Análise dos desfechos maternos, fetais e neonatais na gravidez de pacientes com lúpus eritematoso sistêmico / Marcela Ignacchiti Lacerda Ávila – 2021. O objetivo desta tese foi avaliar os desfechos da gravidez em um grupo de gestantes com lúpus eritematoso sistêmico, com foco no impacto da nefrite lúpica, particularmente a glomerulonefrite proliferativa (GNP) e o conhecimento de danos permanentes (SDI) acumulados antes da gravidez, como fatores de risco associados a resultados maternos, fetais e neonatais adversos. Proporcionalmente ao aumento da sobrevida, nas últimas décadas, também houve aumento de internações e de morbidade e danos permanentes em pacientes com LES e NL, principalmente devido às complicações inerentes à doença, ao seu tratamento e comorbidades. como aterosclerose, diabetes mellitus e osteoporose (22).
Entretanto, nem todos os pacientes com esses marcadores apresentam doença ativa, e para determinar a ativação não é recomendado confiar apenas em um desses parâmetros devido à natureza multissistêmica do lúpus e à flutuação da atividade intra e interpaciente (é) ao longo do período. tempo (37-39). Ambos os estudos apresentaram pacientes com nefrite em remissão, com taxas de reativação renal próximas de 10–15%, semelhantes às descritas na literatura (60). Em geral, os pacientes com NL apresentam maior morbidade, incluindo eclâmpsia, acidente vascular cerebral e morte (45).
O estudo 2 desta tese, no entanto, analisou o impacto potencial do ICS > 1 no início do pré-natal sobre resultados adversos da gravidez e mostrou que gestantes com ICS > 1 podem ter maior risco de resultados adversos maternos, fetais e neonatais quando comparadas . naqueles com SDI = 0. A maioria dos pacientes com LES é acometida pela doença na fase reprodutiva da vida, e uma gravidez nesse grupo não é incomum na prática clínica. Embora vários estudos tenham analisado a evolução e os fatores associados a desfechos adversos na gravidez em pacientes com LES, poucos foram realizados em países em desenvolvimento como o Brasil.
Avaliar os resultados maternos, fetais e neonatais em uma coorte de gestantes com lúpus eritematoso sistêmico.
Objetivos específicos
SLE activity at conception and during pregnancy was measured by the Systemic Lupus Erythematosus Disease Activity Index (SLEPDAI), as well as steroid and/or immunosuppressive adjustments due to active disease. Update of the revised American College of Rheumatology criteria for the classification of systemic lupus erythematosus. Clinical profile of pregnant women with systemic lupus erythematosus Hospital de Clínicas FUPR.
Systemic lupus erythematosus and risk of preterm birth: a systematic review and meta-analysis of observational studies. EULAR recommendations for women's health and the management of family planning, assisted reproduction, pregnancy and menopause in patients with systemic lupus erythematosus and/or antiphospholipid syndrome. The clinical utility of measuring complement and anti-dsDNA antibodies during pregnancy in patients with systemic lupus erythematosus.
Impact of hydroxychloroquine on preterm delivery and intrauterine growth restriction in pregnant women with systemic lupus erythematosus: a descriptive cohort study. Systemic lupus erythematosus (SLE) mainly affects women of reproductive age and pregnancy is common in this population.
Materials and Methods
Measures of disease activity and damage in pediatric systemic lupus erythematosus: British Isles Lupus Assessment Group (BILAG), European Consensus Lupus Activity Measurement (ECLAM), Systemic Lupus Activity Measure (SLAM), Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), Physician's Global Assessment of disease activity (MD Global), and systemic lupus international collaborating clinics/American College of Rheumatology Damage Index (SLICC/ACR DI; SDI). Early damage as measured by the SLICC/ACR damage index is a predictor of mortality in systemic lupus erythematosus, Lupus. The systemic lupus international collaborating clinics/ American College of Rheumatology (SLICC/ACR) damage index for systemic lupus erythematosus international comparison.
Predictors of postnatal damage accumulate in systemic lupus erythematosus: data from LUMINA, an American multiethnic cohort (XXXVIII), Rheumatology (Oxford). Factors associated with damage accumulation in patients with systemic lupus erythematosus: results from the initial Systemic Lupus International Collaborating Clinics (SLICC) Cohort. Incidence and risk factors for hospitalizations in systemic lupus erythematosus: a prospective study of the Hopkins Lupus Cohort.
Rate and risk factors for frequent hospitalization in systemic lupus erythematosus: results from the Korean Lupus Network Registry. Early injury as measured by the SLICC/ACR Injury Index is a predictor of hospitalization in systemic lupus erythematosus (SLE). Early injury as measured by the SLICC/ACR injury index is a predictor of mortality in systemic lupus erythematosus.
The development and initial validation of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index for systemic lupus erythematosus. The reliability of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index in patients with systemic lupus erythematosus. High predictive value of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology damage index for survival in systemic lupus erythematosus.
Initial and accumulated damage as predictors of mortality in Brazilian patients with systemic lupus erythematosus: a cohort study. Assessment of patients with systemic lupus erythematosus and use of lupus disease activity indices. Reliability and validity of the Systemic Lupus Activity Measure-Revised (SLAM-R) for measuring clinical disease activity in systemic lupus erythematosus.
Identification of clinical predictors of flare in patients with systemic lupus erythematosus: a 24-month prospective cohort study. A systematic review and meta-analysis of pregnancy outcomes in patients with systemic lupus erythematosus and lupus nephritis. Predictors of postnatal injury increase in systemic lupus erythematosus: data from LUMINA, a US multiethnic cohort (XXXVIII).
Objective: To analyze the incidence and risk factors associated with infections during pregnancy in patients with systemic lupus erythematosus (SLE).
