FIGURA 18 – Sumário esquemático dos resultados representando o efeito do exercício físico no controle da biodisponibilidade do NO. As indicações assinaladas com setas contínuas ( )são observações provenientes do presente estudo e as indicações com setas tracejadas ( ) são resultados provenientes da literatura e são discutidos acima.
7 CONCLUSÃO
A partir dos resultados obtidos, pode-se concluir que o exercício físico aeróbico melhora a função vasomotora dependente do endotélio em aorta de ratos
NO
O2-
NAD(P)H oxidase
Exercício Físico:
shear stress
eNOS H
2O
2 Estresse oxidativo SOD sinalização aguda resultados literatura Função Endotelial crônicanormais e que esse efeito é garantido por um aumento na biodisponibilidade do óxido nítrico vascular. Por sua vez, a maior biodisponibilidade de NO ocorre devido a sua síntese aumentada pela eNOS e é auxiliada pela maior ativação da SOD uma vez que a produção de superóxido também é aumentada em função da ativação da NADP(H) oxidase.
O exercício físico também aumenta a formação do peróxido de hidrogênio nos vasos e apesar da maior produção de espécies reativas de oxigênio, a realização do esforço moderado (55-60% capacidade máxima) não está associada a uma situação de estresse oxidativo vascular.
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