. Association between reduced sleep and weight gain in women. Am J Epidemiol. 2006 Nov 15;164(10):947-54.

91. Giebelhaus V, Strohl KP, Lormes W, Lehmann M, Netzer N. Physical Exercise as an Adjunct Therapy in Sleep Apnea-An Open Trial. Sleep Breath. 2000;4(4):173-6.

92. Norman JF, Von Essen SG, Fuchs RH, McElligott M. Exercise training effect on obstructive sleep apnea syndrome. Sleep Res Online. 2000;3(3):121-9.

93. Ahima RS, Saper CB, Flier JS, Elmquist JK. Leptin regulation of neuroendocrine systems. Front Neuroendocrinol. 2000;21(3):263-307.

94. van der Lely AJ, Tschop M, Heiman ML, Ghigo E. Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev. 2004 Jun;25(3):426-57.

95. Spiegel K, Tasali E, Penev P, Van Cauter E. Brief communication: Sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite. Ann Intern Med. 2004 Dec 7;141(11):846-50.

96. Vener KJ, Szabo S, Moore JG. The effect of shift work on gastrointestinal (GI) function: a review. Chronobiologia. 1989 Oct-Dec;16(4):421-39.

97. Taheri S, Lin L, Austin D, Young T, Mignot E. Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index. PLoS Med. 2004 Dec;1(3):e62.

98. Lennernäs MAC, Åkerstedt T, Hagman U, Bruce Å, Hambraeus L. A new approach for evaluation of meal quality and meal patterns. Journal of Human Nutrition and Dietetics. 1993;6(3):261-73.

99. Sarni R. Avaliação antropométrica e de composição corporal. In: Silva M, Mura J, editors. Tratado de alimentação, nutrição de dietoterapia. São Paulo: Roca; 2007. p. 131-40. 100. Nacif M, Viebig R. Avaliação antropométrica no ciclo da vida: uma visão prática. 2nd ed. São Paullo: Metha; 2011. 168 p.

101. Ryo M, Maeda K, Onda T, Katashima M, Okumiya A, Nishida M, et al. A new simple method for the measurement of visceral fat accumulation by bioelectrical impedance. Diabetes Care. 2005 Feb;28(2):451-3.

102. Talluri T, Lietdke RJ, Evangelisti A, Talluri J, Maggia G. Fat-free mass qualitative assessment with bioelectric impedance analysis (BIA). Ann N Y Acad Sci. 1999 Apr 20;873:94-8.

103. Baumgartner RN, Chumlea WC, Roche AF. Estimation of body composition from bioelectric impedance of body segments. Am J Clin Nutr. 1989 Aug;50(2):221-6.

104. Segal KR, Van Loan M, Fitzgerald PI, Hodgdon JA, Van Itallie TB. Lean body mass estimation by bioelectrical impedance analysis: a four-site cross-validation study. Am J Clin Nutr. 1988 Jan;47(1):7-14.

105. Davies RJ, Ali NJ, Stradling JR. Neck circumference and other clinical features in the diagnosis of the obstructive sleep apnoea syndrome. Thorax. 1992;47(2):101-5.

106. Hoffstein V, Mateika S. Differences in abdominal and neck circumferences in patients with and without obstructive sleep apnoea. Eur Respir J. 1992 Apr;5(4):377-81.

107. Mortimore IL, Marshall I, Wraith PK, Sellar RJ, Douglas NJ. Neck and total body fat

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